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Entry version 164 (16 Oct 2019)
Sequence version 2 (07 Jul 2009)
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Protein

Remodeling and spacing factor 1

Gene

RSF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for assembly of regular nucleosome arrays by the RSF chromatin-remodeling complex (PubMed:12972596). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11944984, PubMed:11788598).3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri891 – 941PHD-typePROSITE-ProRule annotationAdd BLAST51

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Remodeling and spacing factor 1
Short name:
Rsf-1
Alternative name(s):
HBV pX-associated protein 8
Hepatitis B virus X-associated protein
p325 subunit of RSF chromatin-remodeling complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RSF1
Synonyms:HBXAP, XAP8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18118 RSF1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
608522 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96T23

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
51773

Open Targets

More...
OpenTargetsi
ENSG00000048649

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA29210

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96T23

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RSF1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
251757329

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000593261 – 1441Remodeling and spacing factor 1Add BLAST1441

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki136Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki215Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei227PhosphoserineCombined sources1
Cross-linki236Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki243Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki248Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki252Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki254Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki277Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki277Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki284Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki288Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki294Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki305Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki306Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki309Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki323Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki327Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki337Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki342Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki358Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki373Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki381Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki390Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei392PhosphoserineCombined sources1
Modified residuei397PhosphoserineCombined sources1
Cross-linki400Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki405Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki415Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki419Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei429PhosphoserineCombined sources1
Cross-linki439Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki456Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki456Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki463Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki468Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei473PhosphoserineCombined sources1
Cross-linki498Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei524PhosphoserineCombined sources1
Cross-linki565Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei570PhosphoserineCombined sources1
Modified residuei604PhosphoserineCombined sources1
Modified residuei622PhosphoserineCombined sources1
Modified residuei628PhosphothreonineCombined sources1
Modified residuei629PhosphoserineCombined sources1
Cross-linki662Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki663Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki670Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki677Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki698Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki709Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei748PhosphoserineCombined sources1
Cross-linki758Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki768Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki795Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki799Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei882PhosphoserineCombined sources1
Cross-linki1039Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1050N6-acetyllysineCombined sources1
Modified residuei1096PhosphoserineCombined sources1
Modified residuei1098PhosphoserineCombined sources1
Modified residuei1105PhosphoserineCombined sources1
Modified residuei1221PhosphoserineCombined sources1
Modified residuei1223PhosphoserineCombined sources1
Modified residuei1226PhosphoserineCombined sources1
Modified residuei1258PhosphoserineCombined sources1
Modified residuei1277PhosphoserineCombined sources1
Modified residuei1278PhosphothreonineCombined sources1
Modified residuei1305PhosphothreonineCombined sources1
Modified residuei1325PhosphoserineCombined sources1
Modified residuei1336PhosphoserineCombined sources1
Modified residuei1339N6-acetyllysineCombined sources1
Modified residuei1345PhosphoserineCombined sources1
Modified residuei1359PhosphoserineCombined sources1
Modified residuei1375PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q96T23

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96T23

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q96T23

MaxQB - The MaxQuant DataBase

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MaxQBi
Q96T23

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96T23

PeptideAtlas

More...
PeptideAtlasi
Q96T23

PRoteomics IDEntifications database

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PRIDEi
Q96T23

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
78175 [Q96T23-1]
78176 [Q96T23-2]
78177 [Q96T23-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96T23

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96T23

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000048649 Expressed in 225 organ(s), highest expression level in forebrain

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96T23 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96T23 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB022626
HPA046129
HPA057547
HPA064567

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SMARCA5/SNF2H to form the RSF complex (PubMed:12972596).

