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UniProtKB - Q96T25 (ZIC5_HUMAN)
Protein
Zinc finger protein ZIC 5
Gene
ZIC5
Organism
Homo sapiens (Human)
Status
Functioni
Essential for neural crest development, converting cells from an epidermal fate to a neural crest cell fate. Binds to DNA (By similarity).
By similarityCaution
It is uncertain whether Met-1 or Met-25 is the initiator.Curated
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 458 – 485 | C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST | 28 | |
Zinc fingeri | 491 – 515 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 521 – 545 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 551 – 575 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- central nervous system development Source: GO_Central
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Differentiation, Neurogenesis |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q96T25 |
SignaLinki | Q96T25 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein ZIC 5Alternative name(s): Zinc finger protein of the cerebellum 5 |
Gene namesi | Name:ZIC5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20322, ZIC5 |
MIMi | 617896, gene |
neXtProti | NX_Q96T25 |
VEuPathDBi | HostDB:ENSG00000139800 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 85416 |
OpenTargetsi | ENSG00000139800 |
PharmGKBi | PA134941698 |
Miscellaneous databases
Pharosi | Q96T25, Tbio |
Genetic variation databases
BioMutai | ZIC5 |
DMDMi | 327478546 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047255 | 1 – 663 | Zinc finger protein ZIC 5Add BLAST | 663 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 578 | PhosphoserineBy similarity | 1 | |
Modified residuei | 582 | PhosphoserineBy similarity | 1 | |
Modified residuei | 600 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q96T25 |
jPOSTi | Q96T25 |
MassIVEi | Q96T25 |
MaxQBi | Q96T25 |
PaxDbi | Q96T25 |
PeptideAtlasi | Q96T25 |
PRIDEi | Q96T25 |
ProteomicsDBi | 78178 |
PTM databases
iPTMneti | Q96T25 |
PhosphoSitePlusi | Q96T25 |
Expressioni
Gene expression databases
Bgeei | ENSG00000139800, Expressed in cerebellar vermis and 39 other tissues |
Genevisiblei | Q96T25, HS |
Organism-specific databases
HPAi | ENSG00000139800, Tissue enhanced (brain, choroid plexus, testis) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 124522, 4 interactors |
IntActi | Q96T25, 1 interactor |
MINTi | Q96T25 |
STRINGi | 9606.ENSP00000267294 |
Miscellaneous databases
RNActi | Q96T25, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 97 – 117 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 137 – 195 | DisorderedSequence analysisAdd BLAST | 59 | |
Regioni | 213 – 275 | DisorderedSequence analysisAdd BLAST | 63 | |
Regioni | 347 – 379 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 403 – 433 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 572 – 592 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 631 – 663 | DisorderedSequence analysisAdd BLAST | 33 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 146 – 176 | Pro residuesSequence analysisAdd BLAST | 31 | |
Compositional biasi | 351 – 371 | Pro residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 406 – 428 | Pro residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 631 – 649 | Polar residuesSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Belongs to the GLI C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 458 – 485 | C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST | 28 | |
Zinc fingeri | 491 – 515 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 521 – 545 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 551 – 575 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000154200 |
HOGENOMi | CLU_002678_37_3_1 |
InParanoidi | Q96T25 |
OMAi | PPHGVFI |
OrthoDBi | 592023at2759 |
PhylomeDBi | Q96T25 |
TreeFami | TF351425 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type IPR041643, Znf_ZIC |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits PF18366, zf_ZIC, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
i Sequence
Sequence statusi: Complete.
Q96T25-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFLKAGRGNK VPPVRVYGPD CVVLMEPPLS KRNPPALRLA DLATAQVQPL
60 70 80 90 100
QNMTGFPALA GPPAHSQLRA AVAHLRLRDL GADPGVATTP LGPEHMAQAS
110 120 130 140 150
TLGLSPPSQA FPAHPEAPAA AARAAALVAH PGAGSYPCGG GSSGAQPSAP
160 170 180 190 200
PPPAPPLPPT PSPPPPPPPP PPPALSGYTT TNSGGGGSSG KGHSRDFVLR
210 220 230 240 250
RDLSATAPAA AMHGAPLGGE QRSGTGSPQH PAPPPHSAGM FISASGTYAG
260 270 280 290 300
PDGSGGPALF PALHDTPGAP GGHPHPLNGQ MRLGLAAAAA AAAAELYGRA
310 320 330 340 350
EPPFAPRSGD AHYGAVAAAA AAALHGYGAV NLNLNLAAAA AAAAAGPGPH
360 370 380 390 400
LQHHAPPPAP PPPPAPAQHP HQHHPHLPGA AGAFLRYMRQ PIKQELICKW
410 420 430 440 450
IDPDELAGLP PPPPPPPPPP PPPPAGGAKP CSKTFGTMHE LVNHVTVEHV
460 470 480 490 500
GGPEQSSHVC FWEDCPREGK PFKAKYKLIN HIRVHTGEKP FPCPFPGCGK
510 520 530 540 550
VFARSENLKI HKRTHTGEKP FKCEFDGCDR KFANSSDRKK HSHVHTSDKP
560 570 580 590 600
YYCKIRGCDK SYTHPSSLRK HMKIHCKSPP PSPGPLGYSS VGTPVGAPLS
610 620 630 640 650
PVLDPARSHS STLSPQVTNL NEWYVCQASG APSHLHTPSS NGTTSETEDE
660
EIYGNPEVVR TIH
Sequence cautioni
The sequence AAK55418 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_079268 | 410 – 414 | Missing 1 Publication | 5 | |
Natural variantiVAR_079269 | 610 | S → F1 PublicationCorresponds to variant dbSNP:rs201876139Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF378304 mRNA Translation: AAK55418.1 Different initiation. AL355338 Genomic DNA No translation available. |
RefSeqi | NP_149123.2, NM_033132.3 |
Genome annotation databases
Ensembli | ENST00000267294.5; ENSP00000267294.4; ENSG00000139800.9 |
GeneIDi | 85416 |
KEGGi | hsa:85416 |
MANE-Selecti | ENST00000267294.5; ENSP00000267294.4; NM_033132.5; NP_149123.3 |
UCSCi | uc001vom.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF378304 mRNA Translation: AAK55418.1 Different initiation. AL355338 Genomic DNA No translation available. |
RefSeqi | NP_149123.2, NM_033132.3 |
3D structure databases
AlphaFoldDBi | Q96T25 |
SMRi | Q96T25 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124522, 4 interactors |
IntActi | Q96T25, 1 interactor |
MINTi | Q96T25 |
STRINGi | 9606.ENSP00000267294 |
PTM databases
iPTMneti | Q96T25 |
PhosphoSitePlusi | Q96T25 |
Genetic variation databases
BioMutai | ZIC5 |
DMDMi | 327478546 |
Proteomic databases
EPDi | Q96T25 |
jPOSTi | Q96T25 |
MassIVEi | Q96T25 |
MaxQBi | Q96T25 |
PaxDbi | Q96T25 |
PeptideAtlasi | Q96T25 |
PRIDEi | Q96T25 |
ProteomicsDBi | 78178 |
Protocols and materials databases
Antibodypediai | 10971, 117 antibodies from 25 providers |
DNASUi | 85416 |
Genome annotation databases
Ensembli | ENST00000267294.5; ENSP00000267294.4; ENSG00000139800.9 |
GeneIDi | 85416 |
KEGGi | hsa:85416 |
MANE-Selecti | ENST00000267294.5; ENSP00000267294.4; NM_033132.5; NP_149123.3 |
UCSCi | uc001vom.2, human |
Organism-specific databases
CTDi | 85416 |
DisGeNETi | 85416 |
GeneCardsi | ZIC5 |
HGNCi | HGNC:20322, ZIC5 |
HPAi | ENSG00000139800, Tissue enhanced (brain, choroid plexus, testis) |
MIMi | 617896, gene |
neXtProti | NX_Q96T25 |
OpenTargetsi | ENSG00000139800 |
PharmGKBi | PA134941698 |
VEuPathDBi | HostDB:ENSG00000139800 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000154200 |
HOGENOMi | CLU_002678_37_3_1 |
InParanoidi | Q96T25 |
OMAi | PPHGVFI |
OrthoDBi | 592023at2759 |
PhylomeDBi | Q96T25 |
TreeFami | TF351425 |
Enzyme and pathway databases
PathwayCommonsi | Q96T25 |
SignaLinki | Q96T25 |
Miscellaneous databases
BioGRID-ORCSi | 85416, 6 hits in 1103 CRISPR screens |
ChiTaRSi | ZIC5, human |
GenomeRNAii | 85416 |
Pharosi | Q96T25, Tbio |
PROi | PR:Q96T25 |
RNActi | Q96T25, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000139800, Expressed in cerebellar vermis and 39 other tissues |
Genevisiblei | Q96T25, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type IPR041643, Znf_ZIC |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits PF18366, zf_ZIC, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZIC5_HUMAN | |
Accessioni | Q96T25Primary (citable) accession number: Q96T25 Secondary accession number(s): Q5VYB0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 23, 2003 |
Last sequence update: | April 5, 2011 | |
Last modified: | May 25, 2022 | |
This is version 154 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families