UniProtKB - Q96T17 (MA7D2_HUMAN)
Protein
MAP7 domain-containing protein 2
Gene
MAP7D2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- microtubule cytoskeleton organization Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q96T17 |
Names & Taxonomyi
Protein namesi | Recommended name: MAP7 domain-containing protein 2 |
Gene namesi | Name:MAP7D2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000184368.15 |
HGNCi | HGNC:25899, MAP7D2 |
neXtProti | NX_Q96T17 |
Subcellular locationi
Cytoskeleton
- microtubule cytoskeleton Source: GO_Central
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 256714 |
OpenTargetsi | ENSG00000184368 |
PharmGKBi | PA162394971 |
Miscellaneous databases
Pharosi | Q96T17, Tdark |
Polymorphism and mutation databases
BioMutai | MAP7D2 |
DMDMi | 296434580 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000306809 | 1 – 732 | MAP7 domain-containing protein 2Add BLAST | 732 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Isoform 5 (identifier: Q96T17-5) | |||||
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
jPOSTi | Q96T17 |
MassIVEi | Q96T17 |
MaxQBi | Q96T17 |
PeptideAtlasi | Q96T17 |
PRIDEi | Q96T17 |
ProteomicsDBi | 12313 78169 [Q96T17-1] 78170 [Q96T17-2] 78171 [Q96T17-3] 78172 [Q96T17-4] |
PTM databases
iPTMneti | Q96T17 |
PhosphoSitePlusi | Q96T17 |
Expressioni
Gene expression databases
Bgeei | ENSG00000184368, Expressed in frontal cortex and 152 other tissues |
Genevisiblei | Q96T17, HS |
Organism-specific databases
HPAi | ENSG00000184368, Tissue enhanced (brain, epididymis) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 129178, 33 interactors |
IntActi | Q96T17, 33 interactors |
MINTi | Q96T17 |
STRINGi | 9606.ENSP00000368964 |
Miscellaneous databases
RNActi | Q96T17, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 51 – 146 | Sequence analysisAdd BLAST | 96 |
Sequence similaritiesi
Belongs to the MAP7 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QTSG, Eukaryota |
GeneTreei | ENSGT00950000182941 |
HOGENOMi | CLU_017315_1_0_1 |
InParanoidi | Q96T17 |
OMAi | SPVKYRF |
OrthoDBi | 265189at2759 |
PhylomeDBi | Q96T17 |
TreeFami | TF332273 |
Family and domain databases
InterProi | View protein in InterPro IPR008604, MAP7_fam |
Pfami | View protein in Pfam PF05672, MAP7, 1 hit |
s (5)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q96T17-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MERGGGGSGT GSRPEGTARG TSLPGKIAEP GAVRTSQPNY RPQGMEGFLK
60 70 80 90 100
SDERQRLAKE RREEREKCLA AREQQILEKQ KRARLQYEKQ MEERWRKLEE
110 120 130 140 150
QRQREDQKRA AVEEKRKQKL REEEERLEAM MRRSLERTQQ LELKKKYSWG
160 170 180 190 200
APLAIGPGGH DACDKLSTST MSLPKPTEPP MNKRLSSSTV AISYSPDRVF
210 220 230 240 250
HVCPRLAPLG PLNPSYKSSP TRNIEKKKAT STSTSGAGDV GKEALSGGEA
260 270 280 290 300
SLVEKVKRGQ RTATSLPVVN FGSPLRRCEF SGGIPKRPSS PVISKTATKA
310 320 330 340 350
YPQSPKTTKP PYPGSPVKYR LPALSGQDMP KRKAEKEKSN KEREGTLAQQ
360 370 380 390 400
AAGPQGEEAL EKHVVDKHAS EKHAAAAGGK AENSAALGKP TAGTTDAGEA
410 420 430 440 450
AKILAEKRRQ ARLQKEQEEQ ERLEKEEQDR LEREELKRKA EEERLRLEEE
460 470 480 490 500
ARKQEEERKR QEEEKKKQEG EEKRKAGEEA KRKAEEELLL KEKQEQEKQE
510 520 530 540 550
KAMIEKQKEA AETKAREVAE QMRLEREQIM LQIEQERLER KKRIDEIMKR
560 570 580 590 600
TRKSDVSPQV KKEDPKVGVQ PAVCVEKKTK LVVPNKMEIN GLNTCQEVNG
610 620 630 640 650
VDHAAPETYP QDIFSNGLKP AGGLIHLDAL DGKSNSLDDS TEEVQSMDVS
660 670 680 690 700
PVSKEELISI PEFSPVSEMI PGVSLDQNGT GNARALQDLL DFTGPPTFPK
710 720 730
RSSENLSLDD CNKNLIEGFN SPGQETPLNT FC
Sequence cautioni
The sequence BAC05407 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 14 | P → L in AAH89400 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 423 | L → V in BAB55093 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 557 | S → P in BAB55093 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 590 | N → S in BAH11884 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035450 | 32 | A → P in a breast cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_035313 | 182 | N → S1 PublicationCorresponds to variant dbSNP:rs34519770Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_044657 | 1 – 44 | Missing in isoform 5. 1 PublicationAdd BLAST | 44 | |
Alternative sequenceiVSP_028490 | 161 | D → DGESENTPPPPLGLAASTLP PDAGTTAAAAESTN in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_043337 | 162 – 206 | Missing in isoform 4. 1 PublicationAdd BLAST | 45 | |
Alternative sequenceiVSP_028491 | 198 – 201 | RVFH → QAEG in isoform 3. 1 Publication | 4 | |
Alternative sequenceiVSP_028492 | 198 | R → RAHHMHLSPMEAILVSRLLT PTQSSLARSRASVMLSGQAN DS in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_044658 | 199 – 206 | Missing in isoform 5. 1 Publication | 8 | |
Alternative sequenceiVSP_028493 | 202 – 732 | Missing in isoform 3. 1 PublicationAdd BLAST | 531 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK027409 mRNA Translation: BAB55093.1 AK098768 mRNA Translation: BAC05407.1 Different initiation. AK294788 mRNA Translation: BAH11884.1 AK296319 mRNA Translation: BAH12313.1 AL732366 Genomic DNA No translation available. BC037165 mRNA Translation: AAH37165.1 BC089400 mRNA Translation: AAH89400.1 BC136379 mRNA Translation: AAI36380.1 |
CCDSi | CCDS14195.1 [Q96T17-1] CCDS55384.1 [Q96T17-5] CCDS55385.1 [Q96T17-4] CCDS55386.1 [Q96T17-2] |
RefSeqi | NP_001161937.1, NM_001168465.1 [Q96T17-2] NP_001161938.1, NM_001168466.1 [Q96T17-4] NP_001161939.1, NM_001168467.1 [Q96T17-5] NP_689993.2, NM_152780.3 [Q96T17-1] |
Genome annotation databases
Ensembli | ENST00000379643; ENSP00000368964; ENSG00000184368 [Q96T17-2] ENST00000379651; ENSP00000368972; ENSG00000184368 [Q96T17-1] ENST00000443379; ENSP00000388239; ENSG00000184368 [Q96T17-4] ENST00000452324; ENSP00000413301; ENSG00000184368 [Q96T17-5] |
GeneIDi | 256714 |
KEGGi | hsa:256714 |
UCSCi | uc004czr.3, human [Q96T17-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK027409 mRNA Translation: BAB55093.1 AK098768 mRNA Translation: BAC05407.1 Different initiation. AK294788 mRNA Translation: BAH11884.1 AK296319 mRNA Translation: BAH12313.1 AL732366 Genomic DNA No translation available. BC037165 mRNA Translation: AAH37165.1 BC089400 mRNA Translation: AAH89400.1 BC136379 mRNA Translation: AAI36380.1 |
CCDSi | CCDS14195.1 [Q96T17-1] CCDS55384.1 [Q96T17-5] CCDS55385.1 [Q96T17-4] CCDS55386.1 [Q96T17-2] |
RefSeqi | NP_001161937.1, NM_001168465.1 [Q96T17-2] NP_001161938.1, NM_001168466.1 [Q96T17-4] NP_001161939.1, NM_001168467.1 [Q96T17-5] NP_689993.2, NM_152780.3 [Q96T17-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 129178, 33 interactors |
IntActi | Q96T17, 33 interactors |
MINTi | Q96T17 |
STRINGi | 9606.ENSP00000368964 |
PTM databases
iPTMneti | Q96T17 |
PhosphoSitePlusi | Q96T17 |
Polymorphism and mutation databases
BioMutai | MAP7D2 |
DMDMi | 296434580 |
Proteomic databases
jPOSTi | Q96T17 |
MassIVEi | Q96T17 |
MaxQBi | Q96T17 |
PeptideAtlasi | Q96T17 |
PRIDEi | Q96T17 |
ProteomicsDBi | 12313 78169 [Q96T17-1] 78170 [Q96T17-2] 78171 [Q96T17-3] 78172 [Q96T17-4] |
Protocols and materials databases
Antibodypediai | 63281, 15 antibodies |
Genome annotation databases
Ensembli | ENST00000379643; ENSP00000368964; ENSG00000184368 [Q96T17-2] ENST00000379651; ENSP00000368972; ENSG00000184368 [Q96T17-1] ENST00000443379; ENSP00000388239; ENSG00000184368 [Q96T17-4] ENST00000452324; ENSP00000413301; ENSG00000184368 [Q96T17-5] |
GeneIDi | 256714 |
KEGGi | hsa:256714 |
UCSCi | uc004czr.3, human [Q96T17-1] |
Organism-specific databases
CTDi | 256714 |
DisGeNETi | 256714 |
EuPathDBi | HostDB:ENSG00000184368.15 |
GeneCardsi | MAP7D2 |
HGNCi | HGNC:25899, MAP7D2 |
HPAi | ENSG00000184368, Tissue enhanced (brain, epididymis) |
neXtProti | NX_Q96T17 |
OpenTargetsi | ENSG00000184368 |
PharmGKBi | PA162394971 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QTSG, Eukaryota |
GeneTreei | ENSGT00950000182941 |
HOGENOMi | CLU_017315_1_0_1 |
InParanoidi | Q96T17 |
OMAi | SPVKYRF |
OrthoDBi | 265189at2759 |
PhylomeDBi | Q96T17 |
TreeFami | TF332273 |
Enzyme and pathway databases
PathwayCommonsi | Q96T17 |
Miscellaneous databases
BioGRID-ORCSi | 256714, 5 hits in 471 CRISPR screens |
ChiTaRSi | MAP7D2, human |
GenomeRNAii | 256714 |
Pharosi | Q96T17, Tdark |
PROi | PR:Q96T17 |
RNActi | Q96T17, protein |
Gene expression databases
Bgeei | ENSG00000184368, Expressed in frontal cortex and 152 other tissues |
Genevisiblei | Q96T17, HS |
Family and domain databases
InterProi | View protein in InterPro IPR008604, MAP7_fam |
Pfami | View protein in Pfam PF05672, MAP7, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MA7D2_HUMAN | |
Accessioni | Q96T17Primary (citable) accession number: Q96T17 Secondary accession number(s): B7Z2J8 Q8N792 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 2, 2007 |
Last sequence update: | May 18, 2010 | |
Last modified: | December 2, 2020 | |
This is version 123 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - SIMILARITY comments
Index of protein domains and families - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations