UniProtKB - Q96T55 (KCNKG_HUMAN)
Protein
Potassium channel subfamily K member 16
Gene
KCNK16
Organism
Homo sapiens (Human)
Status
Functioni
Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K+ currents.
Miscellaneous
Inhibited by Ba2+, quinine, quinidine, chloroform and halothane. Activated at alkaline pH.
GO - Molecular functioni
- potassium channel activity Source: MGI
- potassium ion leak channel activity Source: GO_Central
- voltage-gated ion channel activity Source: UniProtKB-KW
GO - Biological processi
- potassium ion transmembrane transport Source: GO_Central
- potassium ion transport Source: MGI
- regulation of ion transmembrane transport Source: UniProtKB-KW
- stabilization of membrane potential Source: GO_Central
Keywordsi
Molecular function | Ion channel, Potassium channel, Voltage-gated channel |
Biological process | Ion transport, Potassium transport, Transport |
Ligand | Potassium |
Enzyme and pathway databases
PathwayCommonsi | Q96T55 |
Reactomei | R-HSA-1299361, TWIK-related alkaline pH activated K+ channel (TALK) R-HSA-5576886, Phase 4 - resting membrane potential |
Protein family/group databases
TCDBi | 1.A.1.9.10, the voltage-gated ion channel (vic) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Potassium channel subfamily K member 16Alternative name(s): 2P domain potassium channel Talk-1 TWIK-related alkaline pH-activated K(+) channel 1 Short name: TALK-1 |
Gene namesi | Name:KCNK16 Synonyms:TALK1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000095981.10 |
HGNCi | HGNC:14464, KCNK16 |
MIMi | 607369, gene |
neXtProti | NX_Q96T55 |
Subcellular locationi
Other locations
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 13 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 14 – 34 | HelicalSequence analysisAdd BLAST | 21 | |
Intramembranei | 98 – 116 | Pore-forming; Name=Pore-forming 1Sequence analysisAdd BLAST | 19 | |
Transmembranei | 120 – 140 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 141 – 165 | CytoplasmicSequence analysisAdd BLAST | 25 | |
Transmembranei | 166 – 186 | HelicalSequence analysisAdd BLAST | 21 | |
Intramembranei | 202 – 221 | Pore-forming; Name=Pore-forming 2Sequence analysisAdd BLAST | 20 | |
Transmembranei | 238 – 258 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 259 – 309 | CytoplasmicSequence analysisAdd BLAST | 51 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 83795 |
OpenTargetsi | ENSG00000095981 |
PharmGKBi | PA30057 |
Miscellaneous databases
Pharosi | Q96T55, Tdark |
Polymorphism and mutation databases
BioMutai | KCNK16 |
DMDMi | 24636281 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000101767 | 1 – 309 | Potassium channel subfamily K member 16Add BLAST | 309 |
Proteomic databases
PaxDbi | Q96T55 |
PRIDEi | Q96T55 |
ProteomicsDBi | 78192 [Q96T55-1] 78193 [Q96T55-3] 78194 [Q96T55-4] 78195 [Q96T55-5] |
PTM databases
iPTMneti | Q96T55 |
PhosphoSitePlusi | Q96T55 |
Expressioni
Tissue specificityi
Highly expressed in pancreas. Not detectable in the other tissues tested.1 Publication
Gene expression databases
Bgeei | ENSG00000095981, Expressed in islet of Langerhans and 29 other tissues |
ExpressionAtlasi | Q96T55, baseline and differential |
Genevisiblei | Q96T55, HS |
Organism-specific databases
HPAi | ENSG00000095981, Tissue enhanced (pancreas, stomach) |
Interactioni
Subunit structurei
Homodimer.
