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UniProtKB - Q97UY8 (GLCV_SACS2)
Protein
Glucose import ATP-binding protein GlcV
Gene
glcV
Organism
Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus)
Status
Functioni
Part of the ABC transporter complex GlcSTUV involved in glucose uptake (Probable). Responsible for energy coupling to the transport system (PubMed:12823973, PubMed:14607117).
In vitro, as a free subunit, exhibits a constitutive ATPase activity (PubMed:11807278).
2 Publications3 PublicationsCatalytic activityi
- This reaction proceeds in the forward1 Publication direction.
Kineticsi
- KM=290 µM for ATP1 Publication
pH dependencei
Optimum pH is 6.5 for ATPase activity.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 89 | ATP1 Publication | 1 | |
Binding sitei | 166 | ATP1 Publication | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 40 – 46 | ATP1 Publication | 7 |
GO - Molecular functioni
- ABC-type ferric iron transporter activity Source: InterPro
- ATP binding Source: UniProtKB-KW
GO - Biological processi
- carbohydrate transport Source: UniProtKB-KW
Keywordsi
Molecular function | Translocase |
Biological process | Sugar transport, Transport |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 7.5.2.B8, 6163 |
Protein family/group databases
TCDBi | 3.A.1.1.13, the atp-binding cassette (abc) superfamily |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:glcV1 Publication Ordered Locus Names:SSO2850Imported |
Organismi | Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) |
Taxonomic identifieri | 273057 [NCBI] |
Taxonomic lineagei | Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Saccharolobus › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Peripheral membrane protein Curated
Plasma Membrane
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 142 | S → A: Decrease in ATPase activity. Can form dimers. 1 Publication | 1 | |
Mutagenesisi | 144 | G → A: Loss of ATPase activity. Cannot form dimers. Forms an active heterodimer; when associated with A-166. 1 Publication | 1 | |
Mutagenesisi | 166 | E → A: Loss of ATPase activity. Can form dimers in the presence of ATP-Mg(2+). Forms an active heterodimer; when associated with A-144. 1 Publication | 1 | |
Mutagenesisi | 166 | E → Q: Strong decrease in ATPase activity. Can form dimers in the presence of ATP alone, without Mg(2+). 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000447615 | 1 – 353 | Glucose import ATP-binding protein GlcVAdd BLAST | 353 |
Interactioni
Subunit structurei
The complex is composed of two ATP-binding proteins (GlcV), two transmembrane proteins (GlcT and GlcU) and a solute-binding protein (GlcS) (Probable). Forms transient head-to-tail homodimers in the presence of ATP-Mg2+ (PubMed:14607117).
1 Publication1 PublicationProtein-protein interaction databases
STRINGi | 273057.SSO2850 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q97UY8 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q97UY8 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 241 | ABC transporterPROSITE-ProRule annotationAdd BLAST | 238 |
Domaini
Consists of a typical ABC-ATPase domain, comprising two subdomains, connected by a linker region to a C-terminal domain of unknown function.1 Publication
Sequence similaritiesi
Belongs to the ABC transporter superfamily.
Phylogenomic databases
eggNOGi | arCOG00175, Archaea |
HOGENOMi | CLU_000604_1_1_2 |
InParanoidi | Q97UY8 |
OMAi | VRKNMSF |
PhylomeDBi | Q97UY8 |
Family and domain databases
CDDi | cd03259, ABC_Carb_Solutes_like, 1 hit |
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003439, ABC_transporter-like_ATP-bd IPR017871, ABC_transporter-like_CS IPR015853, ABC_transpr_FbpC IPR040856, GlcV_C IPR008995, Mo/tungstate-bd_C_term_dom IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00005, ABC_tran, 1 hit PF17847, GlcV_C_terminal, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF50331, SSF50331, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q97UY8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVRIIVKNVS KVFKKGKVVA LDNVNINIEN GERFGILGPS GAGKTTFMRI
60 70 80 90 100
IAGLDVPSTG ELYFDDRLVA SNGKLIVPPE DRKIGMVFQT WALYPNLTAF
110 120 130 140 150
ENIAFPLTNM KMSKEEIRKR VEEVAKILDI HHVLNHFPRE LSGGQQQRVA
160 170 180 190 200
LARALVKDPS LLLLDEPFSN LDARMRDSAR ALVKEVQSRL GVTLLVVSHD
210 220 230 240 250
PADIFAIADR VGVLVKGKLV QVGKPEDLYD NPVSIQVASL IGEINELEGK
260 270 280 290 300
VTNEGVVIGS LRFPVSVSSD RAIIGIRPED VKLSKDVIKD DSWILVGKGK
310 320 330 340 350
VKVIGYQGGL FRITITPLDS EEEIFTYSDH PIHSGEEVLV YVRKDKIKVF
EKN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE006641 Genomic DNA Translation: AAK42960.1 |
PIRi | A90463 |
RefSeqi | WP_010924001.1, NC_002754.1 |
Genome annotation databases
EnsemblBacteriai | AAK42960; AAK42960; SSO2850 |
GeneIDi | 27429116 |
KEGGi | sso:SSO2850 |
PATRICi | fig|273057.12.peg.2936 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE006641 Genomic DNA Translation: AAK42960.1 |
PIRi | A90463 |
RefSeqi | WP_010924001.1, NC_002754.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1OXS | X-ray | 1.65 | C | 1-353 | [»] | |
1OXT | X-ray | 2.10 | A/B/D | 1-353 | [»] | |
1OXU | X-ray | 2.10 | A/B/C | 1-353 | [»] | |
1OXV | X-ray | 1.95 | A/B/D | 1-353 | [»] | |
1OXX | X-ray | 1.45 | K | 1-353 | [»] | |
SMRi | Q97UY8 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 273057.SSO2850 |
Protein family/group databases
TCDBi | 3.A.1.1.13, the atp-binding cassette (abc) superfamily |
Genome annotation databases
EnsemblBacteriai | AAK42960; AAK42960; SSO2850 |
GeneIDi | 27429116 |
KEGGi | sso:SSO2850 |
PATRICi | fig|273057.12.peg.2936 |
Phylogenomic databases
eggNOGi | arCOG00175, Archaea |
HOGENOMi | CLU_000604_1_1_2 |
InParanoidi | Q97UY8 |
OMAi | VRKNMSF |
PhylomeDBi | Q97UY8 |
Enzyme and pathway databases
BRENDAi | 7.5.2.B8, 6163 |
Miscellaneous databases
EvolutionaryTracei | Q97UY8 |
Family and domain databases
CDDi | cd03259, ABC_Carb_Solutes_like, 1 hit |
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003439, ABC_transporter-like_ATP-bd IPR017871, ABC_transporter-like_CS IPR015853, ABC_transpr_FbpC IPR040856, GlcV_C IPR008995, Mo/tungstate-bd_C_term_dom IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00005, ABC_tran, 1 hit PF17847, GlcV_C_terminal, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF50331, SSF50331, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GLCV_SACS2 | |
Accessioni | Q97UY8Primary (citable) accession number: Q97UY8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 3, 2019 |
Last sequence update: | October 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 141 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families