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Entry version 126 (08 May 2019)
Sequence version 1 (01 Dec 2001)
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Protein

Mitochondrial inner membrane protease subunit 2

Gene

IMMP2L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei43By similarity1
Active sitei91By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S26.A09

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mitochondrial inner membrane protease subunit 2 (EC:3.4.21.-)
Alternative name(s):
IMP2-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IMMP2L
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14598 IMMP2L

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605977 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96T52

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei19 – 37HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Gilles de la Tourette syndrome (GTS)1 Publication
The disease may be caused by mutations affecting the gene represented in this entry.
Disease descriptionNeurologic disorder manifested particularly by motor and vocal tics and associated with behavioral abnormalities.
Related information in OMIM

Organism-specific databases

DisGeNET

More...
DisGeNETi
83943
MIMi137580 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000184903

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
856 NON RARE IN EUROPE: Tourette syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134887258

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IMMP2L

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74752143

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002595771 – 175Mitochondrial inner membrane protease subunit 2Add BLAST175

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96T52

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96T52

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96T52

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96T52

PeptideAtlas

More...
PeptideAtlasi
Q96T52

PRoteomics IDEntifications database

More...
PRIDEi
Q96T52

ProteomicsDB human proteome resource

More...
ProteomicsDBi
78187
78188 [Q96T52-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96T52

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96T52

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in all tissues tested except adult liver and lung.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000184903 Expressed in 175 organ(s), highest expression level in skeletal muscle tissue

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96T52 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96T52 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA026711

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of 2 subunits, IMMPL1 and IMMPL2.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123826, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q96T52, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000384966

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96T52

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S26 family. IMP2 subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1568 Eukaryota
COG0681 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00550000075044

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96T52

KEGG Orthology (KO)

More...
KOi
K09648

Identification of Orthologs from Complete Genome Data

More...
OMAi
KYKFSHG

Database of Orthologous Groups

More...
OrthoDBi
1211147at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96T52

TreeFam database of animal gene trees

More...
TreeFami
TF315065

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037730 IMP2
IPR036286 LexA/Signal_pep-like_sf
IPR000223 Pept_S26A_signal_pept_1
IPR019758 Pept_S26A_signal_pept_1_CS
IPR015927 Peptidase_S24_S26A/B/C

The PANTHER Classification System

More...
PANTHERi
PTHR46041:SF2 PTHR46041:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00717 Peptidase_S24, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00727 LEADERPTASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51306 SSF51306, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02227 sigpep_I_bact, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00761 SPASE_I_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96T52-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQSQGWVKR YIKAFCKGFF VAVPVAVTFL DRVACVARVE GASMQPSLNP
60 70 80 90 100
GGSQSSDVVL LNHWKVRNFE VHRGDIVSLV SPKNPEQKII KRVIALEGDI
110 120 130 140 150
VRTIGHKNRY VKVPRGHIWV EGDHHGHSFD SNSFGPVSLG LLHAHATHIL
160 170
WPPERWQKLE SVLPPERLPV QREEE
Length:175
Mass (Da):19,718
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF328B36EA1BED29F
GO
Isoform 2 (identifier: Q96T52-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     103-110: TIGHKNRY → DGRKLKRI
     111-175: Missing.

Note: No experimental confirmation available.
Show »
Length:110
Mass (Da):12,259
Checksum:iA8A5A2CB8B120D4F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JQE1C9JQE1_HUMAN
Mitochondrial inner membrane protea...
IMMP2L
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JVB0C9JVB0_HUMAN
Mitochondrial inner membrane protea...
IMMP2L
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DG32A0A0C4DG32_HUMAN
Mitochondrial inner membrane protea...
IMMP2L
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_021474103 – 110TIGHKNRY → DGRKLKRI in isoform 2. 1 Publication8
Alternative sequenceiVSP_021475111 – 175Missing in isoform 2. 1 PublicationAdd BLAST65

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF359563 mRNA Translation: AAK52905.1
AC005161 Genomic DNA Translation: AAS07432.1
AC005166 Genomic DNA Translation: AAS02043.1
AC006392 Genomic DNA Translation: AAS07496.1
AC006392 Genomic DNA Translation: AAS07497.1
AC073326 Genomic DNA Translation: AAS07528.1
BC008497 mRNA Translation: AAH08497.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5753.1 [Q96T52-1]
CCDS87540.1 [Q96T52-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001231535.1, NM_001244606.1 [Q96T52-1]
NP_115938.1, NM_032549.3 [Q96T52-1]
XP_005250687.1, XM_005250630.3
XP_016868194.1, XM_017012705.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000331762; ENSP00000329553; ENSG00000184903 [Q96T52-1]
ENST00000405709; ENSP00000384966; ENSG00000184903 [Q96T52-1]
ENST00000447215; ENSP00000388327; ENSG00000184903 [Q96T52-2]
ENST00000452895; ENSP00000399353; ENSG00000184903 [Q96T52-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
83943

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:83943

UCSC genome browser

More...
UCSCi
uc003vfq.3 human [Q96T52-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF359563 mRNA Translation: AAK52905.1
AC005161 Genomic DNA Translation: AAS07432.1
AC005166 Genomic DNA Translation: AAS02043.1
AC006392 Genomic DNA Translation: AAS07496.1
AC006392 Genomic DNA Translation: AAS07497.1
AC073326 Genomic DNA Translation: AAS07528.1
BC008497 mRNA Translation: AAH08497.1
CCDSiCCDS5753.1 [Q96T52-1]
CCDS87540.1 [Q96T52-2]
RefSeqiNP_001231535.1, NM_001244606.1 [Q96T52-1]
NP_115938.1, NM_032549.3 [Q96T52-1]
XP_005250687.1, XM_005250630.3
XP_016868194.1, XM_017012705.1

3D structure databases

SMRiQ96T52
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123826, 2 interactors
IntActiQ96T52, 1 interactor
STRINGi9606.ENSP00000384966

Protein family/group databases

MEROPSiS26.A09

PTM databases

iPTMnetiQ96T52
PhosphoSitePlusiQ96T52

Polymorphism and mutation databases

BioMutaiIMMP2L
DMDMi74752143

Proteomic databases

EPDiQ96T52
jPOSTiQ96T52
MaxQBiQ96T52
PaxDbiQ96T52
PeptideAtlasiQ96T52
PRIDEiQ96T52
ProteomicsDBi78187
78188 [Q96T52-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331762; ENSP00000329553; ENSG00000184903 [Q96T52-1]
ENST00000405709; ENSP00000384966; ENSG00000184903 [Q96T52-1]
ENST00000447215; ENSP00000388327; ENSG00000184903 [Q96T52-2]
ENST00000452895; ENSP00000399353; ENSG00000184903 [Q96T52-1]
GeneIDi83943
KEGGihsa:83943
UCSCiuc003vfq.3 human [Q96T52-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
83943
DisGeNETi83943

GeneCards: human genes, protein and diseases

More...
GeneCardsi
IMMP2L
HGNCiHGNC:14598 IMMP2L
HPAiHPA026711
MIMi137580 phenotype
605977 gene
neXtProtiNX_Q96T52
OpenTargetsiENSG00000184903
Orphaneti856 NON RARE IN EUROPE: Tourette syndrome
PharmGKBiPA134887258

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1568 Eukaryota
COG0681 LUCA
GeneTreeiENSGT00550000075044
InParanoidiQ96T52
KOiK09648
OMAiKYKFSHG
OrthoDBi1211147at2759
PhylomeDBiQ96T52
TreeFamiTF315065

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
IMMP2L human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
83943

Protein Ontology

More...
PROi
PR:Q96T52

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000184903 Expressed in 175 organ(s), highest expression level in skeletal muscle tissue
ExpressionAtlasiQ96T52 baseline and differential
GenevisibleiQ96T52 HS

Family and domain databases

InterProiView protein in InterPro
IPR037730 IMP2
IPR036286 LexA/Signal_pep-like_sf
IPR000223 Pept_S26A_signal_pept_1
IPR019758 Pept_S26A_signal_pept_1_CS
IPR015927 Peptidase_S24_S26A/B/C
PANTHERiPTHR46041:SF2 PTHR46041:SF2, 1 hit
PfamiView protein in Pfam
PF00717 Peptidase_S24, 1 hit
PRINTSiPR00727 LEADERPTASE
SUPFAMiSSF51306 SSF51306, 1 hit
TIGRFAMsiTIGR02227 sigpep_I_bact, 1 hit
PROSITEiView protein in PROSITE
PS00761 SPASE_I_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIMP2L_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96T52
Secondary accession number(s): Q75MF1
, Q75MN9, Q75MP0, Q75MS5, Q75MS8, Q96HJ2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: December 1, 2001
Last modified: May 8, 2019
This is version 126 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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