UniProtKB - Q96T88 (UHRF1_HUMAN)
E3 ubiquitin-protein ligase UHRF1
UHRF1
Functioni
Catalytic activityi
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 316 | Histone H3K4me0 binding | 1 | |
Sitei | 327 | Histone H3R2me0 binding | 1 | |
Sitei | 330 | Histone H3R2me0 binding | 1 | |
Binding sitei | 469 | Methylcytosine | 1 | |
Sitei | 479 | Required to confer preferential recognition of cytosine over thymine | 1 | |
Sitei | 489 | Required to discriminate between hemimethylated DNA versus symmetrically methylated DNA | 1 | |
Sitei | 491 | Required for affinity and specificity for 5-mCpG sequence | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 310 – 366 | PHD-typePROSITE-ProRule annotationAdd BLAST | 57 | |
Zinc fingeri | 724 – 763 | RING-typePROSITE-ProRule annotationAdd BLAST | 40 |
GO - Molecular functioni
- cis-regulatory region sequence-specific DNA binding Source: BHF-UCL
- hemi-methylated DNA-binding Source: UniProtKB
- histone binding Source: UniProtKB
- identical protein binding Source: BHF-UCL
- methylated histone binding Source: UniProtKB
- methyl-CpG binding Source: UniProtKB
- nucleosomal histone binding Source: BHF-UCL
- ubiquitin protein ligase activity Source: BHF-UCL
- ubiquitin-protein transferase activity Source: UniProtKB
- zinc ion binding Source: UniProtKB
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- DNA repair Source: UniProtKB-KW
- histone monoubiquitination Source: BHF-UCL
- histone ubiquitination Source: UniProtKB
- maintenance of DNA methylation Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- positive regulation of cellular protein metabolic process Source: BHF-UCL
- positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity Source: BHF-UCL
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- protein autoubiquitination Source: UniProtKB
- protein ubiquitination Source: GO_Central
- regulation of epithelial cell proliferation Source: BHF-UCL
- ubiquitin-dependent protein catabolic process Source: UniProtKB
Keywordsi
Molecular function | Chromatin regulator, DNA-binding, Repressor, Transferase |
Biological process | Cell cycle, DNA damage, DNA repair, Transcription, Transcription regulation, Ubl conjugation pathway |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q96T88 |
Reactomei | R-HSA-5334118, DNA methylation |
SignaLinki | Q96T88 |
SIGNORi | Q96T88 |
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: E3 ubiquitin-protein ligase UHRF1 (EC:2.3.2.27)Alternative name(s): Inverted CCAAT box-binding protein of 90 kDa Nuclear protein 95 Nuclear zinc finger protein Np95 Short name: HuNp95 Short name: hNp95 RING finger protein 106 RING-type E3 ubiquitin transferase UHRF1 Transcription factor ICBP90 Ubiquitin-like PHD and RING finger domain-containing protein 1 Short name: hUHRF1 Ubiquitin-like-containing PHD and RING finger domains protein 1 |
Gene namesi | Name:UHRF1 Synonyms:ICBP90, NP95, RNF106 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12556, UHRF1 |
MIMi | 607990, gene |
neXtProti | NX_Q96T88 |
VEuPathDBi | HostDB:ENSG00000276043.4 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation5 Publications
Note: Localizes to replication foci. Enriched in pericentric heterochromatin. Also localizes to euchromatic regions.
