UniProtKB - Q96TC7 (RMD3_HUMAN)
Regulator of microtubule dynamics protein 3
RMDN3
Functioni
Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis.
2 PublicationsGO - Molecular functioni
- microtubule binding Source: UniProtKB
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- cell differentiation Source: UniProtKB-KW
- cellular calcium ion homeostasis Source: UniProtKB
Keywordsi
Biological process | Apoptosis, Differentiation |
Enzyme and pathway databases
PathwayCommonsi | Q96TC7 |
SignaLinki | Q96TC7 |
SIGNORi | Q96TC7 |
Names & Taxonomyi
Protein namesi | Recommended name: Regulator of microtubule dynamics protein 3Short name: RMD-3 Short name: hRMD-3 Alternative name(s): Cerebral protein 10 Protein FAM82A2 Protein FAM82C Protein tyrosine phosphatase-interacting protein 51 TCPTP-interacting protein 51 |
Gene namesi | Name:RMDN3 Synonyms:FAM82A2, FAM82C, PTPIP51 ORF Names:hucep-10, UNQ3122/PRO10274 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25550, RMDN3 |
MIMi | 611873, gene |
neXtProti | NX_Q96TC7 |
VEuPathDBi | HostDB:ENSG00000137824 |
Subcellular locationi
Mitochondrion
- Mitochondrion outer membrane 4 Publications; Single-pass membrane protein 1 Publication
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Nucleus
- Nucleus 1 Publication
Cytoskeleton
- spindle 1 Publication
- spindle pole 1 Publication
Note: In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles.1 Publication
Cytoskeleton
- mitotic spindle pole Source: UniProtKB
- spindle microtubule Source: UniProtKB
Extracellular region or secreted
- intercellular bridge Source: HPA
Mitochondrion
- mitochondrial outer membrane Source: UniProtKB
- mitochondrion Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: GO_Central
- integral component of membrane Source: UniProtKB-KW
- organelle membrane contact site Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 12 | Mitochondrial intermembraneCuratedAdd BLAST | 12 | |
Transmembranei | 13 – 35 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 36 – 470 | CytoplasmicCuratedAdd BLAST | 435 |
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, Membrane, Microtubule, Mitochondrion, Mitochondrion outer membrane, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 157 – 172 | Missing : Reduces interaction with MOSPD2. 1 PublicationAdd BLAST | 16 |
Organism-specific databases
DisGeNETi | 55177 |
OpenTargetsi | ENSG00000137824 |
PharmGKBi | PA162387926 |
Miscellaneous databases
Pharosi | Q96TC7, Tbio |
Genetic variation databases
BioMutai | RMDN3 |
DMDMi | 147643203 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000287510 | 1 – 470 | Regulator of microtubule dynamics protein 3Add BLAST | 470 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 44 | PhosphoserineCombined sources | 1 | |
Modified residuei | 46 | PhosphoserineCombined sources | 1 | |
Modified residuei | 50 | PhosphoserineCombined sources | 1 | |
Modified residuei | 57 | PhosphoserineBy similarity | 1 | |
Modified residuei | 183 | PhosphoserineCombined sources | 1 | |
Modified residuei | 193 | PhosphoserineCombined sources | 1 | |
Modified residuei | 212 | PhosphoserineCombined sources | 1 | |
Modified residuei | 232 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q96TC7 |
jPOSTi | Q96TC7 |
MassIVEi | Q96TC7 |
MaxQBi | Q96TC7 |
PaxDbi | Q96TC7 |
PeptideAtlasi | Q96TC7 |
PRIDEi | Q96TC7 |
ProteomicsDBi | 78224 [Q96TC7-1] 78225 [Q96TC7-2] |
TopDownProteomicsi | Q96TC7-1 [Q96TC7-1] Q96TC7-2 [Q96TC7-2] |
PTM databases
iPTMneti | Q96TC7 |
PhosphoSitePlusi | Q96TC7 |
SwissPalmi | Q96TC7 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000137824, Expressed in frontal cortex and 235 other tissues |
ExpressionAtlasi | Q96TC7, baseline and differential |
Genevisiblei | Q96TC7, HS |
Organism-specific databases
HPAi | ENSG00000137824, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with PTPN2.
Interacts with microtubules.
Interacts with VAPB.
Interacts (FFAT motif) with MOSPD2 (via MSP domain) (PubMed:29858488).
