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Protein

Undecaprenyl-diphosphatase 1

Gene

uppP1

Organism
Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAntibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase 1UniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance protein 1UniRule annotation
Undecaprenyl pyrophosphate phosphatase 1UniRule annotation
Gene namesi
Name:uppP1UniRule annotation
Synonyms:bacA1, upk1
Ordered Locus Names:CA_C0501
OrganismiClostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Taxonomic identifieri272562 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000000814 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei47 – 67HelicalUniRule annotationAdd BLAST21
Transmembranei85 – 105HelicalUniRule annotationAdd BLAST21
Transmembranei113 – 133HelicalUniRule annotationAdd BLAST21
Transmembranei150 – 170HelicalUniRule annotationAdd BLAST21
Transmembranei196 – 216HelicalUniRule annotationAdd BLAST21
Transmembranei225 – 245HelicalUniRule annotationAdd BLAST21
Transmembranei253 – 273HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001511341 – 274Undecaprenyl-diphosphatase 1Add BLAST274

Interactioni

Protein-protein interaction databases

STRINGi272562.CA_C0501

Structurei

3D structure databases

SMRiQ97LQ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DWR Bacteria
COG1968 LUCA
HOGENOMiHOG000218356
KOiK06153
OMAiPDARMGW

Family and domain databases

HAMAPiMF_01006 Undec_diphosphatase, 1 hit
InterProiView protein in InterPro
IPR003824 UppP
PANTHERiPTHR30622 PTHR30622, 1 hit
PfamiView protein in Pfam
PF02673 BacA, 1 hit
TIGRFAMsiTIGR00753 undec_PP_bacA, 1 hit

Sequencei

Sequence statusi: Complete.

Q97LQ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEHIEILKAI FLGIVEGITE WLPISSTGHM ILVNEFIRLN VTEAFKQVFL
60 70 80 90 100
VVIQLGAILS VVLLYFNKLI PFSLNGGFYL KKDVVSMWIK IIISCIPATI
110 120 130 140 150
VGIPFDDKID ALFYNYQTVS ITLISFGILF IMIENHNKGK HPRITSISEI
160 170 180 190 200
TYTTAVLIGI FQLIAAVFPG TSRSGATIVG ALLIGVSRTV AAEYTFFLAI
210 220 230 240 250
PVMFGASLLK LFKFGLHFTS TEITILFIGM LSAFIVSILA IKFLMIYIKR
260 270
HDFKAFGWYR IILGCAVLVY FLIV
Length:274
Mass (Da):30,605
Last modified:October 1, 2001 - v1
Checksum:i4282F96E396E7028
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001437 Genomic DNA Translation: AAK78481.1
PIRiF96961
RefSeqiNP_347141.1, NC_003030.1
WP_010963823.1, NC_003030.1

Genome annotation databases

EnsemblBacteriaiAAK78481; AAK78481; CA_C0501
GeneIDi1116684
KEGGicac:CA_C0501
PATRICifig|272562.8.peg.700

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001437 Genomic DNA Translation: AAK78481.1
PIRiF96961
RefSeqiNP_347141.1, NC_003030.1
WP_010963823.1, NC_003030.1

3D structure databases

SMRiQ97LQ3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272562.CA_C0501

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK78481; AAK78481; CA_C0501
GeneIDi1116684
KEGGicac:CA_C0501
PATRICifig|272562.8.peg.700

Phylogenomic databases

eggNOGiENOG4105DWR Bacteria
COG1968 LUCA
HOGENOMiHOG000218356
KOiK06153
OMAiPDARMGW

Family and domain databases

HAMAPiMF_01006 Undec_diphosphatase, 1 hit
InterProiView protein in InterPro
IPR003824 UppP
PANTHERiPTHR30622 PTHR30622, 1 hit
PfamiView protein in Pfam
PF02673 BacA, 1 hit
TIGRFAMsiTIGR00753 undec_PP_bacA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUPPP1_CLOAB
AccessioniPrimary (citable) accession number: Q97LQ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: October 1, 2001
Last modified: October 10, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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