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Protein

Oxysterol-binding protein-related protein 9

Gene

OSBPL9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processLipid transport, Transport
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-HSA-192105 Synthesis of bile acids and bile salts

Names & Taxonomyi

Protein namesi
Recommended name:
Oxysterol-binding protein-related protein 9
Short name:
ORP-9
Short name:
OSBP-related protein 9
Gene namesi
Name:OSBPL9
Synonyms:ORP9, OSBP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000117859.18
HGNCiHGNC:16386 OSBPL9
MIMi606737 gene
neXtProtiNX_Q96SU4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi114883
OpenTargetsiENSG00000117859
PharmGKBiPA32833

Polymorphism and mutation databases

BioMutaiOSBPL9
DMDMi20139075

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001003792 – 736Oxysterol-binding protein-related protein 9Add BLAST735

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei306PhosphoserineCombined sources1
Modified residuei324PhosphoserineCombined sources1
Modified residuei325PhosphoserineCombined sources1
Modified residuei326PhosphoserineCombined sources1
Modified residuei329PhosphoserineCombined sources1
Modified residuei611PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ96SU4
MaxQBiQ96SU4
PaxDbiQ96SU4
PeptideAtlasiQ96SU4
PRIDEiQ96SU4
ProteomicsDBi78150
78151 [Q96SU4-2]
78152 [Q96SU4-3]
78153 [Q96SU4-4]
78154 [Q96SU4-5]
78155 [Q96SU4-6]
78156 [Q96SU4-7]

PTM databases

iPTMnetiQ96SU4
PhosphoSitePlusiQ96SU4

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000117859
CleanExiHS_OSBPL9
ExpressionAtlasiQ96SU4 baseline and differential
GenevisibleiQ96SU4 HS

Organism-specific databases

HPAiHPA027378
HPA027397

Interactioni

Subunit structurei

Heterodimer with OSBPL11 (PubMed:20599956). Interacts with OSBPL10 (PubMed:22906437).2 Publications

Protein-protein interaction databases

BioGridi125384, 26 interactors
ELMiQ96SU4
IntActiQ96SU4, 21 interactors
MINTiQ96SU4
STRINGi9606.ENSP00000412733

Structurei

3D structure databases

ProteinModelPortaliQ96SU4
SMRiQ96SU4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 99PHPROSITE-ProRule annotationAdd BLAST98

Sequence similaritiesi

Belongs to the OSBP family.Curated

Phylogenomic databases

eggNOGiKOG2210 Eukaryota
ENOG410XRW6 LUCA
GeneTreeiENSGT00550000074515
HOGENOMiHOG000233872
HOVERGENiHBG053376
InParanoidiQ96SU4
KOiK20465
OMAiKMASIME
OrthoDBiEOG091G0FV2
PhylomeDBiQ96SU4
TreeFamiTF312807

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR037239 OSBP_sf
IPR000648 Oxysterol-bd
IPR018494 Oxysterol-bd_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR10972 PTHR10972, 1 hit
PfamiView protein in Pfam
PF01237 Oxysterol_BP, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SUPFAMiSSF144000 SSF144000, 1 hit
PROSITEiView protein in PROSITE
PS01013 OSBP, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequences (7)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96SU4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASIMEGPLS KWTNVMKGWQ YRWFVLDYNA GLLSYYTSKD KMMRGSRRGC
60 70 80 90 100
VRLRGAVIGI DDEDDSTFTI TVDQKTFHFQ ARDADEREKW IHALEETILR
110 120 130 140 150
HTLQLQGLDS GFVPSVQDFD KKLTEADAYL QILIEQLKLF DDKLQNCKED
160 170 180 190 200
EQRKKIETLK ETTNSMVESI KHCIVLLQIA KDQSNAEKHA DGMISTINPV
210 220 230 240 250
DAIYQPSPLE PVISTMPSQT VLPPEPVQLC KSEQRPSSLP VGPVLATLGH
260 270 280 290 300
HQTPTPNSTG SGHSPPSSSL TSPSHVNLSP NTVPEFSYSS SEDEFYDADE
310 320 330 340 350
FHQSGSSPKR LIDSSGSASV LTHSSSGNSL KRPDTTESLN SSLSNGTSDA
360 370 380 390 400
DLFDSHDDRD DDAEAGSVEE HKSVIMHLLS QVRLGMDLTK VVLPTFILER
410 420 430 440 450
RSLLEMYADF FAHPDLFVSI SDQKDPKDRM VQVVKWYLSA FHAGRKGSVA
460 470 480 490 500
KKPYNPILGE IFQCHWTLPN DTEENTELVS EGPVPWVSKN SVTFVAEQVS
510 520 530 540 550
HHPPISAFYA ECFNKKIQFN AHIWTKSKFL GMSIGVHNIG QGCVSCLDYD
560 570 580 590 600
EHYILTFPNG YGRSILTVPW VELGGECNIN CSKTGYSANI IFHTKPFYGG
610 620 630 640 650
KKHRITAEIF SPNDKKSFCS IEGEWNGVMY AKYATGENTV FVDTKKLPII
660 670 680 690 700
KKKVRKLEDQ NEYESRSLWK DVTFNLKIRD IDAATEAKHR LEERQRAEAR
710 720 730
ERKEKEIQWE TRLFHEDGEC WVYDEPLLKR LGAAKH
Length:736
Mass (Da):83,185
Last modified:February 11, 2002 - v2
Checksum:iA689D5D68E95EC6C
GO
Isoform 2 (identifier: Q96SU4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     182-194: Missing.

Note: No experimental confirmation available.
Show »
Length:723
Mass (Da):81,787
Checksum:i78932D752B0723F6
GO
Isoform 3 (identifier: Q96SU4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: Missing.
     98-106: ILRHTLQLQ → MAFLLATCG
     182-194: Missing.

Show »
Length:626
Mass (Da):70,237
Checksum:i1C984FB8AB2CDFBD
GO
Isoform 4 (identifier: Q96SU4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-165: Missing.

Show »
Length:571
Mass (Da):63,926
Checksum:iAA036C69EDF55051
GO
Isoform 5 (identifier: Q96SU4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-165: Missing.
     182-194: Missing.

Show »
Length:558
Mass (Da):62,528
Checksum:i199A2599C5758F91
GO
Isoform 6 (identifier: Q96SU4-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     106-106: Q → QISTTLAFFQSSGISPVLEFSKII
     182-194: Missing.

Note: No experimental confirmation available.
Show »
Length:746
Mass (Da):84,255
Checksum:iB1F7010845472342
GO
Isoform 7 (identifier: Q96SU4-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     38-54: Missing.

Show »
Length:719
Mass (Da):81,166
Checksum:iBB27FF9E489B52F0
GO

Sequence cautioni

The sequence CAH71119 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti295F → L in BAC03727 (PubMed:14702039).Curated1
Sequence conflicti735K → R in BAB55312 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_069380266P → L1 PublicationCorresponds to variant dbSNP:rs140080386Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0367791 – 165Missing in isoform 4 and isoform 5. 3 PublicationsAdd BLAST165
Alternative sequenceiVSP_0367801 – 97Missing in isoform 3. 1 PublicationAdd BLAST97
Alternative sequenceiVSP_04363038 – 54Missing in isoform 7. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_03678198 – 106ILRHTLQLQ → MAFLLATCG in isoform 3. 1 Publication9
Alternative sequenceiVSP_043631106Q → QISTTLAFFQSSGISPVLEF SKII in isoform 6. 1 Publication1
Alternative sequenceiVSP_003782182 – 194Missing in isoform 2, isoform 3, isoform 5 and isoform 6. 2 PublicationsAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF392445 mRNA Translation: AAL40658.1
AY178997 mRNA Translation: AAO20108.1
AK022554 mRNA Translation: BAB14096.1
AK027535 mRNA Translation: BAB55184.1
AK027707 mRNA Translation: BAB55312.1
AK056617 mRNA Translation: BAG51766.1
AK091703 mRNA Translation: BAC03727.1
CR457288 mRNA Translation: CAG33569.1
AL772260, AL050343, AL831767 Genomic DNA Translation: CAH71118.1
AL772260, AL050343, AL831767 Genomic DNA Translation: CAH71119.1 Different initiation.
AL831767, AL050343, AL772260 Genomic DNA Translation: CAI14843.1
AL831767, AL050343, AL772260 Genomic DNA Translation: CAI14844.1
AL050343, AL772260, AL831767 Genomic DNA Translation: CAI22219.1
AL050343, AL772260, AL831767 Genomic DNA Translation: CAI22220.1
AL050343 Genomic DNA Translation: CAI22221.1
CH471059 Genomic DNA Translation: EAX06810.1
CH471059 Genomic DNA Translation: EAX06813.1
CH471059 Genomic DNA Translation: EAX06816.1
CH471059 Genomic DNA Translation: EAX06819.1
CH471059 Genomic DNA Translation: EAX06817.1
BC025978 mRNA Translation: AAH25978.1
CCDSiCCDS41332.3 [Q96SU4-1]
CCDS41333.2 [Q96SU4-7]
CCDS41334.1 [Q96SU4-5]
CCDS44145.1 [Q96SU4-6]
CCDS55598.1 [Q96SU4-2]
CCDS558.1 [Q96SU4-3]
CCDS81322.1 [Q96SU4-4]
RefSeqiNP_001317509.1, NM_001330580.1 [Q96SU4-4]
NP_078862.4, NM_024586.5 [Q96SU4-1]
NP_683702.1, NM_148904.3 [Q96SU4-5]
NP_683703.1, NM_148905.3 [Q96SU4-5]
NP_683704.2, NM_148906.2 [Q96SU4-7]
NP_683705.1, NM_148907.2 [Q96SU4-3]
NP_683706.3, NM_148908.3 [Q96SU4-2]
NP_683707.3, NM_148909.3 [Q96SU4-6]
XP_006710386.1, XM_006710323.2 [Q96SU4-4]
XP_006710387.1, XM_006710324.3 [Q96SU4-5]
XP_006710388.1, XM_006710325.3 [Q96SU4-5]
XP_006710389.1, XM_006710326.2 [Q96SU4-5]
XP_011538905.1, XM_011540603.2 [Q96SU4-4]
XP_011538906.1, XM_011540604.2 [Q96SU4-4]
XP_016855708.1, XM_017000219.1 [Q96SU4-5]
XP_016855709.1, XM_017000220.1 [Q96SU4-5]
XP_016855710.1, XM_017000221.1 [Q96SU4-5]
UniGeneiHs.21938
Hs.738830

Genome annotation databases

EnsembliENST00000361556; ENSP00000354970; ENSG00000117859 [Q96SU4-3]
ENST00000371714; ENSP00000360779; ENSG00000117859 [Q96SU4-2]
ENST00000428468; ENSP00000407168; ENSG00000117859 [Q96SU4-1]
ENST00000447887; ENSP00000412733; ENSG00000117859 [Q96SU4-6]
ENST00000453295; ENSP00000413263; ENSG00000117859 [Q96SU4-7]
ENST00000462759; ENSP00000433279; ENSG00000117859 [Q96SU4-5]
ENST00000486942; ENSP00000431980; ENSG00000117859 [Q96SU4-5]
ENST00000531828; ENSP00000433083; ENSG00000117859 [Q96SU4-4]
GeneIDi114883
KEGGihsa:114883
UCSCiuc001cst.5 human [Q96SU4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOSBL9_HUMAN
AccessioniPrimary (citable) accession number: Q96SU4
Secondary accession number(s): B1AKJ8
, B3KPQ4, D3DQ31, Q5TFC0, Q6IA67, Q86YQ3, Q8NB17, Q8TAS8, Q96SK4, Q9H9X2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: February 11, 2002
Last modified: July 18, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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