UniProtKB - Q96TC7 (RMD3_HUMAN)

BLAST

>sp|Q96TC7|RMD3_HUMAN Regulator of microtubule dynamics protein 3 OS=Homo sapiens OX=9606 GN=RMDN3 PE=1 SV=2
MSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPG
RHVMLLRAVPGGAGDASVLPSLPREGQEKVLDRLDFVLTSLVALRREVEELRSSLRGLAG
EIVGEVRCHMEENQRVARRRRFPFVRERSDSTGSSSVYFTASSGATFTDAESEGGYTTAN
AESDNERDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLP
LLQQADELHRGDEQGKREGFQLLLNNKLVYGSRQDFLWRLARAYSDMCELTEEVSEKKSY
ALDGKEEAEAALEKGDESADCHLWYAVLCGQLAEHESIQRRIQSGFSFKEHVDKAIALQP
ENPMAHFLLGRWCYQVSHLSWLEKKTATALLESPLSATVEDALQSFLKAEELQPGFSKAG
RVYISKCYRELGKNSEARWWMKLALELPDVTKEDLAIQKDLEELEVILRD

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History
Entry version 128 (10 Oct 2018)
Sequence version 2 (15 May 2007)
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Protein

Regulator of microtubule dynamics protein 3

Gene

RMDN3

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis.2 Publications

GO - Biological processⁱ

apoptotic process Source: UniProtKB-KW
cell differentiation Source: UniProtKB-KW
cellular calcium ion homeostasis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22131369

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Apoptosis, Differentiation

Biological process

Apoptosis, Differentiation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Regulator of microtubule dynamics protein 3 Short name: RMD-3 Short name: hRMD-3 Alternative name(s): Cerebral protein 10 Protein FAM82A2 Protein FAM82C Protein tyrosine phosphatase-interacting protein 51 TCPTP-interacting protein 51
Gene namesⁱ	Name:RMDN3 Synonyms:FAM82A2, FAM82C, PTPIP51 ORF Names:hucep-10, UNQ3122/PRO10274
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000137824.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:25550 RMDN3
MIMⁱ	611873 gene
neXtProtⁱ	NX_Q96TC7

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	13 – 35	HelicalSequence analysisAdd BLAST		23

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton, Membrane, Microtubule, Mitochondrion, Mitochondrion outer membrane, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	55177
Open Targets More...OpenTargetsⁱ	ENSG00000137824
PharmGKBⁱ	PA162387926

Polymorphism and mutation databases

BioMutaⁱ	RMDN3
DMDMⁱ	147643203

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000287510	1 – 470	Regulator of microtubule dynamics protein 3Add BLAST		470

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	44	PhosphoserineCombined sources	1
Modified residueⁱ	46	PhosphoserineCombined sources	1
Modified residueⁱ	50	PhosphoserineCombined sources	1
Modified residueⁱ	57	PhosphoserineBy similarity	1
Modified residueⁱ	183	PhosphoserineCombined sources	1
Modified residueⁱ	193	PhosphoserineCombined sources	1
Modified residueⁱ	212	PhosphoserineCombined sources	1
Modified residueⁱ	232	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q96TC7
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96TC7
PaxDbⁱ	Q96TC7
PeptideAtlas More...PeptideAtlasⁱ	Q96TC7
PRIDEⁱ	Q96TC7
ProteomicsDBⁱ	78224 78225 [Q96TC7-2]
TopDownProteomicsⁱ	Q96TC7-1 [Q96TC7-1] Q96TC7-2 [Q96TC7-2]

PTM databases

iPTMnetⁱ	Q96TC7
PhosphoSitePlusⁱ	Q96TC7
SwissPalmⁱ	Q96TC7

Expressionⁱ

Tissue specificityⁱ

Present at high level in epidermis and seminiferous epithelium: while basal cells in the epidermis and spermatogonia show no perceptible amount, keratinocytes of suprabasal layers and differentiating first-order spermatocytes up to spermatids exhibit high expression. In skeletal muscle, its presence is restricted to fibers of the fast twitch type. In surface epithelia containing ciliated cells, it is associated with the microtubular structures responsible for ciliary movement. Also present in specific structures of the central nervous system such as neurons of the hippocampal region, ganglion cells of the autonomic nervous system, and axons of the peripheral nervous system (at protein level). Widely expressed.2 Publications

