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Protein

Integrator complex subunit 14

Gene

INTS14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.By similarity

GO - Biological processi

  • snRNA 3'-end processing Source: GO_Central
  • snRNA transcription by RNA polymerase II Source: Reactome

Enzyme and pathway databases

ReactomeiR-HSA-6807505 RNA polymerase II transcribes snRNA genes

Names & Taxonomyi

Protein namesi
Recommended name:
Integrator complex subunit 14Imported
Alternative name(s):
von Willebrand factor A domain-containing protein 9
Gene namesi
Name:INTS14Imported
Synonyms:C15orf44Imported, VWA9Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000138614.14
HGNCiHGNC:25372 INTS14
neXtProtiNX_Q96SY0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000138614
PharmGKBiPA142672279

Polymorphism and mutation databases

BioMutaiVWA9
DMDMi156631025

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002962661 – 518Integrator complex subunit 14Add BLAST518

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei418N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ96SY0
MaxQBiQ96SY0
PaxDbiQ96SY0
PeptideAtlasiQ96SY0
PRIDEiQ96SY0
ProteomicsDBi78159
78160 [Q96SY0-2]
78161 [Q96SY0-3]

PTM databases

iPTMnetiQ96SY0
PhosphoSitePlusiQ96SY0

Expressioni

Tissue specificityi

Strongly expressed in numerous cancer cells compared with their non-cancerous counterparts (lung, prostate, colon, stomach and skin).1 Publication

Gene expression databases

BgeeiENSG00000138614 Expressed in 185 organ(s), highest expression level in lung
CleanExiHS_C15orf44
ExpressionAtlasiQ96SY0 baseline and differential
GenevisibleiQ96SY0 HS

Organism-specific databases

HPAiHPA040255
HPA040651

Interactioni

Protein-protein interaction databases

BioGridi123520, 51 interactors
IntActiQ96SY0, 35 interactors
STRINGi9606.ENSP00000326379

Structurei

3D structure databases

ProteinModelPortaliQ96SY0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 204VWFAAdd BLAST203

Sequence similaritiesi

Belongs to the INTS14 family.Curated

Phylogenomic databases

eggNOGiENOG410IF13 Eukaryota
ENOG410XP9S LUCA
GeneTreeiENSGT00390000009486
HOGENOMiHOG000006970
HOVERGENiHBG103632
InParanoidiQ96SY0
PhylomeDBiQ96SY0
TreeFamiTF323245

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR039841 INTS14
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PANTHERiPTHR13532:SF3 PTHR13532:SF3, 1 hit
PfamiView protein in Pfam
PF13519 VWA_2, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96SY0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPTVVVMDVS LSMTRPVSIE GSEEYQRKHL AAHGLTMLFE HMATNYKLEF
60 70 80 90 100
TALVVFSSLW ELMVPFTRDY NTLQEALSNM DDYDKTCLES ALVGVCNIVQ
110 120 130 140 150
QEWGGAIPCQ VVLVTDGCLG IGRGSLRHSL ATQNQRSESN RFPLPFPFPS
160 170 180 190 200
KLYIMCMANL EELQSTDSLE CLERLIDLNN GEGQIFTIDG PLCLKNVQSM
210 220 230 240 250
FGKLIDLAYT PFHAVLKCGH LTADVQVFPR PEPFVVDEEI DPIPKVINTD
260 270 280 290 300
LEIVGFIDIA DISSPPVLSR HLVLPIALNK EGDEVGTGIT DDNEDENSAN
310 320 330 340 350
QIAGKIPNFC VLLHGSLKVE GMVAIVQLGP EWHGMLYSQA DSKKKSNLMM
360 370 380 390 400
SLFEPGPEPL PWLGKMAQLG PISDAKENPY GEDDNKSPFP LQPKNKRSYA
410 420 430 440 450
QNVTVWIKPS GLQTDVQKIL RNARKLPEKT QTFYKELNRL RKAALAFGFL
460 470 480 490 500
DLLKGVADML ERECTLLPET AHPDAAFQLT HAAQQLKLAS TGTSEYAAYD
510
QNITPLHTDF SGSSTERI
Length:518
Mass (Da):57,471
Last modified:July 24, 2007 - v2
Checksum:i5B05ED69BA6451BD
GO
Isoform 2 (identifier: Q96SY0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     75-86: EALSNMDDYDKT → VQNVVSYCMYRA
     87-518: Missing.

