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Entry version 112 (26 Feb 2020)
Sequence version 1 (01 Oct 2001)
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Protein

Hydroxylamine reductase 1

Gene

hcp1

Organism
Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the reduction of hydroxylamine to form NH3 and H2O.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi5Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi8Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi17Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi23Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi227Iron-oxo-sulfur (4Fe-2O-2S); via tele nitrogenUniRule annotation1
Metal bindingi251Iron-oxo-sulfur (4Fe-2O-2S)UniRule annotation1
Metal bindingi295Iron-oxo-sulfur (4Fe-2O-2S)UniRule annotation1
Metal bindingi384Iron-oxo-sulfur (4Fe-2O-2S); via persulfide groupUniRule annotation1
Metal bindingi412Iron-oxo-sulfur (4Fe-2O-2S)UniRule annotation1
Metal bindingi437Iron-oxo-sulfur (4Fe-2O-2S)UniRule annotation1
Metal bindingi472Iron-oxo-sulfur (4Fe-2O-2S)UniRule annotation1
Metal bindingi474Iron-oxo-sulfur (4Fe-2O-2S)UniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Hydroxylamine reductase 1UniRule annotation (EC:1.7.99.1UniRule annotation)
Alternative name(s):
Hybrid-cluster protein 1UniRule annotation
Short name:
HCP 1UniRule annotation
Prismane protein 1UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:hcp1UniRule annotation
Ordered Locus Names:CA_C2750
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiClostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri272562 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000814 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001516701 – 530Hydroxylamine reductase 1Add BLAST530

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei384Cysteine persulfideUniRule annotation1

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q97FI7

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
272562.CA_C2750

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q97FI7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the HCP family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105EJ7 Bacteria
COG1151 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_038344_2_0_9

KEGG Orthology (KO)

More...
KOi
K05601

Identification of Orthologs from Complete Genome Data

More...
OMAi
CAYAQGM

Database of Orthologous Groups

More...
OrthoDBi
337713at2

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01914 HCP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1270.20, 2 hits
3.40.50.2030, 2 hits

HAMAP database of protein families

More...
HAMAPi
MF_00069 Hydroxylam_reduct, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004137 HCP/CODH
IPR010048 Hydroxylam_reduct
IPR016099 Prismane-like_a/b-sand
IPR011254 Prismane-like_sf
IPR016100 Prismane_a-bundle

The PANTHER Classification System

More...
PANTHERi
PTHR30109 PTHR30109, 1 hit
PTHR30109:SF0 PTHR30109:SF0, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03063 Prismane, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000076 HCP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56821 SSF56821, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01703 hybrid_clust, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q97FI7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSMFCYQCQE AAGCKGCTVR GVCGKTEDLA KKQDLLIYTL KVVSLYNVEA
60 70 80 90 100
RKLNLVNKEI DNYIVDSLFA TITNANFDEN IFTERIEKGI KYKEELKKQI
110 120 130 140 150
SAAGGNVNLN EKTEAVGVLS TENEDIRSLR ELLTYGIKGM AAYLKHARNL
160 170 180 190 200
SYEDSNIQGF MSKALAATLD DTLGADELVA LALECGKYGV DAMALLDKAN
210 220 230 240 250
TETYGNPEIT KVNIGTRNNP GILISGHDLK DIEELLKQTE GTGVDVYTHS
260 270 280 290 300
EMLPANYYPA FKKYSHFVGN YGNAWWKQNE EFESFNGPIL MTTNCIVPPK
310 320 330 340 350
ASYIDRMYTT GVTGYPGVKH IENGEPKDFS AIIEHAKKCA PPTEIEKGEI
360 370 380 390 400
IGGFAHNQVI ALADKVVEAV KSGAIKRFYV MAGCDGRAKT RNYYTDFAKA
410 420 430 440 450
LPKDAVILTA GCAKYKYNKL DLGDIGGIPR VLDAGQCNDS YSLVVIALKL
460 470 480 490 500
KEVFGLNDIN ELPIAYNIAW YEQKAVIVLL ALLHLGVKNI HLGPTLPAFL
510 520 530
SPNVAKVLVD NFGIGGITNV EDDIKMFENL
Length:530
Mass (Da):58,304
Last modified:October 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF9E1644E53E98A2F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE001437 Genomic DNA Translation: AAK80696.1

Protein sequence database of the Protein Information Resource

More...
PIRi
E97238

NCBI Reference Sequences

More...
RefSeqi
NP_349356.3, NC_003030.1
WP_010966037.1, NC_003030.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAK80696; AAK80696; CA_C2750

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1118933

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cac:CA_C2750

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|272562.8.peg.2938

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001437 Genomic DNA Translation: AAK80696.1
PIRiE97238
RefSeqiNP_349356.3, NC_003030.1
WP_010966037.1, NC_003030.1

3D structure databases

SMRiQ97FI7
ModBaseiSearch...

Protein-protein interaction databases

STRINGi272562.CA_C2750

Proteomic databases

PRIDEiQ97FI7

Genome annotation databases

EnsemblBacteriaiAAK80696; AAK80696; CA_C2750
GeneIDi1118933
KEGGicac:CA_C2750
PATRICifig|272562.8.peg.2938

Phylogenomic databases

eggNOGiENOG4105EJ7 Bacteria
COG1151 LUCA
HOGENOMiCLU_038344_2_0_9
KOiK05601
OMAiCAYAQGM
OrthoDBi337713at2

Family and domain databases

CDDicd01914 HCP, 1 hit
Gene3Di1.20.1270.20, 2 hits
3.40.50.2030, 2 hits
HAMAPiMF_00069 Hydroxylam_reduct, 1 hit
InterProiView protein in InterPro
IPR004137 HCP/CODH
IPR010048 Hydroxylam_reduct
IPR016099 Prismane-like_a/b-sand
IPR011254 Prismane-like_sf
IPR016100 Prismane_a-bundle
PANTHERiPTHR30109 PTHR30109, 1 hit
PTHR30109:SF0 PTHR30109:SF0, 1 hit
PfamiView protein in Pfam
PF03063 Prismane, 1 hit
PIRSFiPIRSF000076 HCP, 1 hit
SUPFAMiSSF56821 SSF56821, 1 hit
TIGRFAMsiTIGR01703 hybrid_clust, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHCP1_CLOAB
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q97FI7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 1, 2001
Last modified: February 26, 2020
This is version 112 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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