CuratedBinary interactionsi
Q96T55
With | #Exp. | IntAct |
---|---|---|
OTX1 [P32242] | 3 | EBI-10294109,EBI-740446 |
Protein-protein interaction databases
BioGRIDi | 123763, 24 interactors |
IntActi | Q96T55, 15 interactors |
STRINGi | 9606.ENSP00000391498 |
Miscellaneous databases
RNActi | Q96T55, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1418, Eukaryota |
GeneTreei | ENSGT00940000159813 |
HOGENOMi | CLU_022504_6_0_1 |
InParanoidi | Q96T55 |
OMAi | YGEGFYF |
OrthoDBi | 897327at2759 |
PhylomeDBi | Q96T55 |
TreeFami | TF313947 |
Family and domain databases
InterProi | View protein in InterPro IPR003280, 2pore_dom_K_chnl IPR003092, 2pore_dom_K_chnl_TASK IPR013099, K_chnl_dom |
Pfami | View protein in Pfam PF07885, Ion_trans_2, 2 hits |
PRINTSi | PR01333, 2POREKCHANEL PR01095, TASKCHANNEL |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform a (identifier: Q96T55-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPSAGLCSCW GGRVLPLLLA YVCYLLLGAT IFQLLERQAE AQSRDQFQLE
60 70 80 90 100
KLRFLENYTC LDQWAMEQFV QVIMEAWVKG VNPKGNSTNP SNWDFGSSFF
110 120 130 140 150
FAGTVVTTIG YGNLAPSTEA GQVFCVFYAL LGIPLNVIFL NHLGTGLRAH
160 170 180 190 200
LAAIERWEDR PRRSQVLQVL GLALFLTLGT LVILIFPPMV FSHVEGWSFS
210 220 230 240 250
EGFYFAFITL STIGFGDYVV GTDPSKHYIS VYRSLAAIWI LLGLAWLALI
260 270 280 290 300
LPLGPLLLHR CCQLWLLSLR QGCGAKAAPG RRPRRGSTAA RGVQVTPQDF
PISKKGLGS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD6RC57 | D6RC57_HUMAN | Potassium channel subfamily K membe... | KCNK16 | 197 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 49 | L → S in AAP82866 (PubMed:12724142).Curated | 1 | |
Sequence conflicti | 149 | A → V in AAP82867 (PubMed:12724142).Curated | 1 | |
Sequence conflicti | 200 | S → G in AAP82866 (PubMed:12724142).Curated | 1 | |
Sequence conflicti | 205 – 207 | FAF → LLS in AAP82867 (PubMed:12724142).Curated | 3 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_063636 | 215 | F → L. Corresponds to variant dbSNP:rs9462527Ensembl. | 1 | |
Natural variantiVAR_063637 | 275 | A → G. Corresponds to variant dbSNP:rs1535500Ensembl. | 1 | |
Natural variantiVAR_052430 | 301 | P → H2 PublicationsCorresponds to variant dbSNP:rs11756091Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_039863 | 222 – 309 | TDPSK…KGLGS → HPLNFITPSGLLPSQEPFQT PHGKPESQQIPGSFQKVSSM NVWPLSGMHSPGLAFPLPDC NIPDQERFRPLHPGAWKFWP LPLPSSNSKWAPMWLGSSAQ V in isoform c. 2 PublicationsAdd BLAST | 88 | |
Alternative sequenceiVSP_039864 | 222 – 268 | Missing in isoform d. 1 PublicationAdd BLAST | 47 | |
Alternative sequenceiVSP_039865 | 269 – 309 | LRQGC…KGLGS → RGLGVKDGAASDPSGLPRPQ KIPISA in isoform b. 2 PublicationsAdd BLAST | 41 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF358909 mRNA Translation: AAK49532.1 AY253145 mRNA Translation: AAP82866.1 AY253146 mRNA Translation: AAP82867.1 AY253147 mRNA Translation: AAP82868.1 EU978943 mRNA Translation: ACH86102.1 AL136087 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03982.1 CH471081 Genomic DNA Translation: EAX03984.1 CH471081 Genomic DNA Translation: EAX03985.1 BC111860 mRNA Translation: AAI11861.1 |
CCDSi | CCDS47420.1 [Q96T55-5] CCDS47421.1 [Q96T55-4] CCDS47422.1 [Q96T55-3] CCDS4843.1 [Q96T55-1] |
RefSeqi | NP_001128577.1, NM_001135105.1 [Q96T55-4] NP_001128578.1, NM_001135106.1 [Q96T55-3] NP_001128579.1, NM_001135107.1 [Q96T55-5] NP_115491.1, NM_032115.3 [Q96T55-1] XP_016866835.1, XM_017011346.1 [Q96T55-5] |
Genome annotation databases
Ensembli | ENST00000373227; ENSP00000362324; ENSG00000095981 [Q96T55-5] ENST00000373229; ENSP00000362326; ENSG00000095981 [Q96T55-1] ENST00000425054; ENSP00000391498; ENSG00000095981 [Q96T55-4] ENST00000437525; ENSP00000415375; ENSG00000095981 [Q96T55-3] |
