ZIC5

Functionⁱ

Essential for neural crest development, converting cells from an epidermal fate to a neural crest cell fate. Binds to DNA (By similarity).By similarity

Caution

It is uncertain whether Met-1 or Met-25 is the initiator.Curated

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	458 – 485	C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST	28
Zinc fingerⁱ	491 – 515	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	521 – 545	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	551 – 575	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	25

GO - Molecular functionⁱ

DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
metal ion binding Source: UniProtKB-KW
RNA polymerase II regulatory region sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell differentiation Source: UniProtKB-KW
nervous system development Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding
Biological process	Differentiation, Neurogenesis
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein ZIC 5 Alternative name(s): Zinc finger protein of the cerebellum 5
Gene namesⁱ	Name:ZIC5
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 13

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000139800.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:20322 ZIC5
MIMⁱ	617896 gene
neXtProtⁱ	NX_Q96T25

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	85416
Open Targets More...OpenTargetsⁱ	ENSG00000139800
PharmGKBⁱ	PA134941698

Polymorphism and mutation databases

BioMutaⁱ	ZIC5
DMDMⁱ	327478546

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047255	1 – 663	Zinc finger protein ZIC 5Add BLAST		663

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	578	PhosphoserineBy similarity	1
Modified residueⁱ	582	PhosphoserineBy similarity	1
Modified residueⁱ	600	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q96T25
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96T25
PaxDbⁱ	Q96T25
PeptideAtlas More...PeptideAtlasⁱ	Q96T25
PRIDEⁱ	Q96T25
ProteomicsDBⁱ	78178

PTM databases

iPTMnetⁱ	Q96T25
PhosphoSitePlusⁱ	Q96T25

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000139800 Expressed in 28 organ(s), highest expression level in cerebellar vermis
CleanExⁱ	HS_ZIC5
Genevisibleⁱ	Q96T25 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA074045

HPAⁱ

HPA074045

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	124522, 1 interactor
IntActⁱ	Q96T25, 1 interactor
Molecular INTeraction database More...MINTⁱ	Q96T25
STRINGⁱ	9606.ENSP00000267294

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96T25
SMRⁱ	Q96T25
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	106 – 424	Pro-richAdd BLAST		319
Compositional biasⁱ	286 – 345	Ala-richAdd BLAST		60

Sequence similaritiesⁱ

Belongs to the GLI C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	458 – 485	C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST	28
Zinc fingerⁱ	491 – 515	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	521 – 545	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	551 – 575	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	25

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140802
HOGENOMⁱ	HOG000232057
HOVERGENⁱ	HBG007135
InParanoidⁱ	Q96T25
KEGG Orthology (KO) More...KOⁱ	K09226
OMAⁱ	TPFGPEH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0M59
PhylomeDBⁱ	Q96T25
TreeFamⁱ	TF351425

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 5 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Q96T25-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MFLKAGRGNK VPPVRVYGPD CVVLMEPPLS KRNPPALRLA DLATAQVQPL 
        60         70         80         90        100
QNMTGFPALA GPPAHSQLRA AVAHLRLRDL GADPGVATTP LGPEHMAQAS 
       110        120        130        140        150
TLGLSPPSQA FPAHPEAPAA AARAAALVAH PGAGSYPCGG GSSGAQPSAP 
       160        170        180        190        200
PPPAPPLPPT PSPPPPPPPP PPPALSGYTT TNSGGGGSSG KGHSRDFVLR 
       210        220        230        240        250
RDLSATAPAA AMHGAPLGGE QRSGTGSPQH PAPPPHSAGM FISASGTYAG 
       260        270        280        290        300
PDGSGGPALF PALHDTPGAP GGHPHPLNGQ MRLGLAAAAA AAAAELYGRA 
       310        320        330        340        350
EPPFAPRSGD AHYGAVAAAA AAALHGYGAV NLNLNLAAAA AAAAAGPGPH 
       360        370        380        390        400
LQHHAPPPAP PPPPAPAQHP HQHHPHLPGA AGAFLRYMRQ PIKQELICKW 
       410        420        430        440        450
IDPDELAGLP PPPPPPPPPP PPPPAGGAKP CSKTFGTMHE LVNHVTVEHV 
       460        470        480        490        500
GGPEQSSHVC FWEDCPREGK PFKAKYKLIN HIRVHTGEKP FPCPFPGCGK 
       510        520        530        540        550
VFARSENLKI HKRTHTGEKP FKCEFDGCDR KFANSSDRKK HSHVHTSDKP 
       560        570        580        590        600
YYCKIRGCDK SYTHPSSLRK HMKIHCKSPP PSPGPLGYSS VGTPVGAPLS 
       610        620        630        640        650
PVLDPARSHS STLSPQVTNL NEWYVCQASG APSHLHTPSS NGTTSETEDE 
       660 
EIYGNPEVVR TIH

