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Protein

Thiamine thiazole synthase

Gene

thi4

Organism
Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.UniRule annotation

Cofactori

Fe2+UniRule annotation

Pathwayi: thiamine diphosphate biosynthesis

This protein is involved in the pathway thiamine diphosphate biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway thiamine diphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei44NADUniRule annotation1
Binding sitei71NAD; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei135NAD; via amide nitrogen and carbonyl oxygenUniRule annotation1
Metal bindingi165Iron; shared with adjacent protomerUniRule annotation1
Metal bindingi180IronUniRule annotation1
Binding sitei230NAD; via amide nitrogenUniRule annotation1
Binding sitei240GlycineUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi63 – 64NADUniRule annotation2
Nucleotide bindingi163 – 165NAD; shared with adjacent protomerUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processThiamine biosynthesis
LigandIron, Metal-binding, NAD

Enzyme and pathway databases

BioCyciSTOK273063:G1G3D-432-MONOMER
UniPathwayiUPA00060

Names & Taxonomyi

Protein namesi
Recommended name:
Thiamine thiazole synthaseUniRule annotation (EC:4.-.-.-UniRule annotation)
Gene namesi
Name:thi4UniRule annotation
Ordered Locus Names:STK_03610
OrganismiSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Taxonomic identifieri273063 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001015 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003007411 – 266Thiamine thiazole synthaseAdd BLAST266

Interactioni

Subunit structurei

Homooctamer; tetramer of dimers.UniRule annotation

Protein-protein interaction databases

STRINGi273063.ST0361

Structurei

3D structure databases

ProteinModelPortaliQ975R0
SMRiQ975R0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the THI4 family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00574 Archaea
COG1635 LUCA
HOGENOMiHOG000106048
KOiK22699
OMAiMWGGGMM
OrthoDBiPOG093Z09PU

Family and domain databases

Gene3Di3.50.50.60, 1 hit
HAMAPiMF_00304 Thi4, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR002922 Thi4_fam
IPR022828 Thi4_prok
SUPFAMiSSF51905 SSF51905, 1 hit
TIGRFAMsiTIGR00292 TIGR00292, 1 hit

Sequencei

Sequence statusi: Complete.

Q975R0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSNSIKVKQ VDEVKISKYI LKYTFQDWED IVESDVVIVG AGPSGMTAAY
60 70 80 90 100
YLAKAGLKTV VFERRLSFGG GIGGGAMLFH KIVIESPADE ILKEMKIKLN
110 120 130 140 150
KVEEGVYIVD SAEFMAKLAA SAIDAGAKII HGVTVDDVIF RENPLKVVGV
160 170 180 190 200
AVEWTATQMA GLHVDPLFIS AKAVVDATGH DAEVISVAAR KIPELNIVIP
210 220 230 240 250
GEKSAYSETA EELTVENTGM VAPGLYAAGM AVTEVKGLPR MGPIFGAMVL
260
SGKRVAEIII KDLRYS
Length:266
Mass (Da):28,473
Last modified:December 1, 2001 - v1
Checksum:iB8584E4825C17770
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000023 Genomic DNA Translation: BAB65340.1
RefSeqiWP_010978323.1, NC_003106.2

Genome annotation databases

EnsemblBacteriaiBAB65340; BAB65340; STK_03610
GeneIDi1458284
KEGGisto:STK_03610
PATRICifig|273063.9.peg.420

Similar proteinsi

Entry informationi

Entry nameiTHI4_SULTO
AccessioniPrimary (citable) accession number: Q975R0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 1, 2001
Last modified: July 18, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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