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Protein

Cytochrome P450 2S1

Gene

CYP2S1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has a potential importance for extrahepatic xenobiotic metabolism.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi440Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-211958 Miscellaneous substrates
R-HSA-211981 Xenobiotics
R-HSA-211999 CYP2E1 reactions

Chemistry databases

SwissLipidsiSLP:000001465

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2S1 (EC:1.14.14.1)
Alternative name(s):
CYPIIS1
Gene namesi
Name:CYP2S1
ORF Names:UNQ891/PRO1906
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000167600.13
HGNCiHGNC:15654 CYP2S1
MIMi611529 gene
neXtProtiNX_Q96SQ9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi29785
OpenTargetsiENSG00000167600
PharmGKBiPA27113

Polymorphism and mutation databases

BioMutaiCYP2S1
DMDMi48428134

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517801 – 504Cytochrome P450 2S1Add BLAST504

Proteomic databases

MaxQBiQ96SQ9
PaxDbiQ96SQ9
PeptideAtlasiQ96SQ9
PRIDEiQ96SQ9
ProteomicsDBi78138
78139 [Q96SQ9-2]

PTM databases

iPTMnetiQ96SQ9
PhosphoSitePlusiQ96SQ9

Expressioni

Tissue specificityi

High level of expression in trachea, lung, stomach, small intestine, and spleen.1 Publication

Gene expression databases

BgeeiENSG00000167600 Expressed in 111 organ(s), highest expression level in jejunal mucosa
CleanExiHS_CYP2S1
ExpressionAtlasiQ96SQ9 baseline and differential
GenevisibleiQ96SQ9 HS

Organism-specific databases

HPAiHPA049227
HPA069248

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ADAMTSL4Q6UY14-33EBI-8633740,EBI-10173507

Protein-protein interaction databases

BioGridi118915, 38 interactors
IntActiQ96SQ9, 3 interactors
MINTiQ96SQ9
STRINGi9606.ENSP00000308032

Structurei

3D structure databases

ProteinModelPortaliQ96SQ9
SMRiQ96SQ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140831
HOGENOMiHOG000036992
HOVERGENiHBG015789
InParanoidiQ96SQ9
KOiK07420
OMAiKFTMLAL
OrthoDBiEOG091G0BT8
PhylomeDBiQ96SQ9
TreeFamiTF352043

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR008067 Cyt_P450_E_grp-I_CYP2A-like
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR01684 EP450ICYP2A
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96SQ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEATGTWALL LALALLLLLT LALSGTRARG HLPPGPTPLP LLGNLLQLRP
60 70 80 90 100
GALYSGLMRL SKKYGPVFTI YLGPWRPVVV LVGQEAVREA LGGQAEEFSG
110 120 130 140 150
RGTVAMLEGT FDGHGVFFSN GERWRQLRKF TMLALRDLGM GKREGEELIQ
160 170 180 190 200
AEARCLVETF QGTEGRPFDP SLLLAQATSN VVCSLLFGLR FSYEDKEFQA
210 220 230 240 250
VVRAAGGTLL GVSSQGGQTY EMFSWFLRPL PGPHKQLLHH VSTLAAFTVR
260 270 280 290 300
QVQQHQGNLD ASGPARDLVD AFLLKMAQEE QNPGTEFTNK NMLMTVIYLL
310 320 330 340 350
FAGTMTVSTT VGYTLLLLMK YPHVQKWVRE ELNRELGAGQ APSLGDRTRL
360 370 380 390 400
PYTDAVLHEA QRLLALVPMG IPRTLMRTTR FRGYTLPQGT EVFPLLGSIL
410 420 430 440 450
HDPNIFKHPE EFNPDRFLDA DGRFRKHEAF LPFSLGKRVC LGEGLAKAEL
460 470 480 490 500
FLFFTTILQA FSLESPCPPD TLSLKPTVSG LFNIPPAFQL QVRPTDLHST

TQTR
Length:504
Mass (Da):55,817
Last modified:June 7, 2004 - v2
Checksum:i853513370F65E25A
GO
Isoform 2 (identifier: Q96SQ9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     488-504: FQLQVRPTDLHSTTQTR → STVGMDRVNV...KYSPSAITST

