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Protein

Nucleoside diphosphate kinase

Gene

ndk

Organism
Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.UniRule annotation

Catalytic activityi

ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei9ATPUniRule annotation1
Binding sitei57ATPUniRule annotation1
Binding sitei85ATPUniRule annotation1
Binding sitei91ATPUniRule annotation1
Binding sitei102ATPUniRule annotation1
Binding sitei112ATPUniRule annotation1
Active sitei115Pros-phosphohistidine intermediateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processNucleotide metabolism
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTVOL273116:G1G3C-479-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate kinaseUniRule annotation (EC:2.7.4.6UniRule annotation)
Short name:
NDKUniRule annotation
Short name:
NDP kinaseUniRule annotation
Alternative name(s):
Nucleoside-2-P kinaseUniRule annotation
Gene namesi
Name:ndkUniRule annotation
Ordered Locus Names:TV0450
ORF Names:TVG0438422
OrganismiThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Taxonomic identifieri273116 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaDiaforarchaea groupThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
Proteomesi
  • UP000001017 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001371051 – 147Nucleoside diphosphate kinaseAdd BLAST147

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi273116.TVN0452

Structurei

3D structure databases

ProteinModelPortaliQ97BK5
SMRiQ97BK5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NDK family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04313 Archaea
COG0105 LUCA
KOiK00940
OMAiKIVAMKM
OrthoDBiPOG093Z0ECU

Family and domain databases

Gene3Di3.30.70.141, 1 hit
HAMAPiMF_00451 NDP_kinase, 1 hit
InterProiView protein in InterPro
IPR034907 NDK-like_dom
IPR036850 NDK-like_dom_sf
IPR001564 Nucleoside_diP_kinase
IPR023005 Nucleoside_diP_kinase_AS
PfamiView protein in Pfam
PF00334 NDK, 1 hit
PRINTSiPR01243 NUCDPKINASE
SMARTiView protein in SMART
SM00562 NDK, 1 hit
SUPFAMiSSF54919 SSF54919, 1 hit
PROSITEiView protein in PROSITE
PS00469 NDP_KINASES, 1 hit

Sequencei

Sequence statusi: Complete.

Q97BK5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDRTLVLLKP DAVKRRLVGK IIERFEEKGL KIVAMKFMQM TKDQAKTHYS
60 70 80 90 100
VHQNKPFFND LVNYITSGPI VAMILEGAHA IEIVRLMSGA TDGSKAQPGT
110 120 130 140
IRGDYSMGIE KNIIHASDSL EAYNHEMPIF FSDNEIIEWA YGDEVIY
Length:147
Mass (Da):16,664
Last modified:October 1, 2001 - v1
Checksum:iA9798CA986236CFD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000011 Genomic DNA Translation: BAB59592.1
RefSeqiWP_010916710.1, NC_002689.2

Genome annotation databases

EnsemblBacteriaiBAB59592; BAB59592; BAB59592
GeneIDi1440968
KEGGitvo:TVG0438422

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000011 Genomic DNA Translation: BAB59592.1
RefSeqiWP_010916710.1, NC_002689.2

3D structure databases

ProteinModelPortaliQ97BK5
SMRiQ97BK5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273116.TVN0452

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB59592; BAB59592; BAB59592
GeneIDi1440968
KEGGitvo:TVG0438422

Phylogenomic databases

eggNOGiarCOG04313 Archaea
COG0105 LUCA
KOiK00940
OMAiKIVAMKM
OrthoDBiPOG093Z0ECU

Enzyme and pathway databases

BioCyciTVOL273116:G1G3C-479-MONOMER

Family and domain databases

Gene3Di3.30.70.141, 1 hit
HAMAPiMF_00451 NDP_kinase, 1 hit
InterProiView protein in InterPro
IPR034907 NDK-like_dom
IPR036850 NDK-like_dom_sf
IPR001564 Nucleoside_diP_kinase
IPR023005 Nucleoside_diP_kinase_AS
PfamiView protein in Pfam
PF00334 NDK, 1 hit
PRINTSiPR01243 NUCDPKINASE
SMARTiView protein in SMART
SM00562 NDK, 1 hit
SUPFAMiSSF54919 SSF54919, 1 hit
PROSITEiView protein in PROSITE
PS00469 NDP_KINASES, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNDK_THEVO
AccessioniPrimary (citable) accession number: Q97BK5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: October 1, 2001
Last modified: October 10, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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