Nucleus
- nuclear matrix Source: BHF-UCL
- nucleoplasm Source: HPA
- nucleus Source: BHF-UCL
Other locations
- chromatin Source: UniProtKB
- euchromatin Source: UniProtKB
- heterochromatin Source: UniProtKB
- replication fork Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 142 | D → A: Impaired binding to histone H3 without affecting the protein folding; when associated with A-153. 1 Publication | 1 | |
Mutagenesisi | 145 | D → A: Impaired binding to histone H3. 1 Publication | 1 | |
Mutagenesisi | 152 | F → A: Impaired binding to histone H3. 1 Publication | 1 | |
Mutagenesisi | 153 | E → A: Impaired binding to histone H3 without affecting the protein folding; when associated with A-142. 1 Publication | 1 | |
Mutagenesisi | 188 | Y → A: Impaired binding to histone H3. 2 Publications | 1 | |
Mutagenesisi | 190 | D → A: Slightly impaired binding to histone H3. 1 Publication | 1 | |
Mutagenesisi | 191 | Y → A: Impaired binding to histone H3. 1 Publication | 1 | |
Mutagenesisi | 295 – 296 | RR → AA: Disrupts the simultaneous binding to H3R2me0 and H3K9me3. 1 Publication | 2 | |
Mutagenesisi | 298 | S → A: Diminishes phosphorylation by PKA. 1 Publication | 1 | |
Mutagenesisi | 330 | Q → A or K: Does not affect ability to bind histone H3 peptide. 1 Publication | 1 | |
Mutagenesisi | 334 – 335 | DE → AA: Abolishes binding to histone H3. 1 Publication | 2 | |
Mutagenesisi | 334 | D → A: Impaired binding to histone H3. 3 Publications | 1 | |
Mutagenesisi | 337 | D → A: Impaired binding to histone H3. 3 Publications | 1 | |
Mutagenesisi | 433 | R → A: Does not affect ability to bind DNA. 1 Publication | 1 | |
Mutagenesisi | 443 | R → A: Decreased ability to bind DNA. 1 Publication | 1 | |
Mutagenesisi | 448 | G → D: Decreased affinity for DNA. 1 Publication | 1 | |
Mutagenesisi | 466 | Y → G: Decreased ability to bind DNA. 1 Publication | 1 | |
Mutagenesisi | 469 | D → G: Abolishes ability to bind hemimethylated DNA. | 1 | |
Mutagenesisi | 489 | N → A: Abolishes specificity to hemimethylated DNA. 1 Publication | 1 | |
Mutagenesisi | 491 | R → A: Decreased binding to methylated DNA but does not affect ability to bind DNA. 2 Publications | 1 | |
Mutagenesisi | 639 | S → A: Prevents phosphorylation by CDK1 during M phase, leading to increased stability. 1 Publication | 1 | |
Mutagenesisi | 639 | S → D: Mimics phosphorylation; impaired interaction with USP7, leading to decreased stability. 1 Publication | 1 | |
Mutagenesisi | 651 | S → A: No effect on in vitro phosphorylation by PKA. 1 Publication | 1 | |
Mutagenesisi | 666 | S → A: No effect on in vitro phosphorylation by PKA. 1 Publication | 1 | |
Mutagenesisi | 741 | H → A: Abolishes E3 ubiquitin-protein ligase activity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 29128 |
OpenTargetsi | ENSG00000276043 |
PharmGKBi | PA37196 |
Miscellaneous databases
Pharosi | Q96T88, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2424510 |
Genetic variation databases
BioMutai | UHRF1 |
DMDMi | 67462077 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056144 | 1 – 793 | E3 ubiquitin-protein ligase UHRF1Add BLAST | 793 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 76 | PhosphoserineCombined sources | 1 | |
Modified residuei | 91 | PhosphoserineCombined sources | 1 | |
Modified residuei | 95 | PhosphoserineBy similarity | 1 | |
Modified residuei | 165 | PhosphoserineBy similarity | 1 | |
Cross-linki | 279 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 287 | PhosphoserineCombined sources | 1 | |
Modified residuei | 298 | Phosphoserine; by PKA2 Publications | 1 | |
Modified residuei | 368 | PhosphoserineCombined sources | 1 | |
Cross-linki | 385 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 399 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 546 | N6-acetyllysine; alternateCombined sources | 1 | |
Cross-linki | 546 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 639 | Phosphoserine; by CDK1Combined sources1 Publication | 1 | |
Modified residuei | 651 | PhosphoserineCombined sources | 1 | |
Cross-linki | 670 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 707 | PhosphoserineCombined sources | 1 | |
Modified residuei | 709 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q96T88 |
jPOSTi | Q96T88 |
MassIVEi | Q96T88 |
MaxQBi | Q96T88 |
PeptideAtlasi | Q96T88 |
PRIDEi | Q96T88 |
ProteomicsDBi | 78215 [Q96T88-1] |
PTM databases
iPTMneti | Q96T88 |
PhosphoSitePlusi | Q96T88 |
SwissPalmi | Q96T88 |
Expressioni
Tissue specificityi
Developmental stagei
Inductioni
Gene expression databases
Bgeei | ENSG00000276043, Expressed in oocyte and 170 other tissues |
ExpressionAtlasi | Q96T88, baseline and differential |
Genevisiblei | Q96T88, HS |
Organism-specific databases
HPAi | ENSG00000276043, Tissue enriched (lymphoid) |
Interactioni
Subunit structurei
Interacts with DNMT3A and DNMT3B (By similarity).
Interacts with DNMT1; the interaction is direct.
Interacts with USP7; leading to its deubiquitination.
Interacts with histone H3.
Interacts with HDAC1, but not with HDAC2.
Interacts with UHRF1BP1.
Interacts with PML.
Interacts with EHMT2. Binds hemimethylated CpG containing oligonucleotides.
By similarity10 PublicationsBinary interactionsi
Hide detailsQ96T88
With | #Exp. | IntAct |
---|---|---|
DNMT1 [P26358] | 12 | EBI-1548946,EBI-719459 |
DNMT3A [Q9Y6K1] | 7 | EBI-1548946,EBI-923653 |
DNMT3B [Q9UBC3] | 7 | EBI-1548946,EBI-80125 |
GO - Molecular functioni
- histone binding Source: UniProtKB
- identical protein binding Source: BHF-UCL
- methylated histone binding Source: UniProtKB
- nucleosomal histone binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 118893, 121 interactors |
IntActi | Q96T88, 34 interactors |
MINTi | Q96T88 |
STRINGi | 9606.ENSP00000479617 |
Chemistry databases
BindingDBi | Q96T88 |
Miscellaneous databases
RNActi | Q96T88, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | Q96T88 |
SASBDBi | Q96T88 |
SMRi | Q96T88 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q96T88 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 78 | Ubiquitin-likePROSITE-ProRule annotationAdd BLAST | 78 | |
Domaini | 419 – 582 | YDGPROSITE-ProRule annotationAdd BLAST | 164 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 133 – 209 | Tudor-like 1Add BLAST | 77 | |
Regioni | 216 – 283 | Tudor-like 2Add BLAST | 68 | |
Regioni | 296 – 301 | Linker | 6 | |
Regioni | 333 – 337 | Histone H3R2me0 binding | 5 | |
Regioni | 353 – 355 | Histone H3R2me0 binding | 3 | |
Regioni | 445 – 446 | Required to promote base flippingBy similarity | 2 | |
Regioni | 463 – 464 | Methylcytosine binding | 2 | |
Regioni | 466 – 469 | Required for formation of a 5-methylcytosine-binding pocket | 4 | |
Regioni | 478 – 481 | Required for formation of a 5-methylcytosine-binding pocket | 4 |
Domaini
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 310 – 366 | PHD-typePROSITE-ProRule annotationAdd BLAST | 57 | |
Zinc fingeri | 724 – 763 | RING-typePROSITE-ProRule annotationAdd BLAST | 40 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | ENOG502QRDQ, Eukaryota |
GeneTreei | ENSGT00390000008296 |
HOGENOMi | CLU_022357_0_0_1 |
InParanoidi | Q96T88 |
OrthoDBi | 705927at2759 |
PhylomeDBi | Q96T88 |
Family and domain databases
DisProti | DP01651 |
Gene3Di | 2.30.280.10, 1 hit 3.30.40.10, 1 hit |
IDEALi | IID00327 |
InterProi | View protein in InterPro IPR015947, PUA-like_sf IPR036987, SRA-YDG_sf IPR003105, SRA_YDG IPR021991, TTD_dom IPR000626, Ubiquitin-like_dom IPR029071, Ubiquitin-like_domsf IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF00628, PHD, 1 hit PF02182, SAD_SRA, 1 hit PF12148, TTD, 1 hit PF00240, ubiquitin, 1 hit |
SMARTi | View protein in SMART SM00249, PHD, 1 hit SM00184, RING, 2 hits SM00466, SRA, 1 hit SM00213, UBQ, 1 hit |
SUPFAMi | SSF54236, SSF54236, 1 hit SSF57903, SSF57903, 1 hit SSF88697, SSF88697, 1 hit |
PROSITEi | View protein in PROSITE PS50053, UBIQUITIN_2, 1 hit PS51015, YDG, 1 hit PS01359, ZF_PHD_1, 1 hit PS50016, ZF_PHD_2, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MWIQVRTMDG RQTHTVDSLS RLTKVEELRR KIQELFHVEP GLQRLFYRGK
60 70 80 90 100
QMEDGHTLFD YEVRLNDTIQ LLVRQSLVLP HSTKERDSEL SDTDSGCCLG
110 120 130 140 150
QSESDKSSTH GEAAAETDSR PADEDMWDET ELGLYKVNEY VDARDTNMGA
160 170 180 190 200
WFEAQVVRVT RKAPSRDEPC SSTSRPALEE DVIYHVKYDD YPENGVVQMN
210 220 230 240 250
SRDVRARART IIKWQDLEVG QVVMLNYNPD NPKERGFWYD AEISRKRETR
260 270 280 290 300
TARELYANVV LGDDSLNDCR IIFVDEVFKI ERPGEGSPMV DNPMRRKSGP
310 320 330 340 350
SCKHCKDDVN RLCRVCACHL CGGRQDPDKQ LMCDECDMAF HIYCLDPPLS
360 370 380 390 400
SVPSEDEWYC PECRNDASEV VLAGERLRES KKKAKMASAT SSSQRDWGKG
410 420 430 440 450
MACVGRTKEC TIVPSNHYGP IPGIPVGTMW RFRVQVSESG VHRPHVAGIH
460 470 480 490 500
GRSNDGAYSL VLAGGYEDDV DHGNFFTYTG SGGRDLSGNK RTAEQSCDQK
510 520 530 540 550
LTNTNRALAL NCFAPINDQE GAEAKDWRSG KPVRVVRNVK GGKNSKYAPA
560 570 580 590 600
EGNRYDGIYK VVKYWPEKGK SGFLVWRYLL RRDDDEPGPW TKEGKDRIKK
610 620 630 640 650
LGLTMQYPEG YLEALANRER EKENSKREEE EQQEGGFASP RTGKGKWKRK
660 670 680 690 700
SAGGGPSRAG SPRRTSKKTK VEPYSLTAQQ SSLIREDKSN AKLWNEVLAS
710 720 730 740 750
LKDRPASGSP FQLFLSKVEE TFQCICCQEL VFRPITTVCQ HNVCKDCLDR
760 770 780 790
SFRAQVFSCP ACRYDLGRSY AMQVNQPLQT VLNQLFPGYG NGR
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WTW0 | A0A087WTW0_HUMAN | RING-type E3 ubiquitin transferase | UHRF1 | 857 | Annotation score: | ||
A0A087WVR3 | A0A087WVR3_HUMAN | RING-type E3 ubiquitin transferase | UHRF1 hCG_23497 | 806 | Annotation score: | ||
A0A087WWG9 | A0A087WWG9_HUMAN | E3 ubiquitin-protein ligase UHRF1 | UHRF1 | 496 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 383 | K → E in BAF82078 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 383 | K → N in AAF28469 (PubMed:10646863).Curated | 1 | |
Sequence conflicti | 457 | A → S in AAF28469 (PubMed:10646863).Curated | 1 | |
Sequence conflicti | 675 | S → N in BAF82078 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_022554 | 240 | D → H1 PublicationCorresponds to variant dbSNP:rs17886098Ensembl. | 1 | |
Natural variantiVAR_022555 | 379 | E → K2 PublicationsCorresponds to variant dbSNP:rs17885791Ensembl. | 1 | |
Natural variantiVAR_022556 | 638 | A → T2 PublicationsCorresponds to variant dbSNP:rs2307209Ensembl. | 1 | |
Natural variantiVAR_022557 | 642 | T → M1 PublicationCorresponds to variant dbSNP:rs17884843Ensembl. | 1 | |
Natural variantiVAR_022558 | 713 | L → F1 PublicationCorresponds to variant dbSNP:rs17883563Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_044394 | 1 | M → MGVFAVPPLSSDTM in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF129507 mRNA Translation: AAF28469.1 AB177623 mRNA Translation: BAF36719.1 AB177624 mRNA Translation: BAF36720.1 AB075601 mRNA Translation: BAC20576.1 AF274048 mRNA Translation: AAK55744.1 EF560733 mRNA Translation: ABQ59043.1 AK025578 mRNA Translation: BAB15177.1 Different initiation. AK289389 mRNA Translation: BAF82078.1 AK314579 mRNA Translation: BAG37156.1 AY787925 Genomic DNA Translation: AAV40831.1 AC027319 Genomic DNA No translation available. AC053467 Genomic DNA Translation: AAF64067.1 CH471139 Genomic DNA Translation: EAW69187.1 BC113875 mRNA Translation: AAI13876.2 |
CCDSi | CCDS74262.1 [Q96T88-2] CCDS74263.1 [Q96T88-1] |
