UniProtKB - Q96ST2 (IWS1_HUMAN)
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>sp|Q96ST2|IWS1_HUMAN Protein IWS1 homolog OS=Homo sapiens OX=9606 GN=IWS1 PE=1 SV=2 MDSEYYSGDQSDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGL PKGHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDS ESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKP QISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENE ELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVS DSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKF HSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDS DSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGES GDEEEEEFTGFNQEDLEEEKGETQVKEAEDSDSDDNIKRGKHMDFLSDFEMMLQRKKSMS GKRRRNRDGGTFISDADDVVSAMIVKMNEAAEEDRQLNNQKKPALKKLTLLPAVVMHLKK QDLKETFIDSGVMSAIKEWLSPLPDRSLPALKIREELLKILQELPSVSQETLKHSGIGRA VMYLYKHPKESRSNKDMAGKLINEWSRPIFGLTSNYKGMTREEREQRDLEQMPQRRRMNS TGGQTPRRDLEKVLTGEEKALRPGDPGFCARARVPMPSNKDYVVRPKWNVEMESSRFQAT SKKGISRLDKQMRKFTDIRKKSRSAHAVKISIEGNKMPLCommunity curation ()Add a publicationFeedback
Protein IWS1 homolog
IWS1
Annotation score:5 out of 5
<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>Select a section on the left to see content.
<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni
<p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
- Ref.7"A putative transcriptional elongation factor hIws1 is essential for mammalian cell proliferation."
Liu Z., Zhou Z., Chen G., Bao S.
Biochem. Biophys. Res. Commun. 353:47-53(2007) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH PRMT5. - Ref.8"The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export."
Yoh S.M., Cho H., Pickle L., Evans R.M., Jones K.A.
Genes Dev. 21:160-174(2007) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH SUPT6H AND ALYREF. - Ref.9"The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation."
Yoh S.M., Lucas J.S., Jones K.A.
Genes Dev. 22:3422-3434(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INTERACTION WITH SETD2 AND SUPT6H.
<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi
- mRNA processing Source: UniProtKB-KW
- poly(A)+ mRNA export from nucleus Source: GO_Central
<p>Inferred from Biological aspect of Ancestor</p>
<p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p>
<p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p>
Inferred from biological aspect of ancestori
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
- regulation of histone H3-K36 trimethylation Source: UniProtKB
<p>Inferred from Mutant Phenotype</p>
<p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p>
<p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p>
Inferred from mutant phenotypei
- Ref.9"The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation."
Yoh S.M., Lucas J.S., Jones K.A.
Genes Dev. 22:3422-3434(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INTERACTION WITH SETD2 AND SUPT6H.
- regulation of histone H4 acetylation Source: UniProtKBInferred from mutant phenotypei
- Ref.9"The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation."
Yoh S.M., Lucas J.S., Jones K.A.
Genes Dev. 22:3422-3434(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INTERACTION WITH SETD2 AND SUPT6H.
- regulation of mRNA export from nucleus Source: UniProtKBInferred from mutant phenotypei
- Ref.8"The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export."
Yoh S.M., Cho H., Pickle L., Evans R.M., Jones K.A.
Genes Dev. 21:160-174(2007) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH SUPT6H AND ALYREF.
- regulation of mRNA processing Source: UniProtKBInferred from mutant phenotypei
- Ref.8"The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export."
Yoh S.M., Cho H., Pickle L., Evans R.M., Jones K.A.
Genes Dev. 21:160-174(2007) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH SUPT6H AND ALYREF.
