UniProtKB - Q96WV5 (COPA_SCHPO)
Protein
Putative coatomer subunit alpha
Gene
SPBPJ4664.04
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).By similarity
GO - Molecular functioni
- structural molecule activity Source: InterPro
GO - Biological processi
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: PomBase
- intracellular protein transport Source: GO_Central
- intra-Golgi vesicle-mediated transport Source: GO_Central
- retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Source: PomBase
Keywordsi
Biological process | ER-Golgi transport, Protein transport, Transport |
Enzyme and pathway databases
Reactomei | R-SPO-6807878, COPI-mediated anterograde transport R-SPO-6811434, COPI-dependent Golgi-to-ER retrograde traffic |
Names & Taxonomyi
Protein namesi | Recommended name: Putative coatomer subunit alphaAlternative name(s): Alpha-coat protein Short name: Alpha-COP |
Gene namesi | ORF Names:SPBPJ4664.04 |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPBPJ4664.04 |
VEuPathDBi | FungiDB:SPBPJ4664.04 |
Subcellular locationi
Golgi apparatus
Other locations
Golgi apparatus
- COPI vesicle coat Source: PomBase
- Golgi apparatus Source: PomBase
- Golgi membrane Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: PomBase
Keywords - Cellular componenti
Cytoplasm, Golgi apparatus, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000316543 | 1 – 1207 | Putative coatomer subunit alphaAdd BLAST | 1207 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 409 | Phosphoserine1 Publication | 1 | |
Modified residuei | 942 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | Q96WV5 |
PaxDbi | Q96WV5 |
PRIDEi | Q96WV5 |
PTM databases
iPTMneti | Q96WV5 |
Interactioni
Subunit structurei
Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
By similarityBinary interactionsi
Q96WV5
With | #Exp. | IntAct |
---|---|---|
P68978 from Human adenovirus C serotype 2. | 2 | EBI-8503699,EBI-4407041 |
Protein-protein interaction databases
BioGRIDi | 277920, 9 interactors |
IntActi | Q96WV5, 7 interactors |
MINTi | Q96WV5 |
STRINGi | 4896.SPBPJ4664.04.1 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q96WV5 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 9 – 50 | WD 1Add BLAST | 42 | |
Repeati | 51 – 90 | WD 2Add BLAST | 40 | |
Repeati | 93 – 134 | WD 3Add BLAST | 42 | |
Repeati | 135 – 174 | WD 4Add BLAST | 40 | |
Repeati | 210 – 249 | WD 5Add BLAST | 40 | |
Repeati | 254 – 293 | WD 6Add BLAST | 40 | |
Repeati | 296 – 336 | WD 7Add BLAST | 41 | |
Repeati | 370 – 411 | WD 8Add BLAST | 42 |
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG0292, Eukaryota |
HOGENOMi | CLU_007565_1_0_1 |
InParanoidi | Q96WV5 |
OMAi | GNQVFCL |
PhylomeDBi | Q96WV5 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR016391, Coatomer_asu IPR010714, Coatomer_asu_C IPR006692, Coatomer_WD-assoc_reg IPR020472, G-protein_beta_WD-40_rep IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF04053, Coatomer_WDAD, 1 hit PF06957, COPI_C, 1 hit PF00400, WD40, 5 hits |
PIRSFi | PIRSF003354, Coatomer_alpha_subunit, 1 hit |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 2 hits PS50082, WD_REPEATS_2, 6 hits PS50294, WD_REPEATS_REGION, 1 hit |
i Sequence
Sequence statusi: Complete.
