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Protein

DNA polymerase III PolC-type

Gene

polC

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-directed DNA polymerase, Exonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Transferase
Biological processDNA replication

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
SPNE170187:G1FZB-280-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA polymerase III PolC-typeUniRule annotation (EC:2.7.7.7UniRule annotation)
Short name:
PolIIIUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:polCUniRule annotation
Ordered Locus Names:SP_0274
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri170187 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000585 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002045981 – 1463DNA polymerase III PolC-typeAdd BLAST1463

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q97SQ2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q97SQ2

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini425 – 581ExonucleaseAdd BLAST157

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA polymerase type-C family. PolC subfamily.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105DE5 Bacteria
COG2176 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000058064

KEGG Orthology (KO)

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KOi
K03763

Identification of Orthologs from Complete Genome Data

More...
OMAi
YYAAYFT

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.420.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00356 DNApol_PolC, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011708 DNA_pol3_alpha_NTPase_dom
IPR024754 DNA_polC-like_N_II
IPR028112 DNA_polC-type_N_I
IPR006054 DnaQ
IPR013520 Exonuclease_RNaseT/DNA_pol3
IPR012340 NA-bd_OB-fold
IPR004013 PHP_dom
IPR003141 Pol/His_phosphatase_N
IPR006308 PolC_gram_pos
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14480 DNA_pol3_a_NI, 1 hit
PF11490 DNA_pol3_a_NII, 1 hit
PF07733 DNA_pol3_alpha, 2 hits
PF02811 PHP, 1 hit
PF00929 RNase_T, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00479 EXOIII, 1 hit
SM00481 POLIIIAc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50249 SSF50249, 1 hit
SSF53098 SSF53098, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00573 dnaq, 1 hit
TIGR01405 polC_Gram_pos, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q97SQ2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNSFEILMN QLGMPAEMRQ APALAQANIE RVVVHKISKV WEFHFVFSNI
60 70 80 90 100
LPIEIFLELK KGLSEEFSKT GNKAVFEIKA RSQEFSNQLL QSYYREAFSE
110 120 130 140 150
GPCASQGFKS LYQNLQVRAE GNQLFIEGSE AIDKEHFKKN HLPNLAKQLE
160 170 180 190 200
KFGFPTFNCQ VEKNDVLTQE QEEAFHAENE QIVQAANEEA LRAMEQLEQM
210 220 230 240 250
APPPAEEKPA FDFQAKKAAA KPKLDKAEIT PMIEVTTEEN RLVFEGVVFD
260 270 280 290 300
VEQKVTRTGR VLINFKMTDY TSSFSMQKWV KNEEEAQKFD LIKKNSWLRV
310 320 330 340 350
RGNVEMNNFT RDLTMNVQDL QEVVHYERKD LMPEGERRVE FHAHTNMSTM
360 370 380 390 400
DALPEVEEIV ATAAKWGHKA VAITDHGNVQ SFPHGYKAAK KAGIQLIYGM
410 420 430 440 450
EANIVEDRVP IVYNEVEMDL SEATYVVFDV ETTGLSAIYN DLIQVAASKM
460 470 480 490 500
YKGNVIAEFD EFINPGHPLS AFTTELTGIT DDHVKNAKPL EQVLQEFQEF
510 520 530 540 550
CKDTVLVAHN ATFDVGFMNA NYERHDLPKI SQPVIDTLEF ARNLYPEYKR
560 570 580 590 600
HGLGPLTKRF GVALEHHHMA NYDAEATGRL LFIFIKEVAE KHGVTDLARL
610 620 630 640 650
NIDLISPDSY KKARIKHATI YVKNQVGLKN IFKLVSLSNT KYFEGVPRIP
660 670 680 690 700
RTVLDAHREG LILGSACSEG EVFDVVVSQG VDAAVEVAKY YDFIEVMPPA
710 720 730 740 750
IYAPLIAKEQ VKDMEELQTI IKSLIEVGDR LGKPVLATGN VHYIEPEEEI
760 770 780 790 800
YREIIVRSLG QGAMINRTIG HGEHAQPAPL PKAHFRTTNE MLDEFAFLGE
810 820 830 840 850
ELARKLVIEN TNALAEIFES VEVVKGDLYT PFIDKAEETV AELTYKKAFE
860 870 880 890 900
IYGNPLPDIV DLRIEKELTS ILGNGFAVIY LASQMLVQRS NERGYLVGSR
910 920 930 940 950
GSVGSSFVAT MIGITEVNPL SPHYVCGQCQ YSEFITDGSY GSGFDMPHKD
960 970 980 990 1000
CPNCGHKLSK NGQDIPFETF LGFDGDKVPD IDLNFSGEDQ PSAHLDVRDI
1010 1020 1030 1040 1050
FGEEYAFRAG TVGTVAAKTA YGFVKGYERD YGKFYRDAEV ERLAQGAAGV
1060 1070 1080 1090 1100
KRTTGQHPGG IVVIPNYMDV YDFTPVQYPA DDVTAEWQTT HFNFHDIDEN
1110 1120 1130 1140 1150
VLKLDVLGHD DPTMIRKLQD LSGIDPNKIP MDDEGVMALF SGTDVLGVTP
1160 1170 1180 1190 1200
EQIGTPTGML GIPEFGTNFV RGMVDETHPT TFAELLQLSG LSHGTDVWLG
1210 1220 1230 1240 1250
NAQDLIKQGI ADLSTVIGCR DDIMVYLMHA GLEPKMAFTI MERVRKGLWL
1260 1270 1280 1290 1300
KISEEERNGY IEAMKANKVP EWYIESCGKI KYMFPKAHAA AYVMMALRVA
1310 1320 1330 1340 1350
YFKVHHPIYY YCAYFSIRAK AFDIKTMGAG LEVIKRRMEE ISEKRKNNEA
1360 1370 1380 1390 1400
SNVEIDLYTT LEIVNEMWER GFKFGKLDLY CSQATEFLID GDTLIPPFVA
1410 1420 1430 1440 1450
MDGLGENVAK QLVRAREEGE FLSKTELRKR GGLSSTLVEK MDEMGILGNM
1460
PEDNQLSLFD ELF
Length:1,463
Mass (Da):164,741
Last modified:October 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i800406C459477AEA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE005672 Genomic DNA Translation: AAK74452.1

