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UniProtKB - Q96T88 (UHRF1_HUMAN)

Protein

E3 ubiquitin-protein ligase UHRF1

Gene

UHRF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. May be involved in DNA repair.9 Publications

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei316Histone H3K4me01
Binding sitei327Histone H3R2me01
Binding sitei330Histone H3R2me01
Binding sitei469Methylcytosine1
Sitei479Required to confer preferential recognition of cytosine over thymine1
Sitei489Required to discriminate between hemimethylated DNA versus symmetrically methylated DNA1
Sitei491Required for affinity and specificity for 5-mCpG sequence1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri310 – 366PHD-typePROSITE-ProRule annotationAdd BLAST57
Zinc fingeri724 – 763RING-typePROSITE-ProRule annotationAdd BLAST40

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionChromatin regulator, DNA-binding, Repressor, Transferase
Biological processCell cycle, DNA damage, DNA repair, Transcription, Transcription regulation, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-5334118 DNA methylation
SignaLinkiQ96T88
SIGNORiQ96T88
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase UHRF1 (EC:2.3.2.27)
Alternative name(s):
Inverted CCAAT box-binding protein of 90 kDa
Nuclear protein 95
Nuclear zinc finger protein Np95
Short name:
HuNp95
Short name:
hNp95
RING finger protein 106
RING-type E3 ubiquitin transferase UHRF1
Transcription factor ICBP90
Ubiquitin-like PHD and RING finger domain-containing protein 1
Short name:
hUHRF1
Ubiquitin-like-containing PHD and RING finger domains protein 1
Gene namesi
Name:UHRF1
Synonyms:ICBP90, NP95, RNF106
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000276043.4
HGNCiHGNC:12556 UHRF1
MIMi607990 gene
neXtProtiNX_Q96T88

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Defects in UHRF1 may be a cause of cancers. Overexpressed in many different forms of human cancers, including bladder, breast, cervical, colorectal and prostate cancers, as well as pancreatic adenocarcinomas, rhabdomyosarcomas and gliomas. Plays an important role in the correlation of histone modification and gene silencing in cancer progression. Expression is associated with a poor prognosis in patients with various cancers, suggesting that it participates in cancer progression.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi142D → A: Impaired binding to histone H3 without affecting the protein folding; when associated with A-153. 1 Publication1
Mutagenesisi145D → A: Impaired binding to histone H3. 1 Publication1
Mutagenesisi152F → A: Impaired binding to histone H3. 1 Publication1
Mutagenesisi153E → A: Impaired binding to histone H3 without affecting the protein folding; when associated with A-142. 1 Publication1
Mutagenesisi188Y → A: Impaired binding to histone H3. 2 Publications1
Mutagenesisi190D → A: Slightly impaired binding to histone H3. 1 Publication1
Mutagenesisi191Y → A: Impaired binding to histone H3. 1 Publication1
Mutagenesisi295 – 296RR → AA: Disrupts the simultaneous binding to H3R2me0 and H3K9me3. 1 Publication2
Mutagenesisi298S → A: Diminishes phosphorylation by PKA. 1 Publication1
Mutagenesisi330Q → A or K: Does not affect ability to bind histone H3 peptide. 1 Publication1
Mutagenesisi334 – 335DE → AA: Abolishes binding to histone H3. 1 Publication2
Mutagenesisi334D → A: Impaired binding to histone H3. 3 Publications1
Mutagenesisi337D → A: Impaired binding to histone H3. 3 Publications1
Mutagenesisi433R → A: Does not affect ability to bind DNA. 1 Publication1
Mutagenesisi443R → A: Decreased ability to bind DNA. 1 Publication1
Mutagenesisi448G → D: Decreased affinity for DNA. 1 Publication1
Mutagenesisi466Y → G: Decreased ability to bind DNA. 1 Publication1
Mutagenesisi469D → G: Abolishes ability to bind hemimethylated DNA. 1
Mutagenesisi489N → A: Abolishes specificity to hemimethylated DNA. 1 Publication1
Mutagenesisi491R → A: Decreased binding to methylated DNA but does not affect ability to bind DNA. 2 Publications1
Mutagenesisi639S → A: Prevents phosphorylation by CDK1 during M phase, leading to increased stability. 1 Publication1
Mutagenesisi639S → D: Mimics phosphorylation; impaired interaction with USP7, leading to decreased stability. 1 Publication1
Mutagenesisi651S → A: No effect on in vitro phosphorylation by PKA. 1 Publication1
Mutagenesisi666S → A: No effect on in vitro phosphorylation by PKA. 1 Publication1
Mutagenesisi741H → A: Abolishes E3 ubiquitin-protein ligase activity. 1 Publication1

