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Protein

Calcium-gated potassium channel TvoK

Gene

tvoK

Organism
Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium-gated potassium channel. Can also be activated by Mg2+, Mn2+ and Ni2+.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionIon channel, Potassium channel
Biological processIon transport, Potassium transport, Transport
LigandCalcium, Magnesium, Manganese, Metal-binding, Nickel, Potassium

Enzyme and pathway databases

BioCyciTVOL273116:G1G3C-1080-MONOMER

Protein family/group databases

TCDBi1.A.1.13.3 the voltage-gated ion channel (vic) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-gated potassium channel TvoKCurated
Gene namesi
Name:tvoK1 Publication
ORF Names:TVG1041141Imported
OrganismiThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Taxonomic identifieri273116 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaDiaforarchaea groupThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
Proteomesi
  • UP000001017 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei19 – 39HelicalSequence analysisAdd BLAST21
Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Transmembranei80 – 100HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi111R → N: Reduces levels of the soluble RCK domain. 1 Publication1
Mutagenesisi114K → N: Does not affect levels of the soluble RCK domain. 1 Publication1
Mutagenesisi115L → N: Abolishes expression of the soluble RCK domain. 1 Publication1
Mutagenesisi117K → N: Does not affect levels of the soluble RCK domain. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004392371 – 348Calcium-gated potassium channel TvoKAdd BLAST348

Interactioni

Subunit structurei

Heterooctamer composed of four full-length subunits and four soluble RCK domains.1 Publication

Protein-protein interaction databases

STRINGi273116.TVN0988

Structurei

3D structure databases

ProteinModelPortaliQ979Z2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini122 – 253RCK N-terminalPROSITE-ProRule annotationAdd BLAST132
Domaini266 – 348RCK C-terminalPROSITE-ProRule annotationAdd BLAST83

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiarCOG01958 Archaea
COG1226 LUCA
KOiK10716
OMAiAMIIEGN
OrthoDBiPOG093Z055I

Family and domain databases

InterProiView protein in InterPro
IPR003280 2pore_dom_K_chnl
IPR013099 K_chnl_dom
IPR036291 NAD(P)-bd_dom_sf
IPR006037 RCK_C
IPR003148 RCK_N
PfamiView protein in Pfam
PF07885 Ion_trans_2, 1 hit
PF02254 TrkA_N, 1 hit
PRINTSiPR01333 2POREKCHANEL
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS51202 RCK_C, 1 hit
PS51201 RCK_N, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket
Isoform 1Curated (identifier: Q979Z2-1) [UniParc]FASTAAdd to basket
Also known as: Calcium-gated potassium channelCurated

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRPFRTLVKV LQKIESSPLT KVFMAFIIVV LIGSYLEFLT QRNVKYSEIK
60 70 80 90 100
NYFTAIWFTM ETVTTVGYGD VVPVSNLGRV VAMLIMVSGI GLLGTLTATI
110 120 130 140 150
SAYLFQIRIE RRGKLEKRLK NHTIICNWNA YTRNIIEGNR DEEAAPIVIL
160 170 180 190 200
SENTDNSEKY QNVFFVKGDC TSEDDLKNAA IEDAARVVIM SDIENNAIPE
210 220 230 240 250
DLLDAKTLLS IFTVRKLNNA VEIIAEVRDE KNKKHAVSAG ATEVLSVGEL
260 270 280 290 300
SSRLISRSIS NPGLTDFILK SLSETEDFKI FSIEACGILP GMTVKDAASN
310 320 330 340
LAEVCVIISV ISKGKIEYPP DRSYKIGAGD YVVFLAKNKK EVEEAIKG
Length:348
Mass (Da):38,605
Last modified:October 1, 2001 - v1
Checksum:i706E08967EABA376
GO
Isoform 2Curated (identifier: Q979Z2-2) [UniParc]FASTAAdd to basket
Also known as: Soluble RCK domainCurated

The sequence of this isoform differs from the canonical sequence as follows:
     1-114: Missing.
     115-115: L → M

Note: Starts at UUG codon.1 Publication
Show »
Length:234
Mass (Da):25,769
Checksum:iD9878C4BDA2C92E6
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0591601 – 114Missing in isoform 2. 1 PublicationAdd BLAST114
Alternative sequenceiVSP_059161115L → M in isoform 2. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000011 Genomic DNA Translation: BAB60160.1
RefSeqiWP_010917246.1, NC_002689.2

Genome annotation databases

EnsemblBacteriaiBAB60160; BAB60160; BAB60160
GeneIDi1441128
KEGGitvo:TVG1041141

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000011 Genomic DNA Translation: BAB60160.1
RefSeqiWP_010917246.1, NC_002689.2

3D structure databases

ProteinModelPortaliQ979Z2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273116.TVN0988

Protein family/group databases

TCDBi1.A.1.13.3 the voltage-gated ion channel (vic) superfamily

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB60160; BAB60160; BAB60160
GeneIDi1441128
KEGGitvo:TVG1041141

Phylogenomic databases

eggNOGiarCOG01958 Archaea
COG1226 LUCA
KOiK10716
OMAiAMIIEGN
OrthoDBiPOG093Z055I

Enzyme and pathway databases

BioCyciTVOL273116:G1G3C-1080-MONOMER

Family and domain databases

InterProiView protein in InterPro
IPR003280 2pore_dom_K_chnl
IPR013099 K_chnl_dom
IPR036291 NAD(P)-bd_dom_sf
IPR006037 RCK_C
IPR003148 RCK_N
PfamiView protein in Pfam
PF07885 Ion_trans_2, 1 hit
PF02254 TrkA_N, 1 hit
PRINTSiPR01333 2POREKCHANEL
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS51202 RCK_C, 1 hit
PS51201 RCK_N, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTVOK_THEVO
AccessioniPrimary (citable) accession number: Q979Z2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2017
Last sequence update: October 1, 2001
Last modified: November 7, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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