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Protein

Fructose-bisphosphate aldolase class 1

Gene

fda

Organism
Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase (pfkA)
  4. Fructose-bisphosphate aldolase class 1 (fda)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei176Proton acceptorUniRule annotation1
Active sitei213Schiff-base intermediate with dihydroxyacetone-PUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processGlycolysis
LigandSchiff base

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00183

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase class 1UniRule annotation (EC:4.1.2.13UniRule annotation)
Alternative name(s):
Fructose-bisphosphate aldolase class I
Short name:
FBP aldolaseUniRule annotation
Gene namesi
Name:fdaUniRule annotation
Ordered Locus Names:CA_P0064
Encoded oniPlasmid pSOL10 Publication
OrganismiClostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Taxonomic identifieri272562 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000000814 Componenti: Plasmid pSOL1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002168991 – 295Fructose-bisphosphate aldolase class 1Add BLAST295

Structurei

3D structure databases

ProteinModelPortaliQ97TN4
SMRiQ97TN4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I fructose-bisphosphate aldolase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000073502
KOiK01623
OMAiVFGTKER

Family and domain databases

Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00729 FBP_aldolase_1, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR000741 FBA_I
IPR023014 FBA_I_Gram+-type
PfamiView protein in Pfam
PF00274 Glycolytic, 1 hit

Sequencei

Sequence statusi: Complete.

Q97TN4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNETQMNRIS KDKGFIAALD QSGGSTPKAL LQYGIKENSY SNDEEMFNLV
60 70 80 90 100
HEMRKRIIKS TAFNSKYILG AILFENTMYR TIDHKYTADY LWNEKNIVPF
110 120 130 140 150
LKIDKGLSEL ENGVQLMKPI TNLDELLKAA IEKNIFGTKM RSFIKEANSK
160 170 180 190 200
GIKMVVDQQF ELADKIANQG LVPIIEPEVD IKSTDKEKSE ELLKLEISKH
210 220 230 240 250
LSDLDKETKV MLKLSIPTKD NFYSDLMKDP HVVRIVALSG GYSQSEANER
260 270 280 290
LSRNNGLIAS FSRALSENLS IDQTDEEFNE TLSNSIKEIY EASIT
Length:295
Mass (Da):33,505
Last modified:October 1, 2001 - v1
Checksum:i75C866B87CB11551
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001438 Genomic DNA Translation: AAK76810.1
RefSeqiNP_149228.1, NC_001988.2
WP_010890749.1, NC_001988.2

Genome annotation databases

EnsemblBacteriaiAAK76810; AAK76810; CA_P0064
GeneIDi1116069
KEGGicac:CA_P0064
PATRICifig|272562.8.peg.64

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001438 Genomic DNA Translation: AAK76810.1
RefSeqiNP_149228.1, NC_001988.2
WP_010890749.1, NC_001988.2

3D structure databases

ProteinModelPortaliQ97TN4
SMRiQ97TN4
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK76810; AAK76810; CA_P0064
GeneIDi1116069
KEGGicac:CA_P0064
PATRICifig|272562.8.peg.64

Phylogenomic databases

HOGENOMiHOG000073502
KOiK01623
OMAiVFGTKER

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00183

Family and domain databases

Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00729 FBP_aldolase_1, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR000741 FBA_I
IPR023014 FBA_I_Gram+-type
PfamiView protein in Pfam
PF00274 Glycolytic, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiALF1_CLOAB
AccessioniPrimary (citable) accession number: Q97TN4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: October 1, 2001
Last modified: October 10, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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