Organism-specific databases

DisGeNETi29128
OpenTargetsiENSG00000276043
PharmGKBiPA37196

Chemistry databases

ChEMBLiCHEMBL2424510

Polymorphism and mutation databases

BioMutaiUHRF1
DMDMi67462077

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000561441 – 793E3 ubiquitin-protein ligase UHRF1Add BLAST793

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei76PhosphoserineCombined sources1
Modified residuei91PhosphoserineCombined sources1
Modified residuei95PhosphoserineBy similarity1
Modified residuei165PhosphoserineBy similarity1
Cross-linki279Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei287PhosphoserineCombined sources1
Modified residuei298Phosphoserine; by PKA2 Publications1
Modified residuei368PhosphoserineCombined sources1
Cross-linki385Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei399N6-acetyllysineCombined sources1
Modified residuei546N6-acetyllysine; alternateCombined sources1
Cross-linki546Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei639Phosphoserine; by CDK1Combined sources1 Publication1
Modified residuei651PhosphoserineCombined sources1
Cross-linki670Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei707PhosphoserineCombined sources1
Modified residuei709PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylation at Ser-298 of the linker region decreases the binding to H3K9me3. Phosphorylation at Ser-639 by CDK1 during M phase impairs interaction with USP7, preventing deubiquitination and leading to degradation by the proteasome.3 Publications
Ubiquitinated; which leads to proteasomal degradation. Autoubiquitinated; interaction with USP7 leads to deubiquitination and prevents degradation. Ubiquitination and degradation takes place during M phase, when phosphorylation at Ser-639 prevents intereaction with USP7 and subsequent deubiquitination. Polyubiquitination may be stimulated by DNA damage.4 Publications

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ96T88
MaxQBiQ96T88
PeptideAtlasiQ96T88
PRIDEiQ96T88
ProteomicsDBi78215

PTM databases

iPTMnetiQ96T88
PhosphoSitePlusiQ96T88

Expressioni

Tissue specificityi

Expressed in thymus, bone marrow, testis, lung and heart. Overexpressed in breast cancer.3 Publications

Developmental stagei

Expressed in fetal thymus, liver and kidney.1 Publication

Inductioni

Up-regulated in proliferating cells, and down-regulated in quiescent cells. Down-regulated upon adriamycin-induced DNA damage, in a p53/TP53 and CDKN1A-dependent way. Induced by E2F1 transcription factor.4 Publications

Gene expression databases

BgeeiENSG00000276043 Expressed in 149 organ(s), highest expression level in oocyte
CleanExiHS_UHRF1
ExpressionAtlasiQ96T88 baseline and differential
GenevisibleiQ96T88 HS

Organism-specific databases

HPAiHPA049408
HPA055446

Interactioni

Subunit structurei

Interacts with DNMT3A and DNMT3B (By similarity). Interacts with DNMT1; the interaction is direct. Interacts with USP7; leading to its deubiquitination. Interacts with histone H3. Interacts with HDAC1, but not with HDAC2. Interacts with UHRF1BP1. Interacts with PML. Interacts with EHMT2. Binds hemimethylated CpG containing oligonucleotides.By similarity10 Publications

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi118893, 91 interactors
IntActiQ96T88, 16 interactors
MINTiQ96T88

Chemistry databases

BindingDBiQ96T88

Structurei

Secondary structure

1793
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ96T88
SMRiQ96T88
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96T88

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 78Ubiquitin-likePROSITE-ProRule annotationAdd BLAST78
Domaini419 – 582YDGPROSITE-ProRule annotationAdd BLAST164

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni133 – 209Tudor-like 1Add BLAST77
Regioni216 – 283Tudor-like 2Add BLAST68
Regioni296 – 301Linker6
Regioni333 – 337Histone H3R2me0 binding5
Regioni353 – 355Histone H3R2me0 binding3
Regioni445 – 446Required to promote base flippingBy similarity2
Regioni463 – 464Methylcytosine binding2
Regioni466 – 469Required for formation of a 5-methylcytosine-binding pocket4
Regioni478 – 481Required for formation of a 5-methylcytosine-binding pocket4

