UniProtKB - Q96SR6 (ZN382_HUMAN)
Protein
Zinc finger protein 382
Gene
ZNF382
Organism
Homo sapiens (Human)
Status
Functioni
Functions as a sequence-specific transcriptional repressor.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 212 – 234 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 296 – 318 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 324 – 346 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 352 – 374 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 380 – 402 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 408 – 430 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 436 – 458 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 464 – 486 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 492 – 514 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 520 – 542 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q96SR6 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
SIGNORi | Q96SR6 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 382Alternative name(s): KRAB/zinc finger suppressor protein 1 Short name: KS1 Multiple zinc finger and krueppel-associated box protein KS1 |
Gene namesi | Name:ZNF382 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17409, ZNF382 |
MIMi | 609516, gene |
neXtProti | NX_Q96SR6 |
VEuPathDBi | HostDB:ENSG00000161298.16 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 84911 |
OpenTargetsi | ENSG00000161298 |
PharmGKBi | PA134869965 |
Miscellaneous databases
Pharosi | Q96SR6, Tdark |
Genetic variation databases
BioMutai | ZNF382 |
DMDMi | 313104256 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047549 | 1 – 550 | Zinc finger protein 382Add BLAST | 550 |
Proteomic databases
jPOSTi | Q96SR6 |
MassIVEi | Q96SR6 |
MaxQBi | Q96SR6 |
PaxDbi | Q96SR6 |
PeptideAtlasi | Q96SR6 |
PRIDEi | Q96SR6 |
ProteomicsDBi | 78140 [Q96SR6-1] 78141 [Q96SR6-2] 78142 [Q96SR6-3] |
PTM databases
iPTMneti | Q96SR6 |
PhosphoSitePlusi | Q96SR6 |
Expressioni
Tissue specificityi
Specifically expressed in heart with a weaker expression also detected in skeletal muscle.1 Publication
Developmental stagei
Primarily detected in 34 day-old embryos. Widely expressed at different levels during embryonic development where it is predominantly expressed in cerebellum, kidney, and cerebrum and to a lesser extent in lung, heart, skeletal muscle, tongue, and adrenal gland.1 Publication
Gene expression databases
Bgeei | ENSG00000161298, Expressed in right hemisphere of cerebellum and 135 other tissues |
ExpressionAtlasi | Q96SR6, baseline and differential |
Genevisiblei | Q96SR6, HS |
Organism-specific databases
HPAi | ENSG00000161298, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Interacts with TRIM28; enhances the transcriptional repressor activity.
By similarityProtein-protein interaction databases
BioGRIDi | 124348, 3 interactors |
IntActi | Q96SR6, 1 interactor |
STRINGi | 9606.ENSP00000292928 |
Miscellaneous databases
RNActi | Q96SR6, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 7 – 78 | KRABPROSITE-ProRule annotationAdd BLAST | 72 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 105 | Mediates interaction with TRIM28By similarityAdd BLAST | 105 | |
Regioni | 5 – 46 | Represses transcriptionBy similarityAdd BLAST | 42 | |
Regioni | 70 – 211 | Represses transcriptionBy similarityAdd BLAST | 142 | |
Regioni | 296 – 550 | Required for transcriptional repression activity; probably mediates sequence-specific DNA-bindingBy similarityAdd BLAST | 255 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 212 – 234 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 296 – 318 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 324 – 346 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 352 – 374 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 380 – 402 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 408 – 430 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 436 – 458 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 464 – 486 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 492 – 514 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 520 – 542 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162338 |
HOGENOMi | CLU_002678_44_5_1 |
InParanoidi | Q96SR6 |
OMAi | SFEHNEC |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q96SR6 |
TreeFami | TF337898 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 9 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 10 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 9 hits PS50157, ZINC_FINGER_C2H2_2, 10 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q96SR6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPLQGSVSFK DVTVDFTQEE WQQLDPAQKA LYRDVMLENY CHFVSVGFHM
60 70 80 90 100
AKPDMIRKLE QGEELWTQRI FPSYSYLEED GKTEDVLVKF KEYQDRHSRP
110 120 130 140 150
LIFINHKKLI KERSNIYGKT FTLGKNRISK TILCEYKPDG KVLKNISELV
160 170 180 190 200
IRNISPIKEK FGDSTGWEKS LLNTKHEKIH PAVNLHKQTE RVLSGKQELI
210 220 230 240 250
QHQKVQAPEQ PFDHNECEKS FLMKGMLFTH TRAHRGERTF EYNKDGIAFI
260 270 280 290 300
EKSSLSVHPS NLMEKKPSAY NKYGKFLCRK PVFIMPQRPQ TEEKPFHCPY
310 320 330 340 350
CGNNFRRKSY LIEHQRIHTG EKPYVCNQCG KAFRQKTALT LHEKTHIEGK
