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Entry version 145 (13 Feb 2019)
Sequence version 2 (11 Feb 2002)
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Protein

Oxysterol-binding protein-related protein 9

Gene

OSBPL9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • lipid binding Source: GO_Central
  • sterol binding Source: GO_Central
  • sterol transporter activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processLipid transport, Transport
LigandLipid-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-192105 Synthesis of bile acids and bile salts

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Oxysterol-binding protein-related protein 9
Short name:
ORP-9
Short name:
OSBP-related protein 9
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OSBPL9
Synonyms:ORP9, OSBP4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000117859.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16386 OSBPL9

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606737 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96SU4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
114883

Open Targets

More...
OpenTargetsi
ENSG00000117859

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA32833

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
OSBPL9

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20139075

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001003792 – 736Oxysterol-binding protein-related protein 9Add BLAST735

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei306PhosphoserineCombined sources1
Modified residuei324PhosphoserineCombined sources1
Modified residuei325PhosphoserineCombined sources1
Modified residuei326PhosphoserineCombined sources1
Modified residuei329PhosphoserineCombined sources1
Modified residuei611PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96SU4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96SU4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96SU4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96SU4

PeptideAtlas

More...
PeptideAtlasi
Q96SU4

PRoteomics IDEntifications database

More...
PRIDEi
Q96SU4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
78150
78151 [Q96SU4-2]
78152 [Q96SU4-3]
78153 [Q96SU4-4]
78154 [Q96SU4-5]
78155 [Q96SU4-6]
78156 [Q96SU4-7]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96SU4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96SU4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000117859 Expressed in 223 organ(s), highest expression level in kidney

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96SU4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96SU4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA027378
HPA027397

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer with OSBPL11 (PubMed:20599956). Interacts with OSBPL10 (PubMed:22906437).2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125384, 27 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q96SU4

Protein interaction database and analysis system

More...
IntActi
Q96SU4, 22 interactors

Molecular INTeraction database

More...
MINTi
Q96SU4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000412733

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q96SU4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96SU4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 99PHPROSITE-ProRule annotationAdd BLAST98

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the OSBP family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2210 Eukaryota
ENOG410XRW6 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154690

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000233872

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG053376

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96SU4

KEGG Orthology (KO)

More...
KOi
K20465

Identification of Orthologs from Complete Genome Data

More...
OMAi
NPVDGIY

Database of Orthologous Groups

More...
OrthoDBi
949920at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96SU4

TreeFam database of animal gene trees

More...
TreeFami
TF312807

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037239 OSBP_sf
IPR000648 Oxysterol-bd
IPR018494 Oxysterol-bd_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain

The PANTHER Classification System

More...
PANTHERi
PTHR10972 PTHR10972, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01237 Oxysterol_BP, 1 hit
PF00169 PH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233 PH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF144000 SSF144000, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01013 OSBP, 1 hit
PS50003 PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96SU4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASIMEGPLS KWTNVMKGWQ YRWFVLDYNA GLLSYYTSKD KMMRGSRRGC
60 70 80 90 100
VRLRGAVIGI DDEDDSTFTI TVDQKTFHFQ ARDADEREKW IHALEETILR
110 120 130 140 150
HTLQLQGLDS GFVPSVQDFD KKLTEADAYL QILIEQLKLF DDKLQNCKED
160 170 180 190 200
EQRKKIETLK ETTNSMVESI KHCIVLLQIA KDQSNAEKHA DGMISTINPV
210 220 230 240 250
DAIYQPSPLE PVISTMPSQT VLPPEPVQLC KSEQRPSSLP VGPVLATLGH
260 270 280 290 300
HQTPTPNSTG SGHSPPSSSL TSPSHVNLSP NTVPEFSYSS SEDEFYDADE
310 320 330 340 350
FHQSGSSPKR LIDSSGSASV LTHSSSGNSL KRPDTTESLN SSLSNGTSDA
360 370 380 390 400
DLFDSHDDRD DDAEAGSVEE HKSVIMHLLS QVRLGMDLTK VVLPTFILER
410 420 430 440 450
RSLLEMYADF FAHPDLFVSI SDQKDPKDRM VQVVKWYLSA FHAGRKGSVA
460 470 480 490 500
KKPYNPILGE IFQCHWTLPN DTEENTELVS EGPVPWVSKN SVTFVAEQVS
510 520 530 540 550
HHPPISAFYA ECFNKKIQFN AHIWTKSKFL GMSIGVHNIG QGCVSCLDYD
560 570 580 590 600
EHYILTFPNG YGRSILTVPW VELGGECNIN CSKTGYSANI IFHTKPFYGG
610 620 630 640 650
KKHRITAEIF SPNDKKSFCS IEGEWNGVMY AKYATGENTV FVDTKKLPII
660 670 680 690 700
KKKVRKLEDQ NEYESRSLWK DVTFNLKIRD IDAATEAKHR LEERQRAEAR
710 720 730
ERKEKEIQWE TRLFHEDGEC WVYDEPLLKR LGAAKH
Length:736
Mass (Da):83,185
Last modified:February 11, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA689D5D68E95EC6C
GO
Isoform 2 (identifier: Q96SU4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     182-194: Missing.

Note: No experimental confirmation available.
Show »
Length:723
Mass (Da):81,787
Checksum:i78932D752B0723F6
GO
Isoform 3 (identifier: Q96SU4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: Missing.
     98-106: ILRHTLQLQ → MAFLLATCG
     182-194: Missing.

Show »
Length:626
Mass (Da):70,237
Checksum:i1C984FB8AB2CDFBD
GO
Isoform 4 (identifier: Q96SU4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-165: Missing.

Show »
Length:571
Mass (Da):63,926
Checksum:iAA036C69EDF55051
GO
Isoform 5 (identifier: Q96SU4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-165: Missing.
     182-194: Missing.

Show »
Length:558
Mass (Da):62,528
Checksum:i199A2599C5758F91
GO
Isoform 6 (identifier: Q96SU4-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     106-106: Q → QISTTLAFFQSSGISPVLEFSKII
     182-194: Missing.

Note: No experimental confirmation available.
Show »
Length:746
Mass (Da):84,255
Checksum:iB1F7010845472342
GO
Isoform 7 (identifier: Q96SU4-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     38-54: Missing.

Show »
Length:719
Mass (Da):81,166
Checksum:iBB27FF9E489B52F0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PNR1E9PNR1_HUMAN
Oxysterol-binding protein-related p...
OSBPL9
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YE19H0YE19_HUMAN
Oxysterol-binding protein-related p...
OSBPL9
196Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A096LPC8A0A096LPC8_HUMAN
Oxysterol-binding protein-related p...
OSBPL9
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PK98E9PK98_HUMAN
Oxysterol-binding protein-related p...
OSBPL9
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G8JLK0G8JLK0_HUMAN
Oxysterol-binding protein-related p...
OSBPL9
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YE93H0YE93_HUMAN
Oxysterol-binding protein-related p...
OSBPL9
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDB5H0YDB5_HUMAN
Oxysterol-binding protein-related p...
OSBPL9
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YCW0H0YCW0_HUMAN
Oxysterol-binding protein-related p...
OSBPL9
34Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PLH0E9PLH0_HUMAN
Oxysterol-binding protein-related p...
OSBPL9
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJ80E9PJ80_HUMAN
Oxysterol-binding protein-related p...
OSBPL9
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti295F → L in BAC03727 (PubMed:14702039).Curated1
Sequence conflicti735K → R in BAB55312 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_069380266P → L1 PublicationCorresponds to variant dbSNP:rs140080386Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0367791 – 165Missing in isoform 4 and isoform 5. 3 PublicationsAdd BLAST165
Alternative sequenceiVSP_0367801 – 97Missing in isoform 3. 1 PublicationAdd BLAST97
Alternative sequenceiVSP_04363038 – 54Missing in isoform 7. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_03678198 – 106ILRHTLQLQ → MAFLLATCG in isoform 3. 1 Publication9
Alternative sequenceiVSP_043631106Q → QISTTLAFFQSSGISPVLEF SKII in isoform 6. 1 Publication1
Alternative sequenceiVSP_003782182 – 194Missing in isoform 2, isoform 3, isoform 5 and isoform 6. 2 PublicationsAdd BLAST13

