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Protein

Selenocysteine insertion sequence-binding protein 2

Gene

SECISBP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB.

GO - Molecular functioni

  • mRNA 3'-UTR binding Source: UniProtKB
  • ribonucleoprotein complex binding Source: GO_Central
  • RNA binding Source: UniProtKB
  • selenocysteine insertion sequence binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processProtein biosynthesis

Enzyme and pathway databases

ReactomeiR-HSA-2408557 Selenocysteine synthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Selenocysteine insertion sequence-binding protein 2
Short name:
SECIS-binding protein 2
Gene namesi
Name:SECISBP2
Synonyms:SBP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000187742.14
HGNCiHGNC:30972 SECISBP2
MIMi607693 gene
neXtProtiNX_Q96T21

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion, Nucleus

Pathology & Biotechi

Involvement in diseasei

Abnormal thyroid hormone metabolism (ATHYHM)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder associated with a reduction in type II iodothyronine deiodinase activity.
See also OMIM:609698
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_025282540R → Q in ATHYHM. 1 PublicationCorresponds to variant dbSNP:rs119461976EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi79048
MalaCardsiSECISBP2
MIMi609698 phenotype
OpenTargetsiENSG00000187742
Orphaneti171706 Short stature-delayed bone age due to thyroid hormone metabolism deficiency
PharmGKBiPA134863749

Polymorphism and mutation databases

BioMutaiSECISBP2
DMDMi52788293

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000976551 – 854Selenocysteine insertion sequence-binding protein 2Add BLAST854

Proteomic databases

EPDiQ96T21
MaxQBiQ96T21
PaxDbiQ96T21
PeptideAtlasiQ96T21
PRIDEiQ96T21
ProteomicsDBi78173
78174 [Q96T21-2]

PTM databases

iPTMnetiQ96T21
PhosphoSitePlusiQ96T21

Expressioni

Tissue specificityi

Expressed at high levels in testis.1 Publication

Gene expression databases

BgeeiENSG00000187742 Expressed in 217 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_SECISBP2
ExpressionAtlasiQ96T21 baseline and differential
GenevisibleiQ96T21 HS

Organism-specific databases

HPAiHPA044314
HPA054905

Interactioni

Subunit structurei

Interacts with SELB.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
GOLGA2Q083793EBI-954116,EBI-618309

Protein-protein interaction databases

BioGridi122507, 7 interactors
IntActiQ96T21, 9 interactors
MINTiQ96T21
STRINGi9606.ENSP00000364965

Structurei

3D structure databases

DisProtiDP00420
ProteinModelPortaliQ96T21
SMRiQ96T21
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni673 – 694RNA-bindingSequence analysisAdd BLAST22

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi380 – 387Nuclear localization signalSequence analysis8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi380 – 387Poly-Lys8

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IEN2 Eukaryota
ENOG410Z16U LUCA
GeneTreeiENSGT00490000043356
HOGENOMiHOG000132996
HOVERGENiHBG056137
InParanoidiQ96T21
KOiK19539
OMAiSCAATYY
OrthoDBiEOG091G0NY1
PhylomeDBiQ96T21
TreeFamiTF328821

Family and domain databases

Gene3Di3.30.1330.30, 1 hit
InterProiView protein in InterPro
IPR029064 L30e-like
IPR004038 Ribosomal_L7Ae/L30e/S12e/Gad45
IPR040051 SECISBP2
PANTHERiPTHR13284 PTHR13284, 2 hits
PfamiView protein in Pfam
PF01248 Ribosomal_L7Ae, 1 hit
SUPFAMiSSF55315 SSF55315, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96T21-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASEGPREPE SEGIKLSADV KPFVPRFAGL NVAWLESSEA CVFPSSAATY
60 70 80 90 100
YPFVQEPPVT EQKIYTEDMA FGASTFPPQY LSSEITLHPY AYSPYTLDST
110 120 130 140 150
QNVYSVPGSQ YLYNQPSCYR GFQTVKHRNE NTCPLPQEMK ALFKKKTYDE
160 170 180 190 200
KKTYDQQKFD SERADGTISS EIKSARGSHH LSIYAENSLK SDGYHKRTDR
210 220 230 240 250
KSRIIAKNVS TSKPEFEFTT LDFPELQGAE NNMSEIQKQP KWGPVHSVST
260 270 280 290 300
DISLLREVVK PAAVLSKGEI VVKNNPNESV TANAATNSPS CTRELSWTPM
310 320 330 340 350
GYVVRQTLST ELSAAPKNVT SMINLKTIAS SADPKNVSIP SSEALSSDPS
360 370 380 390 400
YNKEKHIIHP TQKSKASQGS DLEQNEASRK NKKKKEKSTS KYEVLTVQEP
410 420 430 440 450
PRIEDAEEFP NLAVASERRD RIETPKFQSK QQPQDNFKNN VKKSQLPVQL
460 470 480 490 500
DLGGMLTALE KKQHSQHAKQ SSKPVVVSVG AVPVLSKECA SGERGRRMSQ
510 520 530 540 550
MKTPHNPLDS SAPLMKKGKQ REIPKAKKPT SLKKIILKER QERKQRLQEN
560 570 580 590 600
AVSPAFTSDD TQDGESGGDD QFPEQAELSG PEGMDELIST PSVEDKSEEP
610 620 630 640 650
PGTELQRDTE ASHLAPNHTT FPKIHSRRFR DYCSQMLSKE VDACVTDLLK
660 670 680 690 700
ELVRFQDRMY QKDPVKAKTK RRLVLGLREV LKHLKLKKLK CVIISPNCEK
710 720 730 740 750
IQSKGGLDDT LHTIIDYACE QNIPFVFALN RKALGRSLNK AVPVSVVGIF
760 770 780 790 800
SYDGAQDQFH KMVELTVAAR QAYKTMLENV QQELVGEPRP QAPPSLPTQG
810 820 830 840 850
PSCPAEDGPP ALKEKEEPHY IEIWKKHLEA YSGCTLELEE SLEASTSQMM

NLNL
Length:854
Mass (Da):95,462
Last modified:September 27, 2004 - v2
Checksum:iA911370853BE4E6E
GO
Isoform 2 (identifier: Q96T21-2) [UniParc]FASTAAdd to basket
Also known as: mtSBP2

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: Missing.
     74-101: STFPPQYLSSEITLHPYAYSPYTLDSTQ → MVRVLRSMCLPQLCSHILSVCSGTTSDR

Note: Contains a transit peptide at positions 1-15.
Show »
Length:781
Mass (Da):87,393
Checksum:i1D88AA98E858F00F
GO
Isoform 3 (identifier: Q96T21-3) [UniParc]FASTAAdd to basket
Also known as: SBP2_delta2

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: Missing.

Show »
Length:786
Mass (Da):87,985
Checksum:i87F5B414EEB2D3BC
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5HYY5Q5HYY5_HUMAN
Selenocysteine insertion sequence-b...
SECISBP2
275Annotation score:
Q4V370Q4V370_HUMAN
Selenocysteine insertion sequence-b...
SECISBP2
60Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti553S → G in AAH36109 (PubMed:15489334).Curated1
Sequence conflicti797P → L in AAK57518 (PubMed:12095701).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061704428Q → E. Corresponds to variant dbSNP:rs45452691Ensembl.1
Natural variantiVAR_025282540R → Q in ATHYHM. 1 PublicationCorresponds to variant dbSNP:rs119461976EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0390701 – 73Missing in isoform 2. 2 PublicationsAdd BLAST73
Alternative sequenceiVSP_0557551 – 68Missing in isoform 3. CuratedAdd BLAST68
Alternative sequenceiVSP_03907174 – 101STFPP…LDSTQ → MVRVLRSMCLPQLCSHILSV CSGTTSDR in isoform 2. 2 PublicationsAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380995 mRNA Translation: AAK57518.1
AL136881 mRNA Translation: CAB66815.1
AK290182 mRNA Translation: BAF82871.1
BX000356 Genomic DNA No translation available.
AL160054 Genomic DNA No translation available.
AL929575 Genomic DNA No translation available.
CH471089 Genomic DNA Translation: EAW62763.1
CH471089 Genomic DNA Translation: EAW62764.1
BC023142 mRNA Translation: AAH23142.2
BC036109 mRNA Translation: AAH36109.1
CCDSiCCDS65076.1 [Q96T21-2]
CCDS65077.1 [Q96T21-3]
CCDS6683.1 [Q96T21-1]
RefSeqiNP_001269617.1, NM_001282688.1
NP_001269618.1, NM_001282689.1 [Q96T21-2]
NP_076982.3, NM_024077.4 [Q96T21-1]
XP_006717345.1, XM_006717282.2 [Q96T21-2]
XP_011517302.1, XM_011519000.2 [Q96T21-3]
UniGeneiHs.59804
Hs.667515

Genome annotation databases

EnsembliENST00000339901; ENSP00000364959; ENSG00000187742 [Q96T21-2]
ENST00000375807; ENSP00000364965; ENSG00000187742 [Q96T21-1]
ENST00000534113; ENSP00000436650; ENSG00000187742 [Q96T21-3]
GeneIDi79048
KEGGihsa:79048
UCSCiuc004aqj.3 human [Q96T21-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380995 mRNA Translation: AAK57518.1
AL136881 mRNA Translation: CAB66815.1
AK290182 mRNA Translation: BAF82871.1
BX000356 Genomic DNA No translation available.
AL160054 Genomic DNA No translation available.
AL929575 Genomic DNA No translation available.
CH471089 Genomic DNA Translation: EAW62763.1
CH471089 Genomic DNA Translation: EAW62764.1
BC023142 mRNA Translation: AAH23142.2
BC036109 mRNA Translation: AAH36109.1
CCDSiCCDS65076.1 [Q96T21-2]
CCDS65077.1 [Q96T21-3]
CCDS6683.1 [Q96T21-1]
RefSeqiNP_001269617.1, NM_001282688.1
NP_001269618.1, NM_001282689.1 [Q96T21-2]
NP_076982.3, NM_024077.4 [Q96T21-1]
XP_006717345.1, XM_006717282.2 [Q96T21-2]
XP_011517302.1, XM_011519000.2 [Q96T21-3]
UniGeneiHs.59804
Hs.667515

3D structure databases

DisProtiDP00420
ProteinModelPortaliQ96T21
SMRiQ96T21
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122507, 7 interactors
IntActiQ96T21, 9 interactors
MINTiQ96T21
STRINGi9606.ENSP00000364965

PTM databases

iPTMnetiQ96T21
PhosphoSitePlusiQ96T21

Polymorphism and mutation databases

BioMutaiSECISBP2
DMDMi52788293

Proteomic databases

EPDiQ96T21
MaxQBiQ96T21
PaxDbiQ96T21
PeptideAtlasiQ96T21
PRIDEiQ96T21
ProteomicsDBi78173
78174 [Q96T21-2]

Protocols and materials databases

DNASUi79048
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339901; ENSP00000364959; ENSG00000187742 [Q96T21-2]
ENST00000375807; ENSP00000364965; ENSG00000187742 [Q96T21-1]
ENST00000534113; ENSP00000436650; ENSG00000187742 [Q96T21-3]
GeneIDi79048
KEGGihsa:79048
UCSCiuc004aqj.3 human [Q96T21-1]

Organism-specific databases

CTDi79048
DisGeNETi79048
EuPathDBiHostDB:ENSG00000187742.14
GeneCardsiSECISBP2
HGNCiHGNC:30972 SECISBP2
HPAiHPA044314
HPA054905
MalaCardsiSECISBP2
MIMi607693 gene
609698 phenotype
neXtProtiNX_Q96T21
OpenTargetsiENSG00000187742
Orphaneti171706 Short stature-delayed bone age due to thyroid hormone metabolism deficiency
PharmGKBiPA134863749
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEN2 Eukaryota
ENOG410Z16U LUCA
GeneTreeiENSGT00490000043356
HOGENOMiHOG000132996
HOVERGENiHBG056137
InParanoidiQ96T21
KOiK19539
OMAiSCAATYY
OrthoDBiEOG091G0NY1
PhylomeDBiQ96T21
TreeFamiTF328821

Enzyme and pathway databases

ReactomeiR-HSA-2408557 Selenocysteine synthesis

Miscellaneous databases

ChiTaRSiSECISBP2 human
GeneWikiiSECISBP2
GenomeRNAii79048
PROiPR:Q96T21
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000187742 Expressed in 217 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_SECISBP2
ExpressionAtlasiQ96T21 baseline and differential
GenevisibleiQ96T21 HS

Family and domain databases

Gene3Di3.30.1330.30, 1 hit
InterProiView protein in InterPro
IPR029064 L30e-like
IPR004038 Ribosomal_L7Ae/L30e/S12e/Gad45
IPR040051 SECISBP2
PANTHERiPTHR13284 PTHR13284, 2 hits
PfamiView protein in Pfam
PF01248 Ribosomal_L7Ae, 1 hit
SUPFAMiSSF55315 SSF55315, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSEBP2_HUMAN
AccessioniPrimary (citable) accession number: Q96T21
Secondary accession number(s): F8W892
, Q5HYY1, Q7L1Z0, Q8IYC0, Q9H0A1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: September 27, 2004
Last modified: November 7, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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