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UniProtKB - Q96T37 (RBM15_HUMAN)

Entry version 186 (11 Dec 2019)
Sequence version 2 (27 Jun 2003)
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Protein

RNA-binding protein 15

Gene

RBM15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311).By similarity1 Publication4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processHost-virus interaction

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q96T37

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA-binding protein 15Curated
Alternative name(s):
One-twenty two protein 11 Publication
RNA-binding motif protein 151 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RBM151 PublicationImported
Synonyms:OTT1 Publication, OTT11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000162775.14

Human Gene Nomenclature Database

More...HGNCi		HGNC:14959 RBM15

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606077 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96T37

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving RBM15 may be a cause of acute megakaryoblastic leukemia. Translocation t(1;22)(p13;q13) with MKL1. Although both reciprocal fusion transcripts are detected in acute megakaryoblastic leukemia (AMKL, FAB-M7), the RBM15-MKL1 chimeric protein has all the putative functional domains encoded by each gene and is the candidate oncogene.2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi574 – 578RDRDR → KDKDK: Decreased, but not abolished methylation by PRMT1. 1 Publication5
Mutagenesisi578R → K: Decreased methylation by PRMT1, leading to decreased ubiquitination by CNOT4. 1 Publication1
Mutagenesisi795K → A: Disrupts interaction with SETD1B. 1 Publication1
Mutagenesisi898K → A: Disrupts interaction with SETD1B. 1 Publication1
Mutagenesisi923F → A: Disrupts interaction with SETD1B. 1 Publication1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei954 – 955Breakpoint for translocation to form RBM15-MKL12 Publications2

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

More...DisGeNETi		64783

MalaCards human disease database

More...MalaCardsi		RBM15

Open Targets

More...OpenTargetsi		ENSG00000162775

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		402023 Megakaryoblastic acute myeloid leukemia with t(1;22)(p13;q13)

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA34264

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96T37 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RBM15

Domain mapping of disease mutations (DMDM)

More...DMDMi		32363506

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000817771 – 977RNA-binding protein 15Add BLAST977

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei109PhosphoserineCombined sources1
Modified residuei179PhosphoserineCombined sources1
Modified residuei208PhosphoserineCombined sources1
Modified residuei210PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki246Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei253PhosphoserineCombined sources1
Modified residuei257PhosphoserineCombined sources1
Modified residuei259PhosphoserineCombined sources1
Modified residuei266PhosphotyrosineCombined sources1
Modified residuei292PhosphoserineCombined sources1
Modified residuei294PhosphoserineCombined sources1
Modified residuei365PhosphoserineCombined sources1
Cross-linki406Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki420Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki445Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei450N6-acetyllysineCombined sources1
Modified residuei568PhosphothreonineCombined sources1
Modified residuei578Asymmetric dimethylarginine; alternate; by PRMT11 Publication1
Modified residuei578Omega-N-methylarginine; alternate; by PRMT11 Publication1
Modified residuei622PhosphoserineCombined sources1
Modified residuei656PhosphoserineCombined sources1
Modified residuei670PhosphoserineCombined sources1
Modified residuei674PhosphoserineCombined sources1
Modified residuei700PhosphoserineCombined sources1
Modified residuei741PhosphoserineCombined sources1
Cross-linki744Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei765PhosphoserineCombined sources1
Modified residuei767PhosphoserineCombined sources1
Modified residuei781PhosphoserineCombined sources1
Modified residuei935PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Methylated at Arg-578 by PRMT1, leading to promote ubiquitination by CNOT4 and subsequent degradation by the proteasome.1 Publication
Ubiquitinated by CNOT4 following methylation at Arg-578 by PRMT1.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96T37

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96T37

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96T37

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96T37

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96T37

PeptideAtlas

More...PeptideAtlasi		Q96T37

PRoteomics IDEntifications database

More...PRIDEi		Q96T37

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		78180 [Q96T37-1]
78181 [Q96T37-2]
78182 [Q96T37-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96T37

