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Entry version 152 (17 Jun 2020)
Sequence version 1 (01 Dec 2001)
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Protein

Zinc finger protein 587

Gene

ZNF587

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri92 – 114C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri492 – 514C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri520 – 542C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri548 – 570C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436 Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 587
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF587
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000198466.11

Human Gene Nomenclature Database

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HGNCi
HGNC:30955 ZNF587

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q96SQ5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000198466

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134940421

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q96SQ5 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
ZNF587

Domain mapping of disease mutations (DMDM)

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DMDMi
74762694

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002339871 – 575Zinc finger protein 587Add BLAST575

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96SQ5

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q96SQ5

MaxQB - The MaxQuant DataBase

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MaxQBi
Q96SQ5

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96SQ5

PeptideAtlas

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PeptideAtlasi
Q96SQ5

PRoteomics IDEntifications database

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PRIDEi
Q96SQ5

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
32198
78135 [Q96SQ5-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q96SQ5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q96SQ5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198466 Expressed in mammary gland and 229 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96SQ5 HS

Organism-specific databases

Human Protein Atlas

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HPAi
ENSG00000198466 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q96SQ5
With#Exp.IntAct
ADAMTSL4 - isoform 3 [Q6UY14-3]3EBI-6427977,EBI-10173507
AQP6 [Q13520]3EBI-6427977,EBI-13059134
ASB15 [Q8WXK1]3EBI-6427977,EBI-12809012
ASB6 [Q9NWX5]3EBI-6427977,EBI-6425205
AXIN2 [Q9Y2T1]3EBI-6427977,EBI-4400025
BEGAIN [Q9BUH8]3EBI-6427977,EBI-742722
C17orf50 [Q8WW18]3EBI-6427977,EBI-12877892
CARD10 [Q9BWT7]3EBI-6427977,EBI-3866279
CARD9 [Q9H257]3EBI-6427977,EBI-751319
CARD9 - isoform 2 [Q9H257-2]3EBI-6427977,EBI-11530605
CCDC125 [Q86Z20]3EBI-6427977,EBI-11977221
CCDC136 - isoform 2 [Q96JN2-2]3EBI-6427977,EBI-10171416
CCDC85B [Q15834]3EBI-6427977,EBI-739674
CEP44 [Q9C0F1]6EBI-6427977,EBI-744115
CEP70 [Q8NHQ1]6EBI-6427977,EBI-739624
CHRDL2 - isoform 2 [Q6WN34-2]3EBI-6427977,EBI-12593838
CSRNP1 [Q96S65]3EBI-6427977,EBI-4311573
CYSRT1 [A8MQ03]3EBI-6427977,EBI-3867333
DEF8 - isoform 2 [Q6ZN54-2]3EBI-6427977,EBI-12346463
DHX57 [Q6P158]3EBI-6427977,EBI-1051531
EFEMP2 [O95967]3EBI-6427977,EBI-743414
FCHSD2 - isoform 3 [O94868-3]3EBI-6427977,EBI-11958845
FHL3 [Q13643]3EBI-6427977,EBI-741101
FHL5 [Q5TD97]3EBI-6427977,EBI-750641
FSD2 [A1L4K1]6EBI-6427977,EBI-5661036
FST [P19883]3EBI-6427977,EBI-1571188
GOLGA2 [Q08379]3EBI-6427977,EBI-618309
GOLGA6L9 [A6NEM1]3EBI-6427977,EBI-5916454
GOPC [Q9HD26]3EBI-6427977,EBI-349832
GSC2 [O15499]3EBI-6427977,EBI-19954058
HMBOX1 [Q6NT76]3EBI-6427977,EBI-2549423
HOOK2 - isoform 2 [Q96ED9-2]3EBI-6427977,EBI-10961706
HOXA1 [P49639]5EBI-6427977,EBI-740785
HSF2BP [O75031]3EBI-6427977,EBI-7116203
IGFBP6 [P24592]3EBI-6427977,EBI-947015
IKBKG [Q9Y6K9]3EBI-6427977,EBI-81279
IKZF1 - isoform Ik7 [Q13422-7]3EBI-6427977,EBI-11522367
IKZF3 [Q9UKT9]3EBI-6427977,EBI-747204
INSC [Q1MX18]3EBI-6427977,EBI-12081118
ISY1 - isoform 2 [Q9ULR0-1]3EBI-6427977,EBI-18398632
KATNBL1 [Q9H079]3EBI-6427977,EBI-715394
KCTD7 - isoform 2 [Q96MP8-2]3EBI-6427977,EBI-11954971
KPRP [Q5T749]3EBI-6427977,EBI-10981970
KRT31 [Q15323]3EBI-6427977,EBI-948001
KRT38 [O76015]3EBI-6427977,EBI-1047263
KRT40 [Q6A162]6EBI-6427977,EBI-10171697
KRTAP1-1 [Q07627]3EBI-6427977,EBI-11959885
KRTAP10-10 [P60014]3EBI-6427977,EBI-11955579
KRTAP10-11 [P60412]3EBI-6427977,EBI-10217483
KRTAP10-5 [P60370]6EBI-6427977,EBI-10172150
KRTAP10-7 [P60409]6EBI-6427977,EBI-10172290
KRTAP10-8 [P60410]6EBI-6427977,EBI-10171774
KRTAP10-9 [P60411]6EBI-6427977,EBI-10172052
KRTAP12-2 [P59991]3EBI-6427977,EBI-10176379
KRTAP12-3 [P60328]3EBI-6427977,EBI-11953334
KRTAP2-3 [P0C7H8]3EBI-6427977,EBI-10196781
KRTAP2-4 [Q9BYR9]3EBI-6427977,EBI-14065470
KRTAP5-7 [Q6L8G8]3EBI-6427977,EBI-11987425
KRTAP5-9 [P26371]6EBI-6427977,EBI-3958099
LDOC1 [O95751]3EBI-6427977,EBI-740738
LHX3 - isoform B [Q9UBR4-2]3EBI-6427977,EBI-12039345
LIMS1 - isoform 3 [P48059-3]3EBI-6427977,EBI-12864460
LMO3 - isoform 4 [Q8TAP4-4]3EBI-6427977,EBI-11742507
LRP2BP [Q9P2M1]3EBI-6427977,EBI-18273118
LZTS1 [Q9Y250]3EBI-6427977,EBI-1216080
MCCD1 [P59942]3EBI-6427977,EBI-11987923
MDFI [Q99750]8EBI-6427977,EBI-724076
MEOX2 [P50222]3EBI-6427977,EBI-748397
MEOX2 [Q6FHY5]3EBI-6427977,EBI-16439278
MID2 - isoform 2 [Q9UJV3-2]6EBI-6427977,EBI-10172526
MKRN3 [Q13064]3EBI-6427977,EBI-2340269
MTUS2 [Q5JR59]3EBI-6427977,EBI-742948
MTUS2 - isoform 2 [Q5JR59-3]5EBI-6427977,EBI-11522433
MYF5 [P13349]5EBI-6427977,EBI-17491620
NDUFB7 [P17568]3EBI-6427977,EBI-1246238
NEK6 - isoform 4 [Q9HC98-4]3EBI-6427977,EBI-11750983
NKAPL [Q5M9Q1]3EBI-6427977,EBI-11423380
NOTCH2NLA [Q7Z3S9]3EBI-6427977,EBI-945833
NOTCH2NLC [P0DPK4]3EBI-6427977,EBI-22310682
NR1D2 [Q6NSM0]3EBI-6427977,EBI-10250949
PBX2 [P40425]3EBI-6427977,EBI-348489
PDE4DIP - isoform 2 [Q5VU43-2]3EBI-6427977,EBI-9640281
PLSCR1 [O15162]3EBI-6427977,EBI-740019
PNMA2 [Q9UL42]6EBI-6427977,EBI-302355
PRDM14 [Q9GZV8]3EBI-6427977,EBI-3957793
PRPF31 [Q8WWY3]6EBI-6427977,EBI-1567797
RORB - isoform 1 [Q92753-1]3EBI-6427977,EBI-18560266
RUNDC3A [Q59EK9]3EBI-6427977,EBI-747225
RUNDC3A - isoform 3 [Q59EK9-3]3EBI-6427977,EBI-11957366
SMYD5 [Q6GMV2]3EBI-6427977,EBI-11057552
SOX13 [Q9UN79]3EBI-6427977,EBI-3928516
SPRED1 [Q7Z699]3EBI-6427977,EBI-5235340
SPRY2 [O43597]3EBI-6427977,EBI-742487
SPRY3 [O43610]3EBI-6427977,EBI-12290641
SSX2IP [Q9Y2D8]3EBI-6427977,EBI-2212028
STX11 [O75558]8EBI-6427977,EBI-714135
TCF4 [P15884]3EBI-6427977,EBI-533224
TCF4 - isoform SEF2-1D [P15884-3]3EBI-6427977,EBI-13636688
TENM4 [Q6N022]3EBI-6427977,EBI-12827077
TFIP11 [Q9UBB9]3EBI-6427977,EBI-1105213
TNS2 [Q63HR2]6EBI-6427977,EBI-949753
TRAF1 [Q13077]6EBI-6427977,EBI-359224
TRIB3 [Q96RU7]3EBI-6427977,EBI-492476
TRIM23 [P36406]3EBI-6427977,EBI-740098
TRIM27 [P14373]3EBI-6427977,EBI-719493
TRIM36 [Q9NQ86]3EBI-6427977,EBI-2341518
TRIM37 [O94972]3EBI-6427977,EBI-741602
TRIM41 [Q8WV44]6EBI-6427977,EBI-725997
TRIM54 [Q9BYV2]6EBI-6427977,EBI-2130429
TSC1 [Q86WV8]3EBI-6427977,EBI-12806590
TSGA10 [Q9BZW7]3EBI-6427977,EBI-744794
TXK [P42681]3EBI-6427977,EBI-7877438
VPS52 [Q8N1B4]3EBI-6427977,EBI-2799833
VWC2 [Q2TAL6]3EBI-6427977,EBI-11957238
ZBTB43 [O43298]3EBI-6427977,EBI-740718
ZBTB8A [Q96BR9]6EBI-6427977,EBI-742740
ZGPAT - isoform 2 [Q8N5A5-2]3EBI-6427977,EBI-10183064
ZIM2 [Q9NZV7]3EBI-6427977,EBI-11962760
ZKSCAN8 [Q15776]3EBI-6427977,EBI-2602314
ZNF286A [Q9HBT8]3EBI-6427977,EBI-10754950
ZNF330 [Q9Y3S2]3EBI-6427977,EBI-373456
ZNF417 [Q8TAU3]3EBI-6427977,EBI-740727
ZNF547 [Q8IVP9]3EBI-6427977,EBI-12895421
ZNF774 [Q6NX45]3EBI-6427977,EBI-10251462
ZNF829 - isoform 3 [Q3KNS6-3]3EBI-6427977,EBI-18036029
ZNF837 [Q96EG3]3EBI-6427977,EBI-11962574
ZRANB1 [Q9UGI0]3EBI-6427977,EBI-527853