Protein sequence database of the Protein Information Resource

More...
PIRi
C95032

NCBI Reference Sequences

More...
RefSeqi
WP_000071390.1, NZ_AKVY01000001.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAK74452; AAK74452; SP_0274

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spn:SP_0274

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005672 Genomic DNA Translation: AAK74452.1
PIRiC95032
RefSeqiWP_000071390.1, NZ_AKVY01000001.1

3D structure databases

ProteinModelPortaliQ97SQ2
SMRiQ97SQ2
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK74452; AAK74452; SP_0274
KEGGispn:SP_0274

Phylogenomic databases

eggNOGiENOG4105DE5 Bacteria
COG2176 LUCA
HOGENOMiHOG000058064
KOiK03763
OMAiYYAAYFT

Enzyme and pathway databases

BioCyciSPNE170187:G1FZB-280-MONOMER

Family and domain databases

Gene3Di3.30.420.10, 1 hit
HAMAPiMF_00356 DNApol_PolC, 1 hit
InterProiView protein in InterPro
IPR011708 DNA_pol3_alpha_NTPase_dom
IPR024754 DNA_polC-like_N_II
IPR028112 DNA_polC-type_N_I
IPR006054 DnaQ
IPR013520 Exonuclease_RNaseT/DNA_pol3
IPR012340 NA-bd_OB-fold
IPR004013 PHP_dom
IPR003141 Pol/His_phosphatase_N
IPR006308 PolC_gram_pos
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PfamiView protein in Pfam
PF14480 DNA_pol3_a_NI, 1 hit
PF11490 DNA_pol3_a_NII, 1 hit
PF07733 DNA_pol3_alpha, 2 hits
PF02811 PHP, 1 hit
PF00929 RNase_T, 1 hit
SMARTiView protein in SMART
SM00479 EXOIII, 1 hit
SM00481 POLIIIAc, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
SSF53098 SSF53098, 1 hit
TIGRFAMsiTIGR00573 dnaq, 1 hit
TIGR01405 polC_Gram_pos, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDPO3_STRPN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q97SQ2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: October 1, 2001
Last modified: December 5, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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