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Protein

Paired amphipathic helix protein Sin3a

Gene

SIN3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in he control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor
Biological processBiological rhythms, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3899300 SUMOylation of transcription cofactors
R-HSA-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-HSA-427413 NoRC negatively regulates rRNA expression
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-HSA-9022538 Loss of MECP2 binding ability to 5mC-DNA
R-HSA-9022692 Regulation of MECP2 expression and activity
R-HSA-9022699 MECP2 regulates neuronal receptors and channels
R-HSA-9022702 MECP2 regulates transcription of neuronal ligands
R-HSA-983231 Factors involved in megakaryocyte development and platelet production

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q96ST3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Paired amphipathic helix protein Sin3a
Alternative name(s):
Histone deacetylase complex subunit Sin3a
Transcriptional corepressor Sin3a
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SIN3AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000169375.15

Human Gene Nomenclature Database

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HGNCi
HGNC:19353 SIN3A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607776 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96ST3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
25942

MalaCards human disease database

More...
MalaCardsi
SIN3A

Open Targets

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OpenTargetsi
ENSG00000169375

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
94065 15q24 microdeletion syndrome
500166 SIN3A-related intellectual disability syndrome due to a point mutation

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134993567

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SIN3A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
37999759

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001215371 – 1273Paired amphipathic helix protein Sin3aAdd BLAST1273

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei10PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki122Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki134Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei277PhosphoserineCombined sources1
Modified residuei284PhosphothreonineBy similarity1
Modified residuei469N6-acetyllysineCombined sources1
Cross-linki563Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei832PhosphoserineCombined sources1
Modified residuei860PhosphoserineCombined sources1
Modified residuei865N6-acetyllysineBy similarity1
Modified residuei875N6-acetyllysineBy similarity1
Modified residuei940PhosphoserineCombined sources1
Modified residuei1089PhosphoserineCombined sources1
Modified residuei1112PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

SUMO1 sumoylated by TOPORS. Probably desumoylated by SENP2.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q96ST3

MaxQB - The MaxQuant DataBase

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MaxQBi
Q96ST3

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96ST3

PeptideAtlas

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PeptideAtlasi
Q96ST3

PRoteomics IDEntifications database

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PRIDEi
Q96ST3

ProteomicsDB human proteome resource

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ProteomicsDBi
78146

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96ST3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q96ST3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000169375 Expressed in 195 organ(s), highest expression level in secondary oocyte

CleanEx database of gene expression profiles

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CleanExi
HS_SIN3A

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96ST3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96ST3 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB004506
HPA047213
HPA062123

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ARID4B, BRMS1L, HCFC1, HDAC1, HDAC2, MXI1, SAP30L, SAP130, SFPQ and TOPORS. Interacts with OGT (via TPRs 1-6); the interaction mediates transcriptional repression in parallel with histone deacetylase (By similarity). Interacts with BAZ2A, MXD3, MXD4, MBD2, DACH1, NCOR1, NR4A2, REST, RLIM, SAP30, SETDB1, SMYD2, and SUDS3. Interacts with PHF12 in a complex composed of HDAC1, PHF12 and SAP30. Interacts with TET1; the interaction recruits SIN3A to gene promoters. The large PER complex involved in the histone deacetylation is composed of at least HDAC1, PER2, SFPQ and SIN3A. Interacts with KLF11 (By similarity). Interacts with PPHLN1 (PubMed:17963697). Found in a complex with YY1, GON4L and HDAC1 (By similarity). Interacts (via PAH2) with FOXK1 (By similarity). Found in a complex composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1. Interacts with SINHCAF (By similarity).By similarity11 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
117439, 214 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-3321 SIN3A histone deacetylase complex
CPX-3323 SIN3A histone deacetylase complex, ES cell-specific variant

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q96ST3

Database of interacting proteins

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DIPi
DIP-31515N

Protein interaction database and analysis system

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IntActi
Q96ST3, 52 interactors

Molecular INTeraction database

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MINTi
Q96ST3

STRING: functional protein association networks

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STRINGi
9606.ENSP00000353622

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q96ST3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96ST3

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini119 – 189PAH 1PROSITE-ProRule annotationAdd BLAST71
Domaini300 – 383PAH 2PROSITE-ProRule annotationAdd BLAST84
Domaini456 – 525PAH 3PROSITE-ProRule annotationAdd BLAST70

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni119 – 196Interaction with HCFC11 PublicationAdd BLAST78
Regioni205 – 480Interaction with RESTBy similarityAdd BLAST276
Regioni458 – 525Interaction with SAP30By similarityAdd BLAST68
Regioni523 – 850Interaction with NCOR1By similarityAdd BLAST328
Regioni524 – 659Interaction with SUDS3 and SAP1301 PublicationAdd BLAST136
Regioni687 – 829Interaction with HDAC1 and ARID4B1 PublicationAdd BLAST143
Regioni888 – 967Interaction with OGT1 PublicationAdd BLAST80

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili903 – 932Sequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi218 – 285Pro-richAdd BLAST68
Compositional biasi835 – 841Poly-Glu7

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4204 Eukaryota
COG5602 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155491

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG060425

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96ST3

KEGG Orthology (KO)

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KOi
K11644

Identification of Orthologs from Complete Genome Data

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OMAi
QKPCSGR

Database of Orthologous Groups

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OrthoDBi
EOG091G03HY

Database for complete collections of gene phylogenies

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PhylomeDBi
Q96ST3

TreeFam database of animal gene trees

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TreeFami
TF106187

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR013194 HDAC_interact_dom
IPR003822 PAH
IPR036600 PAH_sf
IPR039774 Sin3-like
IPR031693 Sin3_C
IPR037969 SIN3A

The PANTHER Classification System

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PANTHERi
PTHR12346 PTHR12346, 1 hit
PTHR12346:SF2 PTHR12346:SF2, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF02671 PAH, 3 hits
PF08295 Sin3_corepress, 1 hit
PF16879 Sin3a_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00761 HDAC_interact, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47762 SSF47762, 3 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51477 PAH, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

Q96ST3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRRLDDQES PVYAAQQRRI PGSTEAFPHQ HRVLAPAPPV YEAVSETMQS
60 70 80 90 100
ATGIQYSVTP SYQVSAMPQS SGSHGPAIAA VHSSHHHPTA VQPHGGQVVQ
110 120 130 140 150
SHAHPAPPVA PVQGQQQFQR LKVEDALSYL DQVKLQFGSQ PQVYNDFLDI
160 170 180 190 200
MKEFKSQSID TPGVISRVSQ LFKGHPDLIM GFNTFLPPGY KIEVQTNDMV
210 220 230 240 250
NVTTPGQVHQ IPTHGIQPQP QPPPQHPSQP SAQSAPAPAQ PAPQPPPAKV
260 270 280 290 300
SKPSQLQAHT PASQQTPPLP PYASPRSPPV QPHTPVTISL GTAPSLQNNQ
310 320 330 340 350
PVEFNHAINY VNKIKNRFQG QPDIYKAFLE ILHTYQKEQR NAKEAGGNYT
360 370 380 390 400
PALTEQEVYA QVARLFKNQE DLLSEFGQFL PDANSSVLLS KTTAEKVDSV
410 420 430 440 450
RNDHGGTVKK PQLNNKPQRP SQNGCQIRRH PTGTTPPVKK KPKLLNLKDS
460 470 480 490 500
SMADASKHGG GTESLFFDKV RKALRSAEAY ENFLRCLVIF NQEVISRAEL
510 520 530 540 550
VQLVSPFLGK FPELFNWFKN FLGYKESVHL ETYPKERATE GIAMEIDYAS
560 570 580 590 600
CKRLGSSYRA LPKSYQQPKC TGRTPLCKEV LNDTWVSFPS WSEDSTFVSS
610 620 630 640 650
KKTQYEEHIY RCEDERFELD VVLETNLATI RVLEAIQKKL SRLSAEEQAK
660 670 680 690 700
FRLDNTLGGT SEVIHRKALQ RIYADKAADI IDGLRKNPSI AVPIVLKRLK
710 720 730 740 750
MKEEEWREAQ RGFNKVWREQ NEKYYLKSLD HQGINFKQND TKVLRSKSLL
760 770 780 790 800
NEIESIYDER QEQATEENAG VPVGPHLSLA YEDKQILEDA AALIIHHVKR
810 820 830 840 850
QTGIQKEDKY KIKQIMHHFI PDLLFAQRGD LSDVEEEEEE EMDVDEATGA
860 870 880 890 900
VKKHNGVGGS PPKSKLLFSN TAAQKLRGMD EVYNLFYVNN NWYIFMRLHQ
910 920 930 940 950
ILCLRLLRIC SQAERQIEEE NREREWEREV LGIKRDKSDS PAIQLRLKEP
960 970 980 990 1000
MDVDVEDYYP AFLDMVRSLL DGNIDSSQYE DSLREMFTIH AYIAFTMDKL
1010 1020 1030 1040 1050
IQSIVRQLQH IVSDEICVQV TDLYLAENNN GATGGQLNTQ NSRSLLESTY
1060 1070 1080 1090 1100
QRKAEQLMSD ENCFKLMFIQ SQGQVQLTIE LLDTEEENSD DPVEAERWSD
1110 1120 1130 1140 1150
YVERYMNSDT TSPELREHLA QKPVFLPRNL RRIRKCQRGR EQQEKEGKEG
1160 1170 1180 1190 1200
NSKKTMENVD SLDKLECRFK LNSYKMVYVI KSEDYMYRRT ALLRAHQSHE
1210 1220 1230 1240 1250
RVSKRLHQRF QAWVDKWTKE HVPREMAAET SKWLMGEGLE GLVPCTTTCD
1260 1270
TETLHFVSIN KYRVKYGTVF KAP
Length:1,273
Mass (Da):145,175
Last modified:October 24, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE6A329BE0EAD84CD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BP90H3BP90_HUMAN
Paired amphipathic helix protein Si...
SIN3A
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQL7H3BQL7_HUMAN
Paired amphipathic helix protein Si...
SIN3A
156Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BT34H3BT34_HUMAN
Paired amphipathic helix protein Si...
SIN3A
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BNZ3H3BNZ3_HUMAN
Paired amphipathic helix protein Si...
SIN3A
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQ88H3BQ88_HUMAN
Paired amphipathic helix protein Si...
SIN3A
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQ76H3BQ76_HUMAN
Paired amphipathic helix protein Si...
SIN3A
107Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BNA0H3BNA0_HUMAN
Paired amphipathic helix protein Si...
SIN3A
130Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BMA2H3BMA2_HUMAN
Paired amphipathic helix protein Si...
SIN3A
18Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti163G → R in AAK95854 (Ref. 4) Curated1
Sequence conflicti170 – 177QLFKGHPD → HYSKGPPI in AAK95854 (Ref. 4) Curated8
Sequence conflicti182 – 192FNTFLPPGYKI → IQHLFAPWATKM in AAK95854 (Ref. 4) CuratedAdd BLAST11
Sequence conflicti216I → T in BAC04801 (PubMed:14702039).Curated1
Sequence conflicti386S → F in AAK95854 (Ref. 4) Curated1
Sequence conflicti536E → D in AAK95854 (Ref. 4) Curated1
Sequence conflicti562P → G in AAK95854 (Ref. 4) Curated1
Sequence conflicti575 – 576PL → GV in AAK95854 (Ref. 4) Curated2
Sequence conflicti595S → C in AAK95854 (Ref. 4) Curated1
Sequence conflicti618 – 620ELD → DLM in AAK95854 (Ref. 4) Curated3
Sequence conflicti1009Q → R in BAC11280 (PubMed:14702039).Curated1
Sequence conflicti1247 – 1248TT → NN in AAP97288 (Ref. 1) Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0621291156M → L. Corresponds to variant dbSNP:rs60213317Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF418569 mRNA Translation: AAP97288.1
BC018973 mRNA Translation: AAH18973.1
BC137098 mRNA Translation: AAI37099.1
BC137099 mRNA Translation: AAI37100.1
AK027559 mRNA Translation: BAB55197.1
AK074903 mRNA Translation: BAC11280.1
AK096477 mRNA Translation: BAC04801.1
AY044430 mRNA Translation: AAK95854.1
AL117513 mRNA Translation: CAB55972.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10279.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T17282

NCBI Reference Sequences

More...
RefSeqi
NP_001138829.1, NM_001145357.1
NP_001138830.1, NM_001145358.1
NP_056292.1, NM_015477.2
XP_006720528.1, XM_006720465.3
XP_006720529.1, XM_006720466.3
XP_006720530.1, XM_006720467.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.513039

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000360439; ENSP00000353622; ENSG00000169375
ENST00000394947; ENSP00000378402; ENSG00000169375
ENST00000394949; ENSP00000378403; ENSG00000169375

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
25942

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:25942

UCSC genome browser

More...
UCSCi
uc002bai.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF418569 mRNA Translation: AAP97288.1
BC018973 mRNA Translation: AAH18973.1
BC137098 mRNA Translation: AAI37099.1
BC137099 mRNA Translation: AAI37100.1
AK027559 mRNA Translation: BAB55197.1
AK074903 mRNA Translation: BAC11280.1
AK096477 mRNA Translation: BAC04801.1
AY044430 mRNA Translation: AAK95854.1
AL117513 mRNA Translation: CAB55972.1
CCDSiCCDS10279.1
PIRiT17282
RefSeqiNP_001138829.1, NM_001145357.1
NP_001138830.1, NM_001145358.1
NP_056292.1, NM_015477.2
XP_006720528.1, XM_006720465.3
XP_006720529.1, XM_006720466.3
XP_006720530.1, XM_006720467.3
UniGeneiHs.513039

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PO4model-B295-383[»]
ProteinModelPortaliQ96ST3
SMRiQ96ST3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117439, 214 interactors
ComplexPortaliCPX-3321 SIN3A histone deacetylase complex
CPX-3323 SIN3A histone deacetylase complex, ES cell-specific variant
CORUMiQ96ST3
DIPiDIP-31515N
IntActiQ96ST3, 52 interactors
MINTiQ96ST3
STRINGi9606.ENSP00000353622

PTM databases

iPTMnetiQ96ST3
PhosphoSitePlusiQ96ST3

Polymorphism and mutation databases

BioMutaiSIN3A
DMDMi37999759

Proteomic databases

EPDiQ96ST3
MaxQBiQ96ST3
PaxDbiQ96ST3
PeptideAtlasiQ96ST3
PRIDEiQ96ST3
ProteomicsDBi78146

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360439; ENSP00000353622; ENSG00000169375
ENST00000394947; ENSP00000378402; ENSG00000169375
ENST00000394949; ENSP00000378403; ENSG00000169375
GeneIDi25942
KEGGihsa:25942
UCSCiuc002bai.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
25942
DisGeNETi25942
EuPathDBiHostDB:ENSG00000169375.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SIN3A

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0012443
HIX0019634
HIX0172841
HGNCiHGNC:19353 SIN3A
HPAiCAB004506
HPA047213
HPA062123
MalaCardsiSIN3A
MIMi607776 gene
neXtProtiNX_Q96ST3
OpenTargetsiENSG00000169375
Orphaneti94065 15q24 microdeletion syndrome
500166 SIN3A-related intellectual disability syndrome due to a point mutation
PharmGKBiPA134993567

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4204 Eukaryota
COG5602 LUCA
GeneTreeiENSGT00940000155491
HOVERGENiHBG060425
InParanoidiQ96ST3
KOiK11644
OMAiQKPCSGR
OrthoDBiEOG091G03HY
PhylomeDBiQ96ST3
TreeFamiTF106187

Enzyme and pathway databases

ReactomeiR-HSA-3899300 SUMOylation of transcription cofactors
R-HSA-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-HSA-427413 NoRC negatively regulates rRNA expression
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-HSA-9022538 Loss of MECP2 binding ability to 5mC-DNA
R-HSA-9022692 Regulation of MECP2 expression and activity
R-HSA-9022699 MECP2 regulates neuronal receptors and channels
R-HSA-9022702 MECP2 regulates transcription of neuronal ligands
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
SIGNORiQ96ST3

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SIN3A human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SIN3A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
25942

Protein Ontology

More...
PROi
PR:Q96ST3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000169375 Expressed in 195 organ(s), highest expression level in secondary oocyte
CleanExiHS_SIN3A
ExpressionAtlasiQ96ST3 baseline and differential
GenevisibleiQ96ST3 HS

Family and domain databases

InterProiView protein in InterPro
IPR013194 HDAC_interact_dom
IPR003822 PAH
IPR036600 PAH_sf
IPR039774 Sin3-like
IPR031693 Sin3_C
IPR037969 SIN3A
PANTHERiPTHR12346 PTHR12346, 1 hit
PTHR12346:SF2 PTHR12346:SF2, 1 hit
PfamiView protein in Pfam
PF02671 PAH, 3 hits
PF08295 Sin3_corepress, 1 hit
PF16879 Sin3a_C, 1 hit
SMARTiView protein in SMART
SM00761 HDAC_interact, 1 hit
SUPFAMiSSF47762 SSF47762, 3 hits
PROSITEiView protein in PROSITE
PS51477 PAH, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSIN3A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96ST3
Secondary accession number(s): B2RNS5
, Q8N8N4, Q8NC83, Q8WV18, Q96L98, Q9UFQ1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: October 24, 2003
Last modified: December 5, 2018
This is version 175 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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