RefSeqi | NP_001041666.1, NM_001048201.2 [Q96T88-1] NP_001276979.1, NM_001290050.1 [Q96T88-1] NP_001276980.1, NM_001290051.1 [Q96T88-1] NP_001276981.1, NM_001290052.1 [Q96T88-1] NP_037414.3, NM_013282.4 |
Genome annotation databases
Ensembli | ENST00000612630; ENSP00000484739; ENSG00000276043 [Q96T88-1] ENST00000615884; ENSP00000478601; ENSG00000276043 [Q96T88-1] ENST00000616255; ENSP00000478348; ENSG00000276043 [Q96T88-1] ENST00000624301; ENSP00000485604; ENSG00000276043 [Q96T88-1] ENST00000650932; ENSP00000498698; ENSG00000276043 [Q96T88-1] |
GeneIDi | 29128 |
KEGGi | hsa:29128 |
UCSCi | uc032hkj.2, human [Q96T88-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF129507 mRNA Translation: AAF28469.1 AB177623 mRNA Translation: BAF36719.1 AB177624 mRNA Translation: BAF36720.1 AB075601 mRNA Translation: BAC20576.1 AF274048 mRNA Translation: AAK55744.1 EF560733 mRNA Translation: ABQ59043.1 AK025578 mRNA Translation: BAB15177.1 Different initiation. AK289389 mRNA Translation: BAF82078.1 AK314579 mRNA Translation: BAG37156.1 AY787925 Genomic DNA Translation: AAV40831.1 AC027319 Genomic DNA No translation available. AC053467 Genomic DNA Translation: AAF64067.1 CH471139 Genomic DNA Translation: EAW69187.1 BC113875 mRNA Translation: AAI13876.2 |
CCDSi | CCDS74262.1 [Q96T88-2] CCDS74263.1 [Q96T88-1] |
RefSeqi | NP_001041666.1, NM_001048201.2 [Q96T88-1] NP_001276979.1, NM_001290050.1 [Q96T88-1] NP_001276980.1, NM_001290051.1 [Q96T88-1] NP_001276981.1, NM_001290052.1 [Q96T88-1] NP_037414.3, NM_013282.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2FAZ | X-ray | 2.00 | A/B | 1-76 | [»] | |
2L3R | NMR | - | A | 126-285 | [»] | |
2LGG | NMR | - | A | 298-366 | [»] | |
2LGK | NMR | - | A | 298-366 | [»] | |
2LGL | NMR | - | A | 298-366 | [»] | |
2PB7 | X-ray | 1.90 | A | 408-643 | [»] | |
3ASK | X-ray | 2.90 | A/B/C/D | 134-367 | [»] | |
3ASL | X-ray | 1.41 | A | 298-367 | [»] | |
3BI7 | X-ray | 1.70 | A | 414-617 | [»] | |
3CLZ | X-ray | 2.20 | A/B/C/D | 414-617 | [»] | |
3DB3 | X-ray | 2.40 | A | 126-285 | [»] | |
3DB4 | X-ray | 2.40 | A | 126-285 | [»] | |
3DWH | X-ray | 1.95 | A | 414-617 | [»] | |
3FL2 | X-ray | 1.75 | A | 672-793 | [»] | |
3SHB | X-ray | 1.80 | A | 298-366 | [»] | |
3SOU | X-ray | 1.80 | A/B | 298-367 | [»] | |
3SOW | X-ray | 1.95 | A/B | 298-367 | [»] | |
3SOX | X-ray | 2.65 | A/B | 298-367 | [»] | |
3T6R | X-ray | 1.95 | A/B | 299-364 | [»] | |
3ZVY | X-ray | 1.95 | A/B | 296-367 | [»] | |
3ZVZ | X-ray | 1.45 | B | 314-367 | [»] | |
4GY5 | X-ray | 2.96 | A/B/C/D | 134-366 | [»] | |
4QQD | X-ray | 2.28 | A/B | 126-285 | [»] | |
5C6D | X-ray | 2.29 | C/D | 634-665 | [»] | |
5IAY | NMR | - | A | 134-285 | [»] | |
B | 642-657 | [»] | ||||
5XPI | X-ray | 2.20 | A | 127-283 | [»] | |
5YY9 | X-ray | 2.65 | A/B | 123-285 | [»] | |
5YYA | X-ray | 1.70 | A | 123-285 | [»] | |
6B9M | X-ray | 1.68 | D | 638-678 | [»] | |
6IIW | X-ray | 1.70 | A | 299-366 | [»] | |
6VCS | X-ray | 1.70 | A/B/E | 414-617 | [»] | |
6VED | NMR | - | A | 133-300 | [»] | |
BMRBi | Q96T88 | |||||
SASBDBi | Q96T88 | |||||
SMRi | Q96T88 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 118893, 121 interactors |
IntActi | Q96T88, 34 interactors |
MINTi | Q96T88 |
STRINGi | 9606.ENSP00000479617 |