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF392445 mRNA Translation: AAL40658.1
AY178997 mRNA Translation: AAO20108.1
AK022554 mRNA Translation: BAB14096.1
AK027535 mRNA Translation: BAB55184.1
AK027707 mRNA Translation: BAB55312.1
AK056617 mRNA Translation: BAG51766.1
AK091703 mRNA Translation: BAC03727.1
CR457288 mRNA Translation: CAG33569.1
AL050343 Genomic DNA No translation available.
AL772260 Genomic DNA No translation available.
AL831767 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06810.1
CH471059 Genomic DNA Translation: EAX06813.1
CH471059 Genomic DNA Translation: EAX06816.1
CH471059 Genomic DNA Translation: EAX06819.1
CH471059 Genomic DNA Translation: EAX06817.1
BC025978 mRNA Translation: AAH25978.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS41332.3 [Q96SU4-1]
CCDS41333.2 [Q96SU4-7]
CCDS41334.1 [Q96SU4-5]
CCDS44145.1 [Q96SU4-6]
CCDS55598.1 [Q96SU4-2]
CCDS558.1 [Q96SU4-3]
CCDS81322.1 [Q96SU4-4]

NCBI Reference Sequences

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RefSeqi
NP_001317509.1, NM_001330580.1 [Q96SU4-4]
NP_078862.4, NM_024586.5 [Q96SU4-1]
NP_683702.1, NM_148904.3 [Q96SU4-5]
NP_683703.1, NM_148905.3 [Q96SU4-5]
NP_683704.2, NM_148906.2 [Q96SU4-7]
NP_683705.1, NM_148907.2 [Q96SU4-3]
NP_683706.3, NM_148908.3 [Q96SU4-2]
NP_683707.3, NM_148909.3 [Q96SU4-6]
XP_006710386.1, XM_006710323.2 [Q96SU4-4]
XP_006710387.1, XM_006710324.3 [Q96SU4-5]
XP_006710388.1, XM_006710325.3 [Q96SU4-5]
XP_006710389.1, XM_006710326.2 [Q96SU4-5]
XP_011538905.1, XM_011540603.2 [Q96SU4-4]
XP_011538906.1, XM_011540604.2 [Q96SU4-4]
XP_016855708.1, XM_017000219.1 [Q96SU4-5]
XP_016855709.1, XM_017000220.1 [Q96SU4-5]
XP_016855710.1, XM_017000221.1 [Q96SU4-5]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.21938
Hs.738830

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000361556; ENSP00000354970; ENSG00000117859 [Q96SU4-3]
ENST00000371714; ENSP00000360779; ENSG00000117859 [Q96SU4-2]
ENST00000428468; ENSP00000407168; ENSG00000117859 [Q96SU4-1]
ENST00000447887; ENSP00000412733; ENSG00000117859 [Q96SU4-6]
ENST00000453295; ENSP00000413263; ENSG00000117859 [Q96SU4-7]
ENST00000462759; ENSP00000433279; ENSG00000117859 [Q96SU4-5]
ENST00000486942; ENSP00000431980; ENSG00000117859 [Q96SU4-5]
ENST00000531828; ENSP00000433083; ENSG00000117859 [Q96SU4-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
114883

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:114883

UCSC genome browser

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UCSCi
uc001cst.5 human [Q96SU4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF392445 mRNA Translation: AAL40658.1
AY178997 mRNA Translation: AAO20108.1
AK022554 mRNA Translation: BAB14096.1
AK027535 mRNA Translation: BAB55184.1
AK027707 mRNA Translation: BAB55312.1
AK056617 mRNA Translation: BAG51766.1
AK091703 mRNA Translation: BAC03727.1
CR457288 mRNA Translation: CAG33569.1
AL050343 Genomic DNA No translation available.
AL772260 Genomic DNA No translation available.
AL831767 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06810.1
CH471059 Genomic DNA Translation: EAX06813.1
CH471059 Genomic DNA Translation: EAX06816.1
CH471059 Genomic DNA Translation: EAX06819.1
CH471059 Genomic DNA Translation: EAX06817.1
BC025978 mRNA Translation: AAH25978.1
CCDSiCCDS41332.3 [Q96SU4-1]
CCDS41333.2 [Q96SU4-7]
CCDS41334.1 [Q96SU4-5]
CCDS44145.1 [Q96SU4-6]
CCDS55598.1 [Q96SU4-2]
CCDS558.1 [Q96SU4-3]
CCDS81322.1 [Q96SU4-4]
RefSeqiNP_001317509.1, NM_001330580.1 [Q96SU4-4]
NP_078862.4, NM_024586.5 [Q96SU4-1]
NP_683702.1, NM_148904.3 [Q96SU4-5]
NP_683703.1, NM_148905.3 [Q96SU4-5]
NP_683704.2, NM_148906.2 [Q96SU4-7]
NP_683705.1, NM_148907.2 [Q96SU4-3]
NP_683706.3, NM_148908.3 [Q96SU4-2]
NP_683707.3, NM_148909.3 [Q96SU4-6]
XP_006710386.1, XM_006710323.2 [Q96SU4-4]
XP_006710387.1, XM_006710324.3 [Q96SU4-5]
XP_006710388.1, XM_006710325.3 [Q96SU4-5]
XP_006710389.1, XM_006710326.2 [Q96SU4-5]
XP_011538905.1, XM_011540603.2 [Q96SU4-4]
XP_011538906.1, XM_011540604.2 [Q96SU4-4]
XP_016855708.1, XM_017000219.1 [Q96SU4-5]
XP_016855709.1, XM_017000220.1 [Q96SU4-5]
XP_016855710.1, XM_017000221.1 [Q96SU4-5]
UniGeneiHs.21938
Hs.738830