- RNA splicing Source: UniProtKB-KW
- transcription by RNA polymerase II Source: Reactome
- transcription elongation from RNA polymerase II promoter Source: Reactome
<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi
Biological process | mRNA processing, mRNA splicing, mRNA transport, Transcription, Transcription regulation, Transport |
Enzyme and pathway databases
Pathway Commons web resource for biological pathway data More...PathwayCommonsi | Q96ST2 |
Reactome - a knowledgebase of biological pathways and processes More...Reactomei | R-HSA-112382, Formation of RNA Pol II elongation complex R-HSA-674695, RNA Polymerase II Pre-transcription Events R-HSA-75955, RNA Polymerase II Transcription Elongation |
<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi | Recommended name: Protein IWS1 homologAlternative name(s): IWS1-like protein |
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi | Name:IWS1 Synonyms:IWS1L |
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>Organismi | Homo sapiens (Human) |
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri | 9606 [NCBI] |
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineagei | cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo |
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi |
|
Organism-specific databases
Human Gene Nomenclature Database More...HGNCi | HGNC:25467, IWS1 |
neXtProt; the human protein knowledge platform More...neXtProti | NX_Q96ST2 |
Eukaryotic Pathogen, Vector and Host Database Resources More...VEuPathDBi | HostDB:ENSG00000163166.13 |
<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
<p>Manual validated information which has been generated by the UniProtKB automatic annotation system.</p> <p><a href="/manual/evidences#ECO:0000255">More...</a></p> Manual assertion according to rulesi
2 PublicationsManual assertion based on experiment ini
- Ref.7"A putative transcriptional elongation factor hIws1 is essential for mammalian cell proliferation."
Liu Z., Zhou Z., Chen G., Bao S.
Biochem. Biophys. Res. Commun. 353:47-53(2007) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH PRMT5. - Ref.8"The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export."
Yoh S.M., Cho H., Pickle L., Evans R.M., Jones K.A.
Genes Dev. 21:160-174(2007) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH SUPT6H AND ALYREF.
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
<p>Inferred from Direct Assay</p>
<p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p>
<p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p>
Inferred from direct assayi
- Ref.8"The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export."
Yoh S.M., Cho H., Pickle L., Evans R.M., Jones K.A.
Genes Dev. 21:160-174(2007) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH SUPT6H AND ALYREF.
Keywords - Cellular componenti
Nucleus<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi | 476 | I → A: Loss of interaction with PSIP1; when associated with A-477. 1 Publication Manual assertion based on experiment ini
| 1 | |
Mutagenesisi | 477 | F → A: Loss of interaction with PSIP1; when associated with A-476. 1 Publication Manual assertion based on experiment ini
| 1 | |
Mutagenesisi | 480 | S → D: Phosphomimetic mutant. Moderate increase in interaction with PSIP1. 1 Publication Manual assertion based on experiment ini
| 1 |
Organism-specific databases
DisGeNET More...DisGeNETi | 55677 |
Open Targets More...OpenTargetsi | ENSG00000163166 |
The Pharmacogenetics and Pharmacogenomics Knowledge Base More...PharmGKBi | PA144596419 |
Miscellaneous databases
Pharos NIH Druggable Genome Knowledgebase More...Pharosi | Q96ST2, Tbio |
Genetic variation databases
BioMuta curated single-nucleotide variation and disease association database More...BioMutai | IWS1 |
Domain mapping of disease mutations (DMDM) More...DMDMi | 85542184 |
<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000083346 | 1 – 819 | Protein IWS1 homologAdd BLAST | 819 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei | 1 | N-acetylmethionineCombined sources <p>Manually validated information inferred from a combination of experimental and computational evidence.</p> <p><a href="/manual/evidences#ECO:0007744">More...</a></p> Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
Modified residuei | 27 | PhosphoserineBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi | 1 | |
Modified residuei | 54 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
Modified residuei | 69 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
Modified residuei | 157 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
Modified residuei | 159 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
Modified residuei | 183 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
Modified residuei | 196 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
Modified residuei | 198 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
Modified residuei | 209 | PhosphoserineBy similarity Manual assertion inferred from sequence similarity toi | 1 | |
Modified residuei | 235 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
Modified residuei | 237 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
Modified residuei | 248 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
Modified residuei | 250 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
