Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 146 (18 Sep 2019)
Sequence version 2 (27 Sep 2004)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Selenocysteine insertion sequence-binding protein 2

Gene

SECISBP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processProtein biosynthesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2408557 Selenocysteine synthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Selenocysteine insertion sequence-binding protein 2
Short name:
SECIS-binding protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SECISBP2
Synonyms:SBP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30972 SECISBP2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607693 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96T21

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Abnormal thyroid hormone metabolism (ATHYHM)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder associated with a reduction in type II iodothyronine deiodinase activity.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_025282540R → Q in ATHYHM. 1 PublicationCorresponds to variant dbSNP:rs119461976EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
79048

MalaCards human disease database

More...
MalaCardsi
SECISBP2
MIMi609698 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000187742

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
171706 Short stature-delayed bone age due to thyroid hormone metabolism deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134863749

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SECISBP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
52788293

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000976551 – 854Selenocysteine insertion sequence-binding protein 2Add BLAST854

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96T21

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96T21

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96T21

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96T21

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96T21

PeptideAtlas

More...
PeptideAtlasi
Q96T21

PRoteomics IDEntifications database

More...
PRIDEi
Q96T21

ProteomicsDB human proteome resource

More...
ProteomicsDBi
30103
78173 [Q96T21-1]
78174 [Q96T21-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96T21

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96T21

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at high levels in testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000187742 Expressed in 217 organ(s), highest expression level in left lobe of thyroid gland

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96T21 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96T21 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA044314
HPA054905

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SELB.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
GOLGA2Q083793EBI-954116,EBI-618309

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122507, 8 interactors

Protein interaction database and analysis system

More...
IntActi
Q96T21, 12 interactors

Molecular INTeraction database

More...
MINTi
Q96T21

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000364965

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96T21

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni673 – 694RNA-bindingSequence analysisAdd BLAST22

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi380 – 387Nuclear localization signalSequence analysis8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi380 – 387Poly-Lys8

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEN2 Eukaryota
ENOG410Z16U LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00490000043356

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000132996

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96T21

KEGG Orthology (KO)

More...
KOi
K19539

Identification of Orthologs from Complete Genome Data

More...
OMAi
SCAATYY

Database of Orthologous Groups

More...
OrthoDBi
236436at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96T21

TreeFam database of animal gene trees

More...
TreeFami
TF328821

Family and domain databases

Database of protein disorder

More...
DisProti
DP00420

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1330.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029064 L30e-like
IPR004038 Ribosomal_L7Ae/L30e/S12e/Gad45
IPR040051 SECISBP2

The PANTHER Classification System

More...
PANTHERi
PTHR13284 PTHR13284, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01248 Ribosomal_L7Ae, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55315 SSF55315, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96T21-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASEGPREPE SEGIKLSADV KPFVPRFAGL NVAWLESSEA CVFPSSAATY
60 70 80 90 100
YPFVQEPPVT EQKIYTEDMA FGASTFPPQY LSSEITLHPY AYSPYTLDST
110 120 130 140 150
QNVYSVPGSQ YLYNQPSCYR GFQTVKHRNE NTCPLPQEMK ALFKKKTYDE
160 170 180 190 200
KKTYDQQKFD SERADGTISS EIKSARGSHH LSIYAENSLK SDGYHKRTDR
210 220 230 240 250
KSRIIAKNVS TSKPEFEFTT LDFPELQGAE NNMSEIQKQP KWGPVHSVST
260 270 280 290 300
DISLLREVVK PAAVLSKGEI VVKNNPNESV TANAATNSPS CTRELSWTPM
310 320 330 340 350
GYVVRQTLST ELSAAPKNVT SMINLKTIAS SADPKNVSIP SSEALSSDPS
360 370 380 390 400
YNKEKHIIHP TQKSKASQGS DLEQNEASRK NKKKKEKSTS KYEVLTVQEP
410 420 430 440 450
PRIEDAEEFP NLAVASERRD RIETPKFQSK QQPQDNFKNN VKKSQLPVQL
460 470 480 490 500
DLGGMLTALE KKQHSQHAKQ SSKPVVVSVG AVPVLSKECA SGERGRRMSQ
510 520 530 540 550
MKTPHNPLDS SAPLMKKGKQ REIPKAKKPT SLKKIILKER QERKQRLQEN
560 570 580 590 600
AVSPAFTSDD TQDGESGGDD QFPEQAELSG PEGMDELIST PSVEDKSEEP
610 620 630 640 650
PGTELQRDTE ASHLAPNHTT FPKIHSRRFR DYCSQMLSKE VDACVTDLLK
660 670 680 690 700
ELVRFQDRMY QKDPVKAKTK RRLVLGLREV LKHLKLKKLK CVIISPNCEK
710 720 730 740 750
IQSKGGLDDT LHTIIDYACE QNIPFVFALN RKALGRSLNK AVPVSVVGIF
760 770 780 790 800
SYDGAQDQFH KMVELTVAAR QAYKTMLENV QQELVGEPRP QAPPSLPTQG
810 820 830 840 850
PSCPAEDGPP ALKEKEEPHY IEIWKKHLEA YSGCTLELEE SLEASTSQMM

NLNL
Length:854
Mass (Da):95,462
Last modified:September 27, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA911370853BE4E6E
GO
Isoform 2 (identifier: Q96T21-2) [UniParc]FASTAAdd to basket
Also known as: mtSBP2

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: Missing.
     74-101: STFPPQYLSSEITLHPYAYSPYTLDSTQ → MVRVLRSMCLPQLCSHILSVCSGTTSDR

Note: Contains a transit peptide at positions 1-15.
Show »
Length:781
Mass (Da):87,393
Checksum:i1D88AA98E858F00F
GO
Isoform 3 (identifier: Q96T21-3) [UniParc]FASTAAdd to basket
Also known as: SBP2_delta2

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: Missing.

Show »
Length:786
Mass (Da):87,985
Checksum:i87F5B414EEB2D3BC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5HYY5Q5HYY5_HUMAN
Selenocysteine insertion sequence-b...
SECISBP2
275Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q4V370Q4V370_HUMAN
Selenocysteine insertion sequence-b...
SECISBP2
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti553S → G in AAH36109 (PubMed:15489334).Curated1
Sequence conflicti797P → L in AAK57518 (PubMed:12095701).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061704428Q → E. Corresponds to variant dbSNP:rs45452691Ensembl.1
Natural variantiVAR_025282540R → Q in ATHYHM. 1 PublicationCorresponds to variant dbSNP:rs119461976EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0390701 – 73Missing in isoform 2. 2 PublicationsAdd BLAST73
Alternative sequenceiVSP_0557551 – 68Missing in isoform 3. CuratedAdd BLAST68
Alternative sequenceiVSP_03907174 – 101STFPP…LDSTQ → MVRVLRSMCLPQLCSHILSV CSGTTSDR in isoform 2. 2 PublicationsAdd BLAST28

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF380995 mRNA Translation: AAK57518.1
AL136881 mRNA Translation: CAB66815.1
AK290182 mRNA Translation: BAF82871.1
BX000356 Genomic DNA No translation available.
AL160054 Genomic DNA No translation available.
AL929575 Genomic DNA No translation available.
CH471089 Genomic DNA Translation: EAW62763.1
CH471089 Genomic DNA Translation: EAW62764.1
BC023142 mRNA Translation: AAH23142.2
BC036109 mRNA Translation: AAH36109.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS65076.1 [Q96T21-2]
CCDS65077.1 [Q96T21-3]
CCDS6683.1 [Q96T21-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001269617.1, NM_001282688.1
NP_001269618.1, NM_001282689.1 [Q96T21-2]
NP_076982.3, NM_024077.4 [Q96T21-1]
XP_006717345.1, XM_006717282.2 [Q96T21-2]
XP_011517302.1, XM_011519000.2 [Q96T21-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000339901; ENSP00000364959; ENSG00000187742 [Q96T21-2]
ENST00000375807; ENSP00000364965; ENSG00000187742 [Q96T21-1]
ENST00000534113; ENSP00000436650; ENSG00000187742 [Q96T21-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
79048

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79048

UCSC genome browser

More...
UCSCi
uc004aqj.3 human [Q96T21-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380995 mRNA Translation: AAK57518.1
AL136881 mRNA Translation: CAB66815.1
AK290182 mRNA Translation: BAF82871.1
BX000356 Genomic DNA No translation available.
AL160054 Genomic DNA No translation available.
AL929575 Genomic DNA No translation available.
CH471089 Genomic DNA Translation: EAW62763.1
CH471089 Genomic DNA Translation: EAW62764.1
BC023142 mRNA Translation: AAH23142.2
BC036109 mRNA Translation: AAH36109.1
CCDSiCCDS65076.1 [Q96T21-2]
CCDS65077.1 [Q96T21-3]
CCDS6683.1 [Q96T21-1]
RefSeqiNP_001269617.1, NM_001282688.1
NP_001269618.1, NM_001282689.1 [Q96T21-2]
NP_076982.3, NM_024077.4 [Q96T21-1]
XP_006717345.1, XM_006717282.2 [Q96T21-2]
XP_011517302.1, XM_011519000.2 [Q96T21-3]

3D structure databases

SMRiQ96T21
ModBaseiSearch...

Protein-protein interaction databases

BioGridi122507, 8 interactors
IntActiQ96T21, 12 interactors
MINTiQ96T21
STRINGi9606.ENSP00000364965

PTM databases

iPTMnetiQ96T21
PhosphoSitePlusiQ96T21

Polymorphism and mutation databases

BioMutaiSECISBP2
DMDMi52788293

Proteomic databases

EPDiQ96T21
jPOSTiQ96T21
MassIVEiQ96T21
MaxQBiQ96T21
PaxDbiQ96T21
PeptideAtlasiQ96T21
PRIDEiQ96T21
ProteomicsDBi30103
78173 [Q96T21-1]
78174 [Q96T21-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
79048
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339901; ENSP00000364959; ENSG00000187742 [Q96T21-2]
ENST00000375807; ENSP00000364965; ENSG00000187742 [Q96T21-1]
ENST00000534113; ENSP00000436650; ENSG00000187742 [Q96T21-3]
GeneIDi79048
KEGGihsa:79048
UCSCiuc004aqj.3 human [Q96T21-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79048
DisGeNETi79048

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SECISBP2
HGNCiHGNC:30972 SECISBP2
HPAiHPA044314
HPA054905
MalaCardsiSECISBP2
MIMi607693 gene
609698 phenotype
neXtProtiNX_Q96T21
OpenTargetsiENSG00000187742
Orphaneti171706 Short stature-delayed bone age due to thyroid hormone metabolism deficiency
PharmGKBiPA134863749

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IEN2 Eukaryota
ENOG410Z16U LUCA
GeneTreeiENSGT00490000043356
HOGENOMiHOG000132996
InParanoidiQ96T21
KOiK19539
OMAiSCAATYY
OrthoDBi236436at2759
PhylomeDBiQ96T21
TreeFamiTF328821

Enzyme and pathway databases

ReactomeiR-HSA-2408557 Selenocysteine synthesis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SECISBP2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SECISBP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
79048

Pharos

More...
Pharosi
Q96T21

Protein Ontology

More...
PROi
PR:Q96T21

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000187742 Expressed in 217 organ(s), highest expression level in left lobe of thyroid gland
ExpressionAtlasiQ96T21 baseline and differential
GenevisibleiQ96T21 HS

Family and domain databases

DisProtiDP00420
Gene3Di3.30.1330.30, 1 hit
InterProiView protein in InterPro
IPR029064 L30e-like
IPR004038 Ribosomal_L7Ae/L30e/S12e/Gad45
IPR040051 SECISBP2
PANTHERiPTHR13284 PTHR13284, 1 hit
PfamiView protein in Pfam
PF01248 Ribosomal_L7Ae, 1 hit
SUPFAMiSSF55315 SSF55315, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSEBP2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96T21
Secondary accession number(s): F8W892
, Q5HYY1, Q7L1Z0, Q8IYC0, Q9H0A1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: September 27, 2004
Last modified: September 18, 2019
This is version 146 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again