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Entry version 117 (29 Sep 2021)
Sequence version 1 (01 Oct 2001)
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Protein
Submitted name:

Polyketide synthase pksE (Short-chain alcohol dehydrogenase,acyl-carrier-protein S-malonyltransferase,3-oxoacyl-(Acyl-carrier-protein) synthase I domains)

Gene

CA_C3355

Organism
Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferaseImportedARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Polyketide synthase pksE (Short-chain alcohol dehydrogenase,acyl-carrier-protein S-malonyltransferase,3-oxoacyl-(Acyl-carrier-protein) synthase I domains)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:CA_C3355Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiClostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri272562 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesClostridiaEubacterialesClostridiaceaeClostridium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000814 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1753O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

PhosphopantetheinePROSITE-ProRule annotationARBA annotation, PhosphoproteinARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
272562.CA_C3355

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1719 – 1793CarrierInterPro annotationAdd BLAST75

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1711 – 1731Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG3321, Bacteria
COG4221, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000022_35_2_9

Identification of Orthologs from Complete Genome Data

More...
OMAi
DVVWVFS

Database of Orthologous Groups

More...
OrthoDBi
572620at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 1 hit
3.10.129.110, 1 hit
3.40.366.10, 1 hit
3.40.47.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001227, Ac_transferase_dom_sf
IPR036736, ACP-like_sf
IPR014043, Acyl_transferase
IPR016035, Acyl_Trfase/lysoPLipase
IPR018201, Ketoacyl_synth_AS
IPR014031, Ketoacyl_synth_C
IPR014030, Ketoacyl_synth_N
IPR016036, Malonyl_transacylase_ACP-bd
IPR036291, NAD(P)-bd_dom_sf
IPR032821, PKS_assoc
IPR020841, PKS_Beta-ketoAc_synthase_dom
IPR020807, PKS_dehydratase
IPR042104, PKS_dehydratase_sf
IPR013968, PKS_KR
IPR009081, PP-bd_ACP
IPR016039, Thiolase-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00698, Acyl_transf_1, 1 hit
PF16197, KAsynt_C_assoc, 1 hit
PF00109, ketoacyl-synt, 1 hit
PF02801, Ketoacyl-synt_C, 1 hit
PF08659, KR, 1 hit
PF00550, PP-binding, 1 hit
PF14765, PS-DH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00827, PKS_AT, 1 hit
SM00826, PKS_DH, 1 hit
SM00825, PKS_KS, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336, SSF47336, 1 hit
SSF51735, SSF51735, 2 hits
SSF52151, SSF52151, 1 hit
SSF53901, SSF53901, 1 hit
SSF55048, SSF55048, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00606, B_KETOACYL_SYNTHASE, 1 hit
PS50075, CARRIER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q97DW5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKIAIIGLG LRLPGGADNK EKLWDILAKG VDCTIDVPKD RWNIDLFYNP
60 70 80 90 100
DRSAIGKTHA FRGGYLNNID KFDAGFFGIT PREASSMDPQ QRILLETSWE
110 120 130 140 150
AFEDAGIDTT KLAGKDVGVY IGAFTVDYKV LQFNSANQPL LESQSATGDM
160 170 180 190 200
MTMVSNRLSY VYNFTGPSMS IDTACSSSLV SLHLACKAIE NNECSMAIAG
210 220 230 240 250
GVNIMINPQY TIAESKGGFL SPDGRCKSFD AKANGYARGE GAGIVVLKPL
260 270 280 290 300
DKAIEDNDNI YCVIEATAVN QDGHTKGITV PNGEAQEKLM EEVYENAGIS
310 320 330 340 350
AKDISYIEAH GTGTRVGDPI EAKAIGAALG KDRSNTDKCF IGSMKSNIGH
360 370 380 390 400
LESAAGVAAT IKASLMLKKK QIPPSINFNT PNPNIPFDSM CIKVPTKLEK
410 420 430 440 450
LPSKRGKSYI GINCFGFGGT NAHVVMSSYS KNNKASNRNE VTKRELPYVL
460 470 480 490 500
TISARSETAL MELVKKYKKH IRKADDEYSL EDLCYSAARR RAHHNYRMAI
510 520 530 540 550
VFNTKEELCE KIDSFIRKED IEGVFTGGKL SHKKEKAVFV YTGMGPIWWA
560 570 580 590 600
MGRQLLETNK IFRGVIEKCD KFVKEYSGWS LIKELMASED KSKLGETLYA
610 620 630 640 650
QPANFALQIA LTEVWKSLGV IPSAIVGHSV GEVAAAFEAG IFSFEDAMKV
660 670 680 690 700
IIERSRWINE TEGKGTMLAA GISEEEAKSL LEKYKQGMSI AVINSSKSVT
710 720 730 740 750
LSGKREVLES IKEELDKKQV FAKFLNVNAA YHSYEMDKIV GGLKESLLDI
760 770 780 790 800
KPNKAKTPIY STVTGKLMVG TEYGADYWCS NVRNTVRFKE AITNIADDEY
810 820 830 840 850
DTFIEVGPHP VLKTSIQDCF TDLNKQSEVF CSIRRKKNEL MEIVSNLASL
860 870 880 890 900
YVEGYSINWE QTYPVGSYIE LPKYAWQREK YWIESELSQE IRLGKNMDSI
910 920 930 940 950
LGRPLRSEKP SWETEMSEFR NPFLSGHKIQ GAILFPATGY IELAFACAKK
960 970 980 990 1000
VVKDSEFYMK DIQFSRALFL NNDDAPIVRT SYNPSDRTIE VFSRPTSNTN
1010 1020 1030 1040 1050
KWTSHCISKL GRSINFYESR LLSIDEIKDR CTETISKDEF YKYISDYGFQ
1060 1070 1080 1090 1100
YGTSFQGVKK LWRGEDEVLA LIEAPIETLD FKINHVLHPA LLDSTLQSMI
1110 1120 1130 1140 1150
SIMPSVRNAA GEGLIPMGIK GLKVYKKLEP IMWTYAKSRI ATNDYMVADL
1160 1170 1180 1190 1200
KIYDRFGQII AEIDSIEARN INNDEKRDST NIDKCLYSFD WEEKEKAEEA
1210 1220 1230 1240 1250
SMLLGSEEKW VVLCDKSGFG SEFIKLAQSN RVECIPVEYA SNLSGEHIKV
1260 1270 1280 1290 1300
NPEEEESFEK VFIQLSENKK ITKIINLWPL DAHGEESIED KSLKAQTNIG
1310 1320 1330 1340 1350
SIALLNMLKA ISKLNIAPKI WTVTKGSQFV NGIGSEKGLY QSSIWGISRV
1360 1370 1380 1390 1400
FGYNEKPELW GGIVDIDVEA TSNISNIIAL FKEIVLPDRE SEIAFRDNKR
1410 1420 1430 1440 1450
FVSRINRVDT KKNELPIEFD KNSSYLITGA FGALGMLFSK WMIAHGARNL
1460 1470 1480 1490 1500
ILMGRTALPN RCEWRSVDKD SKIFSRIQFV KELERLGANI HIANVDVSDK
1510 1520 1530 1540 1550
DKLKEYVELY KKEDWPKIAG VIHTAGIVRD KPIDSMDLDT FRQVFAPKVQ
1560 1570 1580 1590 1600
GSWNLHEVFS KEKLDFFILF ASVASKLIVS AGQSNYASAN AFIDALANYR
1610 1620 1630 1640 1650
RSKGLPALAI DWGPWSEVGM AEELDLTKYF EERGVGSISP AAGEKILESL
1660 1670 1680 1690 1700
IGTKLSEVCV VPNVKWSLAT KSYLTENIPL TFEHLLEEEK PKNTSHSKNT
1710 1720 1730 1740 1750
ILENDLEEAA IEESMDEKSS VENRLKNIIS DVTKIDASKI KVEDAISDLG
1760 1770 1780 1790
IDSMMANEIK HKIKVNFDIV ISVVELLKGN SIKQLADVMM SKVTA
Length:1,795
Mass (Da):200,669
Last modified:October 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE76CDFAB01D88B58
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE001437 Genomic DNA Translation: AAK81287.1

Protein sequence database of the Protein Information Resource

More...
PIRi
D97312

NCBI Reference Sequences

More...
RefSeqi
NP_349947.1, NC_003030.1
WP_010966627.1, NC_003030.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAK81287; AAK81287; CA_C3355

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
44999850

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cac:CA_C3355

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|272562.8.peg.3536

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001437 Genomic DNA Translation: AAK81287.1
PIRiD97312
RefSeqiNP_349947.1, NC_003030.1
WP_010966627.1, NC_003030.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi272562.CA_C3355

Genome annotation databases

EnsemblBacteriaiAAK81287; AAK81287; CA_C3355
GeneIDi44999850
KEGGicac:CA_C3355
PATRICifig|272562.8.peg.3536

Phylogenomic databases

eggNOGiCOG3321, Bacteria
COG4221, Bacteria
HOGENOMiCLU_000022_35_2_9
OMAiDVVWVFS
OrthoDBi572620at2

Family and domain databases

Gene3Di1.10.1200.10, 1 hit
3.10.129.110, 1 hit
3.40.366.10, 1 hit
3.40.47.10, 1 hit
InterProiView protein in InterPro
IPR001227, Ac_transferase_dom_sf
IPR036736, ACP-like_sf
IPR014043, Acyl_transferase
IPR016035, Acyl_Trfase/lysoPLipase
IPR018201, Ketoacyl_synth_AS
IPR014031, Ketoacyl_synth_C
IPR014030, Ketoacyl_synth_N
IPR016036, Malonyl_transacylase_ACP-bd
IPR036291, NAD(P)-bd_dom_sf
IPR032821, PKS_assoc
IPR020841, PKS_Beta-ketoAc_synthase_dom
IPR020807, PKS_dehydratase
IPR042104, PKS_dehydratase_sf
IPR013968, PKS_KR
IPR009081, PP-bd_ACP
IPR016039, Thiolase-like
PfamiView protein in Pfam
PF00698, Acyl_transf_1, 1 hit
PF16197, KAsynt_C_assoc, 1 hit
PF00109, ketoacyl-synt, 1 hit
PF02801, Ketoacyl-synt_C, 1 hit
PF08659, KR, 1 hit
PF00550, PP-binding, 1 hit
PF14765, PS-DH, 1 hit
SMARTiView protein in SMART
SM00827, PKS_AT, 1 hit
SM00826, PKS_DH, 1 hit
SM00825, PKS_KS, 1 hit
SUPFAMiSSF47336, SSF47336, 1 hit
SSF51735, SSF51735, 2 hits
SSF52151, SSF52151, 1 hit
SSF53901, SSF53901, 1 hit
SSF55048, SSF55048, 1 hit
PROSITEiView protein in PROSITE
PS00606, B_KETOACYL_SYNTHASE, 1 hit
PS50075, CARRIER, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ97DW5_CLOAB
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q97DW5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2001
Last sequence update: October 1, 2001
Last modified: September 29, 2021
This is version 117 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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