Inductionⁱ

By EGF, TGFB1, retinoic acid-and 1,25-dihydroxyvitamin D₃.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000137824 Expressed in 220 organ(s), highest expression level in frontal cortex
CleanExⁱ	HS_FAM82A2
ExpressionAtlasⁱ	Q96TC7 baseline and differential
Genevisibleⁱ	Q96TC7 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA009975

HPAⁱ

HPA009975

Interactionⁱ

Subunit structureⁱ

Interacts with PTPN2. Interacts with microtubules. Interacts with VAPB.3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
PTPN1	P18031	4	EBI-1056589,EBI-968788
YWHAB	P31946	5	EBI-1056589,EBI-359815

Protein-protein interaction databases

BioGridⁱ	120476, 42 interactors
IntActⁱ	Q96TC7, 43 interactors
Molecular INTeraction database More...MINTⁱ	Q96TC7
STRINGⁱ	9606.ENSP00000260385

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96TC7
SMRⁱ	Q96TC7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	92 – 124	Sequence analysisAdd BLAST		33

Domainⁱ

The transmembrane region is required for mitochondrial localization.

Sequence similaritiesⁱ

Belongs to the RMDN family.Curated

Keywords - Domainⁱ

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IIGM Eukaryota ENOG41101S6 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063162
HOVERGENⁱ	HBG072518
InParanoidⁱ	Q96TC7
OMAⁱ	EVRSHME
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0F3V
PhylomeDBⁱ	Q96TC7
TreeFamⁱ	TF315854

Family and domain databases

Gene3Dⁱ	1.25.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR011990 TPR-like_helical_dom_sf
SUPFAMⁱ	SSF48452 SSF48452, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q96TC7-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRLGALGGA RAGLGLLLGT AAGLGFLCLL YSQRWKRTQR HGRSQSLPNS 
        60         70         80         90        100
LDYTQTSDPG RHVMLLRAVP GGAGDASVLP SLPREGQEKV LDRLDFVLTS 
       110        120        130        140        150
LVALRREVEE LRSSLRGLAG EIVGEVRCHM EENQRVARRR RFPFVRERSD 
       160        170        180        190        200
STGSSSVYFT ASSGATFTDA ESEGGYTTAN AESDNERDSD KESEDGEDEV 
       210        220        230        240        250
SCETVKMGRK DSLDLEEEAA SGASSALEAG GSSGLEDVLP LLQQADELHR 
       260        270        280        290        300
GDEQGKREGF QLLLNNKLVY GSRQDFLWRL ARAYSDMCEL TEEVSEKKSY 
       310        320        330        340        350
ALDGKEEAEA ALEKGDESAD CHLWYAVLCG QLAEHESIQR RIQSGFSFKE 
       360        370        380        390        400
HVDKAIALQP ENPMAHFLLG RWCYQVSHLS WLEKKTATAL LESPLSATVE 
       410        420        430        440        450
DALQSFLKAE ELQPGFSKAG RVYISKCYRE LGKNSEARWW MKLALELPDV 
       460        470
TKEDLAIQKD LEELEVILRD

Length:470

Mass (Da):52,118

Last modified:May 15, 2007 - v2

Checksum:ⁱ1C8D1022E6CF7B6A

Isoform 2 (identifier: Q96TC7-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-129: Missing.

« Hide

        10         20         30         40         50
MEENQRVARR RRFPFVRERS DSTGSSSVYF TASSGATFTD AESEGGYTTA 
        60         70         80         90        100
NAESDNERDS DKESEDGEDE VSCETVKMGR KDSLDLEEEA ASGASSALEA 
       110        120        130        140        150
GGSSGLEDVL PLLQQADELH RGDEQGKREG FQLLLNNKLV YGSRQDFLWR 
       160        170        180        190        200
LARAYSDMCE LTEEVSEKKS YALDGKEEAE AALEKGDESA DCHLWYAVLC 
       210        220        230        240        250
GQLAEHESIQ RRIQSGFSFK EHVDKAIALQ PENPMAHFLL GRWCYQVSHL 
       260        270        280        290        300
SWLEKKTATA LLESPLSATV EDALQSFLKA EELQPGFSKA GRVYISKCYR 
       310        320        330        340 
ELGKNSEARW WMKLALELPD VTKEDLAIQK DLEELEVILR D

Note: No experimental confirmation available.

Show »

Length:341

Mass (Da):38,247

Checksum:ⁱ6015D71ECA057A27

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0YNE5	H0YNE5_HUMAN	Regulator of microtubule dynamics p... Regulator of microtubule dynamics protein 3	RMDN3	251	Annotation score:
H0YLG5	H0YLG5_HUMAN	Regulator of microtubule dynamics p... Regulator of microtubule dynamics protein 3	RMDN3	287	Annotation score:
H0YMB1	H0YMB1_HUMAN	Regulator of microtubule dynamics p... Regulator of microtubule dynamics protein 3	RMDN3	306	Annotation score:
H0YLV7	H0YLV7_HUMAN	Regulator of microtubule dynamics p... Regulator of microtubule dynamics protein 3	RMDN3	116	Annotation score:

Sequence cautionⁱ

The sequence BAB15298 differs from that shown. Reason: Erroneous termination at position 453. Translated as Glu.Curated

The sequence BAC85554 differs from that shown. Reason: Frameshift at position 383.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	416	F → V in BAB46923 (Ref. 1) Curated		1
Sequence conflictⁱ	469	R → Q in BAC85554 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_049029	33	Q → H. Corresponds to variant dbSNP:rs11558807Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_025531	1 – 129	Missing in isoform 2. 1 PublicationAdd BLAST		129

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB000782 mRNA Translation: BAB46923.1 AY358793 mRNA Translation: AAQ89153.1 AK001441 mRNA Translation: BAA91693.1 AK025963 mRNA Translation: BAB15298.1 Sequence problems. AK092058 mRNA Translation: BAG52475.1 AK123282 mRNA Translation: BAG53885.1 AK123192 mRNA Translation: BAC85554.1 Frameshift. CH471125 Genomic DNA Translation: EAW92436.1 BC008970 mRNA Translation: AAH08970.2 BC063844 mRNA Translation: AAH63844.1 AJ242719 Genomic DNA Translation: CAC39480.1 BR000691 mRNA Translation: FAA00416.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10063.1 [Q96TC7-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001291731.1, NM_001304802.1 [Q96TC7-1] NP_001310823.1, NM_001323894.1 [Q96TC7-1] NP_001310824.1, NM_001323895.1 [Q96TC7-2] NP_060615.1, NM_018145.2 [Q96TC7-1]
UniGeneⁱ	Hs.511067 Hs.632944

Genome annotation databases

Ensemblⁱ	ENST00000260385; ENSP00000260385; ENSG00000137824 [Q96TC7-1] ENST00000338376; ENSP00000342493; ENSG00000137824 [Q96TC7-1]
GeneIDⁱ	55177
KEGGⁱ	hsa:55177
UCSC genome browser More...UCSCⁱ	uc001zmp.1 human [Q96TC7-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96TC7	Family with sequence similarity 82, member C, isoform CRA_a		HUMAN		470	UniRef100_Q96TC7
Family with sequence similarity 82, member A2		PANTR		470
Regulator of microtubule dynamics protein 3 (Fragment)		HUMAN		287
RMDN3 isoform 11 (Fragment)		PANTR		287
Isoform 2 of Regulator of microtubule dynamics protein 3		HUMAN		341
+2

Protein	Similar proteins		Species	Score	Length	Source
Q96TC7	Family with sequence similarity 82, member C, isoform CRA_a		HUMAN		470	UniRef90_Q96TC7
Family with sequence similarity 82, member A2		PANTR		470
Uncharacterized protein		MACMU		483
Uncharacterized protein		COLAP		472
Uncharacterized protein		CERAT		471
+26

Protein	Similar proteins		Species	Score	Length	Source
Q96TC7	Regulator of microtubule dynamics protein 3		PONAB		470	UniRef50_Q96TC7
Family with sequence similarity 82, member C, isoform CRA_a		HUMAN		470
Family with sequence similarity 82, member A2		PANTR		470
Uncharacterized protein		MACMU		483
Uncharacterized protein		COLAP		472
+91