Note: No experimental confirmation available.
Show »
Length:564
Mass (Da):62,231
Checksum:i03B2E9376A494D12
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R152M0R152_HUMAN
Cytochrome P450 2S1
CYP2S1
175Annotation score:
M0R057M0R057_HUMAN
Cytochrome P450 2S1
CYP2S1
187Annotation score:
M0R2G8M0R2G8_HUMAN
Cytochrome P450 2S1
CYP2S1
165Annotation score:
M0QY51M0QY51_HUMAN
Cytochrome P450 2S1
CYP2S1
60Annotation score:
M0QYI2M0QYI2_HUMAN
Cytochrome P450 2S1
CYP2S1
73Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033820466P → L. Corresponds to variant dbSNP:rs34971233Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010531488 – 504FQLQV…TTQTR → STVGMDRVNVSRVYTAGSHI YTPAVVFRSLSHGPHAHLTH AAKMHNRTPIHNYKGHKATA GLAFHRHKYSPSAITST in isoform 2. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF335278 mRNA Translation: AAK13498.1
AY358603 mRNA Translation: AAQ88966.1
AK027605 mRNA Translation: BAB55227.1
BC033691 mRNA Translation: AAH33691.1
CCDSiCCDS12573.1 [Q96SQ9-1]
PIRiJC7613
RefSeqiNP_085125.1, NM_030622.7 [Q96SQ9-1]
UniGeneiHs.98370

Genome annotation databases

EnsembliENST00000310054; ENSP00000308032; ENSG00000167600 [Q96SQ9-1]
GeneIDi29785
KEGGihsa:29785
UCSCiuc002opw.4 human [Q96SQ9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF335278 mRNA Translation: AAK13498.1
AY358603 mRNA Translation: AAQ88966.1
AK027605 mRNA Translation: BAB55227.1
BC033691 mRNA Translation: AAH33691.1
CCDSiCCDS12573.1 [Q96SQ9-1]
PIRiJC7613
RefSeqiNP_085125.1, NM_030622.7 [Q96SQ9-1]
UniGeneiHs.98370

3D structure databases

ProteinModelPortaliQ96SQ9
SMRiQ96SQ9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118915, 38 interactors
IntActiQ96SQ9, 3 interactors
MINTiQ96SQ9
STRINGi9606.ENSP00000308032

Chemistry databases

SwissLipidsiSLP:000001465

PTM databases

iPTMnetiQ96SQ9
PhosphoSitePlusiQ96SQ9

Polymorphism and mutation databases

BioMutaiCYP2S1
DMDMi48428134

Proteomic databases

MaxQBiQ96SQ9
PaxDbiQ96SQ9
PeptideAtlasiQ96SQ9
PRIDEiQ96SQ9
ProteomicsDBi78138
78139 [Q96SQ9-2]

Protocols and materials databases

DNASUi29785
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310054; ENSP00000308032; ENSG00000167600 [Q96SQ9-1]
GeneIDi29785
KEGGihsa:29785
UCSCiuc002opw.4 human [Q96SQ9-1]

Organism-specific databases

CTDi29785
DisGeNETi29785
EuPathDBiHostDB:ENSG00000167600.13
GeneCardsiCYP2S1
H-InvDBiHIX0015148
HGNCiHGNC:15654 CYP2S1
HPAiHPA049227
HPA069248
MIMi611529 gene
neXtProtiNX_Q96SQ9
OpenTargetsiENSG00000167600
PharmGKBiPA27113
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140831
HOGENOMiHOG000036992
HOVERGENiHBG015789
InParanoidiQ96SQ9
KOiK07420
OMAiKFTMLAL
OrthoDBiEOG091G0BT8
PhylomeDBiQ96SQ9
TreeFamiTF352043

Enzyme and pathway databases

ReactomeiR-HSA-211958 Miscellaneous substrates
R-HSA-211981 Xenobiotics
R-HSA-211999 CYP2E1 reactions

Miscellaneous databases

ChiTaRSiCYP2S1 human
GeneWikiiCYP2S1
GenomeRNAii29785
PROiPR:Q96SQ9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167600 Expressed in 111 organ(s), highest expression level in jejunal mucosa
CleanExiHS_CYP2S1
ExpressionAtlasiQ96SQ9 baseline and differential
GenevisibleiQ96SQ9 HS

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR008067 Cyt_P450_E_grp-I_CYP2A-like
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR01684 EP450ICYP2A
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCP2S1_HUMAN
AccessioniPrimary (citable) accession number: Q96SQ9
Secondary accession number(s): Q9BZ66
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: November 7, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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