Identified in a centromere complex containing histones H2A, H2B and H4, and at least CENPA, CENPB, CENPC, CENPT, CENPN, HJURP, SUPT16H, SSRP1 and RSF1 (PubMed:27499292). Also binds the HBV pX/HBx protein, which is required to activate transcription of the viral genome (PubMed:11944984, PubMed:11788598).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
SMARCA5O602645EBI-926768,EBI-352588

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119724, 35 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-455 RSF complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q96T23

Protein interaction database and analysis system

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IntActi
Q96T23, 31 interactors

Molecular INTeraction database

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MINTi
Q96T23

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000311513

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini17 – 84DDTAdd BLAST68

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili942 – 1012Sequence analysisAdd BLAST71

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi226 – 372Glu-richAdd BLAST147
Compositional biasi875 – 884Poly-Glu10
Compositional biasi1080 – 1083Poly-Ala4
Compositional biasi1146 – 1243Arg-richAdd BLAST98
Compositional biasi1286 – 1292Poly-Glu7
Compositional biasi1419 – 1424Poly-Glu6

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri891 – 941PHD-typePROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IFYI Eukaryota
ENOG410YTDT LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00530000064411

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000154205

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96T23

KEGG Orthology (KO)

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KOi
K11657

Identification of Orthologs from Complete Genome Data

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OMAi
PPEMETS

Database of Orthologous Groups

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OrthoDBi
917466at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q96T23

TreeFam database of animal gene trees

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TreeFami
TF106405

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028938 Rsf-1
IPR028942 WHIM1_dom
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD

The PANTHER Classification System

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PANTHERi
PTHR10615:SF156 PTHR10615:SF156, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00628 PHD, 1 hit
PF15612 WHIM1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00249 PHD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57903 SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Experimental confirmation may be lacking for some isoforms.

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96T23-1) [UniParc]FASTAAdd to basket
Also known as: Alpha, XAP8alpha

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATAAAAAAV MAPPGCPGSC PNFAVVCSFL ERYGPLLDLP ELPFPELERV
60 70 80 90 100
LQAPPPDVGN GEVPKELVEL HLKLMRKIGK SVTADRWEKY LIKICQEFNS
110 120 130 140 150
TWAWEMEKKG YLEMSVECKL ALLKYLCECQ FDDNLKFKNI INEEDADTMR
160 170 180 190 200
LQPIGRDKDG LMYWYQLDQD HNVRMYIEEQ DDQDGSSWKC IVRNRNELAE
210 220 230 240 250
TLALLKAQID PVLLKNSSQQ DNSSRESPSL EDEETKKEEE TPKQEEQKES
260 270 280 290 300
EKMKSEEQPM DLENRSTANV LEETTVKKEK EDEKELVKLP VIVKLEKPLP
310 320 330 340 350
ENEEKKIIKE ESDSFKENVK PIKVEVKECR ADPKDTKSSM EKPVAQEPER
360 370 380 390 400
IEFGGNIKSS HEITEKSTEE TEKLKNDQQA KIPLKKREIK LSDDFDSPVK
410 420 430 440 450
GPLCKSVTPT KEFLKDEIKQ EEETCKRIST ITALGHEGKQ LVNGEVSDER
460 470 480 490 500
VAPNFKTEPI ETKFYETKEE SYSPSKDRNI ITEGNGTESL NSVITSMKTG
510 520 530 540 550
ELEKETAPLR KDADSSISVL EIHSQKAQIE EPDPPEMETS LDSSEMAKDL
560 570 580 590 600
SSKTALSSTE SCTMKGEEKS PKTKKDKRPP ILECLEKLEK SKKTFLDKDA
610 620 630 640 650
QRLSPIPEEV PKSTLESEKP GSPEAAETSP PSNIIDHCEK LASEKEVVEC
660 670 680 690 700
QSTSTVGGQS VKKVDLETLK EDSEFTKVEM DNLDNAQTSG IEEPSETKGS
710 720 730 740 750
MQKSKFKYKL VPEEETTASE NTEITSERQK EGIKLTIRIS SRKKKPDSPP
760 770 780 790 800
KVLEPENKQE KTEKEEEKTN VGRTLRRSPR ISRPTAKVAE IRDQKADKKR
810 820 830 840 850
GEGEDEVEEE STALQKTDKK EILKKSEKDT NSKVSKVKPK GKVRWTGSRT
860 870 880 890 900
RGRWKYSSND ESEGSGSEKS SAASEEEEEK ESEEAILADD DEPCKKCGLP
910 920 930 940 950
NHPELILLCD SCDSGYHTAC LRPPLMIIPD GEWFCPPCQH KLLCEKLEEQ
960 970 980 990 1000
LQDLDVALKK KERAERRKER LVYVGISIEN IIPPQEPDFS EDQEEKKKDS
1010 1020 1030 1040 1050
KKSKANLLER RSTRTRKCIS YRFDEFDEAI DEAIEDDIKE ADGGGVGRGK
1060 1070 1080 1090 1100
DISTITGHRG KDISTILDEE RKENKRPQRA AAARRKKRRR LNDLDSDSNL
1110 1120 1130 1140 1150
DEEESEDEFK ISDGSQDEFV VSDENPDESE EDPPSNDDSD TDFCSRRLRR
1160 1170 1180 1190 1200
HPSRPMRQSR RLRRKTPKKK YSDDDEEEES EENSRDSESD FSDDFSDDFV
1210 1220 1230 1240 1250
ETRRRRSRRN QKRQINYKED SESDGSQKSL RRGKEIRRVH KRRLSSSESE
1260 1270 1280 1290 1300
ESYLSKNSED DELAKESKRS VRKRGRSTDE YSEADEEEEE EEGKPSRKRL
1310 1320 1330 1340 1350
HRIETDEEES CDNAHGDANQ PARDSQPRVL PSEQESTKKP YRIESDEEED
1360 1370 1380 1390 1400
FENVGKVGSP LDYSLVDLPS TNGQSPGKAI ENLIGKPTEK SQTPKDNSTA
1410 1420 1430 1440
SASLASNGTS GGQEAGAPEE EEDELLRVTD LVDYVCNSEQ L
Length:1,441
Mass (Da):163,821
Last modified:July 7, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0FCB9499B5097A2F
GO
Isoform 2 (identifier: Q96T23-2) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     93-123: Missing.

