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UniProtKB - Q96T92 (INSM2_HUMAN)
Protein
Insulinoma-associated protein 2
Gene
INSM2
Organism
Homo sapiens (Human)
Status
Functioni
May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons.
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 263 – 283 | C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 291 – 313 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 426 – 448 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 470 – 492 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 525 – 548 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: GO_Central
- neuron differentiation Source: GO_Central
- regulation of cell cycle process Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q96T92 |
SignaLinki | Q96T92 |
Names & Taxonomyi
Protein namesi | Recommended name: Insulinoma-associated protein 2Alternative name(s): Zinc finger protein IA-6 |
Gene namesi | Name:INSM2 Synonyms:IA6 ORF Names:Nbla106 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17539, INSM2 |
MIMi | 614027, gene |
neXtProti | NX_Q96T92 |
VEuPathDBi | HostDB:ENSG00000168348 |
Subcellular locationi
Nucleus
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: UniProtKB-SubCell
- transcription repressor complex Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 84684 |
OpenTargetsi | ENSG00000168348 |
PharmGKBi | PA134899231 |
Miscellaneous databases
Pharosi | Q96T92, Tbio |
Genetic variation databases
BioMutai | INSM2 |
DMDMi | 296439326 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000331576 | 1 – 566 | Insulinoma-associated protein 2Add BLAST | 566 |
Proteomic databases
MassIVEi | Q96T92 |
PaxDbi | Q96T92 |
PeptideAtlasi | Q96T92 |
PRIDEi | Q96T92 |
ProteomicsDBi | 78217 |
PTM databases
iPTMneti | Q96T92 |
PhosphoSitePlusi | Q96T92 |
Expressioni
Tissue specificityi
Expressed in heart, liver, skeletal muscle, kidney and pancreas, and, to a lesser extent, in brain, lung and spleen. In the pancreas, expressed in islet cells, including insulin- and glucagon-producing alpha- and beta-cells, but not in acinar cells (at protein level). Detected in adrenal glands, particularly in the deeper layer of the cortex (at protein level).1 Publication
Developmental stagei
Expressed in the islet-like cells of the developing pancreas and epithelial cells of the duodenum from gestational weeks 8 to 20 (at protein level).1 Publication
Gene expression databases
Bgeei | ENSG00000168348, Expressed in primary visual cortex and 52 other tissues |
Genevisiblei | Q96T92, HS |
Organism-specific databases
HPAi | ENSG00000168348, Group enriched (brain, retina) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 124201, 3 interactors |
IntActi | Q96T92, 1 interactor |
STRINGi | 9606.ENSP00000306523 |
Miscellaneous databases
RNActi | Q96T92, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 20 | SNAG domainBy similarityAdd BLAST | 20 | |
Regioni | 32 – 117 | DisorderedSequence analysisAdd BLAST | 86 | |
Regioni | 310 – 418 | DisorderedSequence analysisAdd BLAST | 109 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 327 – 345 | Polar residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 354 – 373 | Basic and acidic residuesSequence analysisAdd BLAST | 20 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 263 – 283 | C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 291 – 313 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 426 – 448 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 470 – 492 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 525 – 548 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG3993, Eukaryota |
GeneTreei | ENSGT00940000162391 |
HOGENOMi | CLU_033476_1_0_1 |
InParanoidi | Q96T92 |
OMAi | HLQARDS |
OrthoDBi | 1306883at2759 |
PhylomeDBi | Q96T92 |
TreeFami | TF320538 |
Family and domain databases
InterProi | View protein in InterPro IPR042972, INSM1/2 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR15065, PTHR15065, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
i Sequence
Sequence statusi: Complete.
