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Protein

CRISPR-associated endoribonuclease Cas2 2

Gene

cas22

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette (By similarity).By similarity1 Publication

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi8Magnesium; catalyticSequence analysis1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
Biological processAntiviral defense
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
CRISPR-associated endoribonuclease Cas2 2 (EC:3.1.-.-)
Gene namesi
Name:cas22
Ordered Locus Names:SSO8090
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004169521 – 88CRISPR-associated endoribonuclease Cas2 2Add BLAST88

Proteomic databases

PRIDEiQ97Y85

Interactioni

Subunit structurei

Homodimer, forms a heterotetramer with a Cas1 homodimer.By similarity

Structurei

Secondary structure

188
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 8Combined sources7
Helixi12 – 24Combined sources13
Beta strandi28 – 31Combined sources4
Beta strandi34 – 38Combined sources5
Helixi44 – 54Combined sources11
Turni57 – 59Combined sources3
Beta strandi61 – 67Combined sources7
Helixi69 – 73Combined sources5

3D structure databases

ProteinModelPortaliQ97Y85
SMRiQ97Y85
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ97Y85

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

InParanoidiQ97Y85
KOiK09951
OMAiARCANAQ
OrthoDBiPOG093Z0JHJ

Family and domain databases

HAMAPiMF_01471 Cas2, 1 hit
InterProiView protein in InterPro
IPR021127 CRISPR_associated_Cas2
IPR019199 Virulence_VapD/CRISPR_Cas2
PANTHERiPTHR34405 PTHR34405, 1 hit
PfamiView protein in Pfam
PF09827 CRISPR_Cas2, 1 hit
TIGRFAMsiTIGR01573 cas2, 1 hit

Sequencei

Sequence statusi: Complete.

Q97Y85-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLVVYDVS DDSKRNKLAN NLKKLGLERI QRSAFEGDID SQRVKDLVRV
60 70 80
VKLIVDTNTD IVHIIPLGIR DWERRIVIGR EGLEEWLV
Length:88
Mass (Da):10,224
Last modified:October 1, 2001 - v1
Checksum:i870148D1138A7930
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA Translation: AAK54438.1
RefSeqiWP_009990820.1, NC_002754.1

Genome annotation databases

EnsemblBacteriaiAAK54438; AAK54438; SSO8090
GeneIDi27427816
KEGGisso:SSO8090
PATRICifig|273057.12.peg.1479

Similar proteinsi

Entry informationi

Entry nameiCAS2B_SULSO
AccessioniPrimary (citable) accession number: Q97Y85
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: October 1, 2001
Last modified: May 23, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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