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UniProtKB - Q96T66 (NMNA3_HUMAN)

Protein

Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3

Gene

NMNAT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the formation of NAD+ from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD+. For the pyrophosphorolytic activity, can use NAD+, NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP+, NADPH and NaADP+. Protects against axonal degeneration following injury.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 PublicationNote: Divalent metal cations. Mg2+ confers the highest activity.1 Publication

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activity is strongly inhibited by galotannin. Inhibited by P1-(adenosine-5')-P4-(nicotinic-acid-riboside-5')-tetraphosphate (Nap4AD).1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=209 µM for NMN2 Publications
  2. KM=130 µM for NAD+2 Publications
  3. KM=29 µM for ATP2 Publications
  4. KM=390 µM for PPi2 Publications
  5. KM=276 µM for GTP2 Publications
  6. KM=350 µM for ITP2 Publications
  7. KM=111 µM for NaMN2 Publications
  8. KM=130 µM for NMNH2 Publications
  9. KM=2.01 µM for triazofurin monophosphate2 Publications
  1. Vmax=3.6 µmol/min/mg enzyme for NAD synthesis2 Publications
  2. Vmax=12.8 µmol/min/mg enzyme for pyrophosphorolytic NAD+ cleavage2 Publications
  3. Vmax=2.9 µmol/min/mg enzyme for pyrophosphorolytic NADH cleavage2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes NAD(+) from nicotinamide D-ribonucleotide.
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinamide-nucleotide adenylyltransferase (NMNAT1), Nicotinamide-nucleotide adenylyltransferase, Nicotinamide-nucleotide adenylyltransferase (NMNAT3), Nicotinamide-nucleotide adenylyltransferase (nadD), Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 (NMNAT1), Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 (NMNAT2), Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 (NMNAT3)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes NAD(+) from nicotinamide D-ribonucleotide, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes deamido-NAD(+) from nicotinate D-ribonucleotide.
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 (NMNAT1), Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 (NMNAT2), Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 (NMNAT3)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes deamido-NAD(+) from nicotinate D-ribonucleotide, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei22ATP1 Publication1
Binding sitei56ATP1 Publication1
Binding sitei140ATP; shared with dimeric partner1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi13 – 15ATP1 Publication3
Nucleotide bindingi135 – 137ATP1 Publication3
Nucleotide bindingi203 – 206ATP1 Publication4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • nicotinamide-nucleotide adenylyltransferase activity Source: GO_Central
  • nicotinate-nucleotide adenylyltransferase activity Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processPyridine nucleotide biosynthesis
LigandATP-binding, Magnesium, NAD, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS08953-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.7.7.1 2681
2.7.7.18 2681

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-196807 Nicotinate metabolism

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		Q96T66

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi
UPA00253;UER00332

UPA00253;UER00600

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3Curated
Short name:
NMN/NaMN adenylyltransferase 3
Alternative name(s):
Nicotinamide-nucleotide adenylyltransferase 3
Short name:
NMN adenylyltransferase 3
Nicotinate-nucleotide adenylyltransferase 3 (EC:2.7.7.18)
Short name:
NaMN adenylyltransferase 3
Pyridine nucleotide adenylyltransferase 3 (EC:2.7.7.1)
Short name:
PNAT-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NMNAT3
ORF Names:FKSG76
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000163864.14

Human Gene Nomenclature Database

More...HGNCi		HGNC:20989 NMNAT3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608702 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96T66

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		349565

Open Targets

More...OpenTargetsi		ENSG00000163864

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134952303

Chemistry databases

Drug and drug target database

More...DrugBanki		DB04099 Deamido-Nad+
DB03227 Nicotinamide Mononucleotide

Polymorphism and mutation databases

Domain mapping of disease mutations (DMDM)

More...DMDMi		116242680

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001350161 – 252Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3Add BLAST252

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96T66

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96T66

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96T66

PeptideAtlas

More...PeptideAtlasi		Q96T66

PRoteomics IDEntifications database

More...PRIDEi		Q96T66

ProteomicsDB human proteome resource

More...ProteomicsDBi		78200
78201 [Q96T66-2]
78202 [Q96T66-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96T66

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96T66

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in lung and spleen with lower levels in placenta and kidney.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000163864 Expressed in 184 organ(s), highest expression level in muscle of leg

CleanEx database of gene expression profiles

More...CleanExi		HS_NMNAT3

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96T66 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96T66 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA039077
HPA057402

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		131564, 4 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000340523

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1252
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q96T66

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96T66

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q96T66

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni53 – 55Substrate binding1 Publication3
Regioni90 – 93Substrate binding1 Publication4
Regioni147 – 148Substrate binding1 Publication2

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the eukaryotic NMN adenylyltransferase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3199 Eukaryota
COG1057 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153841

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000216047

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG052640

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96T66

KEGG Orthology (KO)