Note: No experimental confirmation available.
Show »
Length:86
Mass (Da):9,955
Checksum:i4A786D266330D86F
GO
Isoform 4 (identifier: Q96SY0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: Missing.

Show »
Length:439
Mass (Da):48,434
Checksum:i595E0A2240664F2C
GO
Isoform 3 (identifier: Q96SY0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     4-74: VVVMDVSLSM...PFTRDYNTLQ → ESLCRRTVSGDGHG

Note: No experimental confirmation available.
Show »
Length:461
Mass (Da):50,734
Checksum:i0830F22A6AA379FB
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DJL6B4DJL6_HUMAN
Integrator complex subunit 14
INTS14
554Annotation score:
H3BMK7H3BMK7_HUMAN
Integrator complex subunit 14
INTS14
169Annotation score:
B4DVT3B4DVT3_HUMAN
Integrator complex subunit 14
INTS14
482Annotation score:
H3BP17H3BP17_HUMAN
Integrator complex subunit 14
INTS14
154Annotation score:
H3BRY6H3BRY6_HUMAN
Integrator complex subunit 14
INTS14
468Annotation score:
H3BN95H3BN95_HUMAN
Integrator complex subunit 14
INTS14
71Annotation score:
H3BV25H3BV25_HUMAN
Integrator complex subunit 14
INTS14
76Annotation score:
H3BT02H3BT02_HUMAN
Integrator complex subunit 14
INTS14
39Annotation score:
H3BNR6H3BNR6_HUMAN
Integrator complex subunit 14
INTS14
57Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7M → I in AAH37823 (PubMed:15489334).Curated1
Sequence conflicti89E → G in CAB66597 (PubMed:11230166).Curated1
Sequence conflicti177D → Y in BAB55140 (PubMed:14702039).Curated1
Sequence conflicti206D → G in CAB66597 (PubMed:11230166).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0442501 – 79Missing in isoform 4. 1 PublicationAdd BLAST79
Alternative sequenceiVSP_0432774 – 74VVVMD…YNTLQ → ESLCRRTVSGDGHG in isoform 3. 1 PublicationAdd BLAST71
Alternative sequenceiVSP_02718075 – 86EALSN…DYDKT → VQNVVSYCMYRA in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_02718187 – 518Missing in isoform 2. 1 PublicationAdd BLAST432

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136662 mRNA Translation: CAB66597.1
AK301033 mRNA Translation: BAG62647.1
AK027475 mRNA Translation: BAB55140.1
AK293207 mRNA Translation: BAG56747.1
AC027220 Genomic DNA No translation available.
BC037823 mRNA Translation: AAH37823.1
BC007991 mRNA Translation: AAH07991.1
CCDSiCCDS45283.1 [Q96SY0-4]
CCDS55969.1 [Q96SY0-3]
RefSeqiNP_001129515.1, NM_001136043.2 [Q96SY0-4]
NP_001193987.1, NM_001207058.1
NP_001193988.1, NM_001207059.1 [Q96SY0-3]
XP_006720772.1, XM_006720709.3 [Q96SY0-4]
XP_006720774.1, XM_006720711.2 [Q96SY0-4]
XP_011520403.1, XM_011522101.2 [Q96SY0-4]
XP_016878133.1, XM_017022644.1 [Q96SY0-4]
UniGeneiHs.6686

Genome annotation databases

EnsembliENST00000313182; ENSP00000326379; ENSG00000138614 [Q96SY0-1]
ENST00000420799; ENSP00000408429; ENSG00000138614 [Q96SY0-3]
ENST00000431261; ENSP00000402898; ENSG00000138614 [Q96SY0-4]
GeneIDi81556
KEGGihsa:81556
UCSCiuc002ape.5 human [Q96SY0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136662 mRNA Translation: CAB66597.1
AK301033 mRNA Translation: BAG62647.1
AK027475 mRNA Translation: BAB55140.1
AK293207 mRNA Translation: BAG56747.1
AC027220 Genomic DNA No translation available.
BC037823 mRNA Translation: AAH37823.1
BC007991 mRNA Translation: AAH07991.1
CCDSiCCDS45283.1 [Q96SY0-4]
CCDS55969.1 [Q96SY0-3]
RefSeqiNP_001129515.1, NM_001136043.2 [Q96SY0-4]
NP_001193987.1, NM_001207058.1
NP_001193988.1, NM_001207059.1 [Q96SY0-3]
XP_006720772.1, XM_006720709.3 [Q96SY0-4]
XP_006720774.1, XM_006720711.2 [Q96SY0-4]
XP_011520403.1, XM_011522101.2 [Q96SY0-4]
XP_016878133.1, XM_017022644.1 [Q96SY0-4]
UniGeneiHs.6686

3D structure databases

ProteinModelPortaliQ96SY0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123520, 51 interactors
IntActiQ96SY0, 35 interactors
STRINGi9606.ENSP00000326379

PTM databases

iPTMnetiQ96SY0
PhosphoSitePlusiQ96SY0

Polymorphism and mutation databases

BioMutaiVWA9
DMDMi156631025

Proteomic databases

EPDiQ96SY0
MaxQBiQ96SY0
PaxDbiQ96SY0
PeptideAtlasiQ96SY0
PRIDEiQ96SY0
ProteomicsDBi78159
78160 [Q96SY0-2]
78161 [Q96SY0-3]

Protocols and materials databases

DNASUi81556
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313182; ENSP00000326379; ENSG00000138614 [Q96SY0-1]
ENST00000420799; ENSP00000408429; ENSG00000138614 [Q96SY0-3]
ENST00000431261; ENSP00000402898; ENSG00000138614 [Q96SY0-4]
GeneIDi81556
KEGGihsa:81556
UCSCiuc002ape.5 human [Q96SY0-1]

Organism-specific databases

CTDi81556
EuPathDBiHostDB:ENSG00000138614.14
GeneCardsiINTS14
H-InvDBiHIX0012354
HGNCiHGNC:25372 INTS14
HPAiHPA040255
HPA040651
neXtProtiNX_Q96SY0
OpenTargetsiENSG00000138614
PharmGKBiPA142672279
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF13 Eukaryota
ENOG410XP9S LUCA
GeneTreeiENSGT00390000009486
HOGENOMiHOG000006970
HOVERGENiHBG103632
InParanoidiQ96SY0
PhylomeDBiQ96SY0
TreeFamiTF323245

Enzyme and pathway databases

ReactomeiR-HSA-6807505 RNA polymerase II transcribes snRNA genes

Miscellaneous databases

ChiTaRSiVWA9 human
GenomeRNAii81556
PROiPR:Q96SY0

Gene expression databases

BgeeiENSG00000138614 Expressed in 185 organ(s), highest expression level in lung
CleanExiHS_C15orf44
ExpressionAtlasiQ96SY0 baseline and differential
GenevisibleiQ96SY0 HS

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR039841 INTS14
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PANTHERiPTHR13532:SF3 PTHR13532:SF3, 1 hit
PfamiView protein in Pfam
PF13519 VWA_2, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiINT14_HUMAN
AccessioniPrimary (citable) accession number: Q96SY0
Secondary accession number(s): B4DDI6
, B4DVD5, Q49AH8, Q96HX5, Q9H0S5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: November 7, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  3. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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