Show »
Length:1,410
Mass (Da):160,129
Checksum:i0C5AF21D8B1642C4
GO
Isoform 3 (identifier: Q96T23-3) [UniParc]FASTAAdd to basket
Also known as: Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     1-252: Missing.

Show »
Length:1,189
Mass (Da):134,946
Checksum:iF5652F52FD1CFEF0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YER1H0YER1_HUMAN
Remodeling and spacing factor 1
RSF1
702Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YCN2H0YCN2_HUMAN
Remodeling and spacing factor 1
RSF1
803Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDG9H0YDG9_HUMAN
Remodeling and spacing factor 1
RSF1
276Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C306H7C306_HUMAN
Remodeling and spacing factor 1
RSF1
202Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YEX0H0YEX0_HUMAN
Remodeling and spacing factor 1
RSF1
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG43114 differs from that shown. Reason: Frameshift.Curated
The sequence AAH46124 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAK57515 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA91591 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti132D → G in AAG43114 (Ref. 4) Curated1
Sequence conflicti270V → G in AAG43114 (Ref. 4) Curated1
Sequence conflicti276V → G in AAG43114 (Ref. 4) Curated1
Sequence conflicti287V → A in AAG43114 (Ref. 4) Curated1
Sequence conflicti291V → G in AAG43114 (Ref. 4) Curated1
Sequence conflicti305K → N in AAG43114 (Ref. 4) Curated1
Sequence conflicti314 – 315SF → PS in AAG43114 (Ref. 4) Curated2
Sequence conflicti353F → L in AAG43114 (Ref. 4) Curated1
Sequence conflicti381K → E in AAG43114 (Ref. 4) Curated1
Sequence conflicti1063I → V in BAA91591 (PubMed:14702039).Curated1
Sequence conflicti1137D → E in AAK57515 (PubMed:11944984).Curated1
Sequence conflicti1137D → E in AAF61709 (PubMed:11788598).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_061741304E → D. Corresponds to variant dbSNP:rs58758035Ensembl.1
Natural variantiVAR_020885475S → P. Corresponds to variant dbSNP:rs7950873Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0124991 – 252Missing in isoform 3. 2 PublicationsAdd BLAST252
Alternative sequenceiVSP_01250093 – 123Missing in isoform 2. 1 PublicationAdd BLAST31