Domaini

The tudor-like regions specifically recognize and bind histone H3 unmethylated at 'Arg-2' (H3R2me0), while the PHD-type zinc finger specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3). The tudor-like regions simultaneously recognizes H3K9me3 through a conserved aromatic cage in the first tudor-like subdomain and unmodified H3K4 (H3K4me0) within a groove between the tandem subdomains (PubMed:21489993, PubMed:21777816 and PubMed:22100450). The linker region plays a role in the formation of a histone H3-binding hole between the reader modules formed by the tudor-like regions and the PHD-type zinc finger by making extended contacts with the tandem tudor-like regions (PubMed:22837395).1 Publication
The YDG domain (also named SRA domain) specifically recognizes and binds hemimethylated DNA at replication forks (DNA that is only methylated on the mother strand of replicating DNA) (PubMed:17673620). It contains a binding pocket that accommodates the 5-methylcytosine that is flipped out of the duplex DNA. 2 specialized loops reach through the resulting gap in the DNA from both the major and the minor grooves to read the other 3 bases of the CpG duplex. The major groove loop confers both specificity for the CpG dinucleotide and discrimination against methylation of deoxycytidine of the complementary strand (PubMed:18772889). The YDG domain also recognizes and binds 5-hydroxymethylcytosine (5hmC) (PubMed:21731699).3 Publications
The RING finger is required for ubiquitin ligase activity.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri310 – 366PHD-typePROSITE-ProRule annotationAdd BLAST57
Zinc fingeri724 – 763RING-typePROSITE-ProRule annotationAdd BLAST40

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00390000008296
HOGENOMiHOG000124662
HOVERGENiHBG059298
InParanoidiQ96T88
KOiK10638
PhylomeDBiQ96T88

Family and domain databases

Gene3Di2.30.280.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR015947 PUA-like_sf
IPR036987 SRA-YDG_sf
IPR003105 SRA_YDG
IPR021991 TTD_dom
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF00628 PHD, 1 hit
PF02182 SAD_SRA, 1 hit
PF12148 TTD, 1 hit
PF00240 ubiquitin, 1 hit
SMARTiView protein in SMART
SM00249 PHD, 1 hit
SM00184 RING, 2 hits
SM00466 SRA, 1 hit
SM00213 UBQ, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
SSF57903 SSF57903, 1 hit
SSF88697 SSF88697, 1 hit
PROSITEiView protein in PROSITE
PS50053 UBIQUITIN_2, 1 hit
PS51015 YDG, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96T88-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWIQVRTMDG RQTHTVDSLS RLTKVEELRR KIQELFHVEP GLQRLFYRGK 
        60         70         80         90        100
QMEDGHTLFD YEVRLNDTIQ LLVRQSLVLP HSTKERDSEL SDTDSGCCLG 
       110        120        130        140        150
QSESDKSSTH GEAAAETDSR PADEDMWDET ELGLYKVNEY VDARDTNMGA 
       160        170        180        190        200
WFEAQVVRVT RKAPSRDEPC SSTSRPALEE DVIYHVKYDD YPENGVVQMN 
       210        220        230        240        250
SRDVRARART IIKWQDLEVG QVVMLNYNPD NPKERGFWYD AEISRKRETR 
       260        270        280        290        300
TARELYANVV LGDDSLNDCR IIFVDEVFKI ERPGEGSPMV DNPMRRKSGP 
       310        320        330        340        350
SCKHCKDDVN RLCRVCACHL CGGRQDPDKQ LMCDECDMAF HIYCLDPPLS 
       360        370        380        390        400
SVPSEDEWYC PECRNDASEV VLAGERLRES KKKAKMASAT SSSQRDWGKG 
       410        420        430        440        450
MACVGRTKEC TIVPSNHYGP IPGIPVGTMW RFRVQVSESG VHRPHVAGIH 
       460        470        480        490        500
GRSNDGAYSL VLAGGYEDDV DHGNFFTYTG SGGRDLSGNK RTAEQSCDQK 
       510        520        530        540        550
LTNTNRALAL NCFAPINDQE GAEAKDWRSG KPVRVVRNVK GGKNSKYAPA 
       560        570        580        590        600
EGNRYDGIYK VVKYWPEKGK SGFLVWRYLL RRDDDEPGPW TKEGKDRIKK 
       610        620        630        640        650
LGLTMQYPEG YLEALANRER EKENSKREEE EQQEGGFASP RTGKGKWKRK 
       660        670        680        690        700
SAGGGPSRAG SPRRTSKKTK VEPYSLTAQQ SSLIREDKSN AKLWNEVLAS 
       710        720        730        740        750
LKDRPASGSP FQLFLSKVEE TFQCICCQEL VFRPITTVCQ HNVCKDCLDR 
       760        770        780        790 
SFRAQVFSCP ACRYDLGRSY AMQVNQPLQT VLNQLFPGYG NGR
Length:793
Mass (Da):89,814
Last modified:December 1, 2001 - v1
Checksum:iE65B15657525C89F
GO
Isoform 2 (identifier: Q96T88-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGVFAVPPLSSDTM

Note: No experimental confirmation available.
Show »
Length:806
Mass (Da):91,116
Checksum:iBFE365939E846398
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WVR3A0A087WVR3_HUMAN
E3 ubiquitin-protein ligase UHRF1
UHRF1 hCG_23497
806Annotation score:
A0A087WTW0A0A087WTW0_HUMAN
E3 ubiquitin-protein ligase UHRF1
UHRF1
857Annotation score:
A0A087WWG9A0A087WWG9_HUMAN
E3 ubiquitin-protein ligase UHRF1
UHRF1
496Annotation score:

Sequence cautioni

The sequence BAB15177 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti383K → E in BAF82078 (PubMed:14702039).Curated1
Sequence conflicti383K → N in AAF28469 (PubMed:10646863).Curated1
Sequence conflicti457A → S in AAF28469 (PubMed:10646863).Curated1
Sequence conflicti675S → N in BAF82078 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_022554240D → H1 PublicationCorresponds to variant dbSNP:rs17886098Ensembl.1
Natural variantiVAR_022555379E → K2 PublicationsCorresponds to variant dbSNP:rs17885791Ensembl.1
Natural variantiVAR_022556638A → T2 PublicationsCorresponds to variant dbSNP:rs2307209Ensembl.1
Natural variantiVAR_022557642T → M1 PublicationCorresponds to variant dbSNP:rs17884843Ensembl.1
Natural variantiVAR_022558713L → F1 PublicationCorresponds to variant dbSNP:rs17883563Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0443941M → MGVFAVPPLSSDTM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF129507 mRNA Translation: AAF28469.1
AB177623 mRNA Translation: BAF36719.1
AB177624 mRNA Translation: BAF36720.1
AB075601 mRNA Translation: BAC20576.1
AF274048 mRNA Translation: AAK55744.1
EF560733 mRNA Translation: ABQ59043.1
AK025578 mRNA Translation: BAB15177.1 Different initiation.
AK289389 mRNA Translation: BAF82078.1
AK314579 mRNA Translation: BAG37156.1
AY787925 Genomic DNA Translation: AAV40831.1
AC027319 Genomic DNA No translation available.
AC053467 Genomic DNA Translation: AAF64067.1
CH471139 Genomic DNA Translation: EAW69187.1
BC113875 mRNA Translation: AAI13876.2
CCDSiCCDS74262.1 [Q96T88-2]
CCDS74263.1 [Q96T88-1]
RefSeqiNP_001041666.1, NM_001048201.2 [Q96T88-1]
NP_001276979.1, NM_001290050.1 [Q96T88-1]
NP_001276980.1, NM_001290051.1 [Q96T88-1]
NP_001276981.1, NM_001290052.1 [Q96T88-1]
NP_037414.3, NM_013282.4
UniGeneiHs.108106

Genome annotation databases

EnsembliENST00000612630; ENSP00000484739; ENSG00000276043 [Q96T88-1]
ENST00000615884; ENSP00000478601; ENSG00000276043 [Q96T88-1]
ENST00000616255; ENSP00000478348; ENSG00000276043 [Q96T88-1]
ENST00000624301; ENSP00000485604; ENSG00000276043 [Q96T88-1]
GeneIDi29128
KEGGihsa:29128
UCSCiuc032hkj.2 human [Q96T88-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF129507 mRNA Translation: AAF28469.1
AB177623 mRNA Translation: BAF36719.1
AB177624 mRNA Translation: BAF36720.1
AB075601 mRNA Translation: BAC20576.1
AF274048 mRNA Translation: AAK55744.1
EF560733 mRNA Translation: ABQ59043.1
AK025578 mRNA Translation: BAB15177.1 Different initiation.
AK289389 mRNA Translation: BAF82078.1
AK314579 mRNA Translation: BAG37156.1
AY787925 Genomic DNA Translation: AAV40831.1
AC027319 Genomic DNA No translation available.
AC053467 Genomic DNA Translation: AAF64067.1
CH471139 Genomic DNA Translation: EAW69187.1
BC113875 mRNA Translation: AAI13876.2
CCDSiCCDS74262.1 [Q96T88-2]
CCDS74263.1 [Q96T88-1]
RefSeqiNP_001041666.1, NM_001048201.2 [Q96T88-1]
NP_001276979.1, NM_001290050.1 [Q96T88-1]
NP_001276980.1, NM_001290051.1 [Q96T88-1]
NP_001276981.1, NM_001290052.1 [Q96T88-1]
NP_037414.3, NM_013282.4
UniGeneiHs.108106