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
124351, 43 interactors

Protein interaction database and analysis system

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IntActi
Q96SQ5, 127 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000345479

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96SQ5 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96SQ5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini15 – 88KRABPROSITE-ProRule annotationAdd BLAST74

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri92 – 114C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri492 – 514C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri520 – 542C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri548 – 570C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000164176

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002678_44_5_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96SQ5

KEGG Orthology (KO)

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KOi
K09228

Identification of Orthologs from Complete Genome Data

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OMAi
CRKSIRE

Database of Orthologous Groups

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OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q96SQ5

TreeFam database of animal gene trees

More...
TreeFami
TF339848

Family and domain databases

Conserved Domains Database

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CDDi
cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 11 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 9 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q96SQ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAVPRRPT QQGTVTFEDV AVNFSQEEWC LLSEAQRCLY RDVMLENLAL
60 70 80 90 100
ISSLGCWCGS KDEEAPCKQR ISVQRESQSR TPRAGVSPKK AHPCEMCGLI
110 120 130 140 150
LEDVFHFADH QETHHKQKLN RSGACGKNLD DTAYLHQHQK QHIGEKFYRK
160 170 180 190 200
SVREASFVKK RKLRVSQEPF VFREFGKDVL PSSGLCQEEA AVEKTDSETM
210 220 230 240 250
HGPPFQEGKT NYSCGKRTKA FSTKHSVIPH QKLFTRDGCY VCSDCGKSFS
260 270 280 290 300
RYVSFSNHQR DHTAKGPYDC GECGKSYSRK SSLIQHQRVH TGQTAYPCEE
310 320 330 340 350
CGKSFSQKGS LISHQLVHTG EGPYECRECG KSFGQKGNLI QHQQGHTGER
360 370 380 390 400
AYHCGECGKS FRQKFCFINH QRVHTGERPY KCGECGKSFG QKGNLVHHQR
410 420 430 440 450
GHTGERPYEC KECGKSFRYR SHLTEHQRLH TGERPYNCRE CGKLFNRKYH
460 470 480 490 500
LLVHERVHTG ERPYACEVCG KLFGNKHSVT IHQRIHTGER PYECSECGKS
510 520 530 540 550
FLSSSALHVH KRVHSGQKPY KCSECGKSFS ECSSLIKHRR IHTGERPYEC
560 570
TKCGKTFQRS STLLHHQSSH RRKAL
Length:575
Mass (Da):65,622
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i61134F2814963397
GO
Isoform 2 (identifier: Q96SQ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     11-11: Missing.