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96T37

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q96T37

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000162775 Expressed in 233 organ(s), highest expression level in secondary oocyte

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96T37 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96T37 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB015201
HPA019824
HPA049642

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the WMM complex, a N6-methyltransferase complex composed of a catalytic subcomplex, named MAC, and of an associated subcomplex, named MACOM (PubMed:27602518). The MAC subcomplex is composed of METTL3 and METTL14 (PubMed:27602518). The MACOM subcomplex is composed of WTAP, ZC3H13, CBLL1/HAKAI, VIRMA, and, in some cases of RBM15 (RBM15 or RBM15B) (PubMed:27602518). Also component of a MACOM-like complex, named WTAP complex, composed of WTAP, ZC3H13, CBLL1, VIRMA, RBM15, BCLAF1 and THRAP3 (PubMed:24100041).

Interacts with RBPJ (By similarity).

Interacts (via SPOC domain) with SETD1B (PubMed:22927943).

Interacts with NXF1, the interaction is required to promote mRNA export (PubMed:17001072).

Interacts with SF3B1 (PubMed:26575292).

By similarity5 Publications

(Microbial infection) Interacts with Epstein-Barr virus BSFL2/BMLF1.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		122293, 58 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q96T37

Protein interaction database and analysis system

More...IntActi		Q96T37, 33 interactors

Molecular INTeraction database

More...MINTi		Q96T37

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000358799

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96T37 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini170 – 252RRM 1PROSITE-ProRule annotationAdd BLAST83
Domaini374 – 451RRM 2PROSITE-ProRule annotationAdd BLAST78
Domaini455 – 529RRM 3PROSITE-ProRule annotationAdd BLAST75
Domaini777 – 956SPOCPROSITE-ProRule annotationAdd BLAST180

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi60 – 166Gly/Ser-richAdd BLAST107
Compositional biasi616 – 732Arg-richAdd BLAST117

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RRM Spen family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0112 Eukaryota
ENOG410XSAC LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158161

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96T37

KEGG Orthology (KO)

More...KOi		K13190

Identification of Orthologs from Complete Genome Data

More...OMAi		REPWSLE

Database of Orthologous Groups

More...OrthoDBi		367857at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96T37

TreeFam database of animal gene trees

More...TreeFami		TF315637

Family and domain databases

Conserved Domains Database

More...CDDi		cd12553 RRM1_RBM15, 1 hit
cd12555 RRM2_RBM15, 1 hit
cd12557 RRM3_RBM15, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.40.290.10, 1 hit
3.30.70.330, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034470 RBM15_RRM1
IPR034472 RBM15_RRM2
IPR034473 RBM15_RRM3
IPR000504 RRM_dom
IPR016194 SPOC-like_C_dom_sf
IPR012921 SPOC_C
IPR010912 SPOC_met

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00076 RRM_1, 2 hits
PF07744 SPOC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00360 RRM, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF100939 SSF100939, 1 hit
SSF54928 SSF54928, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50102 RRM, 3 hits
PS50917 SPOC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96T37-1) [UniParc]FASTAAdd to basket
Also known as: RBM15s+ae

