Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

2-aminoethanethiol dioxygenase

Gene

ADO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

2-aminoethanethiol + O2 = hypotaurine.1 Publication

Cofactori

Fe cationBy similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDioxygenase, Oxidoreductase
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS17749-MONOMER
BRENDAi1.13.11.19 2681
ReactomeiR-HSA-1614558 Degradation of cysteine and homocysteine

Names & Taxonomyi

Protein namesi
Recommended name:
2-aminoethanethiol dioxygenase (EC:1.13.11.19)
Alternative name(s):
Cysteamine dioxygenase
Gene namesi
Name:ADO
Synonyms:C10orf22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000181915.4
HGNCiHGNC:23506 ADO
MIMi611392 gene
neXtProtiNX_Q96SZ5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi84890
OpenTargetsiENSG00000181915
PharmGKBiPA162375713

Polymorphism and mutation databases

BioMutaiADO
DMDMi88984104

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000897841 – 2702-aminoethanethiol dioxygenaseAdd BLAST270

Proteomic databases

EPDiQ96SZ5
MaxQBiQ96SZ5
PaxDbiQ96SZ5
PeptideAtlasiQ96SZ5
PRIDEiQ96SZ5
ProteomicsDBi78164

PTM databases

iPTMnetiQ96SZ5
PhosphoSitePlusiQ96SZ5

Expressioni

Gene expression databases

BgeeiENSG00000181915 Expressed in 236 organ(s), highest expression level in sperm
CleanExiHS_ADO
GenevisibleiQ96SZ5 HS

Organism-specific databases

HPAiHPA039194
HPA040437

Interactioni

Protein-protein interaction databases

BioGridi124330, 10 interactors
IntActiQ96SZ5, 3 interactors
STRINGi9606.ENSP00000362888

Structurei

3D structure databases

ProteinModelPortaliQ96SZ5
SMRiQ96SZ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG4281 Eukaryota
ENOG4111Y3H LUCA
GeneTreeiENSGT00390000014082
HOGENOMiHOG000037604
HOVERGENiHBG050966
InParanoidiQ96SZ5
KOiK10712
OMAiSCMDKLE
OrthoDBiEOG091G0QE1
PhylomeDBiQ96SZ5
TreeFamiTF314673

Family and domain databases

InterProiView protein in InterPro
IPR012864 PCO/ADO
IPR011051 RmlC_Cupin_sf
PfamiView protein in Pfam
PF07847 PCO_ADO, 1 hit
SUPFAMiSSF51182 SSF51182, 1 hit

Sequencei

Sequence statusi: Complete.

Q96SZ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRDNMASLI QRIARQACLT FRGSGGGRGA SDRDAASGPE APMQPGFPEN
60 70 80 90 100
LSKLKSLLTQ LRAEDLNIAP RKATLQPLPP NLPPVTYMHI YETDGFSLGV
110 120 130 140 150
FLLKSGTSIP LHDHPGMHGM LKVLYGTVRI SCMDKLDAGG GQRPRALPPE
160 170 180 190 200
QQFEPPLQPR EREAVRPGVL RSRAEYTEAS GPCILTPHRD NLHQIDAVEG
210 220 230 240 250
PAAFLDILAP PYDPDDGRDC HYYRVLEPVR PKEASSSACD LPREVWLLET
260 270
PQADDFWCEG EPYPGPKVFP
Length:270
Mass (Da):29,751
Last modified:February 21, 2006 - v2
Checksum:i6B496CCF16E92C9D
GO

Sequence cautioni

The sequence BAB55123 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02533325G → W1 PublicationCorresponds to variant dbSNP:rs2236295Ensembl.1
Natural variantiVAR_02533439P → A2 PublicationsCorresponds to variant dbSNP:rs10995311Ensembl.1
Natural variantiVAR_033691266P → S. Corresponds to variant dbSNP:rs569705Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL133417 Genomic DNA No translation available.
CH471083 Genomic DNA Translation: EAW54235.1
BC018660 mRNA Translation: AAH18660.3
BC028589 mRNA Translation: AAH28589.2
BC067740 mRNA Translation: AAH67740.2
AK027453 mRNA Translation: BAB55123.1 Different initiation.
CCDSiCCDS7266.2
RefSeqiNP_116193.2, NM_032804.5
UniGeneiHs.99821

Genome annotation databases

EnsembliENST00000373783; ENSP00000362888; ENSG00000181915
GeneIDi84890
KEGGihsa:84890
UCSCiuc001jmg.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL133417 Genomic DNA No translation available.
CH471083 Genomic DNA Translation: EAW54235.1
BC018660 mRNA Translation: AAH18660.3
BC028589 mRNA Translation: AAH28589.2
BC067740 mRNA Translation: AAH67740.2
AK027453 mRNA Translation: BAB55123.1 Different initiation.
CCDSiCCDS7266.2
RefSeqiNP_116193.2, NM_032804.5
UniGeneiHs.99821

3D structure databases

ProteinModelPortaliQ96SZ5
SMRiQ96SZ5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124330, 10 interactors
IntActiQ96SZ5, 3 interactors
STRINGi9606.ENSP00000362888

PTM databases

iPTMnetiQ96SZ5
PhosphoSitePlusiQ96SZ5

Polymorphism and mutation databases

BioMutaiADO
DMDMi88984104

Proteomic databases

EPDiQ96SZ5
MaxQBiQ96SZ5
PaxDbiQ96SZ5
PeptideAtlasiQ96SZ5
PRIDEiQ96SZ5
ProteomicsDBi78164

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373783; ENSP00000362888; ENSG00000181915
GeneIDi84890
KEGGihsa:84890
UCSCiuc001jmg.4 human

Organism-specific databases

CTDi84890
DisGeNETi84890
EuPathDBiHostDB:ENSG00000181915.4
GeneCardsiADO
H-InvDBiHIX0008860
HGNCiHGNC:23506 ADO
HPAiHPA039194
HPA040437
MIMi611392 gene
neXtProtiNX_Q96SZ5
OpenTargetsiENSG00000181915
PharmGKBiPA162375713
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4281 Eukaryota
ENOG4111Y3H LUCA
GeneTreeiENSGT00390000014082
HOGENOMiHOG000037604
HOVERGENiHBG050966
InParanoidiQ96SZ5
KOiK10712
OMAiSCMDKLE
OrthoDBiEOG091G0QE1
PhylomeDBiQ96SZ5
TreeFamiTF314673

Enzyme and pathway databases

BioCyciMetaCyc:HS17749-MONOMER
BRENDAi1.13.11.19 2681
ReactomeiR-HSA-1614558 Degradation of cysteine and homocysteine

Miscellaneous databases

ChiTaRSiADO human
GenomeRNAii84890
PROiPR:Q96SZ5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000181915 Expressed in 236 organ(s), highest expression level in sperm
CleanExiHS_ADO
GenevisibleiQ96SZ5 HS

Family and domain databases

InterProiView protein in InterPro
IPR012864 PCO/ADO
IPR011051 RmlC_Cupin_sf
PfamiView protein in Pfam
PF07847 PCO_ADO, 1 hit
SUPFAMiSSF51182 SSF51182, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAEDO_HUMAN
AccessioniPrimary (citable) accession number: Q96SZ5
Secondary accession number(s): B1AL29
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: February 21, 2006
Last modified: September 12, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again