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF380176 mRNA Translation: AAK57515.1 Different initiation.
AF227948 mRNA Translation: AAF61709.2
AP000580 Genomic DNA No translation available.
AP000609 Genomic DNA No translation available.
AP002343 Genomic DNA No translation available.
AF059317 mRNA Translation: AAG43114.1 Sequence problems.
BC046124 mRNA Translation: AAH46124.2 Sequence problems.
AK001268 mRNA Translation: BAA91591.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8253.1 [Q96T23-1]

NCBI Reference Sequences

More...
RefSeqi
NP_057662.3, NM_016578.3 [Q96T23-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000308488; ENSP00000311513; ENSG00000048649 [Q96T23-1]
ENST00000480887; ENSP00000434509; ENSG00000048649 [Q96T23-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
51773

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51773

UCSC genome browser

More...
UCSCi
uc001oym.4 human [Q96T23-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380176 mRNA Translation: AAK57515.1 Different initiation.
AF227948 mRNA Translation: AAF61709.2
AP000580 Genomic DNA No translation available.
AP000609 Genomic DNA No translation available.
AP002343 Genomic DNA No translation available.
AF059317 mRNA Translation: AAG43114.1 Sequence problems.
BC046124 mRNA Translation: AAH46124.2 Sequence problems.
AK001268 mRNA Translation: BAA91591.1 Different initiation.
CCDSiCCDS8253.1 [Q96T23-1]
RefSeqiNP_057662.3, NM_016578.3 [Q96T23-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi119724, 35 interactors
ComplexPortaliCPX-455 RSF complex
CORUMiQ96T23
IntActiQ96T23, 31 interactors
MINTiQ96T23
STRINGi9606.ENSP00000311513

PTM databases

iPTMnetiQ96T23
PhosphoSitePlusiQ96T23

Polymorphism and mutation databases

BioMutaiRSF1
DMDMi251757329

Proteomic databases

EPDiQ96T23
jPOSTiQ96T23
MassIVEiQ96T23
MaxQBiQ96T23
PaxDbiQ96T23
PeptideAtlasiQ96T23
PRIDEiQ96T23
ProteomicsDBi78175 [Q96T23-1]
78176 [Q96T23-2]
78177 [Q96T23-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
51773

Genome annotation databases

EnsembliENST00000308488; ENSP00000311513; ENSG00000048649 [Q96T23-1]
ENST00000480887; ENSP00000434509; ENSG00000048649 [Q96T23-3]
GeneIDi51773
KEGGihsa:51773
UCSCiuc001oym.4 human [Q96T23-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51773
DisGeNETi51773

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RSF1
HGNCiHGNC:18118 RSF1
HPAiCAB022626
HPA046129
HPA057547
HPA064567
MIMi608522 gene
neXtProtiNX_Q96T23
OpenTargetsiENSG00000048649
PharmGKBiPA29210

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFYI Eukaryota
ENOG410YTDT LUCA
GeneTreeiENSGT00530000064411
HOGENOMiHOG000154205
InParanoidiQ96T23
KOiK11657
OMAiPPEMETS
OrthoDBi917466at2759
PhylomeDBiQ96T23
TreeFamiTF106405

Enzyme and pathway databases

ReactomeiR-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
RSF1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
RSF1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
51773
PharosiQ96T23

Protein Ontology

More...
PROi
PR:Q96T23

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000048649 Expressed in 225 organ(s), highest expression level in forebrain
ExpressionAtlasiQ96T23 baseline and differential
GenevisibleiQ96T23 HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR028938 Rsf-1
IPR028942 WHIM1_dom
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR10615:SF156 PTHR10615:SF156, 1 hit
PfamiView protein in Pfam
PF00628 PHD, 1 hit
PF15612 WHIM1, 1 hit
SMARTiView protein in SMART
SM00249 PHD, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRSF1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96T23
Secondary accession number(s): Q86X86
, Q9H3L8, Q9NVZ8, Q9NYU0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: July 7, 2009
Last modified: October 16, 2019
This is version 164 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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