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRTAGRDPVP RRSPRWRRAV PLCETSAGRR VTQLRGDDLR RPATMKGKER 
        60         70         80         90        100
SPVKAKRSRG GEDSTSRGER SKKLGGSGGS NGSSSGKTDS GGGSRRSLHL 
       110        120        130        140        150
DKSSSRGGSR EYDTGGGSSS SRLHSYSSPS TKNSSGGGES RSSSRGGGGE 
       160        170        180        190        200
SRSSGAASSA PGGGDGAEYK TLKISELGSQ LSDEAVEDGL FHEFKRFGDV 
       210        220        230        240        250
SVKISHLSGS GSGDERVAFV NFRRPEDARA AKHARGRLVL YDRPLKIEAV 
       260        270        280        290        300
YVSRRRSRSP LDKDTYPPSA SVVGASVGGH RHPPGGGGGQ RSLSPGGAAL 
       310        320        330        340        350
GYRDYRLQQL ALGRLPPPPP PPLPRDLERE RDYPFYERVR PAYSLEPRVG 
       360        370        380        390        400
AGAGAAPFRE VDEISPEDDQ RANRTLFLGN LDITVTESDL RRAFDRFGVI 
       410        420        430        440        450
TEVDIKRPSR GQTSTYGFLK FENLDMSHRA KLAMSGKIII RNPIKIGYGK 
       460        470        480        490        500
ATPTTRLWVG GLGPWVPLAA LAREFDRFGT IRTIDYRKGD SWAYIQYESL 
       510        520        530        540        550
DAAHAAWTHM RGFPLGGPDR RLRVDFADTE HRYQQQYLQP LPLTHYELVT 
       560        570        580        590        600
DAFGHRAPDP LRGARDRTPP LLYRDRDRDL YPDSDWVPPP PPVRERSTRT 
       610        620        630        640        650
AATSVPAYEP LDSLDRRRDG WSLDRDRGDR DLPSSRDQPR KRRLPEESGG 
       660        670        680        690        700
RHLDRSPESD RPRKRHCAPS PDRSPELSSS RDRYNSDNDR SSRLLLERPS 
       710        720        730        740        750
PIRDRRGSLE KSQGDKRDRK NSASAERDRK HRTTAPTEGK SPLKKEDRSD 
       760        770        780        790        800
GSAPSTSTAS SKLKSPSQKQ DGGTAPVASA SPKLCLAWQG MLLLKNSNFP 
       810        820        830        840        850
SNMHLLQGDL QVASSLLVEG STGGKVAQLK ITQRLRLDQP KLDEVTRRIK 
       860        870        880        890        900
VAGPNGYAIL LAVPGSSDSR SSSSSAASDT ATSTQRPLRN LVSYLKQKQA 
       910        920        930        940        950
AGVISLPVGG NKDKENTGVL HAFPPCEFSQ QFLDSPAKAL AKSEEDYLVM 
       960        970 
IIVRGFGFQI GVRYENKKRE NLALTLL
Length:977
Mass (Da):107,189
Last modified:June 27, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFB26AFE246E40282
GO
Isoform 2 (identifier: Q96T37-2) [UniParc]FASTAAdd to basket
Also known as: RBM15L

The sequence of this isoform differs from the canonical sequence as follows:
     956-977: FGFQIGVRYENKKRENLALTLL → AS

Show »
Length:957
Mass (Da):104,755
Checksum:i72893E069306B4E0
GO
Isoform 3 (identifier: Q96T37-3) [UniParc]FASTAAdd to basket
Also known as: RBM15S

The sequence of this isoform differs from the canonical sequence as follows:
     955-977: GFGFQIGVRYENKKRENLALTLL → AKLVEQRMKIWNSKL

Show »
Length:969
Mass (Da):106,366
Checksum:iE2E52058E76FE38D
GO
Isoform 4 (identifier: Q96T37-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-44: Missing.
     956-977: FGFQIGVRYENKKRENLALTLL → AS