Modified residuei | 261 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
Modified residuei | 263 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
Modified residuei | 274 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
Modified residuei | 276 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
Modified residuei | 287 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
Modified residuei | 289 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
Modified residuei | 300 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
Modified residuei | 302 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
Modified residuei | 304 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
Modified residuei | 313 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
Modified residuei | 315 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
Modified residuei | 329 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
Modified residuei | 333 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
Modified residuei | 351 | PhosphoserineBy similarity Manual assertion inferred from sequence similarity toi | 1 | |
Modified residuei | 362 | PhosphoserineBy similarity Manual assertion inferred from sequence similarity toi | 1 | |
Modified residuei | 363 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
Modified residuei | 365 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
Modified residuei | 377 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
Modified residuei | 398 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
Modified residuei | 400 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
Modified residuei | 415 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
Modified residuei | 420 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
Modified residuei | 422 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
Modified residuei | 426 | PhosphoserineBy similarity Manual assertion inferred from sequence similarity toi | 1 | |
Modified residuei | 435 | PhosphothreonineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
Modified residuei | 438 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
Modified residuei | 440 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
Modified residuei | 461 | Phosphoserine1 Publication Manual assertion based on experiment ini
| 1 | |
Modified residuei | 463 | Phosphoserine1 Publication Manual assertion based on experiment ini
| 1 | |
Modified residuei | 465 | Phosphoserine1 Publication Manual assertion based on experiment ini
| 1 | |
Modified residuei | 480 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
Manual assertion based on experiment ini
| 1 | |
Modified residuei | 489 | Phosphothreonine1 Publication Manual assertion based on experiment ini
| 1 | |
Modified residuei | 511 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
Modified residuei | 513 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
Modified residuei | 725 | PhosphothreonineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 |
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi
Manual assertion based on experiment ini
- Ref.22"Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation."
Sharma S., Cermakova K., De Rijck J., Demeulemeester J., Fabry M., El Ashkar S., Van Belle S., Lepsik M., Tesina P., Duchoslav V., Novak P., Hubalek M., Srb P., Christ F., Rezacova P., Hodges H.C., Debyser Z., Veverka V.
Proc. Natl. Acad. Sci. U.S.A. 115:E7053-E7062(2018) [PubMed] [Europe PMC] [Abstract]Cited for: STRUCTURE BY NMR OF 447-548 IN COMPLEX WITH PSIP1, INTERACTION WITH PSIP1, DOMAIN IBM MOTIF, MUTAGENESIS OF ILE-476; PHE-477 AND SER-480, PHOSPHORYLATION AT SER-461; SER-463; SER-465; SER-480 AND THR-489.
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
Encyclopedia of Proteome Dynamics More...EPDi | Q96ST2 |
jPOST - Japan Proteome Standard Repository/Database More...jPOSTi | Q96ST2 |
MassIVE - Mass Spectrometry Interactive Virtual Environment More...MassIVEi | Q96ST2 |
MaxQB - The MaxQuant DataBase More...MaxQBi | Q96ST2 |
PaxDb, a database of protein abundance averages across all three domains of life More...PaxDbi | Q96ST2 |
PeptideAtlas More...PeptideAtlasi | Q96ST2 |
PRoteomics IDEntifications database More...PRIDEi | Q96ST2 |
ProteomicsDB: a multi-organism proteome resource More...ProteomicsDBi | 78143 [Q96ST2-1] 78144 [Q96ST2-2] 78145 [Q96ST2-3] |
PTM databases
iPTMnet integrated resource for PTMs in systems biology context More...iPTMneti | Q96ST2 |
MetOSite database of methionine sulfoxide sites More...MetOSitei | Q96ST2 |
Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat. More...PhosphoSitePlusi | Q96ST2 |
<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni
Gene expression databases
Bgee dataBase for Gene Expression Evolution More...Bgeei | ENSG00000163166, Expressed in sural nerve and 214 other tissues |
ExpressionAtlas, Differential and Baseline Expression More...ExpressionAtlasi | Q96ST2, baseline and differential |
Genevisible search portal to normalized and curated expression data from Genevestigator More...Genevisiblei | Q96ST2, HS |
Organism-specific databases
Human Protein Atlas More...HPAi | ENSG00000163166, Low tissue specificity |
<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni
<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei
Interacts with SUPT6H; binds preferentially to the POLR2A-bound SUPT6H.
Interacts with ALYREF/THOC4, SETD2 and PRMT5.
Interacts with HDGFRP2.
Interacts (via IBM motif) with PSIP1 (via IBD domain); phosphorylation increases its affinity for PSIP1 (PubMed:29997176).
5 PublicationsManual assertion based on experiment ini
- Ref.7"A putative transcriptional elongation factor hIws1 is essential for mammalian cell proliferation."
Liu Z., Zhou Z., Chen G., Bao S.
Biochem. Biophys. Res. Commun. 353:47-53(2007) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH PRMT5. - Ref.8"The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export."
Yoh S.M., Cho H., Pickle L., Evans R.M., Jones K.A.
Genes Dev. 21:160-174(2007) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH SUPT6H AND ALYREF. - Ref.9"The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation."
Yoh S.M., Lucas J.S., Jones K.A.
Genes Dev. 22:3422-3434(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INTERACTION WITH SETD2 AND SUPT6H. - Ref.21"HDGF-related protein-2 (HRP-2) acts as an oncogene to promote cell growth in hepatocellular carcinoma."
Gao K., Xu C., Jin X., Wumaier R., Ma J., Peng J., Wang Y., Tang Y., Yu L., Zhang P.
Biochem. Biophys. Res. Commun. 458:849-855(2015) [PubMed] [Europe PMC] [Abstract]Cited for: INTERACTION WITH HDGFRP2. - Ref.22"Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation."
Sharma S., Cermakova K., De Rijck J., Demeulemeester J., Fabry M., El Ashkar S., Van Belle S., Lepsik M., Tesina P., Duchoslav V., Novak P., Hubalek M., Srb P., Christ F., Rezacova P., Hodges H.C., Debyser Z., Veverka V.
Proc. Natl. Acad. Sci. U.S.A. 115:E7053-E7062(2018) [PubMed] [Europe PMC] [Abstract]Cited for: STRUCTURE BY NMR OF 447-548 IN COMPLEX WITH PSIP1, INTERACTION WITH PSIP1, DOMAIN IBM MOTIF, MUTAGENESIS OF ILE-476; PHE-477 AND SER-480, PHOSPHORYLATION AT SER-461; SER-463; SER-465; SER-480 AND THR-489.
Protein-protein interaction databases
The Biological General Repository for Interaction Datasets (BioGRID) More...BioGRIDi | 120807, 59 interactors |
Protein interaction database and analysis system More...IntActi | Q96ST2, 28 interactors |
Molecular INTeraction database More...MINTi | Q96ST2 |
STRING: functional protein association networks More...STRINGi | 9606.ENSP00000295321 |
Miscellaneous databases
RNAct, Protein-RNA interaction predictions for model organisms. More...RNActi | Q96ST2, protein |
<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei
Secondary structure
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
<p>This subsection of the <a href="http://www.uniprot.org/help/structure%5Fsection">'Structure'</a> section is used to indicate the positions of experimentally determined helical regions within the protein sequence.<p><a href='/help/helix' target='_top'>More...</a></p>Helixi | 469 – 476 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei | 8 | |
<p>This subsection of the <a href="http://www.uniprot.org/help/structure%5Fsection">'Structure'</a> section is used to indicate the positions of experimentally determined hydrogen-bonded turns within the protein sequence. These elements correspond to the DSSP secondary structure code 'T'.<p><a href='/help/turn' target='_top'>More...</a></p>Turni | 477 – 481 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei | 5 | |
Helixi | 482 – 484 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei | 3 | |
Helixi | 493 – 495 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei | 3 | |
Helixi | 512 – 515 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei | 4 | |
Helixi | 528 – 539 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei | 12 |
3D structure databases
SWISS-MODEL Repository - a database of annotated 3D protein structure models More...SMRi | Q96ST2 |
Database of comparative protein structure models More...ModBasei | Search... |