4 PublicationsBinary interactionsi
Q96TC7
GO - Molecular functioni
- microtubule binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 120476, 346 interactors |
IntActi | Q96TC7, 51 interactors |
MINTi | Q96TC7 |
STRINGi | 9606.ENSP00000260385 |
Miscellaneous databases
RNActi | Q96TC7, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q96TC7 |
SMRi | Q96TC7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 168 – 231 | DisorderedSequence analysisAdd BLAST | 64 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 92 – 124 | Sequence analysisAdd BLAST | 33 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 157 – 172 | FFAT1 PublicationAdd BLAST | 16 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 168 – 182 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 200 – 217 | Basic and acidic residuesSequence analysisAdd BLAST | 18 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coil, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QWUP, Eukaryota |
GeneTreei | ENSGT00950000182992 |
HOGENOMi | CLU_046369_0_2_1 |
InParanoidi | Q96TC7 |
OMAi | QHESMHS |
OrthoDBi | 1380644at2759 |
PhylomeDBi | Q96TC7 |
TreeFami | TF315854 |
Family and domain databases
Gene3Di | 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR011990, TPR-like_helical_dom_sf |
SUPFAMi | SSF48452, SSF48452, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSRLGALGGA RAGLGLLLGT AAGLGFLCLL YSQRWKRTQR HGRSQSLPNS
60 70 80 90 100
LDYTQTSDPG RHVMLLRAVP GGAGDASVLP SLPREGQEKV LDRLDFVLTS
110 120 130 140 150
LVALRREVEE LRSSLRGLAG EIVGEVRCHM EENQRVARRR RFPFVRERSD
160 170 180 190 200
STGSSSVYFT ASSGATFTDA ESEGGYTTAN AESDNERDSD KESEDGEDEV
210 220 230 240 250
SCETVKMGRK DSLDLEEEAA SGASSALEAG GSSGLEDVLP LLQQADELHR
260 270 280 290 300
GDEQGKREGF QLLLNNKLVY GSRQDFLWRL ARAYSDMCEL TEEVSEKKSY
310 320 330 340 350
ALDGKEEAEA ALEKGDESAD CHLWYAVLCG QLAEHESIQR RIQSGFSFKE
360 370 380 390 400
HVDKAIALQP ENPMAHFLLG RWCYQVSHLS WLEKKTATAL LESPLSATVE
410 420 430 440 450
DALQSFLKAE ELQPGFSKAG RVYISKCYRE LGKNSEARWW MKLALELPDV
460 470
TKEDLAIQKD LEELEVILRD
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YLG5 | H0YLG5_HUMAN | Regulator of microtubule dynamics p... | RMDN3 | 287 | Annotation score: | ||
H0YNE5 | H0YNE5_HUMAN | Regulator of microtubule dynamics p... | RMDN3 | 251 | Annotation score: | ||
H0YMB1 | H0YMB1_HUMAN | Regulator of microtubule dynamics p... | RMDN3 | 306 | Annotation score: | ||
H0YLV7 | H0YLV7_HUMAN | Regulator of microtubule dynamics p... | RMDN3 | 116 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 416 | F → V in BAB46923 (Ref. 1) Curated | 1 | |
Sequence conflicti | 469 | R → Q in BAC85554 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049029 | 33 | Q → H. Corresponds to variant dbSNP:rs11558807Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_025531 | 1 – 129 | Missing in isoform 2. 1 PublicationAdd BLAST | 129 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB000782 mRNA Translation: BAB46923.1 AY358793 mRNA Translation: AAQ89153.1 AK001441 mRNA Translation: BAA91693.1 AK025963 mRNA Translation: BAB15298.1 Sequence problems. AK092058 mRNA Translation: BAG52475.1 AK123282 mRNA Translation: BAG53885.1 AK123192 mRNA Translation: BAC85554.1 Frameshift. CH471125 Genomic DNA Translation: EAW92436.1 BC008970 mRNA Translation: AAH08970.2 BC063844 mRNA Translation: AAH63844.1 AJ242719 Genomic DNA Translation: CAC39480.1 BR000691 mRNA Translation: FAA00416.1 |
CCDSi | CCDS10063.1 [Q96TC7-1] |
RefSeqi | NP_001291731.1, NM_001304802.1 [Q96TC7-1] NP_001310823.1, NM_001323894.1 [Q96TC7-1] NP_001310824.1, NM_001323895.1 [Q96TC7-2] NP_060615.1, NM_018145.2 [Q96TC7-1] |
Genome annotation databases
Ensembli | ENST00000260385.10; ENSP00000260385.6; ENSG00000137824.16 ENST00000338376.8; ENSP00000342493.3; ENSG00000137824.16 |
GeneIDi | 55177 |
KEGGi | hsa:55177 |
MANE-Selecti | ENST00000338376.8; ENSP00000342493.3; NM_018145.3; NP_060615.1 |
UCSCi | uc001zmp.1, human [Q96TC7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB000782 mRNA Translation: BAB46923.1 AY358793 mRNA Translation: AAQ89153.1 AK001441 mRNA Translation: BAA91693.1 AK025963 mRNA Translation: BAB15298.1 Sequence problems. AK092058 mRNA Translation: BAG52475.1 AK123282 mRNA Translation: BAG53885.1 AK123192 mRNA Translation: BAC85554.1 Frameshift. CH471125 Genomic DNA Translation: EAW92436.1 BC008970 mRNA Translation: AAH08970.2 BC063844 mRNA Translation: AAH63844.1 AJ242719 Genomic DNA Translation: CAC39480.1 BR000691 mRNA Translation: FAA00416.1 |
CCDSi | CCDS10063.1 [Q96TC7-1] |
RefSeqi | NP_001291731.1, NM_001304802.1 [Q96TC7-1] NP_001310823.1, NM_001323894.1 [Q96TC7-1] NP_001310824.1, NM_001323895.1 [Q96TC7-2] NP_060615.1, NM_018145.2 [Q96TC7-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
7CC7 | X-ray | 1.45 | A | 236-470 | [»] | |
AlphaFoldDBi | Q96TC7 | |||||
SMRi | Q96TC7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 120476, 346 interactors |
IntActi | Q96TC7, 51 interactors |
MINTi | Q96TC7 |
STRINGi | 9606.ENSP00000260385 |
PTM databases
iPTMneti | Q96TC7 |
PhosphoSitePlusi | Q96TC7 |
SwissPalmi | Q96TC7 |
Genetic variation databases
BioMutai | RMDN3 |
DMDMi | 147643203 |
Proteomic databases
EPDi | Q96TC7 |
jPOSTi | Q96TC7 |
MassIVEi | Q96TC7 |
MaxQBi | Q96TC7 |
PaxDbi | Q96TC7 |
PeptideAtlasi | Q96TC7 |
PRIDEi | Q96TC7 |
ProteomicsDBi | 78224 [Q96TC7-1] 78225 [Q96TC7-2] |
TopDownProteomicsi | Q96TC7-1 [Q96TC7-1] Q96TC7-2 [Q96TC7-2] |
Protocols and materials databases
Antibodypediai | 2473, 190 antibodies from 22 providers |
DNASUi | 55177 |
Genome annotation databases
Ensembli | ENST00000260385.10; ENSP00000260385.6; ENSG00000137824.16 ENST00000338376.8; ENSP00000342493.3; ENSG00000137824.16 |
GeneIDi | 55177 |
KEGGi | hsa:55177 |
MANE-Selecti | ENST00000338376.8; ENSP00000342493.3; NM_018145.3; NP_060615.1 |
UCSCi | uc001zmp.1, human [Q96TC7-1] |
Organism-specific databases
CTDi | 55177 |
DisGeNETi | 55177 |
GeneCardsi | RMDN3 |
HGNCi | HGNC:25550, RMDN3 |
HPAi | ENSG00000137824, Low tissue specificity |
MIMi | 611873, gene |
neXtProti | NX_Q96TC7 |
OpenTargetsi | ENSG00000137824 |
PharmGKBi | PA162387926 |
VEuPathDBi | HostDB:ENSG00000137824 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QWUP, Eukaryota |
GeneTreei | ENSGT00950000182992 |
HOGENOMi | CLU_046369_0_2_1 |
InParanoidi | Q96TC7 |
OMAi | QHESMHS |
OrthoDBi | 1380644at2759 |
PhylomeDBi | Q96TC7 |
TreeFami | TF315854 |
Enzyme and pathway databases
PathwayCommonsi | Q96TC7 |
SignaLinki | Q96TC7 |
SIGNORi | Q96TC7 |
Miscellaneous databases
BioGRID-ORCSi | 55177, 9 hits in 1080 CRISPR screens |
ChiTaRSi | RMDN3, human |
GenomeRNAii | 55177 |
Pharosi | Q96TC7, Tbio |
PROi | PR:Q96TC7 |
RNActi | Q96TC7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000137824, Expressed in frontal cortex and 235 other tissues |
ExpressionAtlasi | Q96TC7, baseline and differential |
Genevisiblei | Q96TC7, HS |
Family and domain databases
Gene3Di | 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR011990, TPR-like_helical_dom_sf |
SUPFAMi | SSF48452, SSF48452, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RMD3_HUMAN | |
Accessioni | Q96TC7Primary (citable) accession number: Q96TC7 Secondary accession number(s): A9UMZ9 Q9NVQ6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 15, 2007 |
Last sequence update: | May 15, 2007 | |
Last modified: | May 25, 2022 | |
This is version 151 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families