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Protein

Sodium/hydrogen exchanger 7

Gene

SLC9A7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates electroneutral exchange of protons for Na+ and K+ across endomembranes. May contribute to Golgi volume and cation homeostasis.1 Publication

Miscellaneous

Is not inhibited by amiloride but by benzamil and quinine.

GO - Molecular functioni

  • potassium:proton antiporter activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • sodium:proton antiporter activity Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processAntiport, Ion transport, Potassium transport, Sodium transport, Transport
LigandPotassium, Sodium

Enzyme and pathway databases

ReactomeiR-HSA-425986 Sodium/Proton exchangers

Protein family/group databases

TCDBi2.A.36.1.3 the monovalent cation:proton antiporter-1 (cpa1) family

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/hydrogen exchanger 7
Alternative name(s):
Na(+)/H(+) exchanger 7
Short name:
NHE-7
Solute carrier family 9 member 7
Gene namesi
Name:SLC9A7
Synonyms:NHE7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000065923.9
HGNCiHGNC:17123 SLC9A7
MIMi300368 gene
neXtProtiNX_Q96T83

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei71 – 91HelicalSequence analysisAdd BLAST21
Transmembranei96 – 116HelicalSequence analysisAdd BLAST21
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Transmembranei211 – 231HelicalSequence analysisAdd BLAST21
Transmembranei252 – 272HelicalSequence analysisAdd BLAST21
Transmembranei278 – 298HelicalSequence analysisAdd BLAST21
Transmembranei323 – 343HelicalSequence analysisAdd BLAST21
Transmembranei350 – 370HelicalSequence analysisAdd BLAST21
Transmembranei372 – 392HelicalSequence analysisAdd BLAST21
Transmembranei415 – 435HelicalSequence analysisAdd BLAST21
Transmembranei443 – 463HelicalSequence analysisAdd BLAST21
Transmembranei514 – 534HelicalSequence analysisAdd BLAST21
Transmembranei612 – 632HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000065923
PharmGKBiPA38200

Polymorphism and mutation databases

BioMutaiSLC9A7
DMDMi44888236

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000523631 – 725Sodium/hydrogen exchanger 7Add BLAST725

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei545PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96T83
MaxQBiQ96T83
PaxDbiQ96T83
PeptideAtlasiQ96T83
PRIDEiQ96T83
ProteomicsDBi78214
TopDownProteomicsiQ96T83

PTM databases

iPTMnetiQ96T83
PhosphoSitePlusiQ96T83
SwissPalmiQ96T83

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000065923 Expressed in 192 organ(s), highest expression level in putamen
CleanExiHS_SLC9A7
ExpressionAtlasiQ96T83 baseline and differential
GenevisibleiQ96T83 HS

Organism-specific databases

HPAiHPA048938
HPA075385

Interactioni

Subunit structurei

Interacts with SCAMP1, SCAMP2 and SCAMP5; may participate in its shuttling from trans-Golgi network to recycling endosomes.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi124198, 2 interactors
IntActiQ96T83, 1 interactor
STRINGi9606.ENSP00000330320

Structurei

3D structure databases

ProteinModelPortaliQ96T83
SMRiQ96T83
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1965 Eukaryota
COG0025 LUCA
GeneTreeiENSGT00760000119074
HOGENOMiHOG000172307
HOVERGENiHBG055575
InParanoidiQ96T83
KOiK12041
PhylomeDBiQ96T83
TreeFamiTF318755