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB000782 mRNA Translation: BAB46923.1 AY358793 mRNA Translation: AAQ89153.1 AK001441 mRNA Translation: BAA91693.1 AK025963 mRNA Translation: BAB15298.1 Sequence problems. AK092058 mRNA Translation: BAG52475.1 AK123282 mRNA Translation: BAG53885.1 AK123192 mRNA Translation: BAC85554.1 Frameshift. CH471125 Genomic DNA Translation: EAW92436.1 BC008970 mRNA Translation: AAH08970.2 BC063844 mRNA Translation: AAH63844.1 AJ242719 Genomic DNA Translation: CAC39480.1 BR000691 mRNA Translation: FAA00416.1
CCDSⁱ	CCDS10063.1 [Q96TC7-1]
RefSeqⁱ	NP_001291731.1, NM_001304802.1 [Q96TC7-1] NP_001310823.1, NM_001323894.1 [Q96TC7-1] NP_001310824.1, NM_001323895.1 [Q96TC7-2] NP_060615.1, NM_018145.2 [Q96TC7-1]
UniGeneⁱ	Hs.511067 Hs.632944

3D structure databases

ProteinModelPortalⁱ	Q96TC7
SMRⁱ	Q96TC7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120476, 42 interactors
IntActⁱ	Q96TC7, 43 interactors
MINTⁱ	Q96TC7
STRINGⁱ	9606.ENSP00000260385

PTM databases

iPTMnetⁱ	Q96TC7
PhosphoSitePlusⁱ	Q96TC7
SwissPalmⁱ	Q96TC7

Polymorphism and mutation databases

BioMutaⁱ	RMDN3
DMDMⁱ	147643203

Proteomic databases

EPDⁱ	Q96TC7
MaxQBⁱ	Q96TC7
PaxDbⁱ	Q96TC7
PeptideAtlasⁱ	Q96TC7
PRIDEⁱ	Q96TC7
ProteomicsDBⁱ	78224 78225 [Q96TC7-2]
TopDownProteomicsⁱ	Q96TC7-1 [Q96TC7-1] Q96TC7-2 [Q96TC7-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	55177
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000260385; ENSP00000260385; ENSG00000137824 [Q96TC7-1] ENST00000338376; ENSP00000342493; ENSG00000137824 [Q96TC7-1]
GeneIDⁱ	55177
KEGGⁱ	hsa:55177
UCSCⁱ	uc001zmp.1 human [Q96TC7-1]

Organism-specific databases

CTDⁱ	55177
DisGeNETⁱ	55177
EuPathDBⁱ	HostDB:ENSG00000137824.15
GeneCardsⁱ	RMDN3
HGNCⁱ	HGNC:25550 RMDN3
HPAⁱ	HPA009975
MIMⁱ	611873 gene
neXtProtⁱ	NX_Q96TC7
OpenTargetsⁱ	ENSG00000137824
PharmGKBⁱ	PA162387926
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IIGM Eukaryota ENOG41101S6 LUCA
GeneTreeⁱ	ENSGT00530000063162
HOVERGENⁱ	HBG072518
InParanoidⁱ	Q96TC7
OMAⁱ	EVRSHME
OrthoDBⁱ	EOG091G0F3V
PhylomeDBⁱ	Q96TC7
TreeFamⁱ	TF315854

Miscellaneous databases

ChiTaRSⁱ	RMDN3 human
GenomeRNAiⁱ	55177
Protein Ontology More...PROⁱ	PR:Q96TC7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000137824 Expressed in 220 organ(s), highest expression level in frontal cortex
CleanExⁱ	HS_FAM82A2
ExpressionAtlasⁱ	Q96TC7 baseline and differential
Genevisibleⁱ	Q96TC7 HS

Family and domain databases

Gene3Dⁱ	1.25.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR011990 TPR-like_helical_dom_sf
SUPFAMⁱ	SSF48452 SSF48452, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RMD3_HUMAN
Accessionⁱ	Q96TC7Primary (citable) accession number: Q96TC7 Secondary accession number(s): A9UMZ9 Q9NVQ6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
	Last sequence update:	May 15, 2007
	Last modified:	October 10, 2018
	This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM

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UniProtKB - Q96TC7 (RMD3_HUMAN)

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Regulator of microtubule dynamics protein 3

RMDN3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Nucleus

Cytoskeleton

Other locations

Cytoskeleton

Mitochondrion

Nucleus

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