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Entry version 144 (11 Dec 2019)
Sequence version 1 (01 Dec 2001)
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Protein

Zinc finger and SCAN domain-containing protein 10

Gene

ZSCAN10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Embryonic stem (ES) cell-specific transcription factor required to maintain ES cell pluripotency. Can both activate and /or repress expression of target genes, depending on the context. Specifically binds the 5'-[GA]CGCNNGCG[CT]-3' DNA consensus sequence. Regulates expression of POU5F1/OCT4, ZSCAN4 and ALYREF/THOC4.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri292 – 315C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri321 – 343C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri349 – 371C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri377 – 399C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri421 – 443C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri467 – 489C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri495 – 517C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri523 – 545C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri551 – 573C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri579 – 601C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri607 – 629C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri635 – 657C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri669 – 691C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri697 – 719C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-452723 Transcriptional regulation of pluripotent stem cells

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 10
Alternative name(s):
Zinc finger protein 206
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZSCAN10
Synonyms:ZNF206
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000130182.7

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12997 ZSCAN10

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
618365 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96SZ4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi428Q → R: Abolishes methylation by N6AMT1. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
84891

Open Targets

More...
OpenTargetsi
ENSG00000130182

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162410957

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96SZ4 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZSCAN10

Domain mapping of disease mutations (DMDM)

More...
DMDMi
55976759

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000474521 – 725Zinc finger and SCAN domain-containing protein 10Add BLAST725

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei107PhosphoserineCombined sources1
Modified residuei153PhosphoserineCombined sources1
Modified residuei213PhosphothreonineCombined sources1
Modified residuei428N5-methylglutamine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Methylated at Gln-428 by N6AMT1.1 Publication

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q96SZ4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96SZ4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96SZ4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96SZ4

PeptideAtlas

More...
PeptideAtlasi
Q96SZ4

PRoteomics IDEntifications database

More...
PRIDEi
Q96SZ4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
38166
78162 [Q96SZ4-1]
78163 [Q96SZ4-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96SZ4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96SZ4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000130182 Expressed in 37 organ(s), highest expression level in intestine

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96SZ4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96SZ4 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with POU5F1/OCT4 and SOX2.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
124331, 2 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000252463

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96SZ4 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96SZ4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 71SCAN boxPROSITE-ProRule annotationAdd BLAST71

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi104 – 175Pro-richAdd BLAST72

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri292 – 315C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri321 – 343C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri349 – 371C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri377 – 399C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri421 – 443C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri467 – 489C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri495 – 517C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri523 – 545C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri551 – 573C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri579 – 601C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri607 – 629C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri635 – 657C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri669 – 691C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri697 – 719C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162513

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234619

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96SZ4

KEGG Orthology (KO)

More...
KOi
K09230

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96SZ4

TreeFam database of animal gene trees

More...
TreeFami
TF338010

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.4020.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 11 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 14 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667 SSF57667, 8 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 14 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96SZ4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGPRASLSRL RELCGHWLRP ALHTKKQILE LLVLEQFLSV LPPHLLGRLQ
60 70 80 90 100
GQPLRDGEEV VLLLEGIHRE PSHAGPLDFS CNAGKSCPRA DVTLEEKGCA
110 120 130 140 150
SQVPSHSPKK ELPAEEPSVL GPSDEPPRPQ PRAAQPAEPG QWRLPPSSKQ
160 170 180 190 200
PLSPGPQKTF QALQESSPQG PSPWPEESSR DQELAAVLEC LTFEDVPENK
210 220 230 240 250
AWPAHPLGFG SRTPDKEEFK QEEPKGAAWP TPILAESQAD SPGVPGEPCA
260 270 280 290 300
QSLGRGAAAS GPGEDGSLLG SSEILEVKVA EGVPEPNPEL QFICADCGVS
310 320 330 340 350
FPQLSRLKAH QLRSHPAGRS FLCLCCGKSF GRSSILKLHM RTHTDERPHA
360 370 380 390 400
CHLCGHRFRQ SSHLSKHLLT HSSEPAFLCA ECGRGFQRRA SLVQHLLAHA
410 420 430 440 450
QDQKPPCAPE SKAEAPPLTD VLCSHCGQSF QRRSSLKRHL RIHARDKDRR
460 470 480 490 500
SSEGSGSRRR DSDRRPFVCS DCGKAFRRSE HLVAHRRVHT GERPFSCQAC
510 520 530 540 550
GRSFTQSSQL VSHQRVHTGE KPYACPQCGK RFVRRASLAR HLLTHGGPRP
560 570 580 590 600
HHCTQCGKSF GQTQDLARHQ RSHTGEKPCR CSECGEGFSQ SAHLARHQRI
610 620 630 640 650
HTGEKPHACD TCGHRFRNSS NLARHRRSHT GERPYSCQTC GRSFRRNAHL
660 670 680 690 700
RRHLATHAEP GQEQAEPPQE CVECGKSFSR SCNLLRHLLV HTGARPYSCT
710 720
QCGRSFSRNS HLLRHLRTHA RETLY
Length:725
Mass (Da):80,387
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i046163DA13669F12
GO
Isoform 2 (identifier: Q96SZ4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-339: Missing.