Protein Data Bank in Europe - Knowledge Base More...PDBe-KBi | Search... |
<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati | 235 – 260 | 1Add BLAST | 26 | |
Repeati | 261 – 286 | 2Add BLAST | 26 | |
Repeati | 287 – 296 | 3; half-length | 10 | |
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini | 614 – 692 | TFIIS N-terminalPROSITE-ProRule annotation Manual assertion according to rulesi Add BLAST | 79 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni | 235 – 296 | 3 X approximate tandem repeatsAdd BLAST | 62 | |
Regioni | 523 – 819 | Interaction with SUPT6H and ALYREF1 Publication Manual assertion based on experiment ini
| 297 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi | 469 – 495 | Integrase domain-binding motif (IBM)1 Publication Manual assertion based on experiment ini
| 27 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi | 83 – 509 | Glu-richAdd BLAST | 427 |
<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
evolutionary genealogy of genes: Non-supervised Orthologous Groups More...eggNOGi | KOG1793, Eukaryota |
Ensembl GeneTree More...GeneTreei | ENSGT00720000108834 |
The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms More...HOGENOMi | CLU_018182_0_0_1 |
InParanoid: Eukaryotic Ortholog Groups More...InParanoidi | Q96ST2 |
Identification of Orthologs from Complete Genome Data More...OMAi | EDRPNQH |
Database of Orthologous Groups More...OrthoDBi | 380765at2759 |
Database for complete collections of gene phylogenies More...PhylomeDBi | Q96ST2 |
TreeFam database of animal gene trees More...TreeFami | TF315504 |
Family and domain databases
Gene3D Structural and Functional Annotation of Protein Families More...Gene3Di | 1.20.930.10, 1 hit |
Integrated resource of protein families, domains and functional sites More...InterProi | View protein in InterPro IPR035441, TFIIS/LEDGF_dom_sf IPR017923, TFIIS_N |
Pfam protein domain database More...Pfami | View protein in Pfam PF08711, Med26, 1 hit |
Superfamily database of structural and functional annotation More...SUPFAMi | SSF47676, SSF47676, 1 hit |
PROSITE; a protein domain and family database More...PROSITEi | View protein in PROSITE PS51319, TFIIS_N, 1 hit |
<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i
<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.
This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basketAdded to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MDSEYYSGDQ SDDGGATPVQ DERDSGSDGE DDVNEQHSGS DTGSVERHSE
60 70 80 90 100
NETSDREDGL PKGHHVTDSE NDEPLNLNAS DSESEELHRQ KDSDSESEER
110 120 130 140 150
AEPPASDSEN EDVNQHGSDS ESEETRKLPG SDSENEELLN GHASDSENED
160 170 180 190 200
VGKHPASDSE IEELQKSPAS DSETEDALKP QISDSESEEP PRHQASDSEN
210 220 230 240 250
EEPPKPRMSD SESEELPKPQ VSDSESEEPP RHQASDSENE ELPKPRISDS
260 270 280 290 300
ESEDPPRHQA SDSENEELPK PRISDSESED PPRNQASDSE NEELPKPRVS
310 320 330 340 350
DSESEGPQKG PASDSETEDA SRHKQKPESD DDSDRENKGE DTEMQNDSFH
360 370 380 390 400
SDSHMDRKKF HSSDSEEEEH KKQKMDSDED EKEGEEEKVA KRKAAVLSDS
410 420 430 440 450
EDEEKASAKK SRVVSDADDS DSDAVSDKSG KREKTIASDS EEEAGKELSD
460 470 480 490 500
KKNEEKDLFG SDSESGNEEE NLIADIFGES GDEEEEEFTG FNQEDLEEEK
510 520 530 540 550
GETQVKEAED SDSDDNIKRG KHMDFLSDFE MMLQRKKSMS GKRRRNRDGG
560 570 580 590 600
TFISDADDVV SAMIVKMNEA AEEDRQLNNQ KKPALKKLTL LPAVVMHLKK
610 620 630 640 650
QDLKETFIDS GVMSAIKEWL SPLPDRSLPA LKIREELLKI LQELPSVSQE
660 670 680 690 700
TLKHSGIGRA VMYLYKHPKE SRSNKDMAGK LINEWSRPIF GLTSNYKGMT
710 720 730 740 750
REEREQRDLE QMPQRRRMNS TGGQTPRRDL EKVLTGEEKA LRPGDPGFCA
760 770 780 790 800
RARVPMPSNK DYVVRPKWNV EMESSRFQAT SKKGISRLDK QMRKFTDIRK
810
KSRSAHAVKI SIEGNKMPL
The sequence of this isoform differs from the canonical sequence as follows:
20-344: Missing.
10 20 30 40 50
MDSEYYSGDQ SDDGGATPVQ NDSFHSDSHM DRKKFHSSDS EEEEHKKQKM
60 70 80 90 100
DSDEDEKEGE EEKVAKRKAA VLSDSEDEEK ASAKKSRVVS DADDSDSDAV
110 120 130 140 150
SDKSGKREKT IASDSEEEAG KELSDKKNEE KDLFGSDSES GNEEENLIAD
160 170 180 190 200
IFGESGDEEE EEFTGFNQED LEEEKGETQV KEAEDSDSDD NIKRGKHMDF
210 220 230 240 250
LSDFEMMLQR KKSMSGKRRR NRDGGTFISD ADDVVSAMIV KMNEAAEEDR
260 270 280 290 300
QLNNQKKPAL KKLTLLPAVV MHLKKQDLKE TFIDSGVMSA IKEWLSPLPD
310 320 330 340 350
RSLPALKIRE ELLKILQELP SVSQETLKHS GIGRAVMYLY KHPKESRSNK
360 370 380 390 400
DMAGKLINEW SRPIFGLTSN YKGMTREERE QRDLEQMPQR RRMNSTGGQT
410 420 430 440 450
PRRDLEKVLT GEEKALRPGD PGFCARARVP MPSNKDYVVR PKWNVEMESS
460 470 480 490
RFQATSKKGI SRLDKQMRKF TDIRKKSRSA HAVKISIEGN KMPL
The sequence of this isoform differs from the canonical sequence as follows:
54-260: Missing.
10 20 30 40 50
MDSEYYSGDQ SDDGGATPVQ DERDSGSDGE DDVNEQHSGS DTGSVERHSE
60 70 80 90 100
NETSDSENEE LPKPRISDSE SEDPPRNQAS DSENEELPKP RVSDSESEGP
110 120 130 140 150
QKGPASDSET EDASRHKQKP ESDDDSDREN KGEDTEMQND SFHSDSHMDR
160 170 180 190 200
KKFHSSDSEE EEHKKQKMDS DEDEKEGEEE KVAKRKAAVL SDSEDEEKAS
210 220 230 240 250
AKKSRVVSDA DDSDSDAVSD KSGKREKTIA SDSEEEAGKE LSDKKNEEKD
260 270 280 290 300
LFGSDSESGN EEENLIADIF GESGDEEEEE FTGFNQEDLE EEKGETQVKE
310 320 330 340 350
AEDSDSDDNI KRGKHMDFLS DFEMMLQRKK SMSGKRRRNR DGGTFISDAD
360 370 380 390 400
DVVSAMIVKM NEAAEEDRQL NNQKKPALKK LTLLPAVVMH LKKQDLKETF
410 420 430 440 450
IDSGVMSAIK EWLSPLPDRS LPALKIREEL LKILQELPSV SQETLKHSGI
460 470 480 490 500
GRAVMYLYKH PKESRSNKDM AGKLINEWSR PIFGLTSNYK GMTREEREQR
510 520 530 540 550
DLEQMPQRRR MNSTGGQTPR RDLEKVLTGE EKALRPGDPG FCARARVPMP
560 570 580 590 600
SNKDYVVRPK WNVEMESSRF QATSKKGISR LDKQMRKFTD IRKKSRSAHA
610
VKISIEGNKM PL
<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketEntry | Entry name | Protein names | Gene names | Length | Annotation | ||
---|---|---|---|---|---|---|---|
A0A1B0GW95 | A0A1B0GW95_HUMAN | Protein IWS1 homolog Protein IWS1 homolog | IWS1 | 207 | Annotation score: Annotation score:1 out of 5 <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p> | ||
B8ZZB6 | B8ZZB6_HUMAN | Protein IWS1 homolog Protein IWS1 homolog | IWS1 | 292 | Annotation score: Annotation score:1 out of 5 <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p> | ||
H7C0U1 | H7C0U1_HUMAN | Protein IWS1 homolog Protein IWS1 homolog | IWS1 | 33 | Annotation score: Annotation score:1 out of 5 <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p> |
<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 244 | K → R in BAB55198 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 530 | E → G in BAA91402 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 559 | V → D in BAB55198 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 786 | S → G in BAB55198 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055975 | 390 | A → V. Corresponds to variant dbSNP:rs34377117Ensembl. | 1 | |
Natural variantiVAR_055976 | 425 | V → I. Corresponds to variant dbSNP:rs34785867Ensembl. | 1 |