More...KOi		K06210

Identification of Orthologs from Complete Genome Data

More...OMAi		KYQHNIH

Database of Orthologous Groups

More...OrthoDBi		EOG091G0JTI

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96T66

TreeFam database of animal gene trees

More...TreeFami		TF315035

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.620, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004821 Cyt_trans-like
IPR005248 NadD/NMNAT
IPR014729 Rossmann-like_a/b/a_fold

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01467 CTP_transf_like, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00482 TIGR00482, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96T66-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKSRIPVVLL ACGSFNPITN MHLRMFEVAR DHLHQTGMYQ VIQGIISPVN 
        60         70         80         90        100
DTYGKKDLAA SHHRVAMARL ALQTSDWIRV DPWESEQAQW METVKVLRHH 
       110        120        130        140        150
HSKLLRSPPQ MEGPDHGKAL FSTPAAVPEL KLLCGADVLK TFQTPNLWKD 
       160        170        180        190        200
AHIQEIVEKF GLVCVGRVGH DPKGYIAESP ILRMHQHNIH LAKEPVQNEI 
       210        220        230        240        250
SATYIRRALG QGQSVKYLIP DAVITYIKDH GLYTKGSTWK GKSTQSTEGK 

TS
Length:252
Mass (Da):28,322
Last modified:October 17, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6402CFB2FE789CF4
GO
Isoform 2 (identifier: Q96T66-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: Missing.

Note: No experimental confirmation available.
Show »
Length:215
Mass (Da):24,119
Checksum:i0E445A25C77E1800
GO
Isoform 3 (identifier: Q96T66-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     37-125: Missing.

Note: No experimental confirmation available.
Show »
Length:163
Mass (Da):18,255
Checksum:i0E9550BF1ADADFF2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8YFG2A0A2R8YFG2_HUMAN
Nicotinamide-nucleotide adenylyltra...
NMNAT3
346Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RGH7D6RGH7_HUMAN
Nicotinamide/nicotinic acid mononuc...
NMNAT3
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RHV4D6RHV4_HUMAN
Nicotinamide/nicotinic acid mononuc...
NMNAT3
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R975D6R975_HUMAN
Nicotinamide nucleotide adenylyltra...
NMNAT3 hCG_2022373
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6REC8D6REC8_HUMAN
Nicotinamide nucleotide adenylyltra...
NMNAT3 hCG_2022373
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RGG8D6RGG8_HUMAN
Nicotinamide nucleotide adenylyltra...
NMNAT3 hCG_2022373
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y594A0A2R8Y594_HUMAN
Nicotinamide nucleotide adenylyltra...
NMNAT3 hCG_2022373
170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YGL3A0A2R8YGL3_HUMAN
Nicotinamide/nicotinic acid mononuc...
NMNAT3
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YE08A0A2R8YE08_HUMAN
Nicotinamide/nicotinic acid mononuc...
NMNAT3
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YEU0A0A2R8YEU0_HUMAN
Nicotinamide/nicotinic acid mononuc...
NMNAT3
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti169G → S in AAK52726 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0102671 – 37Missing in isoform 2. 1 PublicationAdd BLAST37
Alternative sequenceiVSP_04320337 – 125Missing in isoform 3. 1 PublicationAdd BLAST89

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF345564 mRNA Translation: AAK52726.1
AK123208 mRNA Translation: BAG53878.1
AC046134 Genomic DNA No translation available.
AC110716 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79023.1
CH471052 Genomic DNA Translation: EAW79024.1
CH471052 Genomic DNA Translation: EAW79025.1
CH471052 Genomic DNA Translation: EAW79030.1
CH471052 Genomic DNA Translation: EAW79031.1
BC034374 mRNA Translation: AAH34374.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3111.1 [Q96T66-2]
CCDS56282.1 [Q96T66-3]
CCDS82846.1 [Q96T66-1]

NCBI Reference Sequences

More...RefSeqi		NP_001186976.1, NM_001200047.2 [Q96T66-3]
NP_001307440.1, NM_001320511.1 [Q96T66-1]
NP_001307441.1, NM_001320512.1 [Q96T66-1]
NP_835471.1, NM_178177.4 [Q96T66-2]
XP_011511092.1, XM_011512790.1 [Q96T66-2]
XP_011511093.1, XM_011512791.2 [Q96T66-2]
XP_016861824.1, XM_017006335.1 [Q96T66-1]
XP_016861825.1, XM_017006336.1 [Q96T66-1]
XP_016861826.1, XM_017006337.1 [Q96T66-1]
XP_016861827.1, XM_017006338.1 [Q96T66-2]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.208673
Hs.745268

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000296202; ENSP00000296202; ENSG00000163864 [Q96T66-1]
ENST00000339837; ENSP00000340523; ENSG00000163864 [Q96T66-2]
ENST00000413939; ENSP00000412953; ENSG00000163864 [Q96T66-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		349565