Q96WV5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEMLTKFESR SSRAKGVAFH PTQPWILTSL HNGRIQLWDY RMGTLLDRFD
60 70 80 90 100
GHDGPVRGIA FHPTQPLFVS GGDDYKVNVW NYKSRKLLFS LCGHMDYVRV
110 120 130 140 150
CTFHHEYPWI LSCSDDQTIR IWNWQSRNCI AILTGHSHYV MCAAFHPSED
160 170 180 190 200
LIVSASLDQT VRVWDISGLR MKNAAPVSMS LEDQLAQAHN SISNDLFGST
210 220 230 240 250
DAIVKFVLEG HDRGVNWCAF HPTLPLILSA GDDRLVKLWR MTASKAWEVD
260 270 280 290 300
TCRGHFNNVS CCLFHPHQEL ILSASEDKTI RVWDLNRRTA VQTFRRDNDR
310 320 330 340 350
FWFITVHPKL NLFAAAHDSG VMVFKLERER PAHALNINTL LYVNKEKSIV
360 370 380 390 400
SYDLLRAQST TVASVKHLGS AWLPPRSLSY NPAEKVALLT SSADNGVYEL
410 420 430 440 450
VNVSSRSNSL PLKDNIKGPG DDAIFVARNR FAVFSRSDQT IEIKDLSNKV
460 470 480 490 500
TKTIQLPEKT RDIFFAGMGH VLLSTATQVH LFDLQQKKIV SSFNANRVKY
510 520 530 540 550
VVWSNDNSQA ALLGKHYVYI VKKNLELITS IHETIRIKSA VWVENNVLLY
560 570 580 590 600
ATLDHLKYAL MSGDTGVIKT LESTLYLVKA KGNMVFALNR AAEPVSFEID
610 620 630 640 650
PTEYLFKLAL LRKDYEQVLH LIQNSNLVGQ AIIAYLQKKG YPEIALQFVE
660 670 680 690 700
DPSTRFELAL ECGNLETALE LARTIDRPEV WSRLASDAMS YGNHKIAEIT
710 720 730 740 750
FQKLRYFEKL SFLYLITGNA EKLQKMAIIA EKRNDTLSLF QNSLYLNEVE
760 770 780 790 800
SRINILEQAG MYPIAYLTAK SNGLEEKAQQ ILSHCNKTEE EIKLPSLGSA
810 820 830 840 850
FTTPVPVNET YTHNWPLLDT SHSTFEKSLQ ERMEQLAIER QEEQESEEEY
860 870 880 890 900
EEVEQSLMDV VDEMSDLAES VPEEEVDGWE VEDLAPEEAV NDVVDDASAF
910 920 930 940 950
VGADEIFLWK RNSPLAADHI AAGDFESAMK ILNKQVGAIN FSPLKTRFLE
960 970 980 990 1000
IYTASRVYLP TISGLDPLVS YVRRNAETAE RSQALPFITR NLASIKSHEL
1010 1020 1030 1040 1050
HEAYRLVKAN KILEAQICFR SIIYLALTTV ANSEEEADEI SALIDECCRY
1060 1070 1080 1090 1100
IVALSCELER RRLGEEDTKR ALELSYYFAS ADLQPMHSII ALRLAINASH
1110 1120 1130 1140 1150
KLKNYKSASF LGNKLLQLAE SGPAAEAANR AITLGDRNPH DAFEIEYDPH
1160 1170 1180 1190 1200
VEMRICPKTL TPVYSGDDFD VCSVCGAVYH KGYVNEVCTV CDVGGIGQKG
TGRRFFA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329671 Genomic DNA Translation: CAC38349.1 |
RefSeqi | NP_595279.1, NM_001021186.2 |
Genome annotation databases
EnsemblFungii | SPBPJ4664.04.1; SPBPJ4664.04.1:pep; SPBPJ4664.04 |
GeneIDi | 2541412 |
KEGGi | spo:SPBPJ4664.04 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329671 Genomic DNA Translation: CAC38349.1 |
RefSeqi | NP_595279.1, NM_001021186.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4J87 | X-ray | 1.67 | A | 1-327 | [»] | |
4J8B | X-ray | 1.88 | A | 1-327 | [»] | |
4J8G | X-ray | 1.90 | A/B | 1-327 | [»] | |
SMRi | Q96WV5 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 277920, 9 interactors |
IntActi | Q96WV5, 7 interactors |
MINTi | Q96WV5 |
STRINGi | 4896.SPBPJ4664.04.1 |
PTM databases
iPTMneti | Q96WV5 |
Proteomic databases
MaxQBi | Q96WV5 |
PaxDbi | Q96WV5 |
PRIDEi | Q96WV5 |
Genome annotation databases
EnsemblFungii | SPBPJ4664.04.1; SPBPJ4664.04.1:pep; SPBPJ4664.04 |
GeneIDi | 2541412 |
KEGGi | spo:SPBPJ4664.04 |
Organism-specific databases
PomBasei | SPBPJ4664.04 |
VEuPathDBi | FungiDB:SPBPJ4664.04 |
Phylogenomic databases
eggNOGi | KOG0292, Eukaryota |
HOGENOMi | CLU_007565_1_0_1 |
InParanoidi | Q96WV5 |
OMAi | GNQVFCL |
PhylomeDBi | Q96WV5 |
Enzyme and pathway databases
Reactomei | R-SPO-6807878, COPI-mediated anterograde transport R-SPO-6811434, COPI-dependent Golgi-to-ER retrograde traffic |
Miscellaneous databases
PROi | PR:Q96WV5 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR016391, Coatomer_asu IPR010714, Coatomer_asu_C IPR006692, Coatomer_WD-assoc_reg IPR020472, G-protein_beta_WD-40_rep IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF04053, Coatomer_WDAD, 1 hit PF06957, COPI_C, 1 hit PF00400, WD40, 5 hits |
PIRSFi | PIRSF003354, Coatomer_alpha_subunit, 1 hit |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 2 hits PS50082, WD_REPEATS_2, 6 hits PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | COPA_SCHPO | |
Accessioni | Q96WV5Primary (citable) accession number: Q96WV5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 147 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references