Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Chemotaxis response regulator protein-glutamate methylesterase

Gene

cheB

Organism
Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR.UniRule annotation

Catalytic activityi

Protein L-glutamate O5-methyl ester + H2O = protein L-glutamate + methanol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei165UniRule annotation1
Active sitei192UniRule annotation1
Active sitei285UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis response regulator protein-glutamate methylesteraseUniRule annotation (EC:3.1.1.61UniRule annotation)
Gene namesi
Name:cheBUniRule annotation
Ordered Locus Names:CA_C2222
OrganismiClostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Taxonomic identifieri272562 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000000814 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001579891 – 345Chemotaxis response regulator protein-glutamate methylesteraseAdd BLAST345

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei564-aspartylphosphateUniRule annotation1

Post-translational modificationi

Phosphorylated by CheA. Phosphorylation suppresses the inhibitory activity of the N-terminal domain.UniRule annotation

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ97GZ3

Interactioni

Protein-protein interaction databases

STRINGi272562.CA_C2222

Structurei

3D structure databases

ProteinModelPortaliQ97GZ3
SMRiQ97GZ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 123Response regulatoryPROSITE-ProRule annotationAdd BLAST119
Domaini153 – 343CheB-type methylesteraseUniRule annotationAdd BLAST191

Domaini

The N-terminal regulatory domain inhibits the activity of the C-terminal effector domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CMP Bacteria
COG2201 LUCA
HOGENOMiHOG000151424
KOiK03412
OMAiMLEMHRA

Family and domain databases

CDDicd16432 CheB_Rec, 1 hit
cd00156 REC, 1 hit
Gene3Di3.40.50.180, 1 hit
HAMAPiMF_00099 CheB_methylest, 1 hit
InterProiView protein in InterPro
IPR035909 CheB_C
IPR011006 CheY-like_superfamily
IPR008248 Sig_transdc_resp-reg_CheB
IPR000673 Sig_transdc_resp-reg_Me-estase
IPR001789 Sig_transdc_resp-reg_receiver
PfamiView protein in Pfam
PF01339 CheB_methylest, 1 hit
PF00072 Response_reg, 1 hit
PIRSFiPIRSF000876 RR_chemtxs_CheB, 1 hit
SMARTiView protein in SMART
SM00448 REC, 1 hit
SUPFAMiSSF52172 SSF52172, 1 hit
SSF52738 SSF52738, 1 hit
PROSITEiView protein in PROSITE
PS50122 CHEB, 1 hit
PS50110 RESPONSE_REGULATORY, 1 hit

Sequencei

Sequence statusi: Complete.

Q97GZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKIKVIVVD DSVLMRRLIC DMLESNDNIE VIGTAINGQD LLNKLKVMKP
60 70 80 90 100
DVITLDIEMP VMNGIETLKA VKSLKIDIPI IVFSSISQKG MKYTMECLYL
110 120 130 140 150
GAFDFIPKPE KPFELSKMKD DLIKRIRVAY SQNTNKNPAP INPVIRRETN
160 170 180 190 200
RISSDSIEAV VIGASTGGPK ALYKVITKFP KDMNVPVFVV QHMPVGFTKA
210 220 230 240 250
FADRLNDNSA IEVKEATDGE TYRKGVVYVA PGGYHMEVDS NSRIKLTKEP
260 270 280 290 300
PIWGVRPAVD KLFISASKIF KSHIVSAVLT GMGKDGSNGT GIIKDNGGVT
310 320 330 340
ISESETTCVI YGMPKAAFET GKVDLVVPID NVADEIIKIV RGLRR
Length:345
Mass (Da):37,974
Last modified:October 1, 2001 - v1
Checksum:iC5D9CCDDB5AF6BAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001437 Genomic DNA Translation: AAK80179.1
PIRiH97173
RefSeqiNP_348839.1, NC_003030.1
WP_010965520.1, NC_003030.1

Genome annotation databases

EnsemblBacteriaiAAK80179; AAK80179; CA_C2222
GeneIDi1118405
KEGGicac:CA_C2222
PATRICifig|272562.8.peg.2423

Similar proteinsi

Entry informationi

Entry nameiCHEB_CLOAB
AccessioniPrimary (citable) accession number: Q97GZ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2001
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health