Family and domain databases

InterProiView protein in InterPro
IPR006153 Cation/H_exchanger
IPR018422 Cation/H_exchanger_CPA1
IPR002090 Na/H_exchanger_6
IPR004709 NaH_exchanger
PANTHERiPTHR10110 PTHR10110, 1 hit
PfamiView protein in Pfam
PF00999 Na_H_Exchanger, 1 hit
PRINTSiPR01084 NAHEXCHNGR
PR01088 NAHEXCHNGR6
TIGRFAMsiTIGR00840 b_cpa1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q96T83-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPGDAARPG SGRATGAPPP RLLLLPLLLG WGLRVAAAAS ASSSGAAAED
60 70 80 90 100
SSAMEELATE KEAEESHRQD SVSLLTFILL LTLTILTIWL FKHRRVRFLH
110 120 130 140 150
ETGLAMIYGL IVGVILRYGT PATSGRDKSL SCTQEDRAFS TLLVNVSGKF
160 170 180 190 200
FEYTLKGEIS PGKINSVEQN DMLRKVTFDP EVFFNILLPP IIFHAGYSLK
210 220 230 240 250
KRHFFRNLGS ILAYAFLGTA VSCFIIGNLM YGVVKLMKIM GQLSDKFYYT
260 270 280 290 300
DCLFFGAIIS ATDPVTVLAI FNELHADVDL YALLFGESVL NDAVAIVLSS
310 320 330 340 350
SIVAYQPAGL NTHAFDAAAF FKSVGIFLGI FSGSFTMGAV TGVNANVTKF
360 370 380 390 400
TKLHCFPLLE TALFFLMSWS TFLLAEACGF TGVVAVLFCG ITQAHYTYNN
410 420 430 440 450
LSVESRSRTK QLFEVLHFLA ENFIFSYMGL ALFTFQKHVF SPIFIIGAFV
460 470 480 490 500
AIFLGRAAHI YPLSFFLNLG RRHKIGWNFQ HMMMFSGLRG AMAFALAIRD
510 520 530 540 550
TASYARQMMF TTTLLIVFFT VWIIGGGTTP MLSWLNIRVG VEEPSEEDQN
560 570 580 590 600
EHHWQYFRVG VDPDQDPPPN NDSFQVLQGD GPDSARGNRT KQESAWIFRL
610 620 630 640 650
WYSFDHNYLK PILTHSGPPL TTTLPAWCGL LARCLTSPQV YDNQEPLREE
660 670 680 690 700
DSDFILTEGD LTLTYGDSTV TANGSSSSHT ASTSLEGSRR TKSSSEEVLE
710 720
RDLGMGDQKV SSRGTRLVFP LEDNA
Length:725
Mass (Da):80,131
Last modified:December 1, 2001 - v1
Checksum:i14E50B197863E38F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WXD1A0A087WXD1_HUMAN
Sodium/hydrogen exchanger
SLC9A7
726Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF298591 mRNA Translation: AAK54508.1
AL050307 Genomic DNA No translation available.
AL022165 Genomic DNA No translation available.
CCDSiCCDS14269.1
RefSeqiNP_115980.1, NM_032591.2
UniGeneiHs.91389

Genome annotation databases

EnsembliENST00000328306; ENSP00000330320; ENSG00000065923
GeneIDi84679
KEGGihsa:84679
UCSCiuc004dgu.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF298591 mRNA Translation: AAK54508.1
AL050307 Genomic DNA No translation available.
AL022165 Genomic DNA No translation available.
CCDSiCCDS14269.1
RefSeqiNP_115980.1, NM_032591.2
UniGeneiHs.91389

3D structure databases

ProteinModelPortaliQ96T83
SMRiQ96T83
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124198, 2 interactors
IntActiQ96T83, 1 interactor
STRINGi9606.ENSP00000330320

Protein family/group databases

TCDBi2.A.36.1.3 the monovalent cation:proton antiporter-1 (cpa1) family

PTM databases

iPTMnetiQ96T83
PhosphoSitePlusiQ96T83
SwissPalmiQ96T83

Polymorphism and mutation databases

BioMutaiSLC9A7
DMDMi44888236

Proteomic databases

EPDiQ96T83
MaxQBiQ96T83
PaxDbiQ96T83
PeptideAtlasiQ96T83
PRIDEiQ96T83
ProteomicsDBi78214
TopDownProteomicsiQ96T83

Protocols and materials databases

DNASUi84679
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328306; ENSP00000330320; ENSG00000065923
GeneIDi84679
KEGGihsa:84679
UCSCiuc004dgu.3 human

Organism-specific databases

CTDi84679
EuPathDBiHostDB:ENSG00000065923.9
GeneCardsiSLC9A7
HGNCiHGNC:17123 SLC9A7
HPAiHPA048938
HPA075385
MIMi300368 gene
neXtProtiNX_Q96T83
OpenTargetsiENSG00000065923
PharmGKBiPA38200
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1965 Eukaryota
COG0025 LUCA
GeneTreeiENSGT00760000119074
HOGENOMiHOG000172307
HOVERGENiHBG055575
InParanoidiQ96T83
KOiK12041
PhylomeDBiQ96T83
TreeFamiTF318755

Enzyme and pathway databases

ReactomeiR-HSA-425986 Sodium/Proton exchangers

Miscellaneous databases

ChiTaRSiSLC9A7 human
GenomeRNAii84679
PROiPR:Q96T83
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000065923 Expressed in 192 organ(s), highest expression level in putamen
CleanExiHS_SLC9A7
ExpressionAtlasiQ96T83 baseline and differential
GenevisibleiQ96T83 HS

Family and domain databases

InterProiView protein in InterPro
IPR006153 Cation/H_exchanger
IPR018422 Cation/H_exchanger_CPA1
IPR002090 Na/H_exchanger_6
IPR004709 NaH_exchanger
PANTHERiPTHR10110 PTHR10110, 1 hit
PfamiView protein in Pfam
PF00999 Na_H_Exchanger, 1 hit
PRINTSiPR01084 NAHEXCHNGR
PR01088 NAHEXCHNGR6
TIGRFAMsiTIGR00840 b_cpa1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSL9A7_HUMAN
AccessioniPrimary (citable) accession number: Q96T83
Secondary accession number(s): O75827, Q5JXP9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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