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FAZX-ray2.00A/B1-76[»]
2L3RNMR-A126-285[»]
2LGGNMR-A298-366[»]
2LGKNMR-A298-366[»]
2LGLNMR-A298-366[»]
2PB7X-ray1.90A408-643[»]
3ASKX-ray2.90A/B/C/D134-367[»]
3ASLX-ray1.41A298-367[»]
3BI7X-ray1.70A414-617[»]
3CLZX-ray2.20A/B/C/D414-617[»]
3DB3X-ray2.40A126-285[»]
3DB4X-ray2.40A126-285[»]
3DWHX-ray1.95A414-617[»]
3FL2X-ray1.75A672-793[»]
3SHBX-ray1.80A298-366[»]
3SOUX-ray1.80A/B298-367[»]
3SOWX-ray1.95A/B298-367[»]
3SOXX-ray2.65A/B298-367[»]
3T6RX-ray1.95A/B299-364[»]
3ZVYX-ray1.95A/B296-367[»]
3ZVZX-ray1.45B314-367[»]
4GY5X-ray2.96A/B/C/D134-366[»]
4QQDX-ray2.28A/B126-285[»]
5C6DX-ray2.29C/D634-665[»]
5IAYNMR-A134-285[»]
B642-657[»]
5XPIX-ray2.20A127-283[»]
6B9MX-ray1.68D638-678[»]
ProteinModelPortaliQ96T88
SMRiQ96T88
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118893, 91 interactors
IntActiQ96T88, 16 interactors
MINTiQ96T88

Chemistry databases

BindingDBiQ96T88
ChEMBLiCHEMBL2424510

PTM databases

iPTMnetiQ96T88
PhosphoSitePlusiQ96T88

Polymorphism and mutation databases

BioMutaiUHRF1
DMDMi67462077

Proteomic databases

EPDiQ96T88
MaxQBiQ96T88
PeptideAtlasiQ96T88
PRIDEiQ96T88
ProteomicsDBi78215

Protocols and materials databases

DNASUi29128
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000612630; ENSP00000484739; ENSG00000276043 [Q96T88-1]
ENST00000615884; ENSP00000478601; ENSG00000276043 [Q96T88-1]
ENST00000616255; ENSP00000478348; ENSG00000276043 [Q96T88-1]
ENST00000624301; ENSP00000485604; ENSG00000276043 [Q96T88-1]
GeneIDi29128
KEGGihsa:29128
UCSCiuc032hkj.2 human [Q96T88-1]

Organism-specific databases

CTDi29128
DisGeNETi29128
EuPathDBiHostDB:ENSG00000276043.4
GeneCardsiUHRF1
HGNCiHGNC:12556 UHRF1
HPAiHPA049408
HPA055446
MIMi607990 gene
neXtProtiNX_Q96T88
OpenTargetsiENSG00000276043
PharmGKBiPA37196
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000008296
HOGENOMiHOG000124662
HOVERGENiHBG059298
InParanoidiQ96T88
KOiK10638
PhylomeDBiQ96T88

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-HSA-5334118 DNA methylation
SignaLinkiQ96T88
SIGNORiQ96T88

Miscellaneous databases

EvolutionaryTraceiQ96T88
GeneWikiiUHRF1
GenomeRNAii29128
PROiPR:Q96T88
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000276043 Expressed in 149 organ(s), highest expression level in oocyte
CleanExiHS_UHRF1
ExpressionAtlasiQ96T88 baseline and differential
GenevisibleiQ96T88 HS

Family and domain databases

Gene3Di2.30.280.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR015947 PUA-like_sf
IPR036987 SRA-YDG_sf
IPR003105 SRA_YDG
IPR021991 TTD_dom
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF00628 PHD, 1 hit
PF02182 SAD_SRA, 1 hit
PF12148 TTD, 1 hit
PF00240 ubiquitin, 1 hit
SMARTiView protein in SMART
SM00249 PHD, 1 hit
SM00184 RING, 2 hits
SM00466 SRA, 1 hit
SM00213 UBQ, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
SSF57903 SSF57903, 1 hit
SSF88697 SSF88697, 1 hit
PROSITEiView protein in PROSITE
PS50053 UBIQUITIN_2, 1 hit
PS51015 YDG, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiUHRF1_HUMAN
AccessioniPrimary (citable) accession number: Q96T88
Secondary accession number(s): A0JBR2
, A8K024, B2RBA9, Q2HIX7, Q8J022, Q9H6S6, Q9P115, Q9P1U7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 168 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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