Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q96SR6 (ZN382_HUMAN)

Entry version 159 (11 Dec 2019)
Sequence version 3 (30 Nov 2010)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Zinc finger protein 382

Gene

ZNF382

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a sequence-specific transcriptional repressor.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri212 – 234C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri492 – 514C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri520 – 542C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-212436 Generic Transcription Pathway

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q96SR6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 382
Alternative name(s):
KRAB/zinc finger suppressor protein 1
Short name:
KS1
Multiple zinc finger and krueppel-associated box protein KS1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF382
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000161298.16

Human Gene Nomenclature Database

More...HGNCi		HGNC:17409 ZNF382

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609516 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96SR6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		84911

Open Targets

More...OpenTargetsi		ENSG00000161298

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134869965

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96SR6 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF382

Domain mapping of disease mutations (DMDM)

More...DMDMi		313104256

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000475491 – 550Zinc finger protein 382Add BLAST550

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96SR6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96SR6

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96SR6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96SR6

PeptideAtlas

More...PeptideAtlasi		Q96SR6

PRoteomics IDEntifications database

More...PRIDEi		Q96SR6

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		78140 [Q96SR6-1]
78141 [Q96SR6-2]
78142 [Q96SR6-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96SR6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96SR6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Specifically expressed in heart with a weaker expression also detected in skeletal muscle.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Primarily detected in 34 day-old embryos. Widely expressed at different levels during embryonic development where it is predominantly expressed in cerebellum, kidney, and cerebrum and to a lesser extent in lung, heart, skeletal muscle, tongue, and adrenal gland.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000161298 Expressed in 116 organ(s), highest expression level in right hemisphere of cerebellum

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96SR6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96SR6 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA049259

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TRIM28; enhances the transcriptional repressor activity.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		124348, 3 interactors

Protein interaction database and analysis system

More...IntActi		Q96SR6, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000292928

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96SR6 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96SR6

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 78KRABPROSITE-ProRule annotationAdd BLAST72

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 105Mediates interaction with TRIM28By similarityAdd BLAST105
Regioni5 – 46Represses transcriptionBy similarityAdd BLAST42
Regioni70 – 211Represses transcriptionBy similarityAdd BLAST142
Regioni296 – 550Required for transcriptional repression activity; probably mediates sequence-specific DNA-bindingBy similarityAdd BLAST255

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri212 – 234C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri492 – 514C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri520 – 542C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162338

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000234617

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96SR6

KEGG Orthology (KO)

More...KOi		K09228

Identification of Orthologs from Complete Genome Data

More...OMAi		SFEHNEC

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96SR6

TreeFam database of animal gene trees

More...TreeFami		TF337898

Family and domain databases

Conserved Domains Database

More...CDDi		cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 9 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 10 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96SR6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPLQGSVSFK DVTVDFTQEE WQQLDPAQKA LYRDVMLENY CHFVSVGFHM 
        60         70         80         90        100
AKPDMIRKLE QGEELWTQRI FPSYSYLEED GKTEDVLVKF KEYQDRHSRP 
       110        120        130        140        150
LIFINHKKLI KERSNIYGKT FTLGKNRISK TILCEYKPDG KVLKNISELV 
       160        170        180        190        200
IRNISPIKEK FGDSTGWEKS LLNTKHEKIH PAVNLHKQTE RVLSGKQELI 
       210        220        230        240        250
QHQKVQAPEQ PFDHNECEKS FLMKGMLFTH TRAHRGERTF EYNKDGIAFI 
       260        270        280        290        300
EKSSLSVHPS NLMEKKPSAY NKYGKFLCRK PVFIMPQRPQ TEEKPFHCPY 
       310        320        330        340        350
CGNNFRRKSY LIEHQRIHTG EKPYVCNQCG KAFRQKTALT LHEKTHIEGK 
       360        370        380        390        400
PFICIDCGKS FRQKATLTRH HKTHTGEKAY ECPQCGSAFR KKSYLIDHQR 
       410        420        430        440        450
THTGEKPYQC NECGKAFIQK TTLTVHQRTH TGEKPYICNE CGKSFCQKTT 
       460        470        480        490        500
LTLHQRIHTG EKPYICNECG KSFRQKAILT VHHRIHTGEK SNGCPQCGKA 
       510        520        530        540        550
FSRKSNLIRH QKTHTGEKPY ECKQCGKFFS CKSNLIVHQK THKVETTGIQ
Length:550
Mass (Da):64,010
Last modified:November 30, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6D0706EA069DDD0B
GO
Isoform 2 (identifier: Q96SR6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-3: MPL → MS

Show »
Length:549
Mass (Da):63,886
Checksum:i7E1ECFED0C1D8816
GO
Isoform 3 (identifier: Q96SR6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     78-78: Missing.

Show »
Length:549
Mass (Da):63,880
Checksum:i6CF371E4DF3F660E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EQ52K7EQ52_HUMAN
Zinc finger protein 382
ZNF382
25Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JME7C9JME7_HUMAN
Zinc finger protein 382
ZNF382
501Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PRV3A0A1W2PRV3_HUMAN
Zinc finger protein 382
ZNF382
277Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EK67K7EK67_HUMAN
Zinc finger protein 382
ZNF382
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti129 – 130Missing in AAM48246 (PubMed:12459182).Curated2
Sequence conflicti129 – 130Missing in AAO72308 (Ref. 2) Curated2
Sequence conflicti129 – 130Missing in BAB55217 (PubMed:14702039).Curated2
Sequence conflicti547T → M in AAI32676 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_054226168E → G2 PublicationsCorresponds to variant dbSNP:rs3108171Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0362241 – 3MPL → MS in isoform 2. 1 Publication3
Alternative sequenceiVSP_03622578Missing in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF513816 mRNA Translation: AAM48246.1
AY227449 mRNA Translation: AAO72308.1
AK027592 mRNA Translation: BAB55217.1
AL832265 mRNA Translation: CAI46159.1
AC074138 Genomic DNA No translation available.
AC092295 Genomic DNA No translation available.
BC132675 mRNA Translation: AAI32676.2

The Consensus CDS (CCDS) project

More...CCDSi		CCDS33004.1 [Q96SR6-1]
CCDS58659.1 [Q96SR6-2]

NCBI Reference Sequences

More...RefSeqi		NP_001243767.1, NM_001256838.1 [Q96SR6-2]
NP_116214.2, NM_032825.4 [Q96SR6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000292928; ENSP00000292928; ENSG00000161298 [Q96SR6-1]
ENST00000435416; ENSP00000410113; ENSG00000161298 [Q96SR6-3]
ENST00000439428; ENSP00000407593; ENSG00000161298 [Q96SR6-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		84911

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:84911

UCSC genome browser

More...UCSCi		uc002oek.5 human [Q96SR6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF513816 mRNA Translation: AAM48246.1
AY227449 mRNA Translation: AAO72308.1
AK027592 mRNA Translation: BAB55217.1
AL832265 mRNA Translation: CAI46159.1
AC074138 Genomic DNA No translation available.
AC092295 Genomic DNA No translation available.
BC132675 mRNA Translation: AAI32676.2
CCDSiCCDS33004.1 [Q96SR6-1]
CCDS58659.1 [Q96SR6-2]
RefSeqiNP_001243767.1, NM_001256838.1 [Q96SR6-2]
NP_116214.2, NM_032825.4 [Q96SR6-1]

3D structure databases

SMRiQ96SR6
ModBaseiSearch...

Protein-protein interaction databases

BioGridi124348, 3 interactors
IntActiQ96SR6, 1 interactor
STRINGi9606.ENSP00000292928

PTM databases

iPTMnetiQ96SR6
PhosphoSitePlusiQ96SR6

Polymorphism and mutation databases

BioMutaiZNF382
DMDMi313104256

Proteomic databases

jPOSTiQ96SR6
MassIVEiQ96SR6
MaxQBiQ96SR6
PaxDbiQ96SR6
PeptideAtlasiQ96SR6
PRIDEiQ96SR6
ProteomicsDBi78140 [Q96SR6-1]
78141 [Q96SR6-2]
78142 [Q96SR6-3]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		84911

Genome annotation databases

EnsembliENST00000292928; ENSP00000292928; ENSG00000161298 [Q96SR6-1]
ENST00000435416; ENSP00000410113; ENSG00000161298 [Q96SR6-3]
ENST00000439428; ENSP00000407593; ENSG00000161298 [Q96SR6-2]
GeneIDi84911
KEGGihsa:84911
UCSCiuc002oek.5 human [Q96SR6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		84911
DisGeNETi84911
EuPathDBiHostDB:ENSG00000161298.16

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF382
HGNCiHGNC:17409 ZNF382
HPAiHPA049259
MIMi609516 gene
neXtProtiNX_Q96SR6
OpenTargetsiENSG00000161298
PharmGKBiPA134869965

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000162338
HOGENOMiHOG000234617
InParanoidiQ96SR6
KOiK09228
OMAiSFEHNEC
OrthoDBi1318335at2759
PhylomeDBiQ96SR6
TreeFamiTF337898

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway
SIGNORiQ96SR6

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZNF382 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		84911
PharosiQ96SR6 Tdark

Protein Ontology

More...PROi		PR:Q96SR6
RNActiQ96SR6 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000161298 Expressed in 116 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasiQ96SR6 baseline and differential
GenevisibleiQ96SR6 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 9 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN382_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96SR6
Secondary accession number(s): A3KMP6
, A8MT55, C9K0V5, Q53ZY8, Q5JPJ2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: November 30, 2010
Last modified: December 11, 2019
This is version 159 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again