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Protein

Glycoprotein hormone alpha-2

Gene

GPHA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production (PubMed:12045258). Plays a central role in controlling thyroid cell metabolism (PubMed:12045258).1 Publication

GO - Molecular functioni

  • hormone activity Source: UniProtKB-KW
  • hormone receptor binding Source: GO_Central
  • protein heterodimerization activity Source: UniProtKB
  • thyrotropin-releasing hormone receptor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-HSA-375281 Hormone ligand-binding receptors
R-HSA-418555 G alpha (s) signalling events
SIGNORiQ96T91

Names & Taxonomyi

Protein namesi
Recommended name:
Glycoprotein hormone alpha-2
Alternative name(s):
Putative secreted protein Zsig51
Thyrostimulin subunit alpha
Gene namesi
Name:GPHA2
Synonyms:GPA2, ZSIG51
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000149735.6
HGNCiHGNC:18054 GPHA2
MIMi609651 gene
neXtProtiNX_Q96T91

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi170589
OpenTargetsiENSG00000149735
PharmGKBiPA28839

Polymorphism and mutation databases

BioMutaiGPHA2
DMDMi48474600

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000001167224 – 129Glycoprotein hormone alpha-2Add BLAST106

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 89PROSITE-ProRule annotation
Glycosylationi37N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi48 ↔ 103PROSITE-ProRule annotation
Disulfide bondi57 ↔ 119PROSITE-ProRule annotation
Disulfide bondi61 ↔ 121PROSITE-ProRule annotation
Glycosylationi81N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96T91
PeptideAtlasiQ96T91
PRIDEiQ96T91
ProteomicsDBi78216

Expressioni

Tissue specificityi

Found in a variety of tissues.1 Publication

Gene expression databases

BgeeiENSG00000149735 Expressed in 76 organ(s), highest expression level in oocyte
CleanExiHS_GPHA2
ExpressionAtlasiQ96T91 baseline and differential
GenevisibleiQ96T91 HS

Interactioni

Subunit structurei

Heterodimer with GPHB5; this heterodimer interacts with thyroid-stimulating hormone receptor (TSHR), and hence stimulates cAMP production.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
GPHB5Q86YW73EBI-11659696,EBI-11659720

GO - Molecular functioni

Protein-protein interaction databases

BioGridi128064, 23 interactors
IntActiQ96T91, 6 interactors
STRINGi9606.ENSP00000279168

Structurei

3D structure databases

ProteinModelPortaliQ96T91
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYM3 Eukaryota
ENOG4112671 LUCA
GeneTreeiENSGT00390000009379
HOGENOMiHOG000236306
HOVERGENiHBG051795
InParanoidiQ96T91
OMAiKVQLQCV
OrthoDBiEOG091G0UTF
PhylomeDBiQ96T91
TreeFamiTF332313

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR006207 Cys_knot_C
IPR029034 Cystine-knot_cytokine
IPR000476 Glyco_hormone
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS01225 CTCK_2, 1 hit
PS50277 GLYCO_HORMONE_ALPHA_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q96T91-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPMASPQTLV LYLLVLAVTE AWGQEAVIPG CHLHPFNVTV RSDRQGTCQG
60 70 80 90 100
SHVAQACVGH CESSAFPSRY SVLVASGYRH NITSVSQCCT ISGLKKVKVQ
110 120
LQCVGSRREE LEIFTARACQ CDMCRLSRY
Length:129
Mass (Da):14,163
Last modified:December 1, 2001 - v1
Checksum:i6E924AF7BE8D7A70
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PLQ0E9PLQ0_HUMAN
Glycoprotein hormone alpha-2
GPHA2
118Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF260739 mRNA Translation: AAK51638.1
BC093960 mRNA Translation: AAH93960.1
BC093962 mRNA Translation: AAH93962.1
BC101523 mRNA Translation: AAI01524.1
CCDSiCCDS8086.1
RefSeqiNP_570125.1, NM_130769.3
XP_011543077.1, XM_011544775.2
XP_011543078.1, XM_011544776.2
UniGeneiHs.436119

Genome annotation databases

EnsembliENST00000279168; ENSP00000279168; ENSG00000149735
ENST00000533257; ENSP00000432918; ENSG00000149735
GeneIDi170589
KEGGihsa:170589
UCSCiuc001oca.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF260739 mRNA Translation: AAK51638.1
BC093960 mRNA Translation: AAH93960.1
BC093962 mRNA Translation: AAH93962.1
BC101523 mRNA Translation: AAI01524.1
CCDSiCCDS8086.1
RefSeqiNP_570125.1, NM_130769.3
XP_011543077.1, XM_011544775.2
XP_011543078.1, XM_011544776.2
UniGeneiHs.436119

3D structure databases

ProteinModelPortaliQ96T91
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128064, 23 interactors
IntActiQ96T91, 6 interactors
STRINGi9606.ENSP00000279168

Polymorphism and mutation databases

BioMutaiGPHA2
DMDMi48474600

Proteomic databases

PaxDbiQ96T91
PeptideAtlasiQ96T91
PRIDEiQ96T91
ProteomicsDBi78216

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000279168; ENSP00000279168; ENSG00000149735
ENST00000533257; ENSP00000432918; ENSG00000149735
GeneIDi170589
KEGGihsa:170589
UCSCiuc001oca.3 human

Organism-specific databases

CTDi170589
DisGeNETi170589
EuPathDBiHostDB:ENSG00000149735.6
GeneCardsiGPHA2
HGNCiHGNC:18054 GPHA2
MIMi609651 gene
neXtProtiNX_Q96T91
OpenTargetsiENSG00000149735
PharmGKBiPA28839
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYM3 Eukaryota
ENOG4112671 LUCA
GeneTreeiENSGT00390000009379
HOGENOMiHOG000236306
HOVERGENiHBG051795
InParanoidiQ96T91
OMAiKVQLQCV
OrthoDBiEOG091G0UTF
PhylomeDBiQ96T91
TreeFamiTF332313

Enzyme and pathway databases

ReactomeiR-HSA-375281 Hormone ligand-binding receptors
R-HSA-418555 G alpha (s) signalling events
SIGNORiQ96T91

Miscellaneous databases

ChiTaRSiGPHA2 human
GeneWikiiGPHA2
GenomeRNAii170589
PROiPR:Q96T91
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000149735 Expressed in 76 organ(s), highest expression level in oocyte
CleanExiHS_GPHA2
ExpressionAtlasiQ96T91 baseline and differential
GenevisibleiQ96T91 HS

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR006207 Cys_knot_C
IPR029034 Cystine-knot_cytokine
IPR000476 Glyco_hormone
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS01225 CTCK_2, 1 hit
PS50277 GLYCO_HORMONE_ALPHA_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGPHA2_HUMAN
AccessioniPrimary (citable) accession number: Q96T91
Secondary accession number(s): Q52LE2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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