Alternative sequence
Sequence databases
Select the link destinations: EMBL nucleotide sequence database More...EMBLiGenBank nucleotide sequence database More...GenBankiDNA Data Bank of Japan; a nucleotide sequence database More...DDBJiLinks Updated | AK000868 mRNA Translation: BAA91402.1 AK001717 mRNA Translation: BAA91858.1 Different initiation. AK027561 mRNA Translation: BAB55198.1 AK056881 mRNA Translation: BAB71301.1 AL834178 mRNA Translation: CAD38875.1 BC065279 mRNA Translation: AAH65279.1 Sequence problems. BC110536 mRNA Translation: AAI10537.1 BC110537 mRNA Translation: AAI10538.1 |
The Consensus CDS (CCDS) project More...CCDSi | CCDS2146.1 [Q96ST2-1] |
NCBI Reference Sequences More...RefSeqi | NP_060439.2, NM_017969.2 [Q96ST2-1] |
Genome annotation databases
Ensembl eukaryotic genome annotation project More...Ensembli | ENST00000295321; ENSP00000295321; ENSG00000163166 [Q96ST2-1] |
Database of genes from NCBI RefSeq genomes More...GeneIDi | 55677 |
KEGG: Kyoto Encyclopedia of Genes and Genomes More...KEGGi | hsa:55677 |
UCSC genome browser More...UCSCi | uc002ton.3, human [Q96ST2-1] |
Keywords - Coding sequence diversityi
Alternative splicing<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi
Protein | Similar proteins | Species | Score | Length | Source | |
---|---|---|---|---|---|---|
Q96ST2 | TFIIS N-terminal domain-containing protein | 854 | UniRef90_Q96ST2 | |||
protein IWS1 homolog isoform X1 | 854 | |||||
TFIIS N-terminal domain-containing protein | 612 | |||||
TFIIS N-terminal domain-containing protein | 824 | |||||
TFIIS N-terminal domain-containing protein | 819 | |||||
+77 | ||||||
Q96ST2-3 | Interacts with SUPT6H, CTD assembly factor 1 | 760 | UniRef90_Q96ST2-3 |
<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK000868 mRNA Translation: BAA91402.1 AK001717 mRNA Translation: BAA91858.1 Different initiation. AK027561 mRNA Translation: BAB55198.1 AK056881 mRNA Translation: BAB71301.1 AL834178 mRNA Translation: CAD38875.1 BC065279 mRNA Translation: AAH65279.1 Sequence problems. BC110536 mRNA Translation: AAI10537.1 BC110537 mRNA Translation: AAI10538.1 |
CCDSi | CCDS2146.1 [Q96ST2-1] |
RefSeqi | NP_060439.2, NM_017969.2 [Q96ST2-1] |
3D structure databases
Select the link destinations: Protein Data Bank Europe More...PDBeiProtein Data Bank RCSB More...RCSB PDBiProtein Data Bank Japan More...PDBjiLinks Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6EMR | NMR | - | A | 447-548 | [»] | |
SMRi | Q96ST2 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 120807, 59 interactors |
IntActi | Q96ST2, 28 interactors |
MINTi | Q96ST2 |
STRINGi | 9606.ENSP00000295321 |
PTM databases
iPTMneti | Q96ST2 |
MetOSitei | Q96ST2 |
PhosphoSitePlusi | Q96ST2 |
Genetic variation databases
BioMutai | IWS1 |
DMDMi | 85542184 |
Proteomic databases
EPDi | Q96ST2 |
jPOSTi | Q96ST2 |
MassIVEi | Q96ST2 |
MaxQBi | Q96ST2 |
PaxDbi | Q96ST2 |
PeptideAtlasi | Q96ST2 |
PRIDEi | Q96ST2 |
ProteomicsDBi | 78143 [Q96ST2-1] 78144 [Q96ST2-2] 78145 [Q96ST2-3] |
