Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Regulator of microtubule dynamics protein 3

Gene

RMDN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis.2 Publications

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • cell differentiation Source: UniProtKB-KW
  • cellular calcium ion homeostasis Source: UniProtKB

Keywordsi

Biological processApoptosis, Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of microtubule dynamics protein 3
Short name:
RMD-3
Short name:
hRMD-3
Alternative name(s):
Cerebral protein 10
Protein FAM82A2
Protein FAM82C
Protein tyrosine phosphatase-interacting protein 51
TCPTP-interacting protein 51
Gene namesi
Name:RMDN3
Synonyms:FAM82A2, FAM82C, PTPIP51
ORF Names:hucep-10, UNQ3122/PRO10274
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000137824.15
HGNCiHGNC:25550 RMDN3
MIMi611873 gene
neXtProtiNX_Q96TC7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 35HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Microtubule, Mitochondrion, Mitochondrion outer membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55177
OpenTargetsiENSG00000137824
PharmGKBiPA162387926

Polymorphism and mutation databases

BioMutaiRMDN3
DMDMi147643203

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002875101 – 470Regulator of microtubule dynamics protein 3Add BLAST470

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei44PhosphoserineCombined sources1
Modified residuei46PhosphoserineCombined sources1
Modified residuei50PhosphoserineCombined sources1
Modified residuei57PhosphoserineBy similarity1
Modified residuei183PhosphoserineCombined sources1
Modified residuei193PhosphoserineCombined sources1
Modified residuei212PhosphoserineCombined sources1
Modified residuei232PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96TC7
MaxQBiQ96TC7
PaxDbiQ96TC7
PeptideAtlasiQ96TC7
PRIDEiQ96TC7
ProteomicsDBi78224
78225 [Q96TC7-2]
TopDownProteomicsiQ96TC7-1 [Q96TC7-1]
Q96TC7-2 [Q96TC7-2]

PTM databases

iPTMnetiQ96TC7
PhosphoSitePlusiQ96TC7
SwissPalmiQ96TC7

Expressioni

Tissue specificityi

Present at high level in epidermis and seminiferous epithelium: while basal cells in the epidermis and spermatogonia show no perceptible amount, keratinocytes of suprabasal layers and differentiating first-order spermatocytes up to spermatids exhibit high expression. In skeletal muscle, its presence is restricted to fibers of the fast twitch type. In surface epithelia containing ciliated cells, it is associated with the microtubular structures responsible for ciliary movement. Also present in specific structures of the central nervous system such as neurons of the hippocampal region, ganglion cells of the autonomic nervous system, and axons of the peripheral nervous system (at protein level). Widely expressed.2 Publications

Inductioni

By EGF, TGFB1, retinoic acid-and 1,25-dihydroxyvitamin D3.1 Publication

Gene expression databases

BgeeiENSG00000137824 Expressed in 220 organ(s), highest expression level in frontal cortex
CleanExiHS_FAM82A2
ExpressionAtlasiQ96TC7 baseline and differential
GenevisibleiQ96TC7 HS

Organism-specific databases

HPAiHPA009975

Interactioni

Subunit structurei

Interacts with PTPN2. Interacts with microtubules. Interacts with VAPB.3 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi120476, 42 interactors
IntActiQ96TC7, 43 interactors
MINTiQ96TC7
STRINGi9606.ENSP00000260385

Structurei

3D structure databases

ProteinModelPortaliQ96TC7
SMRiQ96TC7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili92 – 124Sequence analysisAdd BLAST33

Domaini

The transmembrane region is required for mitochondrial localization.

Sequence similaritiesi

Belongs to the RMDN family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIGM Eukaryota
ENOG41101S6 LUCA
GeneTreeiENSGT00530000063162
HOVERGENiHBG072518
InParanoidiQ96TC7
OMAiEVRSHME
OrthoDBiEOG091G0F3V
PhylomeDBiQ96TC7
TreeFamiTF315854

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR011990 TPR-like_helical_dom_sf
SUPFAMiSSF48452 SSF48452, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96TC7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRLGALGGA RAGLGLLLGT AAGLGFLCLL YSQRWKRTQR HGRSQSLPNS
60 70 80 90 100
LDYTQTSDPG RHVMLLRAVP GGAGDASVLP SLPREGQEKV LDRLDFVLTS
110 120 130 140 150
LVALRREVEE LRSSLRGLAG EIVGEVRCHM EENQRVARRR RFPFVRERSD
160 170 180 190 200
STGSSSVYFT ASSGATFTDA ESEGGYTTAN AESDNERDSD KESEDGEDEV
210 220 230 240 250
SCETVKMGRK DSLDLEEEAA SGASSALEAG GSSGLEDVLP LLQQADELHR
260 270 280 290 300
GDEQGKREGF QLLLNNKLVY GSRQDFLWRL ARAYSDMCEL TEEVSEKKSY
310 320 330 340 350
ALDGKEEAEA ALEKGDESAD CHLWYAVLCG QLAEHESIQR RIQSGFSFKE
360 370 380 390 400
HVDKAIALQP ENPMAHFLLG RWCYQVSHLS WLEKKTATAL LESPLSATVE
410 420 430 440 450
DALQSFLKAE ELQPGFSKAG RVYISKCYRE LGKNSEARWW MKLALELPDV
460 470
TKEDLAIQKD LEELEVILRD
Length:470
Mass (Da):52,118
Last modified:May 15, 2007 - v2
Checksum:i1C8D1022E6CF7B6A
GO
Isoform 2 (identifier: Q96TC7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-129: Missing.

Note: No experimental confirmation available.
Show »
Length:341
Mass (Da):38,247
Checksum:i6015D71ECA057A27
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YNE5H0YNE5_HUMAN
Regulator of microtubule dynamics p...
RMDN3
251Annotation score:
H0YLG5H0YLG5_HUMAN
Regulator of microtubule dynamics p...
RMDN3
287Annotation score:
H0YMB1H0YMB1_HUMAN
Regulator of microtubule dynamics p...
RMDN3
306Annotation score:
H0YLV7H0YLV7_HUMAN
Regulator of microtubule dynamics p...
RMDN3
116Annotation score:

Sequence cautioni

The sequence BAB15298 differs from that shown. Reason: Erroneous termination at position 453. Translated as Glu.Curated
The sequence BAC85554 differs from that shown. Reason: Frameshift at position 383.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti416F → V in BAB46923 (Ref. 1) Curated1
Sequence conflicti469R → Q in BAC85554 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04902933Q → H. Corresponds to variant dbSNP:rs11558807Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0255311 – 129Missing in isoform 2. 1 PublicationAdd BLAST129

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000782 mRNA Translation: BAB46923.1
AY358793 mRNA Translation: AAQ89153.1
AK001441 mRNA Translation: BAA91693.1
AK025963 mRNA Translation: BAB15298.1 Sequence problems.
AK092058 mRNA Translation: BAG52475.1
AK123282 mRNA Translation: BAG53885.1
AK123192 mRNA Translation: BAC85554.1 Frameshift.
CH471125 Genomic DNA Translation: EAW92436.1
BC008970 mRNA Translation: AAH08970.2
BC063844 mRNA Translation: AAH63844.1
AJ242719 Genomic DNA Translation: CAC39480.1
BR000691 mRNA Translation: FAA00416.1
CCDSiCCDS10063.1 [Q96TC7-1]
RefSeqiNP_001291731.1, NM_001304802.1 [Q96TC7-1]
NP_001310823.1, NM_001323894.1 [Q96TC7-1]
NP_001310824.1, NM_001323895.1 [Q96TC7-2]
NP_060615.1, NM_018145.2 [Q96TC7-1]
UniGeneiHs.511067
Hs.632944

Genome annotation databases

EnsembliENST00000260385; ENSP00000260385; ENSG00000137824 [Q96TC7-1]
ENST00000338376; ENSP00000342493; ENSG00000137824 [Q96TC7-1]
GeneIDi55177
KEGGihsa:55177
UCSCiuc001zmp.1 human [Q96TC7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000782 mRNA Translation: BAB46923.1
AY358793 mRNA Translation: AAQ89153.1
AK001441 mRNA Translation: BAA91693.1
AK025963 mRNA Translation: BAB15298.1 Sequence problems.
AK092058 mRNA Translation: BAG52475.1
AK123282 mRNA Translation: BAG53885.1
AK123192 mRNA Translation: BAC85554.1 Frameshift.
CH471125 Genomic DNA Translation: EAW92436.1
BC008970 mRNA Translation: AAH08970.2
BC063844 mRNA Translation: AAH63844.1
AJ242719 Genomic DNA Translation: CAC39480.1
BR000691 mRNA Translation: FAA00416.1
CCDSiCCDS10063.1 [Q96TC7-1]
RefSeqiNP_001291731.1, NM_001304802.1 [Q96TC7-1]
NP_001310823.1, NM_001323894.1 [Q96TC7-1]
NP_001310824.1, NM_001323895.1 [Q96TC7-2]
NP_060615.1, NM_018145.2 [Q96TC7-1]
UniGeneiHs.511067
Hs.632944

3D structure databases

ProteinModelPortaliQ96TC7
SMRiQ96TC7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120476, 42 interactors
IntActiQ96TC7, 43 interactors
MINTiQ96TC7
STRINGi9606.ENSP00000260385

PTM databases

iPTMnetiQ96TC7
PhosphoSitePlusiQ96TC7
SwissPalmiQ96TC7

Polymorphism and mutation databases

BioMutaiRMDN3
DMDMi147643203

Proteomic databases

EPDiQ96TC7
MaxQBiQ96TC7
PaxDbiQ96TC7
PeptideAtlasiQ96TC7
PRIDEiQ96TC7
ProteomicsDBi78224
78225 [Q96TC7-2]
TopDownProteomicsiQ96TC7-1 [Q96TC7-1]
Q96TC7-2 [Q96TC7-2]

Protocols and materials databases

DNASUi55177
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260385; ENSP00000260385; ENSG00000137824 [Q96TC7-1]
ENST00000338376; ENSP00000342493; ENSG00000137824 [Q96TC7-1]
GeneIDi55177
KEGGihsa:55177
UCSCiuc001zmp.1 human [Q96TC7-1]

Organism-specific databases

CTDi55177
DisGeNETi55177
EuPathDBiHostDB:ENSG00000137824.15
GeneCardsiRMDN3
HGNCiHGNC:25550 RMDN3
HPAiHPA009975
MIMi611873 gene
neXtProtiNX_Q96TC7
OpenTargetsiENSG00000137824
PharmGKBiPA162387926
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIGM Eukaryota
ENOG41101S6 LUCA
GeneTreeiENSGT00530000063162
HOVERGENiHBG072518
InParanoidiQ96TC7
OMAiEVRSHME
OrthoDBiEOG091G0F3V
PhylomeDBiQ96TC7
TreeFamiTF315854

Miscellaneous databases

ChiTaRSiRMDN3 human
GenomeRNAii55177
PROiPR:Q96TC7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000137824 Expressed in 220 organ(s), highest expression level in frontal cortex
CleanExiHS_FAM82A2
ExpressionAtlasiQ96TC7 baseline and differential
GenevisibleiQ96TC7 HS

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR011990 TPR-like_helical_dom_sf
SUPFAMiSSF48452 SSF48452, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRMD3_HUMAN
AccessioniPrimary (citable) accession number: Q96TC7
Secondary accession number(s): A9UMZ9
, B3KRR3, Q6ZWE9, Q96H23, Q96SD6, Q9H6G1, Q9NVQ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: October 10, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again