GeneIDi | 83795 |
KEGGi | hsa:83795 |
UCSCi | uc003ooq.3, human [Q96T55-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF358909 mRNA Translation: AAK49532.1 AY253145 mRNA Translation: AAP82866.1 AY253146 mRNA Translation: AAP82867.1 AY253147 mRNA Translation: AAP82868.1 EU978943 mRNA Translation: ACH86102.1 AL136087 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03982.1 CH471081 Genomic DNA Translation: EAX03984.1 CH471081 Genomic DNA Translation: EAX03985.1 BC111860 mRNA Translation: AAI11861.1 |
CCDSi | CCDS47420.1 [Q96T55-5] CCDS47421.1 [Q96T55-4] CCDS47422.1 [Q96T55-3] CCDS4843.1 [Q96T55-1] |
RefSeqi | NP_001128577.1, NM_001135105.1 [Q96T55-4] NP_001128578.1, NM_001135106.1 [Q96T55-3] NP_001128579.1, NM_001135107.1 [Q96T55-5] NP_115491.1, NM_032115.3 [Q96T55-1] XP_016866835.1, XM_017011346.1 [Q96T55-5] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 123763, 24 interactors |
IntActi | Q96T55, 15 interactors |
STRINGi | 9606.ENSP00000391498 |
Protein family/group databases
TCDBi | 1.A.1.9.10, the voltage-gated ion channel (vic) superfamily |
PTM databases
iPTMneti | Q96T55 |
PhosphoSitePlusi | Q96T55 |
Polymorphism and mutation databases
BioMutai | KCNK16 |
DMDMi | 24636281 |
Proteomic databases
PaxDbi | Q96T55 |
PRIDEi | Q96T55 |
ProteomicsDBi | 78192 [Q96T55-1] 78193 [Q96T55-3] 78194 [Q96T55-4] 78195 [Q96T55-5] |
Protocols and materials databases
Antibodypediai | 15706, 34 antibodies |
Genome annotation databases
Ensembli | ENST00000373227; ENSP00000362324; ENSG00000095981 [Q96T55-5] ENST00000373229; ENSP00000362326; ENSG00000095981 [Q96T55-1] ENST00000425054; ENSP00000391498; ENSG00000095981 [Q96T55-4] ENST00000437525; ENSP00000415375; ENSG00000095981 [Q96T55-3] |
GeneIDi | 83795 |
KEGGi | hsa:83795 |
UCSCi | uc003ooq.3, human [Q96T55-1] |
Organism-specific databases
CTDi | 83795 |
DisGeNETi | 83795 |
EuPathDBi | HostDB:ENSG00000095981.10 |
GeneCardsi | KCNK16 |
HGNCi | HGNC:14464, KCNK16 |
HPAi | ENSG00000095981, Tissue enhanced (pancreas, stomach) |
MIMi | 607369, gene |
neXtProti | NX_Q96T55 |
OpenTargetsi | ENSG00000095981 |
PharmGKBi | PA30057 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1418, Eukaryota |
GeneTreei | ENSGT00940000159813 |
HOGENOMi | CLU_022504_6_0_1 |
InParanoidi | Q96T55 |
OMAi | YGEGFYF |
OrthoDBi | 897327at2759 |
PhylomeDBi | Q96T55 |
TreeFami | TF313947 |
Enzyme and pathway databases
PathwayCommonsi | Q96T55 |
Reactomei | R-HSA-1299361, TWIK-related alkaline pH activated K+ channel (TALK) R-HSA-5576886, Phase 4 - resting membrane potential |
Miscellaneous databases
BioGRID-ORCSi | 83795, 4 hits in 837 CRISPR screens |
GeneWikii | KCNK16 |
GenomeRNAii | 83795 |
Pharosi | Q96T55, Tdark |
PROi | PR:Q96T55 |
RNActi | Q96T55, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000095981, Expressed in islet of Langerhans and 29 other tissues |
ExpressionAtlasi | Q96T55, baseline and differential |
Genevisiblei | Q96T55, HS |
Family and domain databases
InterProi | View protein in InterPro IPR003280, 2pore_dom_K_chnl IPR003092, 2pore_dom_K_chnl_TASK IPR013099, K_chnl_dom |
Pfami | View protein in Pfam PF07885, Ion_trans_2, 2 hits |
PRINTSi | PR01333, 2POREKCHANEL PR01095, TASKCHANNEL |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KCNKG_HUMAN | |
Accessioni | Q96T55Primary (citable) accession number: Q96T55 Secondary accession number(s): B5TJL9 Q9H591 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 2002 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 147 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations