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Protein

Zinc finger protein 587

Gene

ZNF587

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri92 – 114C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri492 – 514C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri520 – 542C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri548 – 570C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 587
Gene namesi
Name:ZNF587
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000198466.11
HGNCiHGNC:30955 ZNF587
neXtProtiNX_Q96SQ5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198466
PharmGKBiPA134940421

Polymorphism and mutation databases

BioMutaiZNF587
DMDMi74762694

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002339871 – 575Zinc finger protein 587Add BLAST575

Proteomic databases

EPDiQ96SQ5
MaxQBiQ96SQ5
PaxDbiQ96SQ5
PeptideAtlasiQ96SQ5
PRIDEiQ96SQ5
ProteomicsDBi78135

PTM databases

iPTMnetiQ96SQ5
PhosphoSitePlusiQ96SQ5

Expressioni

Gene expression databases

BgeeiENSG00000198466 Expressed in 230 organ(s), highest expression level in mammary gland
CleanExiHS_ZNF587
ExpressionAtlasiQ96SQ5 baseline and differential
GenevisibleiQ96SQ5 HS

Organism-specific databases

HPAiHPA042125
HPA043288
HPA056213

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi124351, 43 interactors
IntActiQ96SQ5, 126 interactors
STRINGi9606.ENSP00000345479

Structurei

3D structure databases

ProteinModelPortaliQ96SQ5
SMRiQ96SQ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 88KRABPROSITE-ProRule annotationAdd BLAST74

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri92 – 114C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri492 – 514C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri520 – 542C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri548 – 570C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119107
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ96SQ5
KOiK09228
OMAiEPFVFHE
OrthoDBiEOG091G02KC
PhylomeDBiQ96SQ5
TreeFamiTF339848

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 9 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.iShow all

Isoform 1 (identifier: Q96SQ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAVPRRPT QQGTVTFEDV AVNFSQEEWC LLSEAQRCLY RDVMLENLAL
60 70 80 90 100
ISSLGCWCGS KDEEAPCKQR ISVQRESQSR TPRAGVSPKK AHPCEMCGLI
110 120 130 140 150
LEDVFHFADH QETHHKQKLN RSGACGKNLD DTAYLHQHQK QHIGEKFYRK
160 170 180 190 200
SVREASFVKK RKLRVSQEPF VFREFGKDVL PSSGLCQEEA AVEKTDSETM
210 220 230 240 250
HGPPFQEGKT NYSCGKRTKA FSTKHSVIPH QKLFTRDGCY VCSDCGKSFS
260 270 280 290 300
RYVSFSNHQR DHTAKGPYDC GECGKSYSRK SSLIQHQRVH TGQTAYPCEE
310 320 330 340 350
CGKSFSQKGS LISHQLVHTG EGPYECRECG KSFGQKGNLI QHQQGHTGER
360 370 380 390 400
AYHCGECGKS FRQKFCFINH QRVHTGERPY KCGECGKSFG QKGNLVHHQR
410 420 430 440 450
GHTGERPYEC KECGKSFRYR SHLTEHQRLH TGERPYNCRE CGKLFNRKYH
460 470 480 490 500
LLVHERVHTG ERPYACEVCG KLFGNKHSVT IHQRIHTGER PYECSECGKS
510 520 530 540 550
FLSSSALHVH KRVHSGQKPY KCSECGKSFS ECSSLIKHRR IHTGERPYEC
560 570
TKCGKTFQRS STLLHHQSSH RRKAL
Length:575
Mass (Da):65,622
Last modified:December 1, 2001 - v1
Checksum:i61134F2814963397
GO
Isoform 2 (identifier: Q96SQ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     11-11: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:574
Mass (Da):65,494
Checksum:iDED642F4A347D10F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EP41E7EP41_HUMAN
Zinc finger protein 587
ZNF587
532Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04684211Missing in isoform 2. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027616 mRNA Translation: BAB55235.1
AC010326 Genomic DNA No translation available.
AC010522 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72537.1
BC126237 mRNA Translation: AAI26238.1
BC126239 mRNA Translation: AAI26240.1
AK160374 mRNA Translation: BAD18717.1
CCDSiCCDS12964.1 [Q96SQ5-1]
CCDS56110.1 [Q96SQ5-2]
RefSeqiNP_001191746.1, NM_001204817.1 [Q96SQ5-2]
NP_116217.1, NM_032828.3 [Q96SQ5-1]
UniGeneiHs.642598
Hs.744891

Genome annotation databases

EnsembliENST00000339656; ENSP00000345479; ENSG00000198466 [Q96SQ5-1]
ENST00000423137; ENSP00000393865; ENSG00000198466 [Q96SQ5-2]
GeneIDi84914
KEGGihsa:84914
UCSCiuc002qql.4 human [Q96SQ5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZN587_HUMAN
AccessioniPrimary (citable) accession number: Q96SQ5
Secondary accession number(s): A0AV72, G3V0H5, Q6ZMK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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