Note: Produced by alternative initiation of isoform 2.Curated
Show »
Length:913
Mass (Da):99,701
Checksum:i1B4E29CDD062A5AC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WWP4A0A087WWP4_HUMAN
RNA-binding protein 15
RBM15
933Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C001A0A494C001_HUMAN
RNA-binding protein 15
RBM15
896Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A499FJY3A0A499FJY3_HUMAN
RNA-binding protein 15
RBM15
925Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB14088 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB15185 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti99H → L in AAK54722 (PubMed:11431691).Curated1
Sequence conflicti99H → L in AAK54723 (PubMed:11431691).Curated1
Sequence conflicti99H → L in AAK54724 (PubMed:11431691).Curated1
Sequence conflicti99H → L in BAB14088 (Ref. 3) Curated1
Sequence conflicti227D → N in AAI03494 (PubMed:15489334).Curated1
Sequence conflicti705R → G in AAK54722 (PubMed:11431691).Curated1
Sequence conflicti705R → G in AAK54723 (PubMed:11431691).Curated1
Sequence conflicti705R → G in AAK54724 (PubMed:11431691).Curated1
Sequence conflicti705R → G in BAB14088 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0538771 – 44Missing in isoform 4. CuratedAdd BLAST44
Alternative sequenceiVSP_005812955 – 977GFGFQ…ALTLL → AKLVEQRMKIWNSKL in isoform 3. 2 PublicationsAdd BLAST23
Alternative sequenceiVSP_005811956 – 977FGFQI…ALTLL → AS in isoform 2 and isoform 4. 1 PublicationAdd BLAST22

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF368062 mRNA Translation: AAK54722.1
AF368063 mRNA Translation: AAK54723.1
AF368064 mRNA Translation: AAK54724.1
AF364035 mRNA Translation: AAK56920.1 Different termination.
AJ303089 mRNA Translation: CAC38828.1 Different termination.
AJ303090 mRNA Translation: CAC38829.1 Different termination.
AJ297259 Genomic DNA Translation: CAC38861.1
AJ297259 Genomic DNA Translation: CAC38862.1
AK022541 mRNA Translation: BAB14088.1 Different initiation.
AK025596 mRNA Translation: BAB15185.1 Different initiation.
AL355488 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56439.1
BC006397 mRNA Translation: AAH06397.2
BC047479 mRNA Translation: AAH47479.1
BC062316 mRNA Translation: AAH62316.1
BC098140 mRNA Translation: AAH98140.1
BC103493 mRNA Translation: AAI03494.1
BC103507 mRNA Translation: AAI03508.1
BK005915 mRNA Translation: DAA05818.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS59198.1 [Q96T37-3]
CCDS822.1 [Q96T37-1]

NCBI Reference Sequences

More...RefSeqi		NP_001188474.1, NM_001201545.1 [Q96T37-3]
NP_073605.4, NM_022768.4 [Q96T37-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000369784; ENSP00000358799; ENSG00000162775 [Q96T37-1]
ENST00000487146; ENSP00000473552; ENSG00000162775 [Q96T37-3]
ENST00000602849; ENSP00000473638; ENSG00000162775 [Q96T37-2]
ENST00000618772; ENSP00000483133; ENSG00000162775 [Q96T37-1]
ENST00000652342; ENSP00000498328; ENSG00000162775 [Q96T37-4]
ENST00000652747; ENSP00000498634; ENSG00000162775 [Q96T37-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		64783

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:64783

UCSC genome browser

More...UCSCi		uc001dzl.1 human [Q96T37-1]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing, Chromosomal rearrangement

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF368062 mRNA Translation: AAK54722.1
AF368063 mRNA Translation: AAK54723.1
AF368064 mRNA Translation: AAK54724.1
AF364035 mRNA Translation: AAK56920.1 Different termination.
AJ303089 mRNA Translation: CAC38828.1 Different termination.
AJ303090 mRNA Translation: CAC38829.1 Different termination.
AJ297259 Genomic DNA Translation: CAC38861.1
AJ297259 Genomic DNA Translation: CAC38862.1
AK022541 mRNA Translation: BAB14088.1 Different initiation.
AK025596 mRNA Translation: BAB15185.1 Different initiation.
AL355488 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56439.1
BC006397 mRNA Translation: AAH06397.2
BC047479 mRNA Translation: AAH47479.1
BC062316 mRNA Translation: AAH62316.1
BC098140 mRNA Translation: AAH98140.1
BC103493 mRNA Translation: AAI03494.1
BC103507 mRNA Translation: AAI03508.1
BK005915 mRNA Translation: DAA05818.1
CCDSiCCDS59198.1 [Q96T37-3]
CCDS822.1 [Q96T37-1]
RefSeqiNP_001188474.1, NM_001201545.1 [Q96T37-3]
NP_073605.4, NM_022768.4 [Q96T37-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGridi122293, 58 interactors
CORUMiQ96T37
IntActiQ96T37, 33 interactors
MINTiQ96T37
STRINGi9606.ENSP00000358799

PTM databases

iPTMnetiQ96T37
PhosphoSitePlusiQ96T37
SwissPalmiQ96T37

Polymorphism and mutation databases

BioMutaiRBM15
DMDMi32363506

Proteomic databases

EPDiQ96T37
jPOSTiQ96T37
MassIVEiQ96T37
MaxQBiQ96T37
PaxDbiQ96T37
PeptideAtlasiQ96T37
PRIDEiQ96T37
ProteomicsDBi78180 [Q96T37-1]
78181 [Q96T37-2]
78182 [Q96T37-3]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		64783

Genome annotation databases

EnsembliENST00000369784; ENSP00000358799; ENSG00000162775 [Q96T37-1]
ENST00000487146; ENSP00000473552; ENSG00000162775 [Q96T37-3]
ENST00000602849; ENSP00000473638; ENSG00000162775 [Q96T37-2]
ENST00000618772; ENSP00000483133; ENSG00000162775 [Q96T37-1]
ENST00000652342; ENSP00000498328; ENSG00000162775 [Q96T37-4]
ENST00000652747; ENSP00000498634; ENSG00000162775 [Q96T37-3]
GeneIDi64783
KEGGihsa:64783
UCSCiuc001dzl.1 human [Q96T37-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		64783
DisGeNETi64783
EuPathDBiHostDB:ENSG00000162775.14

GeneCards: human genes, protein and diseases

More...GeneCardsi		RBM15
HGNCiHGNC:14959 RBM15
HPAiCAB015201
HPA019824
HPA049642
MalaCardsiRBM15
MIMi606077 gene
neXtProtiNX_Q96T37
OpenTargetsiENSG00000162775
Orphaneti402023 Megakaryoblastic acute myeloid leukemia with t(1;22)(p13;q13)
PharmGKBiPA34264

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0112 Eukaryota
ENOG410XSAC LUCA
GeneTreeiENSGT00940000158161
InParanoidiQ96T37
KOiK13190
OMAiREPWSLE
OrthoDBi367857at2759
PhylomeDBiQ96T37
TreeFamiTF315637

Enzyme and pathway databases

SIGNORiQ96T37

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RBM15 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		RBM15

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		64783
PharosiQ96T37 Tbio

Protein Ontology

More...PROi		PR:Q96T37
RNActiQ96T37 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000162775 Expressed in 233 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiQ96T37 baseline and differential
GenevisibleiQ96T37 HS

Family and domain databases

CDDicd12553 RRM1_RBM15, 1 hit
cd12555 RRM2_RBM15, 1 hit
cd12557 RRM3_RBM15, 1 hit
Gene3Di2.40.290.10, 1 hit
3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034470 RBM15_RRM1
IPR034472 RBM15_RRM2
IPR034473 RBM15_RRM3
IPR000504 RRM_dom
IPR016194 SPOC-like_C_dom_sf
IPR012921 SPOC_C
IPR010912 SPOC_met
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
PF07744 SPOC, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SUPFAMiSSF100939 SSF100939, 1 hit
SSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits
PS50917 SPOC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRBM15_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96T37
Secondary accession number(s): A1A693
, Q3ZB86, Q4V760, Q5D058, Q5T613, Q86VW9, Q96PE4, Q96SC5, Q96SC6, Q96SC9, Q96SD0, Q96T38, Q9BRA5, Q9H6R8, Q9H9Y0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: June 27, 2003
Last modified: December 11, 2019
This is version 186 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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