Show »
Length:386
Mass (Da):43,934
Checksum:i635DE92DB23BD813
GO
Isoform 3 (identifier: Q96SZ4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: MGPRASLSRL...PLDFSCNAGK → MLPVSGGHGA...PGAQPRGAAG
     86-167: Missing.

Show »
Length:643
Mass (Da):69,665
Checksum:i4CF46847F24FE3D6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L1J3I3L1J3_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN10
780Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L0Q3I3L0Q3_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN10
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3NI43I3NI43_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN10
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI14453 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0392211 – 339Missing in isoform 2. 1 PublicationAdd BLAST339
Alternative sequenceiVSP_0546011 – 85MGPRA…CNAGK → MLPVSGGHGATGVPEPAPGA LRPLAAAGSAHQETDPGAAG AGAVPECAASAPPGPPAGAA AQGWGGGGAAARGHPPGAQP RGAAG in isoform 3. 1 PublicationAdd BLAST85
Alternative sequenceiVSP_05460286 – 167Missing in isoform 3. 1 PublicationAdd BLAST82

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK027455 mRNA Translation: BAB55124.1
AK074736 mRNA Translation: BAG51995.1
AC108134 Genomic DNA No translation available.
BC114452 mRNA Translation: AAI14453.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS61813.1 [Q96SZ4-2]
CCDS61814.1 [Q96SZ4-3]

NCBI Reference Sequences

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RefSeqi
NP_001269344.1, NM_001282415.1 [Q96SZ4-2]
NP_001269345.1, NM_001282416.1 [Q96SZ4-3]
NP_116194.2, NM_032805.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000252463; ENSP00000252463; ENSG00000130182 [Q96SZ4-1]
ENST00000538082; ENSP00000440047; ENSG00000130182 [Q96SZ4-3]
ENST00000575108; ENSP00000459520; ENSG00000130182 [Q96SZ4-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
84891

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:84891

UCSC genome browser

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UCSCi
uc002ctv.3 human [Q96SZ4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027455 mRNA Translation: BAB55124.1
AK074736 mRNA Translation: BAG51995.1
AC108134 Genomic DNA No translation available.
BC114452 mRNA Translation: AAI14453.1 Different initiation.
CCDSiCCDS61813.1 [Q96SZ4-2]
CCDS61814.1 [Q96SZ4-3]
RefSeqiNP_001269344.1, NM_001282415.1 [Q96SZ4-2]
NP_001269345.1, NM_001282416.1 [Q96SZ4-3]
NP_116194.2, NM_032805.2

3D structure databases

SMRiQ96SZ4
ModBaseiSearch...

Protein-protein interaction databases

BioGridi124331, 2 interactors
STRINGi9606.ENSP00000252463

PTM databases

iPTMnetiQ96SZ4
PhosphoSitePlusiQ96SZ4

Polymorphism and mutation databases

BioMutaiZSCAN10
DMDMi55976759

Proteomic databases

EPDiQ96SZ4
jPOSTiQ96SZ4
MassIVEiQ96SZ4
PaxDbiQ96SZ4
PeptideAtlasiQ96SZ4
PRIDEiQ96SZ4
ProteomicsDBi38166
78162 [Q96SZ4-1]
78163 [Q96SZ4-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
84891

Genome annotation databases

EnsembliENST00000252463; ENSP00000252463; ENSG00000130182 [Q96SZ4-1]
ENST00000538082; ENSP00000440047; ENSG00000130182 [Q96SZ4-3]
ENST00000575108; ENSP00000459520; ENSG00000130182 [Q96SZ4-2]
GeneIDi84891
KEGGihsa:84891
UCSCiuc002ctv.3 human [Q96SZ4-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
84891
DisGeNETi84891
EuPathDBiHostDB:ENSG00000130182.7

GeneCards: human genes, protein and diseases

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GeneCardsi
ZSCAN10
HGNCiHGNC:12997 ZSCAN10
MIMi618365 gene
neXtProtiNX_Q96SZ4
OpenTargetsiENSG00000130182
PharmGKBiPA162410957

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000162513
HOGENOMiHOG000234619
InParanoidiQ96SZ4
KOiK09230
OrthoDBi1318335at2759
PhylomeDBiQ96SZ4
TreeFamiTF338010

Enzyme and pathway databases

ReactomeiR-HSA-452723 Transcriptional regulation of pluripotent stem cells

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZSCAN10 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84891
PharosiQ96SZ4 Tdark

Protein Ontology

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PROi
PR:Q96SZ4
RNActiQ96SZ4 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000130182 Expressed in 37 organ(s), highest expression level in intestine
ExpressionAtlasiQ96SZ4 baseline and differential
GenevisibleiQ96SZ4 HS

Family and domain databases

Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 11 hits
SMARTiView protein in SMART
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 14 hits
SUPFAMiSSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 14 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZSC10_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96SZ4
Secondary accession number(s): B3KQD3, H0YFS6, Q1WWM2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: December 1, 2001
Last modified: December 11, 2019
This is version 144 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
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