Length:663

Mass (Da):68,448

Last modified:April 5, 2011 - v2

Checksum:ⁱ90C16FF2EEB1F54A

GO

Sequence cautionⁱ

The sequence AAK55418 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_079268	410 – 414	Missing 1 Publication		5
Natural variantⁱVAR_079269	610	S → F1 PublicationCorresponds to variant dbSNP:rs201876139Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF378304 mRNA Translation: AAK55418.1 Different initiation. AL355338 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS9494.2
NCBI Reference Sequences More...RefSeqⁱ	NP_149123.2, NM_033132.3
UniGeneⁱ	Hs.508570

Genome annotation databases

Ensemblⁱ	ENST00000267294; ENSP00000267294; ENSG00000139800
GeneIDⁱ	85416
KEGGⁱ	hsa:85416
UCSC genome browser More...UCSCⁱ	uc001vom.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96T25	LOW QUALITY PROTEIN: zinc finger protein ZIC 5		Enhydra lutris kenyoni		773	UniRef90_Q96T25
Zic family member 5		CANLF		669
Zic family member 5		CALJA		663
Uncharacterized protein		MACFA		226
Zinc finger protein ZIC 5 (Fragment)		MACMU		156
+35

Protein	Similar proteins		Species	Score	Length	Source
Q96T25	Zinc finger protein ZIC 5		MOUSE		622	UniRef50_Q7TQ40
Zinc finger protein of the cerebellum 5 (Fragment)		synthetic construct		275
Zic family member 5		RAT		265
LOW QUALITY PROTEIN: zinc finger protein ZIC 5		Enhydra lutris kenyoni		773
Zic family member 5		CANLF		669
+64

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF378304 mRNA Translation: AAK55418.1 Different initiation. AL355338 Genomic DNA No translation available.
CCDSⁱ	CCDS9494.2
RefSeqⁱ	NP_149123.2, NM_033132.3
UniGeneⁱ	Hs.508570

3D structure databases

ProteinModelPortalⁱ	Q96T25
SMRⁱ	Q96T25
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	124522, 1 interactor
IntActⁱ	Q96T25, 1 interactor
MINTⁱ	Q96T25
STRINGⁱ	9606.ENSP00000267294

PTM databases

iPTMnetⁱ	Q96T25
PhosphoSitePlusⁱ	Q96T25

Polymorphism and mutation databases

BioMutaⁱ	ZIC5
DMDMⁱ	327478546

Proteomic databases

EPDⁱ	Q96T25
MaxQBⁱ	Q96T25
PaxDbⁱ	Q96T25
PeptideAtlasⁱ	Q96T25
PRIDEⁱ	Q96T25
ProteomicsDBⁱ	78178

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000267294; ENSP00000267294; ENSG00000139800
GeneIDⁱ	85416
KEGGⁱ	hsa:85416
UCSCⁱ	uc001vom.2 human

Organism-specific databases

CTDⁱ	85416
DisGeNETⁱ	85416
EuPathDBⁱ	HostDB:ENSG00000139800.8
GeneCardsⁱ	ZIC5
HGNCⁱ	HGNC:20322 ZIC5
HPAⁱ	HPA074045
MIMⁱ	617896 gene
neXtProtⁱ	NX_Q96T25
OpenTargetsⁱ	ENSG00000139800
PharmGKBⁱ	PA134941698
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00900000140802
HOGENOMⁱ	HOG000232057
HOVERGENⁱ	HBG007135
InParanoidⁱ	Q96T25
KOⁱ	K09226
OMAⁱ	TPFGPEH
OrthoDBⁱ	EOG091G0M59
PhylomeDBⁱ	Q96T25
TreeFamⁱ	TF351425

Miscellaneous databases

ChiTaRSⁱ	ZIC5 human
GenomeRNAiⁱ	85416
Protein Ontology More...PROⁱ	PR:Q96T25
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000139800 Expressed in 28 organ(s), highest expression level in cerebellar vermis
CleanExⁱ	HS_ZIC5
Genevisibleⁱ	Q96T25 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 5 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZIC5_HUMAN
Accessionⁱ	Q96T25Primary (citable) accession number: Q96T25 Secondary accession number(s): Q5VYB0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 23, 2003
	Last sequence update:	April 5, 2011
	Last modified:	November 7, 2018
	This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q96T25 (ZIC5_HUMAN)

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Zinc finger protein ZIC 5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