Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

2-aminoethanethiol dioxygenase

Gene

ADO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Fe cationBy similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDioxygenase, Oxidoreductase
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS17749-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.13.11.19 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1614558 Degradation of cysteine and homocysteine

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
2-aminoethanethiol dioxygenase (EC:1.13.11.19)
Alternative name(s):
Cysteamine dioxygenase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADO
Synonyms:C10orf22
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000181915.4

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23506 ADO

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611392 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96SZ5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
84890

Open Targets

More...
OpenTargetsi
ENSG00000181915

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162375713

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ADO

Domain mapping of disease mutations (DMDM)

More...
DMDMi
88984104

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000897841 – 2702-aminoethanethiol dioxygenaseAdd BLAST270

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96SZ5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96SZ5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96SZ5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96SZ5

PeptideAtlas

More...
PeptideAtlasi
Q96SZ5

PRoteomics IDEntifications database

More...
PRIDEi
Q96SZ5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
78164

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96SZ5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96SZ5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000181915 Expressed in 236 organ(s), highest expression level in sperm

CleanEx database of gene expression profiles

More...
CleanExi
HS_ADO

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96SZ5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA039194
HPA040437

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124330, 10 interactors

Protein interaction database and analysis system

More...
IntActi
Q96SZ5, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000362888

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q96SZ5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4281 Eukaryota
ENOG4111Y3H LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000014082

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000037604

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG050966

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96SZ5

KEGG Orthology (KO)

More...
KOi
K10712

Identification of Orthologs from Complete Genome Data

More...
OMAi
SCMDKLE

Database of Orthologous Groups

More...
OrthoDBi
929927at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96SZ5

TreeFam database of animal gene trees

More...
TreeFami
TF314673

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012864 PCO/ADO
IPR011051 RmlC_Cupin_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07847 PCO_ADO, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51182 SSF51182, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q96SZ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRDNMASLI QRIARQACLT FRGSGGGRGA SDRDAASGPE APMQPGFPEN
60 70 80 90 100
LSKLKSLLTQ LRAEDLNIAP RKATLQPLPP NLPPVTYMHI YETDGFSLGV
110 120 130 140 150
FLLKSGTSIP LHDHPGMHGM LKVLYGTVRI SCMDKLDAGG GQRPRALPPE
160 170 180 190 200
QQFEPPLQPR EREAVRPGVL RSRAEYTEAS GPCILTPHRD NLHQIDAVEG
210 220 230 240 250
PAAFLDILAP PYDPDDGRDC HYYRVLEPVR PKEASSSACD LPREVWLLET
260 270
PQADDFWCEG EPYPGPKVFP
Length:270
Mass (Da):29,751
Last modified:February 21, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6B496CCF16E92C9D
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB55123 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02533325G → W1 PublicationCorresponds to variant dbSNP:rs2236295Ensembl.1
Natural variantiVAR_02533439P → A2 PublicationsCorresponds to variant dbSNP:rs10995311Ensembl.1
Natural variantiVAR_033691266P → S. Corresponds to variant dbSNP:rs569705Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL133417 Genomic DNA No translation available.
CH471083 Genomic DNA Translation: EAW54235.1
BC018660 mRNA Translation: AAH18660.3
BC028589 mRNA Translation: AAH28589.2
BC067740 mRNA Translation: AAH67740.2
AK027453 mRNA Translation: BAB55123.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7266.2

NCBI Reference Sequences

More...
RefSeqi
NP_116193.2, NM_032804.5

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.99821

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000373783; ENSP00000362888; ENSG00000181915

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84890

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84890

UCSC genome browser

More...
UCSCi
uc001jmg.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL133417 Genomic DNA No translation available.
CH471083 Genomic DNA Translation: EAW54235.1
BC018660 mRNA Translation: AAH18660.3
BC028589 mRNA Translation: AAH28589.2
BC067740 mRNA Translation: AAH67740.2
AK027453 mRNA Translation: BAB55123.1 Different initiation.
CCDSiCCDS7266.2
RefSeqiNP_116193.2, NM_032804.5
UniGeneiHs.99821

3D structure databases

ProteinModelPortaliQ96SZ5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124330, 10 interactors
IntActiQ96SZ5, 3 interactors
STRINGi9606.ENSP00000362888

PTM databases

iPTMnetiQ96SZ5
PhosphoSitePlusiQ96SZ5

Polymorphism and mutation databases

BioMutaiADO
DMDMi88984104

Proteomic databases

EPDiQ96SZ5
jPOSTiQ96SZ5
MaxQBiQ96SZ5
PaxDbiQ96SZ5
PeptideAtlasiQ96SZ5
PRIDEiQ96SZ5
ProteomicsDBi78164

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373783; ENSP00000362888; ENSG00000181915
GeneIDi84890
KEGGihsa:84890
UCSCiuc001jmg.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84890
DisGeNETi84890
EuPathDBiHostDB:ENSG00000181915.4

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ADO

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0008860
HGNCiHGNC:23506 ADO
HPAiHPA039194
HPA040437
MIMi611392 gene
neXtProtiNX_Q96SZ5
OpenTargetsiENSG00000181915
PharmGKBiPA162375713

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4281 Eukaryota
ENOG4111Y3H LUCA
GeneTreeiENSGT00390000014082
HOGENOMiHOG000037604
HOVERGENiHBG050966
InParanoidiQ96SZ5
KOiK10712
OMAiSCMDKLE
OrthoDBi929927at2759
PhylomeDBiQ96SZ5
TreeFamiTF314673

Enzyme and pathway databases

BioCyciMetaCyc:HS17749-MONOMER
BRENDAi1.13.11.19 2681
ReactomeiR-HSA-1614558 Degradation of cysteine and homocysteine

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ADO human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
84890

Protein Ontology

More...
PROi
PR:Q96SZ5

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000181915 Expressed in 236 organ(s), highest expression level in sperm
CleanExiHS_ADO
GenevisibleiQ96SZ5 HS

Family and domain databases

InterProiView protein in InterPro
IPR012864 PCO/ADO
IPR011051 RmlC_Cupin_sf
PfamiView protein in Pfam
PF07847 PCO_ADO, 1 hit
SUPFAMiSSF51182 SSF51182, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAEDO_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96SZ5
Secondary accession number(s): B1AL29
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: February 21, 2006
Last modified: January 16, 2019
This is version 132 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again