CDK5RAP1

Functionⁱ

Specifically inhibits CDK5 activation by CDK5R1.

Cofactorⁱ

[4Fe-4S] clusterBy similarityNote: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	109	Iron-sulfur (4Fe-4S)By similarity	1
Metal bindingⁱ	145	Iron-sulfur (4Fe-4S)By similarity	1
Metal bindingⁱ	183	Iron-sulfur (4Fe-4S)By similarity	1
Metal bindingⁱ	258	Iron-sulfur (4Fe-4S-S-AdoMet)By similarity	1
Metal bindingⁱ	262	Iron-sulfur (4Fe-4S-S-AdoMet)By similarity	1
Metal bindingⁱ	265	Iron-sulfur (4Fe-4S-S-AdoMet)By similarity	1

GO - Molecular functionⁱ

4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW
N6-isopentenyladenosine methylthiotransferase activity Source: Ensembl
protein-containing complex binding Source: Ensembl
protein kinase binding
Source: UniProtKB
Non-traceable author statementⁱ
- 10721722

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

brain development
Source: UniProtKB
Non-traceable author statementⁱ
- 10915792
mitochondrial tRNA modification Source: Ensembl
negative regulation of cyclin-dependent protein serine/threonine kinase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 11882646
positive regulation of mitochondrial translation Source: Ensembl
positive regulation of translational fidelity Source: Ensembl
regulation of neuron differentiation
Source: UniProtKB
Non-traceable author statementⁱ
- 10721722

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Ligand

4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: CDK5 regulatory subunit-associated protein 1 Alternative name(s): CDK5 activator-binding protein C42
Gene namesⁱ	Name:CDK5RAP1 Synonyms:C20orf34 ORF Names:CGI-05, HSPC167
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000101391.20
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15880 CDK5RAP1
MIMⁱ	608200 gene
neXtProtⁱ	NX_Q96SZ6

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	51654
Open Targets More...OpenTargetsⁱ	ENSG00000101391
PharmGKBⁱ	PA26313

Polymorphism and mutation databases

DMDMⁱ	32129446

DMDMⁱ

32129446

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000141764	1 – 601	CDK5 regulatory subunit-associated protein 1Add BLAST		601

Proteomic databases

EPDⁱ	Q96SZ6
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96SZ6
PaxDbⁱ	Q96SZ6
PeptideAtlas More...PeptideAtlasⁱ	Q96SZ6
PRIDEⁱ	Q96SZ6
ProteomicsDBⁱ	78165 78166 [Q96SZ6-2] 78167 [Q96SZ6-3] 78168 [Q96SZ6-4]

PTM databases

iPTMnetⁱ	Q96SZ6
PhosphoSitePlusⁱ	Q96SZ6

Expressionⁱ

Tissue specificityⁱ

Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000101391 Expressed in 226 organ(s), highest expression level in small intestine Peyer's patch
CleanExⁱ	HS_CDK5RAP1
ExpressionAtlasⁱ	Q96SZ6 baseline and differential
Genevisibleⁱ	Q96SZ6 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA066301

HPAⁱ

HPA066301

Interactionⁱ

Subunit structureⁱ

Interacts with CDK5R1 (p35 form). CDK5RAP1, CDK5RAP2 and CDK5RAP3 show competitive binding to CDK5R1. Forms a complex with CDK5R1 and CDK5.1 Publication

GO - Molecular functionⁱ

protein kinase binding
Source: UniProtKB
Non-traceable author statementⁱ
- 10721722

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	119661, 25 interactors
IntActⁱ	Q96SZ6, 6 interactors
STRINGⁱ	9606.ENSP00000217372

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96SZ6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	100 – 220	MTTase N-terminalAdd BLAST		121
Domainⁱ	515 – 590	TRAMAdd BLAST		76

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	22 – 157	CDK5 activation inhibitionAdd BLAST		136
Regionⁱ	475 – 586	CDK5R1-bindingAdd BLAST		112

Sequence similaritiesⁱ

Belongs to the methylthiotransferase family. MiaB subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG2492 Eukaryota COG0621 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063447
HOVERGENⁱ	HBG050975
InParanoidⁱ	Q96SZ6
OMAⁱ	KVCEHFH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G07M5
PhylomeDBⁱ	Q96SZ6
TreeFamⁱ	TF101033

Family and domain databases

Gene3Dⁱ	3.40.50.12160, 1 hit 3.80.30.20, 1 hit
HAMAPⁱ	MF_01864 tRNA_metthiotr_MiaB, 1 hit
InterProⁱ	View protein in InterPro IPR006638 Elp3/MiaB/NifB IPR005839 Methylthiotransferase IPR020612 Methylthiotransferase_CS IPR013848 Methylthiotransferase_N IPR038135 Methylthiotransferase_N_sf IPR006463 MiaB_methiolase IPR007197 rSAM IPR023404 rSAM_horseshoe IPR002792 TRAM_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04055 Radical_SAM, 1 hit PF01938 TRAM, 1 hit PF00919 UPF0004, 1 hit
SFLDⁱ	SFLDF00273 (dimethylallyl)adenosine_tRNA_, 1 hit SFLDG01061 methylthiotransferase, 2 hits SFLDS00029 Radical_SAM, 3 hits
SMARTⁱ	View protein in SMART SM00729 Elp3, 1 hit
TIGRFAMsⁱ	TIGR00089 TIGR00089, 1 hit
PROSITEⁱ	View protein in PROSITE PS51449 MTTASE_N, 1 hit PS01278 MTTASE_RADICAL, 1 hit PS50926 TRAM, 1 hit

Sequences (6+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 6 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q96SZ6-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHPLQCVLQV QRSLGWGPLA SVSWLSLRMC RAHSSLSSTM CPSPERQEDG 
        60         70         80         90        100
ARKDFSSRLA AGPTFQHFLK SASAPQEKLS SEVEDPPPYL MMDELLGRQR 
       110        120        130        140        150
KVYLETYGCQ MNVNDTEIAW SILQKSGYLR TSNLQEADVI LLVTCSIREK 
       160        170        180        190        200
AEQTIWNRLH QLKALKTRRP RSRVPLRIGI LGCMAERLKE EILNREKMVD 
       210        220        230        240        250
ILAGPDAYRD LPRLLAVAES GQQAANVLLS LDETYADVMP VQTSASATSA 
       260        270        280        290        300
FVSIMRGCDN MCSYCIVPFT RGRERSRPIA SILEEVKKLS EQVFLPPRPP 
       310        320        330        340        350
KVLGLQGLKE VTLLGQNVNS FRDNSEVQFN SAVPTNLSRG FTTNYKTKQG 
       360        370        380        390        400
GLRFAHLLDQ VSRVDPEMRI RFTSPHPKDF PDEVLQLIHE RDNICKQIHL 
       410        420        430        440        450
PAQSGSSRVL EAMRRGYSRE AYVELVHHIR ESIPGVSLSS DFIAGFCGET 
       460        470        480        490        500
EEDHVQTVSL LREVQYNMGF LFAYSMRQKT RAYHRLKDDV PEEVKLRRLE 
       510        520        530        540        550
ELITIFREEA TKANQTSVGC TQLVLVEGLS KRSATDLCGR NDGNLKVIFP 
       560        570        580        590        600
DAEMEDVNNP GLRVRAQPGD YVLVKITSAS SQTLRGHVLC RTTLRDSSAY 

C

Note: May be due to intron retention. No experimental confirmation available.

Length:601

Mass (Da):67,689

Last modified:June 16, 2003 - v2

Checksum:ⁱ4AEBFD7DA5400902

GO

Isoform 2 (identifier: Q96SZ6-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-90: Missing.
293-306: Missing.

« Hide

        10         20         30         40         50
MMDELLGRQR KVYLETYGCQ MNVNDTEIAW SILQKSGYLR TSNLQEADVI 
        60         70         80         90        100
LLVTCSIREK AEQTIWNRLH QLKALKTRRP RSRVPLRIGI LGCMAERLKE 
       110        120        130        140        150
EILNREKMVD ILAGPDAYRD LPRLLAVAES GQQAANVLLS LDETYADVMP 
       160        170        180        190        200
VQTSASATSA FVSIMRGCDN MCSYCIVPFT RGRERSRPIA SILEEVKKLS 
       210        220        230        240        250
EQGLKEVTLL GQNVNSFRDN SEVQFNSAVP TNLSRGFTTN YKTKQGGLRF 
       260        270        280        290        300
AHLLDQVSRV DPEMRIRFTS PHPKDFPDEV LQLIHERDNI CKQIHLPAQS 
       310        320        330        340        350
GSSRVLEAMR RGYSREAYVE LVHHIRESIP GVSLSSDFIA GFCGETEEDH 
       360        370        380        390        400
VQTVSLLREV QYNMGFLFAY SMRQKTRAYH RLKDDVPEEV KLRRLEELIT 
       410        420        430        440        450
IFREEATKAN QTSVGCTQLV LVEGLSKRSA TDLCGRNDGN LKVIFPDAEM 
       460        470        480        490 
EDVNNPGLRV RAQPGDYVLV KITSASSQTL RGHVLCRTTL RDSSAYC

Note: No experimental confirmation available.

Show »

Length:497

Mass (Da):56,223

Checksum:ⁱC8FFBA14A5C3EB09

GO

Isoform 3 (identifier: Q96SZ6-3) [UniParc]FASTA Add to basket

Also known as: a

The sequence of this isoform differs from the canonical sequence as follows:
293-306: Missing.

« Hide

        10         20         30         40         50
MHPLQCVLQV QRSLGWGPLA SVSWLSLRMC RAHSSLSSTM CPSPERQEDG 
        60         70         80         90        100
ARKDFSSRLA AGPTFQHFLK SASAPQEKLS SEVEDPPPYL MMDELLGRQR 
       110        120        130        140        150
KVYLETYGCQ MNVNDTEIAW SILQKSGYLR TSNLQEADVI LLVTCSIREK 
       160        170        180        190        200
AEQTIWNRLH QLKALKTRRP RSRVPLRIGI LGCMAERLKE EILNREKMVD 
       210        220        230        240        250
ILAGPDAYRD LPRLLAVAES GQQAANVLLS LDETYADVMP VQTSASATSA 
       260        270        280        290        300
FVSIMRGCDN MCSYCIVPFT RGRERSRPIA SILEEVKKLS EQGLKEVTLL 
       310        320        330        340        350
GQNVNSFRDN SEVQFNSAVP TNLSRGFTTN YKTKQGGLRF AHLLDQVSRV 
       360        370        380        390        400
DPEMRIRFTS PHPKDFPDEV LQLIHERDNI CKQIHLPAQS GSSRVLEAMR 
       410        420        430        440        450
RGYSREAYVE LVHHIRESIP GVSLSSDFIA GFCGETEEDH VQTVSLLREV 
       460        470        480        490        500
QYNMGFLFAY SMRQKTRAYH RLKDDVPEEV KLRRLEELIT IFREEATKAN 
       510        520        530        540        550
QTSVGCTQLV LVEGLSKRSA TDLCGRNDGN LKVIFPDAEM EDVNNPGLRV 
       560        570        580 
RAQPGDYVLV KITSASSQTL RGHVLCRTTL RDSSAYC

Show »

Length:587

Mass (Da):66,146

Checksum:ⁱ314E826B35C346EB

GO

Isoform 4 (identifier: Q96SZ6-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
293-383: Missing.

« Hide

        10         20         30         40         50
MHPLQCVLQV QRSLGWGPLA SVSWLSLRMC RAHSSLSSTM CPSPERQEDG 
        60         70         80         90        100
ARKDFSSRLA AGPTFQHFLK SASAPQEKLS SEVEDPPPYL MMDELLGRQR 
       110        120        130        140        150
KVYLETYGCQ MNVNDTEIAW SILQKSGYLR TSNLQEADVI LLVTCSIREK 
       160        170        180        190        200
AEQTIWNRLH QLKALKTRRP RSRVPLRIGI LGCMAERLKE EILNREKMVD 
       210        220        230        240        250
ILAGPDAYRD LPRLLAVAES GQQAANVLLS LDETYADVMP VQTSASATSA 
       260        270        280        290        300
FVSIMRGCDN MCSYCIVPFT RGRERSRPIA SILEEVKKLS EQVLQLIHER 
       310        320        330        340        350
DNICKQIHLP AQSGSSRVLE AMRRGYSREA YVELVHHIRE SIPGVSLSSD 
       360        370        380        390        400
FIAGFCGETE EDHVQTVSLL REVQYNMGFL FAYSMRQKTR AYHRLKDDVP 
       410        420        430        440        450
EEVKLRRLEE LITIFREEAT KANQTSVGCT QLVLVEGLSK RSATDLCGRN 
       460        470        480        490        500
DGNLKVIFPD AEMEDVNNPG LRVRAQPGDY VLVKITSASS QTLRGHVLCR 
       510
TTLRDSSAYC

Note: No experimental confirmation available.

Show »

Length:510

Mass (Da):57,413

Checksum:ⁱ8F0DFB3B71E135BB

GO

Isoform 5 (identifier: Q96SZ6-5) [UniParc]FASTA Add to basket

Also known as: CDK5RAP1_v4

The sequence of this isoform differs from the canonical sequence as follows:
     292-305: Missing.
     435-440: GVSLSS → EDTGIS
     441-601: Missing.

« Hide

        10         20         30         40         50
MHPLQCVLQV QRSLGWGPLA SVSWLSLRMC RAHSSLSSTM CPSPERQEDG 
        60         70         80         90        100
ARKDFSSRLA AGPTFQHFLK SASAPQEKLS SEVEDPPPYL MMDELLGRQR 
       110        120        130        140        150
KVYLETYGCQ MNVNDTEIAW SILQKSGYLR TSNLQEADVI LLVTCSIREK 
       160        170        180        190        200
AEQTIWNRLH QLKALKTRRP RSRVPLRIGI LGCMAERLKE EILNREKMVD 
       210        220        230        240        250
ILAGPDAYRD LPRLLAVAES GQQAANVLLS LDETYADVMP VQTSASATSA 
       260        270        280        290        300
FVSIMRGCDN MCSYCIVPFT RGRERSRPIA SILEEVKKLS EQGLKEVTLL 
       310        320        330        340        350
GQNVNSFRDN SEVQFNSAVP TNLSRGFTTN YKTKQGGLRF AHLLDQVSRV 
       360        370        380        390        400
DPEMRIRFTS PHPKDFPDEV LQLIHERDNI CKQIHLPAQS GSSRVLEAMR 
       410        420 
RGYSREAYVE LVHHIRESIP EDTGIS

Note: Mainly expressed in brain, placenta and testis.

Show »

Length:426

Mass (Da):48,072

Checksum:ⁱD74ADCD179EA4FDC

GO

Isoform 6 (identifier: Q96SZ6-6) [UniParc]FASTA Add to basket

Also known as: CDK5RAP1_v3

The sequence of this isoform differs from the canonical sequence as follows:
292-305: Missing.
576-601: ITSASSQTLRGHVLCRTTLRDSSAYC → VRSPFGLLACTVK

« Hide

        10         20         30         40         50
MHPLQCVLQV QRSLGWGPLA SVSWLSLRMC RAHSSLSSTM CPSPERQEDG 
        60         70         80         90        100
ARKDFSSRLA AGPTFQHFLK SASAPQEKLS SEVEDPPPYL MMDELLGRQR 
       110        120        130        140        150
KVYLETYGCQ MNVNDTEIAW SILQKSGYLR TSNLQEADVI LLVTCSIREK 
       160        170        180        190        200
AEQTIWNRLH QLKALKTRRP RSRVPLRIGI LGCMAERLKE EILNREKMVD 
       210        220        230        240        250
ILAGPDAYRD LPRLLAVAES GQQAANVLLS LDETYADVMP VQTSASATSA 
       260        270        280        290        300
FVSIMRGCDN MCSYCIVPFT RGRERSRPIA SILEEVKKLS EQGLKEVTLL 
       310        320        330        340        350
GQNVNSFRDN SEVQFNSAVP TNLSRGFTTN YKTKQGGLRF AHLLDQVSRV 
       360        370        380        390        400
DPEMRIRFTS PHPKDFPDEV LQLIHERDNI CKQIHLPAQS GSSRVLEAMR 
       410        420        430        440        450
RGYSREAYVE LVHHIRESIP GVSLSSDFIA GFCGETEEDH VQTVSLLREV 
       460        470        480        490        500
QYNMGFLFAY SMRQKTRAYH RLKDDVPEEV KLRRLEELIT IFREEATKAN 
       510        520        530        540        550
QTSVGCTQLV LVEGLSKRSA TDLCGRNDGN LKVIFPDAEM EDVNNPGLRV 
       560        570 
RAQPGDYVLV KVRSPFGLLA CTVK

Note: High expression in placenta and lung.

Show »

Length:574

Mass (Da):64,709

Checksum:ⁱA542DA7E2496A56B

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	H0Y721	H0Y721_HUMAN		CDK5 regulatory subunit-associated ... CDK5 regulatory subunit-associated protein 1	CDK5RAP1	256	Annotation score:

Sequence cautionⁱ

The sequence AAD34147 differs from that shown. Reason: Frameshift at positions 3, 32, 128, 133 and 569.Curated

The sequence AAF29131 differs from that shown. Reason: Frameshift at positions 213, 244, 267 and 282.Curated

The sequence BAB55120 differs from that shown. Reason: Erroneous termination at position 500. Translated as Glu.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	213	R → Q in AAH01215 (PubMed:15489334).Curated	1
Sequence conflictⁱ	217	V → D (PubMed:11042152).Curated	1
Sequence conflictⁱ	269	F → L in BAB55120 (PubMed:14702039).Curated	1
Sequence conflictⁱ	282	I → T in BAB55120 (PubMed:14702039).Curated	1
Sequence conflictⁱ	323	D → G in BAB55120 (PubMed:14702039).Curated	1
Sequence conflictⁱ	464	V → A in BAB14760 (PubMed:14702039).Curated	1
Sequence conflictⁱ	511	T → S in AAF29131 (PubMed:11042152).Curated	1
Sequence conflictⁱ	579	Missing (PubMed:10810093).Curated	1
Sequence conflictⁱ	585	R → K in BAB14760 (PubMed:14702039).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_007560	1 – 90	Missing in isoform 2. 1 PublicationAdd BLAST	90
Alternative sequenceⁱVSP_047799	292 – 305	Missing in isoform 5 and isoform 6. 1 PublicationAdd BLAST	14
Alternative sequenceⁱVSP_007561	293 – 383	Missing in isoform 4. 1 PublicationAdd BLAST	91
Alternative sequenceⁱVSP_007562	293 – 306	Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST	14
Alternative sequenceⁱVSP_047800	435 – 440	GVSLSS → EDTGIS in isoform 5. 1 Publication	6
Alternative sequenceⁱVSP_047801	441 – 601	Missing in isoform 5. 1 PublicationAdd BLAST	161
Alternative sequenceⁱVSP_047802	576 – 601	ITSAS…SSAYC → VRSPFGLLACTVK in isoform 6. 1 PublicationAdd BLAST	26

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF152097 mRNA Translation: AAD34147.1 Frameshift. AF161516 mRNA Translation: AAF29131.1 Frameshift. AY462283 mRNA Translation: AAS18317.1 AY462284 mRNA Translation: AAS18318.1 AK023992 mRNA Translation: BAB14760.1 AK027449 mRNA Translation: BAB55120.1 Sequence problems. AK292075 mRNA Translation: BAF84764.1 AL355392 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW76319.1 CH471077 Genomic DNA Translation: EAW76322.1 CH471077 Genomic DNA Translation: EAW76323.1 BC001215 mRNA Translation: AAH01215.1 BC050706 mRNA Translation: AAH50706.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13219.1 [Q96SZ6-3] CCDS63255.1 [Q96SZ6-4]
NCBI Reference Sequences More...RefSeqⁱ	NP_001265097.1, NM_001278168.1 [Q96SZ6-4] NP_001265098.1, NM_001278169.1 NP_057166.4, NM_016082.4 NP_057492.2, NM_016408.3 [Q96SZ6-3]
UniGeneⁱ	Hs.435952

Genome annotation databases

Ensemblⁱ	ENST00000339269; ENSP00000341840; ENSG00000101391 [Q96SZ6-4] ENST00000346416; ENSP00000217372; ENSG00000101391 [Q96SZ6-3] ENST00000357886; ENSP00000350558; ENSG00000101391 [Q96SZ6-1] ENST00000473997; ENSP00000476857; ENSG00000101391 [Q96SZ6-2]
GeneIDⁱ	51654
KEGGⁱ	hsa:51654
UCSC genome browser More...UCSCⁱ	uc002wyz.5 human [Q96SZ6-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length	Source
Q96SZ6	Uncharacterized protein		PONAB		636	UniRef90_Q96SZ6
Uncharacterized protein		NOMLE		601
Uncharacterized protein		MACFA		601
Uncharacterized protein		MACMU		601
Uncharacterized protein		PAPAN		601
+65
Q96SZ6-3	CDK5 regulatory subunit associated protein 1 isoform 2 (Fragment)		HUMAN		587	UniRef90_Q96SZ6-3
Putative cdk5 activator-binding protein		DESRO		592
Uncharacterized protein		MYOLU		591
CDK5 regulatory subunit associated protein 1		HORSE		590
Uncharacterized protein		Cebus capucinus imitator		587
+61
Q96SZ6-4	CDK5 regulatory subunit associated protein 1 isoform 1 (Fragment)		HUMAN		510	UniRef90_Q96SZ6-4
Uncharacterized protein		COLAP		510
Uncharacterized protein		RHIRO		510
Uncharacterized protein		RHIBE		510
Uncharacterized protein		NOMLE		510
+26
Q96SZ6-5	CDK5 regulatory subunit associated protein 1 transcript variant 4 (Fragment)		NEOVI		397	UniRef90_Q96SZ6-5

Protein	Similar proteins		Species	Score	Length	Source
Q96SZ6	CDK5 regulatory subunit-associated protein 1		MOUSE		588	UniRef50_Q96SZ6
CDK5 regulatory subunit-associated protein 1		RAT		586
CDK5RAP1-like protein		DROME		583
Uncharacterized protein		PONAB		636
Uncharacterized protein		PAPAN		601
+633
Q96SZ6-5	CDK5 regulatory subunit associated protein 1 transcript variant 4 (Fragment)		NEOVI		397	UniRef50_Q96SZ6-5
CDK5 regulatory subunit associated protein 1		ORYLA		423
Uncharacterized protein		BAMTH		370
CDK5 regulatory subunit-associated protein 1 isoform 2		SCOMX		402
CDK5 regulatory subunit associated protein 1		TAKRU		382
+8

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF152097 mRNA Translation: AAD34147.1 Frameshift. AF161516 mRNA Translation: AAF29131.1 Frameshift. AY462283 mRNA Translation: AAS18317.1 AY462284 mRNA Translation: AAS18318.1 AK023992 mRNA Translation: BAB14760.1 AK027449 mRNA Translation: BAB55120.1 Sequence problems. AK292075 mRNA Translation: BAF84764.1 AL355392 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW76319.1 CH471077 Genomic DNA Translation: EAW76322.1 CH471077 Genomic DNA Translation: EAW76323.1 BC001215 mRNA Translation: AAH01215.1 BC050706 mRNA Translation: AAH50706.1
CCDSⁱ	CCDS13219.1 [Q96SZ6-3] CCDS63255.1 [Q96SZ6-4]
RefSeqⁱ	NP_001265097.1, NM_001278168.1 [Q96SZ6-4] NP_001265098.1, NM_001278169.1 NP_057166.4, NM_016082.4 NP_057492.2, NM_016408.3 [Q96SZ6-3]
UniGeneⁱ	Hs.435952

3D structure databases

ProteinModelPortalⁱ	Q96SZ6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119661, 25 interactors
IntActⁱ	Q96SZ6, 6 interactors
STRINGⁱ	9606.ENSP00000217372

PTM databases

iPTMnetⁱ	Q96SZ6
PhosphoSitePlusⁱ	Q96SZ6

Polymorphism and mutation databases

DMDMⁱ	32129446

DMDMⁱ

32129446

Proteomic databases

EPDⁱ	Q96SZ6
MaxQBⁱ	Q96SZ6
PaxDbⁱ	Q96SZ6
PeptideAtlasⁱ	Q96SZ6
PRIDEⁱ	Q96SZ6
ProteomicsDBⁱ	78165 78166 [Q96SZ6-2] 78167 [Q96SZ6-3] 78168 [Q96SZ6-4]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	51654
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000339269; ENSP00000341840; ENSG00000101391 [Q96SZ6-4] ENST00000346416; ENSP00000217372; ENSG00000101391 [Q96SZ6-3] ENST00000357886; ENSP00000350558; ENSG00000101391 [Q96SZ6-1] ENST00000473997; ENSP00000476857; ENSG00000101391 [Q96SZ6-2]
GeneIDⁱ	51654
KEGGⁱ	hsa:51654
UCSCⁱ	uc002wyz.5 human [Q96SZ6-1]

Organism-specific databases

CTDⁱ	51654
DisGeNETⁱ	51654
EuPathDBⁱ	HostDB:ENSG00000101391.20
GeneCardsⁱ	CDK5RAP1
HGNCⁱ	HGNC:15880 CDK5RAP1
HPAⁱ	HPA066301
MIMⁱ	608200 gene
neXtProtⁱ	NX_Q96SZ6
OpenTargetsⁱ	ENSG00000101391
PharmGKBⁱ	PA26313
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2492 Eukaryota COG0621 LUCA
GeneTreeⁱ	ENSGT00530000063447
HOVERGENⁱ	HBG050975
InParanoidⁱ	Q96SZ6
OMAⁱ	KVCEHFH
OrthoDBⁱ	EOG091G07M5
PhylomeDBⁱ	Q96SZ6
TreeFamⁱ	TF101033

Miscellaneous databases

ChiTaRSⁱ	CDK5RAP1 human
GeneWikiⁱ	CDK5RAP1
GenomeRNAiⁱ	51654
Protein Ontology More...PROⁱ	PR:Q96SZ6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000101391 Expressed in 226 organ(s), highest expression level in small intestine Peyer's patch
CleanExⁱ	HS_CDK5RAP1
ExpressionAtlasⁱ	Q96SZ6 baseline and differential
Genevisibleⁱ	Q96SZ6 HS

Family and domain databases

Gene3Dⁱ	3.40.50.12160, 1 hit 3.80.30.20, 1 hit
HAMAPⁱ	MF_01864 tRNA_metthiotr_MiaB, 1 hit
InterProⁱ	View protein in InterPro IPR006638 Elp3/MiaB/NifB IPR005839 Methylthiotransferase IPR020612 Methylthiotransferase_CS IPR013848 Methylthiotransferase_N IPR038135 Methylthiotransferase_N_sf IPR006463 MiaB_methiolase IPR007197 rSAM IPR023404 rSAM_horseshoe IPR002792 TRAM_dom
Pfamⁱ	View protein in Pfam PF04055 Radical_SAM, 1 hit PF01938 TRAM, 1 hit PF00919 UPF0004, 1 hit
SFLDⁱ	SFLDF00273 (dimethylallyl)adenosine_tRNA_, 1 hit SFLDG01061 methylthiotransferase, 2 hits SFLDS00029 Radical_SAM, 3 hits
SMARTⁱ	View protein in SMART SM00729 Elp3, 1 hit
TIGRFAMsⁱ	TIGR00089 TIGR00089, 1 hit
PROSITEⁱ	View protein in PROSITE PS51449 MTTASE_N, 1 hit PS01278 MTTASE_RADICAL, 1 hit PS50926 TRAM, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CK5P1_HUMAN
Accessionⁱ	Q96SZ6Primary (citable) accession number: Q96SZ6 Secondary accession number(s): A8K7R0 Q9Y3F0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 16, 2003
	Last sequence update:	June 16, 2003
	Last modified:	November 7, 2018
	This is version 162 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q96SZ6 (CK5P1_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

CDK5 regulatory subunit-associated protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