3D structure databases

ProteinModelPortaliQ96SU4
SMRiQ96SU4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125384, 27 interactors
ELMiQ96SU4
IntActiQ96SU4, 22 interactors
MINTiQ96SU4
STRINGi9606.ENSP00000412733

PTM databases

iPTMnetiQ96SU4
PhosphoSitePlusiQ96SU4

Polymorphism and mutation databases

BioMutaiOSBPL9
DMDMi20139075

Proteomic databases

EPDiQ96SU4
jPOSTiQ96SU4
MaxQBiQ96SU4
PaxDbiQ96SU4
PeptideAtlasiQ96SU4
PRIDEiQ96SU4
ProteomicsDBi78150
78151 [Q96SU4-2]
78152 [Q96SU4-3]
78153 [Q96SU4-4]
78154 [Q96SU4-5]
78155 [Q96SU4-6]
78156 [Q96SU4-7]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361556; ENSP00000354970; ENSG00000117859 [Q96SU4-3]
ENST00000371714; ENSP00000360779; ENSG00000117859 [Q96SU4-2]
ENST00000428468; ENSP00000407168; ENSG00000117859 [Q96SU4-1]
ENST00000447887; ENSP00000412733; ENSG00000117859 [Q96SU4-6]
ENST00000453295; ENSP00000413263; ENSG00000117859 [Q96SU4-7]
ENST00000462759; ENSP00000433279; ENSG00000117859 [Q96SU4-5]
ENST00000486942; ENSP00000431980; ENSG00000117859 [Q96SU4-5]
ENST00000531828; ENSP00000433083; ENSG00000117859 [Q96SU4-4]
GeneIDi114883
KEGGihsa:114883
UCSCiuc001cst.5 human [Q96SU4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
114883
DisGeNETi114883
EuPathDBiHostDB:ENSG00000117859.18

GeneCards: human genes, protein and diseases

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GeneCardsi
OSBPL9
HGNCiHGNC:16386 OSBPL9
HPAiHPA027378
HPA027397
MIMi606737 gene
neXtProtiNX_Q96SU4
OpenTargetsiENSG00000117859
PharmGKBiPA32833

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2210 Eukaryota
ENOG410XRW6 LUCA
GeneTreeiENSGT00940000154690
HOGENOMiHOG000233872
HOVERGENiHBG053376
InParanoidiQ96SU4
KOiK20465
OMAiNPVDGIY
OrthoDBi949920at2759
PhylomeDBiQ96SU4
TreeFamiTF312807

Enzyme and pathway databases

ReactomeiR-HSA-192105 Synthesis of bile acids and bile salts

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
OSBPL9 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
OSBPL9

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
114883

Protein Ontology

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PROi
PR:Q96SU4

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000117859 Expressed in 223 organ(s), highest expression level in kidney
ExpressionAtlasiQ96SU4 baseline and differential
GenevisibleiQ96SU4 HS

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR037239 OSBP_sf
IPR000648 Oxysterol-bd
IPR018494 Oxysterol-bd_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR10972 PTHR10972, 1 hit
PfamiView protein in Pfam
PF01237 Oxysterol_BP, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SUPFAMiSSF144000 SSF144000, 1 hit
PROSITEiView protein in PROSITE
PS01013 OSBP, 1 hit
PS50003 PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOSBL9_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96SU4
Secondary accession number(s): B1AKJ8
, B3KPQ4, D3DQ31, Q5TFC0, Q6IA67, Q86YQ3, Q8NB17, Q8TAS8, Q96SK4, Q9H9X2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: February 11, 2002
Last modified: February 13, 2019
This is version 145 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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