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Entry version 156 (16 Oct 2019)
Sequence version 3 (21 Sep 2011)
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Protein

Protein Niban 2

Gene

NIBAN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein Niban 2Curated
Alternative name(s):
Meg-3
Melanoma invasion by ERK1 Publication
Short name:
MINERVA1 Publication
Niban-like protein 1
Protein FAM129B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NIBAN2Imported
Synonyms:C9orf88, FAM129B1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25282 NIBAN2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614045 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96TA1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi641S → A: Loss of melanoma cell invasion; when associated with A-646; A-665; A-681; A-679 and A-683. 1 Publication1
Mutagenesisi641S → D or E: Promotes melanoma cell invasion; when associated with D/E-633; D/E-652; D/E-668; D/E-679 and D/E-683. 1 Publication1
Mutagenesisi646S → A: Loss of melanoma cell invasion; when associated with A-641; A-665; A-681; A-679 and A-683. 1 Publication1
Mutagenesisi646S → D or E: Promotes melanoma cell invasion; when associated with D/E-628; D/E-652; D/E-668; D/E-679 and D/E-683. 1 Publication1
Mutagenesisi665S → A: Loss of melanoma cell invasion; when associated with A-641; A-646; A-681; A-679 and A-683. 1 Publication1
Mutagenesisi665S → D or E: Promotes melanoma cell invasion; when associated with D/E-628; D/E-633; D/E-668; D/E-679 and D/E-683. 1 Publication1
Mutagenesisi681S → A: Loss of melanoma cell invasion; when associated with A-641; A-646; A-665; A-679 and A-683. 1 Publication1
Mutagenesisi681S → D or E: Promotes melanoma cell invasion; when associated with D/E-628; D/E-633; D/E-652; D/E-679 and D/E-683. 1 Publication1
Mutagenesisi692S → A: Loss of melanoma cell invasion; when associated with A-641; A-646; A-665; A-668 and A-683. 1 Publication1
Mutagenesisi692S → D or E: Promotes melanoma cell invasion; when associated with D/E-628; D/E-633; D/E-652; D/E-668 and D/E-683. 1 Publication1
Mutagenesisi696S → A: Loss of melanoma cell invasion; when associated with A-641; A-646; A-665; A-668 and A-679. 1 Publication1
Mutagenesisi696S → D or E: Promotes melanoma cell invasion; when associated with D/E-628; D/E-633; D/E-652; D/E-668 and D/E-679. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
64855

Open Targets

More...
OpenTargetsi
ENSG00000136830

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162385984

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96TA1

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FAM129B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
347595791

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved2 Publications
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002131212 – 746Protein Niban 2Add BLAST745

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycine2 Publications1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei568PhosphoserineCombined sources1
Modified residuei574PhosphoserineCombined sources1
Modified residuei601PhosphoserineCombined sources1
Modified residuei603PhosphoserineCombined sources1
Modified residuei606PhosphothreonineCombined sources1
Modified residuei609PhosphoserineCombined sources1
Modified residuei624PhosphoserineCombined sources1
Modified residuei638PhosphoserineCombined sources1
Modified residuei641PhosphoserineCombined sources1 Publication1
Modified residuei646PhosphoserineCombined sources1 Publication1
Modified residuei665PhosphoserineCombined sources1 Publication1
Modified residuei681PhosphoserineCombined sources1 Publication1
Modified residuei692PhosphoserineCombined sources1 Publication1
Modified residuei696PhosphoserineCombined sources1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated at Ser-641, Ser-646, Ser-692 and Ser-696 by the BRAF/MKK/ERK signaling cascade. In melanoma cells, the C-terminal phosphorylation may prevent targeting to the plasma membrane.1 Publication
As apoptosis proceeds, degraded via an proteasome-independent pathway, probably by caspases.1 Publication

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-75
CPTAC-968

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96TA1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96TA1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96TA1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96TA1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96TA1

PeptideAtlas

More...
PeptideAtlasi
Q96TA1

PRoteomics IDEntifications database

More...
PRIDEi
Q96TA1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
78220 [Q96TA1-1]
78221 [Q96TA1-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96TA1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96TA1

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q96TA1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000136830 Expressed in 202 organ(s), highest expression level in lower esophagus mucosa

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96TA1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96TA1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA021284
HPA021417
HPA023261
HPA024312

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122328, 41 interactors

Protein interaction database and analysis system

More...
IntActi
Q96TA1, 12 interactors

Molecular INTeraction database

More...
MINTi
Q96TA1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000362409

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96TA1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini68 – 192PHPROSITE-ProRule annotationAdd BLAST125

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Niban family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFR1 Eukaryota
ENOG41102BB LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154149

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000220836

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96TA1

Identification of Orthologs from Complete Genome Data

More...
OMAi
YRQAKGH

Database of Orthologous Groups

More...
OrthoDBi
138545at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96TA1

TreeFam database of animal gene trees

More...
TreeFami
TF333351

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026088 Niban-like
IPR011993 PH-like_dom_sf
IPR001849 PH_domain

The PANTHER Classification System

More...
PANTHERi
PTHR14392 PTHR14392, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50003 PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q96TA1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGDVLSTHLD DARRQHIAEK TGKILTEFLQ FYEDQYGVAL FNSMRHEIEG
60 70 80 90 100
TGLPQAQLLW RKVPLDERIV FSGNLFQHQE DSKKWRNRFS LVPHNYGLVL
110 120 130 140 150
YENKAAYERQ VPPRAVINSA GYKILTSVDQ YLELIGNSLP GTTAKSGSAP
160 170 180 190 200
ILKCPTQFPL ILWHPYARHY YFCMMTEAEQ DKWQAVLQDC IRHCNNGIPE
210 220 230 240 250
DSKVEGPAFT DAIRMYRQSK ELYGTWEMLC GNEVQILSNL VMEELGPELK
260 270 280 290 300
AELGPRLKGK PQERQRQWIQ ISDAVYHMVY EQAKARFEEV LSKVQQVQPA
310 320 330 340 350
MQAVIRTDMD QIITSKEHLA SKIRAFILPK AEVCVRNHVQ PYIPSILEAL
360 370 380 390 400
MVPTSQGFTE VRDVFFKEVT DMNLNVINEG GIDKLGEYME KLSRLAYHPL
410 420 430 440 450
KMQSCYEKME SLRLDGLQQR FDVSSTSVFK QRAQIHMREQ MDNAVYTFET
460 470 480 490 500
LLHQELGKGP TKEELCKSIQ RVLERVLKKY DYDSSSVRKR FFREALLQIS
510 520 530 540 550
IPFLLKKLAP TCKSELPRFQ ELIFEDFARF ILVENTYEEV VLQTVMKDIL
560 570 580 590 600
QAVKEAAVQR KHNLYRDSMV MHNSDPNLHL LAEGAPIDWG EEYSNSGGGG
610 620 630 640 650
SPSPSTPESA TLSEKRRRAK QVVSVVQDEE VGLPFEASPE SPPPASPDGV
660 670 680 690 700
TEIRGLLAQG LRPESPPPAG PLLNGAPAGE SPQPKAAPEA SSPPASPLQH
710 720 730 740
LLPGKAVDLG PPKPSDQETG EQVSSPSSHP ALHTTTEDSA GVQTEF
Length:746
Mass (Da):84,138
Last modified:September 21, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2049835F08356944
GO
Isoform 2 (identifier: Q96TA1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MGDVLSTHLDDARRQHIA → MGWMG

Show »
Length:733
Mass (Da):82,683
Checksum:i38E1C24CF737F3DB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti318H → L in AAK57556 (Ref. 1) Curated1
Sequence conflicti677P → L in AAH01979 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0418101 – 18MGDVL…RQHIA → MGWMG in isoform 2. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF151783 mRNA Translation: AAK57556.1
AF192911 mRNA Translation: AAQ13825.1
AL445222 Genomic DNA No translation available.
AL390116 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87675.1
CH471090 Genomic DNA Translation: EAW87677.1
AB210016 mRNA Translation: BAE06098.1
AL137555 mRNA Translation: CAB70809.1
BC001979 mRNA Translation: AAH01979.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS35144.1 [Q96TA1-2]
CCDS35145.1 [Q96TA1-1]

Protein sequence database of the Protein Information Resource

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PIRi
T46394

NCBI Reference Sequences

More...
RefSeqi
NP_001030611.1, NM_001035534.2 [Q96TA1-2]
NP_073744.2, NM_022833.3 [Q96TA1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000373312; ENSP00000362409; ENSG00000136830 [Q96TA1-1]
ENST00000373314; ENSP00000362411; ENSG00000136830 [Q96TA1-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
64855

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:64855

UCSC genome browser

More...
UCSCi
uc004brh.5 human [Q96TA1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151783 mRNA Translation: AAK57556.1
AF192911 mRNA Translation: AAQ13825.1
AL445222 Genomic DNA No translation available.
AL390116 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87675.1
CH471090 Genomic DNA Translation: EAW87677.1
AB210016 mRNA Translation: BAE06098.1
AL137555 mRNA Translation: CAB70809.1
BC001979 mRNA Translation: AAH01979.2
CCDSiCCDS35144.1 [Q96TA1-2]
CCDS35145.1 [Q96TA1-1]
PIRiT46394
RefSeqiNP_001030611.1, NM_001035534.2 [Q96TA1-2]
NP_073744.2, NM_022833.3 [Q96TA1-1]

3D structure databases

SMRiQ96TA1
ModBaseiSearch...

Protein-protein interaction databases

BioGridi122328, 41 interactors
IntActiQ96TA1, 12 interactors
MINTiQ96TA1
STRINGi9606.ENSP00000362409

PTM databases

iPTMnetiQ96TA1
PhosphoSitePlusiQ96TA1
SwissPalmiQ96TA1

Polymorphism and mutation databases

BioMutaiFAM129B
DMDMi347595791

Proteomic databases

CPTACiCPTAC-75
CPTAC-968
EPDiQ96TA1
jPOSTiQ96TA1
MassIVEiQ96TA1
MaxQBiQ96TA1
PaxDbiQ96TA1
PeptideAtlasiQ96TA1
PRIDEiQ96TA1
ProteomicsDBi78220 [Q96TA1-1]
78221 [Q96TA1-2]

Genome annotation databases

EnsembliENST00000373312; ENSP00000362409; ENSG00000136830 [Q96TA1-1]
ENST00000373314; ENSP00000362411; ENSG00000136830 [Q96TA1-2]
GeneIDi64855
KEGGihsa:64855
UCSCiuc004brh.5 human [Q96TA1-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
64855
DisGeNETi64855

GeneCards: human genes, protein and diseases

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GeneCardsi
NIBAN2
HGNCiHGNC:25282 NIBAN2
HPAiHPA021284
HPA021417
HPA023261
HPA024312
MIMi614045 gene
neXtProtiNX_Q96TA1
OpenTargetsiENSG00000136830
PharmGKBiPA162385984

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IFR1 Eukaryota
ENOG41102BB LUCA
GeneTreeiENSGT00940000154149
HOGENOMiHOG000220836
InParanoidiQ96TA1
OMAiYRQAKGH
OrthoDBi138545at2759
PhylomeDBiQ96TA1
TreeFamiTF333351

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
FAM129B human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
64855
PharosiQ96TA1

Protein Ontology

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PROi
PR:Q96TA1

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000136830 Expressed in 202 organ(s), highest expression level in lower esophagus mucosa
ExpressionAtlasiQ96TA1 baseline and differential
GenevisibleiQ96TA1 HS

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR026088 Niban-like
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR14392 PTHR14392, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNIBA2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96TA1
Secondary accession number(s): Q4LE55
, Q5VVW6, Q5VVW7, Q9BUS2, Q9NT35
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: September 21, 2011
Last modified: October 16, 2019
This is version 156 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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