Protocols and materials databases
Antibodypedia a portal for validated antibodies More...Antibodypediai | 47563, 109 antibodies |
Genome annotation databases
Ensembli | ENST00000295321; ENSP00000295321; ENSG00000163166 [Q96ST2-1] |
GeneIDi | 55677 |
KEGGi | hsa:55677 |
UCSCi | uc002ton.3, human [Q96ST2-1] |
Organism-specific databases
Comparative Toxicogenomics Database More...CTDi | 55677 |
DisGeNETi | 55677 |
GeneCards: human genes, protein and diseases More...GeneCardsi | IWS1 |
HGNCi | HGNC:25467, IWS1 |
HPAi | ENSG00000163166, Low tissue specificity |
neXtProti | NX_Q96ST2 |
OpenTargetsi | ENSG00000163166 |
PharmGKBi | PA144596419 |
VEuPathDBi | HostDB:ENSG00000163166.13 |
GenAtlas: human gene database More...GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1793, Eukaryota |
GeneTreei | ENSGT00720000108834 |
HOGENOMi | CLU_018182_0_0_1 |
InParanoidi | Q96ST2 |
OMAi | EDRPNQH |
OrthoDBi | 380765at2759 |
PhylomeDBi | Q96ST2 |
TreeFami | TF315504 |
Enzyme and pathway databases
PathwayCommonsi | Q96ST2 |
Reactomei | R-HSA-112382, Formation of RNA Pol II elongation complex R-HSA-674695, RNA Polymerase II Pre-transcription Events R-HSA-75955, RNA Polymerase II Transcription Elongation |
Miscellaneous databases
BioGRID ORCS database of CRISPR phenotype screens More...BioGRID-ORCSi | 55677, 45 hits in 1006 CRISPR screens |
ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data More...ChiTaRSi | IWS1, human |
The Gene Wiki collection of pages on human genes and proteins More...GeneWikii | IWS1 |
Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens More...GenomeRNAii | 55677 |
Pharosi | Q96ST2, Tbio |
Protein Ontology More...PROi | PR:Q96ST2 |
RNActi | Q96ST2, protein |
Gene expression databases
Bgeei | ENSG00000163166, Expressed in sural nerve and 214 other tissues |
ExpressionAtlasi | Q96ST2, baseline and differential |
Genevisiblei | Q96ST2, HS |
Family and domain databases
Gene3Di | 1.20.930.10, 1 hit |
InterProi | View protein in InterPro IPR035441, TFIIS/LEDGF_dom_sf IPR017923, TFIIS_N |
Pfami | View protein in Pfam PF08711, Med26, 1 hit |
SUPFAMi | SSF47676, SSF47676, 1 hit |
PROSITEi | View protein in PROSITE PS51319, TFIIS_N, 1 hit |
ProtoNet; Automatic hierarchical classification of proteins More...ProtoNeti | Search... |
MobiDB: a database of protein disorder and mobility annotations More...MobiDBi | Search... |
<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi
<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei | IWS1_HUMAN | |
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>Accessioni | Q96ST2Primary (citable) accession number: Q96ST2 Secondary accession number(s): Q2TB65 , Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8 | |
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 10, 2006 |
Last sequence update: | January 10, 2006 | |
Last modified: | April 7, 2021 | |
This is version 156 of the entry and version 2 of the sequence. See complete history. | ||
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families