Show »
Length:574
Mass (Da):65,494
Checksum:iDED642F4A347D10F
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04684211Missing in isoform 2. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK027616 mRNA Translation: BAB55235.1
AC010326 Genomic DNA No translation available.
AC010522 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72537.1
BC126237 mRNA Translation: AAI26238.1
BC126239 mRNA Translation: AAI26240.1
AK160374 mRNA Translation: BAD18717.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12964.1 [Q96SQ5-1]
CCDS56110.1 [Q96SQ5-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001191746.1, NM_001204817.1 [Q96SQ5-2]
NP_116217.1, NM_032828.3 [Q96SQ5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000339656; ENSP00000345479; ENSG00000198466 [Q96SQ5-1]
ENST00000423137; ENSP00000393865; ENSG00000198466 [Q96SQ5-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
84914

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:84914

UCSC genome browser

More...
UCSCi
uc002qql.4 human [Q96SQ5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027616 mRNA Translation: BAB55235.1
AC010326 Genomic DNA No translation available.
AC010522 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72537.1
BC126237 mRNA Translation: AAI26238.1
BC126239 mRNA Translation: AAI26240.1
AK160374 mRNA Translation: BAD18717.1
CCDSiCCDS12964.1 [Q96SQ5-1]
CCDS56110.1 [Q96SQ5-2]
RefSeqiNP_001191746.1, NM_001204817.1 [Q96SQ5-2]
NP_116217.1, NM_032828.3 [Q96SQ5-1]

3D structure databases

SMRiQ96SQ5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124351, 43 interactors
IntActiQ96SQ5, 127 interactors
STRINGi9606.ENSP00000345479

PTM databases

iPTMnetiQ96SQ5
PhosphoSitePlusiQ96SQ5

Polymorphism and mutation databases

BioMutaiZNF587
DMDMi74762694

Proteomic databases

jPOSTiQ96SQ5
MassIVEiQ96SQ5
MaxQBiQ96SQ5
PaxDbiQ96SQ5
PeptideAtlasiQ96SQ5
PRIDEiQ96SQ5
ProteomicsDBi32198
78135 [Q96SQ5-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
33305 62 antibodies

Genome annotation databases

EnsembliENST00000339656; ENSP00000345479; ENSG00000198466 [Q96SQ5-1]
ENST00000423137; ENSP00000393865; ENSG00000198466 [Q96SQ5-2]
GeneIDi84914
KEGGihsa:84914
UCSCiuc002qql.4 human [Q96SQ5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84914
EuPathDBiHostDB:ENSG00000198466.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZNF587
HGNCiHGNC:30955 ZNF587
HPAiENSG00000198466 Low tissue specificity
neXtProtiNX_Q96SQ5
OpenTargetsiENSG00000198466
PharmGKBiPA134940421

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000164176
HOGENOMiCLU_002678_44_5_1
InParanoidiQ96SQ5
KOiK09228
OMAiCRKSIRE
OrthoDBi1318335at2759
PhylomeDBiQ96SQ5
TreeFamiTF339848

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
84914 14 hits in 797 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ZNF587 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
84914
PharosiQ96SQ5 Tdark

Protein Ontology

More...
PROi
PR:Q96SQ5
RNActiQ96SQ5 protein

Gene expression databases

BgeeiENSG00000198466 Expressed in mammary gland and 229 other tissues
GenevisibleiQ96SQ5 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 11 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 9 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN587_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96SQ5
Secondary accession number(s): A0AV72, G3V0H5, Q6ZMK8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: December 1, 2001
Last modified: June 17, 2020
This is version 152 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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