360 370 380 390 400
PFICIDCGKS FRQKATLTRH HKTHTGEKAY ECPQCGSAFR KKSYLIDHQR
410 420 430 440 450
THTGEKPYQC NECGKAFIQK TTLTVHQRTH TGEKPYICNE CGKSFCQKTT
460 470 480 490 500
LTLHQRIHTG EKPYICNECG KSFRQKAILT VHHRIHTGEK SNGCPQCGKA
510 520 530 540 550
FSRKSNLIRH QKTHTGEKPY ECKQCGKFFS CKSNLIVHQK THKVETTGIQ
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7EQ52 | K7EQ52_HUMAN | Zinc finger protein 382 | ZNF382 | 25 | Annotation score: | ||
C9JME7 | C9JME7_HUMAN | Zinc finger protein 382 | ZNF382 | 501 | Annotation score: | ||
K7EK67 | K7EK67_HUMAN | Zinc finger protein 382 | ZNF382 | 184 | Annotation score: | ||
A0A1W2PRV3 | A0A1W2PRV3_HUMAN | Zinc finger protein 382 | ZNF382 | 277 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 129 – 130 | Missing in AAM48246 (PubMed:12459182).Curated | 2 | |
Sequence conflicti | 129 – 130 | Missing in AAO72308 (Ref. 2) Curated | 2 | |
Sequence conflicti | 129 – 130 | Missing in BAB55217 (PubMed:14702039).Curated | 2 | |
Sequence conflicti | 547 | T → M in AAI32676 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_054226 | 168 | E → G2 PublicationsCorresponds to variant dbSNP:rs3108171Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_036224 | 1 – 3 | MPL → MS in isoform 2. 1 Publication | 3 | |
Alternative sequenceiVSP_036225 | 78 | Missing in isoform 3. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF513816 mRNA Translation: AAM48246.1 AY227449 mRNA Translation: AAO72308.1 AK027592 mRNA Translation: BAB55217.1 AL832265 mRNA Translation: CAI46159.1 AC074138 Genomic DNA No translation available. AC092295 Genomic DNA No translation available. BC132675 mRNA Translation: AAI32676.2 |
CCDSi | CCDS33004.1 [Q96SR6-1] CCDS58659.1 [Q96SR6-2] |
RefSeqi | NP_001243767.1, NM_001256838.1 [Q96SR6-2] NP_116214.2, NM_032825.4 [Q96SR6-1] |
Genome annotation databases
Ensembli | ENST00000292928; ENSP00000292928; ENSG00000161298 [Q96SR6-1] ENST00000435416; ENSP00000410113; ENSG00000161298 [Q96SR6-3] ENST00000439428; ENSP00000407593; ENSG00000161298 [Q96SR6-2] |
GeneIDi | 84911 |
KEGGi | hsa:84911 |
UCSCi | uc002oek.5, human [Q96SR6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF513816 mRNA Translation: AAM48246.1 AY227449 mRNA Translation: AAO72308.1 AK027592 mRNA Translation: BAB55217.1 AL832265 mRNA Translation: CAI46159.1 AC074138 Genomic DNA No translation available. AC092295 Genomic DNA No translation available. BC132675 mRNA Translation: AAI32676.2 |
CCDSi | CCDS33004.1 [Q96SR6-1] CCDS58659.1 [Q96SR6-2] |
RefSeqi | NP_001243767.1, NM_001256838.1 [Q96SR6-2] NP_116214.2, NM_032825.4 [Q96SR6-1] |
3D structure databases
SMRi | Q96SR6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124348, 3 interactors |
IntActi | Q96SR6, 1 interactor |
STRINGi | 9606.ENSP00000292928 |
PTM databases
iPTMneti | Q96SR6 |
PhosphoSitePlusi | Q96SR6 |
Genetic variation databases
BioMutai | ZNF382 |
DMDMi | 313104256 |
Proteomic databases
jPOSTi | Q96SR6 |
MassIVEi | Q96SR6 |
MaxQBi | Q96SR6 |
PaxDbi | Q96SR6 |
PeptideAtlasi | Q96SR6 |
PRIDEi | Q96SR6 |
ProteomicsDBi | 78140 [Q96SR6-1] 78141 [Q96SR6-2] 78142 [Q96SR6-3] |
Protocols and materials databases
Antibodypediai | 16319, 29 antibodies |
DNASUi | 84911 |
Genome annotation databases
Ensembli | ENST00000292928; ENSP00000292928; ENSG00000161298 [Q96SR6-1] ENST00000435416; ENSP00000410113; ENSG00000161298 [Q96SR6-3] ENST00000439428; ENSP00000407593; ENSG00000161298 [Q96SR6-2] |
GeneIDi | 84911 |
KEGGi | hsa:84911 |
UCSCi | uc002oek.5, human [Q96SR6-1] |
Organism-specific databases
CTDi | 84911 |
DisGeNETi | 84911 |
GeneCardsi | ZNF382 |
HGNCi | HGNC:17409, ZNF382 |
HPAi | ENSG00000161298, Tissue enhanced (brain) |
MIMi | 609516, gene |
neXtProti | NX_Q96SR6 |
OpenTargetsi | ENSG00000161298 |
PharmGKBi | PA134869965 |
VEuPathDBi | HostDB:ENSG00000161298.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162338 |
HOGENOMi | CLU_002678_44_5_1 |
InParanoidi | Q96SR6 |
OMAi | SFEHNEC |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q96SR6 |
TreeFami | TF337898 |
Enzyme and pathway databases
PathwayCommonsi | Q96SR6 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
SIGNORi | Q96SR6 |
Miscellaneous databases
BioGRID-ORCSi | 84911, 177 hits in 1008 CRISPR screens |
ChiTaRSi | ZNF382, human |
GenomeRNAii | 84911 |
Pharosi | Q96SR6, Tdark |
PROi | PR:Q96SR6 |
RNActi | Q96SR6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000161298, Expressed in right hemisphere of cerebellum and 135 other tissues |
ExpressionAtlasi | Q96SR6, baseline and differential |
Genevisiblei | Q96SR6, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 9 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 10 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 9 hits PS50157, ZINC_FINGER_C2H2_2, 10 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN382_HUMAN | |
Accessioni | Q96SR6Primary (citable) accession number: Q96SR6 Secondary accession number(s): A3KMP6 Q5JPJ2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 28, 2003 |
Last sequence update: | November 30, 2010 | |
Last modified: | April 7, 2021 | |
This is version 167 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families