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:349565

UCSC genome browser

More...UCSCi		uc003etj.4 human [Q96T66-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF345564 mRNA Translation: AAK52726.1
AK123208 mRNA Translation: BAG53878.1
AC046134 Genomic DNA No translation available.
AC110716 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79023.1
CH471052 Genomic DNA Translation: EAW79024.1
CH471052 Genomic DNA Translation: EAW79025.1
CH471052 Genomic DNA Translation: EAW79030.1
CH471052 Genomic DNA Translation: EAW79031.1
BC034374 mRNA Translation: AAH34374.1
CCDSiCCDS3111.1 [Q96T66-2]
CCDS56282.1 [Q96T66-3]
CCDS82846.1 [Q96T66-1]
RefSeqiNP_001186976.1, NM_001200047.2 [Q96T66-3]
NP_001307440.1, NM_001320511.1 [Q96T66-1]
NP_001307441.1, NM_001320512.1 [Q96T66-1]
NP_835471.1, NM_178177.4 [Q96T66-2]
XP_011511092.1, XM_011512790.1 [Q96T66-2]
XP_011511093.1, XM_011512791.2 [Q96T66-2]
XP_016861824.1, XM_017006335.1 [Q96T66-1]
XP_016861825.1, XM_017006336.1 [Q96T66-1]
XP_016861826.1, XM_017006337.1 [Q96T66-1]
XP_016861827.1, XM_017006338.1 [Q96T66-2]
UniGeneiHs.208673
Hs.745268

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NUPX-ray1.90A/B1-252[»]
1NUQX-ray1.90A/B1-252[»]
1NURX-ray2.15A/B1-252[»]
1NUSX-ray2.20A/B1-252[»]
1NUTX-ray1.90A/B1-252[»]
1NUUX-ray1.90A/B1-252[»]
ProteinModelPortaliQ96T66
SMRiQ96T66
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131564, 4 interactors
STRINGi9606.ENSP00000340523

Chemistry databases

DrugBankiDB04099 Deamido-Nad+
DB03227 Nicotinamide Mononucleotide

PTM databases

iPTMnetiQ96T66
PhosphoSitePlusiQ96T66

Polymorphism and mutation databases

DMDMi116242680

Proteomic databases

EPDiQ96T66
MaxQBiQ96T66
PaxDbiQ96T66
PeptideAtlasiQ96T66
PRIDEiQ96T66
ProteomicsDBi78200
78201 [Q96T66-2]
78202 [Q96T66-3]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		349565
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296202; ENSP00000296202; ENSG00000163864 [Q96T66-1]
ENST00000339837; ENSP00000340523; ENSG00000163864 [Q96T66-2]
ENST00000413939; ENSP00000412953; ENSG00000163864 [Q96T66-3]
GeneIDi349565
KEGGihsa:349565
UCSCiuc003etj.4 human [Q96T66-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		349565
DisGeNETi349565
EuPathDBiHostDB:ENSG00000163864.14

GeneCards: human genes, protein and diseases

More...GeneCardsi		NMNAT3
HGNCiHGNC:20989 NMNAT3
HPAiHPA039077
HPA057402
MIMi608702 gene
neXtProtiNX_Q96T66
OpenTargetsiENSG00000163864
PharmGKBiPA134952303

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3199 Eukaryota
COG1057 LUCA
GeneTreeiENSGT00940000153841
HOGENOMiHOG000216047
HOVERGENiHBG052640
InParanoidiQ96T66
KOiK06210
OMAiKYQHNIH
OrthoDBiEOG091G0JTI
PhylomeDBiQ96T66
TreeFamiTF315035

Enzyme and pathway databases

UniPathwayi
UPA00253;UER00332

UPA00253;UER00600

BioCyciMetaCyc:HS08953-MONOMER
BRENDAi2.7.7.1 2681
2.7.7.18 2681
ReactomeiR-HSA-196807 Nicotinate metabolism
SABIO-RKiQ96T66

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NMNAT3 human
EvolutionaryTraceiQ96T66

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		349565

Protein Ontology

More...PROi		PR:Q96T66

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000163864 Expressed in 184 organ(s), highest expression level in muscle of leg
CleanExiHS_NMNAT3
ExpressionAtlasiQ96T66 baseline and differential
GenevisibleiQ96T66 HS

Family and domain databases

Gene3Di3.40.50.620, 1 hit
InterProiView protein in InterPro
IPR004821 Cyt_trans-like
IPR005248 NadD/NMNAT
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF01467 CTP_transf_like, 1 hit
TIGRFAMsiTIGR00482 TIGR00482, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNMNA3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96T66
Secondary accession number(s): B3KVR6
, D3DNF2, D3DNF3, Q8N4G1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 17, 2006
Last modified: December 5, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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