Chemistry databases
BindingDBi | Q96T88 |
ChEMBLi | CHEMBL2424510 |
PTM databases
iPTMneti | Q96T88 |
PhosphoSitePlusi | Q96T88 |
SwissPalmi | Q96T88 |
Genetic variation databases
BioMutai | UHRF1 |
DMDMi | 67462077 |
Proteomic databases
EPDi | Q96T88 |
jPOSTi | Q96T88 |
MassIVEi | Q96T88 |
MaxQBi | Q96T88 |
PeptideAtlasi | Q96T88 |
PRIDEi | Q96T88 |
ProteomicsDBi | 78215 [Q96T88-1] |
Protocols and materials databases
Antibodypediai | 72541, 391 antibodies |
DNASUi | 29128 |
Genome annotation databases
Ensembli | ENST00000612630; ENSP00000484739; ENSG00000276043 [Q96T88-1] ENST00000615884; ENSP00000478601; ENSG00000276043 [Q96T88-1] ENST00000616255; ENSP00000478348; ENSG00000276043 [Q96T88-1] ENST00000624301; ENSP00000485604; ENSG00000276043 [Q96T88-1] ENST00000650932; ENSP00000498698; ENSG00000276043 [Q96T88-1] |
GeneIDi | 29128 |
KEGGi | hsa:29128 |
UCSCi | uc032hkj.2, human [Q96T88-1] |
Organism-specific databases
CTDi | 29128 |
DisGeNETi | 29128 |
GeneCardsi | UHRF1 |
HGNCi | HGNC:12556, UHRF1 |
HPAi | ENSG00000276043, Tissue enriched (lymphoid) |
MIMi | 607990, gene |
neXtProti | NX_Q96T88 |
OpenTargetsi | ENSG00000276043 |
PharmGKBi | PA37196 |
VEuPathDBi | HostDB:ENSG00000276043.4 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QRDQ, Eukaryota |
GeneTreei | ENSGT00390000008296 |
HOGENOMi | CLU_022357_0_0_1 |
InParanoidi | Q96T88 |
OrthoDBi | 705927at2759 |
PhylomeDBi | Q96T88 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
PathwayCommonsi | Q96T88 |
Reactomei | R-HSA-5334118, DNA methylation |
SignaLinki | Q96T88 |
SIGNORi | Q96T88 |
Miscellaneous databases
BioGRID-ORCSi | 29128, 29 hits in 149 CRISPR screens |
ChiTaRSi | UHRF1, human |
EvolutionaryTracei | Q96T88 |
GeneWikii | UHRF1 |
GenomeRNAii | 29128 |
Pharosi | Q96T88, Tbio |
PROi | PR:Q96T88 |
RNActi | Q96T88, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000276043, Expressed in oocyte and 170 other tissues |
ExpressionAtlasi | Q96T88, baseline and differential |
Genevisiblei | Q96T88, HS |
Family and domain databases
DisProti | DP01651 |
Gene3Di | 2.30.280.10, 1 hit 3.30.40.10, 1 hit |
IDEALi | IID00327 |
InterProi | View protein in InterPro IPR015947, PUA-like_sf IPR036987, SRA-YDG_sf IPR003105, SRA_YDG IPR021991, TTD_dom IPR000626, Ubiquitin-like_dom IPR029071, Ubiquitin-like_domsf IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF00628, PHD, 1 hit PF02182, SAD_SRA, 1 hit PF12148, TTD, 1 hit PF00240, ubiquitin, 1 hit |
SMARTi | View protein in SMART SM00249, PHD, 1 hit SM00184, RING, 2 hits SM00466, SRA, 1 hit SM00213, UBQ, 1 hit |
SUPFAMi | SSF54236, SSF54236, 1 hit SSF57903, SSF57903, 1 hit SSF88697, SSF88697, 1 hit |
PROSITEi | View protein in PROSITE PS50053, UBIQUITIN_2, 1 hit PS51015, YDG, 1 hit PS01359, ZF_PHD_1, 1 hit PS50016, ZF_PHD_2, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UHRF1_HUMAN | |
Accessioni | Q96T88Primary (citable) accession number: Q96T88 Secondary accession number(s): A0JBR2 Q9P1U7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 7, 2005 |
Last sequence update: | December 1, 2001 | |
Last modified: | April 7, 2021 | |
This is version 188 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references