Q96T92-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPRGFLVKRT KRTGGLYRVR LAERVFPLLG PQGAPPFLEE APSASLPGAE
60 70 80 90 100
RATPPTREEP GKGLTAEAAR EQSGSPCRAA GVSPGTGGRE GAEWRAGGRE
110 120 130 140 150
GPGPSPSPSP SPAKPAGAEL RRAFLERCLS SPVSAESFPG GAAAVAAFSC
160 170 180 190 200
SVAPAAAPTP GEQFLLPLRA PFPEPALQPD PAPLSAALQS LKRAAGGERR
210 220 230 240 250
GKAPTDCASG PAAAGIKKPK AMRKLSFADE VTTSPVLGLK IKEEEPGAPS
260 270 280 290 300
RGLGGSRTPL GEFICQLCKE QYADPFALAQ HRCSRIVRVE YRCPECDKVF
310 320 330 340 350
SCPANLASHR RWHKPRPAAA NAATVSSADG KPPSSSSSSS RDSGAIASFL
360 370 380 390 400
AEGKENSRIE RTADQHPQAR DSSGADQHPD SAPRQGLQVL THPEPPLPQG
410 420 430 440 450
PYTEGVLGRR VPVPGSTSGG RGSEIFVCPY CHKKFRRQAY LRKHLSTHEA
460 470 480 490 500
GSARALAPGF GSERGAPLAF ACPLCGAHFP TADIREKHRL WHAVREELLL
510 520 530 540 550
PALAGAPPET SGPSGPSDGS AQQIFSCKHC PSTFFSSPGL TRHINKCHPS
560
ESRQVLLLQM PLRPGC
Sequence cautioni
The sequence AAK49393 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 198 | E → G in BAB69042 (PubMed:12880961).Curated | 1 | |
Sequence conflicti | 330 | G → E in BAC04830 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 390 | L → V in AAK49393 (Ref. 1) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_070885 | 206 | D → G5 PublicationsCorresponds to variant dbSNP:rs1958260Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF260323 mRNA Translation: AAK49393.1 Frameshift. JX403968 mRNA Translation: AFS33107.1 AB037912 mRNA Translation: BAB69042.1 AK096639 mRNA Translation: BAC04830.1 AL160231 Genomic DNA No translation available. CH471078 Genomic DNA Translation: EAW65872.1 BC130377 mRNA Translation: AAI30378.1 BC130379 mRNA Translation: AAI30380.1 |
CCDSi | CCDS9657.1 |
RefSeqi | NP_115983.3, NM_032594.3 |
Genome annotation databases
Ensembli | ENST00000307169; ENSP00000306523; ENSG00000168348 |
GeneIDi | 84684 |
KEGGi | hsa:84684 |
MANE-Selecti | ENST00000307169.4; ENSP00000306523.3; NM_032594.4; NP_115983.3 |
UCSCi | uc001wth.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF260323 mRNA Translation: AAK49393.1 Frameshift. JX403968 mRNA Translation: AFS33107.1 AB037912 mRNA Translation: BAB69042.1 AK096639 mRNA Translation: BAC04830.1 AL160231 Genomic DNA No translation available. CH471078 Genomic DNA Translation: EAW65872.1 BC130377 mRNA Translation: AAI30378.1 BC130379 mRNA Translation: AAI30380.1 |
CCDSi | CCDS9657.1 |
RefSeqi | NP_115983.3, NM_032594.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 124201, 3 interactors |
IntActi | Q96T92, 1 interactor |
STRINGi | 9606.ENSP00000306523 |
PTM databases
iPTMneti | Q96T92 |
PhosphoSitePlusi | Q96T92 |
Genetic variation databases
BioMutai | INSM2 |
DMDMi | 296439326 |
Proteomic databases
MassIVEi | Q96T92 |
PaxDbi | Q96T92 |
PeptideAtlasi | Q96T92 |
PRIDEi | Q96T92 |
ProteomicsDBi | 78217 |
Protocols and materials databases
Antibodypediai | 23212, 77 antibodies from 20 providers |
DNASUi | 84684 |
Genome annotation databases
Ensembli | ENST00000307169; ENSP00000306523; ENSG00000168348 |
GeneIDi | 84684 |
KEGGi | hsa:84684 |
MANE-Selecti | ENST00000307169.4; ENSP00000306523.3; NM_032594.4; NP_115983.3 |
UCSCi | uc001wth.1, human |
Organism-specific databases
CTDi | 84684 |
DisGeNETi | 84684 |
GeneCardsi | INSM2 |
HGNCi | HGNC:17539, INSM2 |
HPAi | ENSG00000168348, Group enriched (brain, retina) |
MIMi | 614027, gene |
neXtProti | NX_Q96T92 |
OpenTargetsi | ENSG00000168348 |
PharmGKBi | PA134899231 |
VEuPathDBi | HostDB:ENSG00000168348 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3993, Eukaryota |
GeneTreei | ENSGT00940000162391 |
HOGENOMi | CLU_033476_1_0_1 |
InParanoidi | Q96T92 |
OMAi | HLQARDS |
OrthoDBi | 1306883at2759 |
PhylomeDBi | Q96T92 |
TreeFami | TF320538 |
Enzyme and pathway databases
PathwayCommonsi | Q96T92 |
SignaLinki | Q96T92 |
Miscellaneous databases
BioGRID-ORCSi | 84684, 11 hits in 1055 CRISPR screens |
GenomeRNAii | 84684 |
Pharosi | Q96T92, Tbio |
PROi | PR:Q96T92 |
RNActi | Q96T92, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000168348, Expressed in primary visual cortex and 52 other tissues |
Genevisiblei | Q96T92, HS |
Family and domain databases
InterProi | View protein in InterPro IPR042972, INSM1/2 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR15065, PTHR15065, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | INSM2_HUMAN | |
Accessioni | Q96T92Primary (citable) accession number: Q96T92 Secondary accession number(s): A1L432 Q96Q84 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 29, 2008 |
Last sequence update: | May 18, 2010 | |
Last modified: | February 23, 2022 | |
This is version 144 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot