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Entry version 174 (16 Oct 2019)
Sequence version 5 (18 May 2010)
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Protein

CDK5 regulatory subunit-associated protein 2

Gene

CDK5RAP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends. Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gamma-TuRC) onto centrosomes (PubMed:26485573). In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery (PubMed:29162697). Required for the recruitment of AKAP9 to centrosomes (PubMed:29162697). Plays a role in neurogenesis (By similarity).By similarity6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-8854518 AURKA Activation by TPX2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CDK5 regulatory subunit-associated protein 2
Alternative name(s):
CDK5 activator-binding protein C48
Centrosome-associated protein 215
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CDK5RAP2
Synonyms:CEP215, KIAA1633
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:18672 CDK5RAP2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
608201 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q96SN8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Microcephaly 3, primary, autosomal recessive (MCPH3)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Affected individuals are mentally retarded. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits due to degenerative brain disorder.
Related information in OMIM

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi938 – 939LP → AA: Loss of interaction with MAPRE1. 1 Publication2
Mutagenesisi1865K → A: No effect on centrosomal attachment, Golgi localization and loss of interaction with CALM1; when associated with A-1869. 1 Publication1
Mutagenesisi1869K → A: No effect on centrosomal attachment, Golgi localization and loss of interaction to CALM1; when associated with A-1865. 1 Publication1

Keywords - Diseasei

Mental retardation, Primary microcephaly

Organism-specific databases

DisGeNET

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DisGeNETi
55755

MalaCards human disease database

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MalaCardsi
CDK5RAP2
MIMi604804 phenotype

Open Targets

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OpenTargetsi
ENSG00000136861

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
2512 Autosomal recessive primary microcephaly

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA38632

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q96SN8

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
CDK5RAP2

Domain mapping of disease mutations (DMDM)

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DMDMi
296439505

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000898351 – 1893CDK5 regulatory subunit-associated protein 2Add BLAST1893

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei547PhosphoserineCombined sources1
Modified residuei1001PhosphothreonineCombined sources1
Modified residuei1238PhosphoserineCombined sources1
Modified residuei1490PhosphoserineCombined sources1
Modified residuei1663PhosphoserineBy similarity1
Modified residuei1666PhosphoserineBy similarity1
Modified residuei1893PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated in vitro by CDK5.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q96SN8

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96SN8

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q96SN8

MaxQB - The MaxQuant DataBase

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MaxQBi
Q96SN8

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96SN8

PeptideAtlas

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PeptideAtlasi
Q96SN8

PRoteomics IDEntifications database

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PRIDEi
Q96SN8

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
78131 [Q96SN8-1]
78132 [Q96SN8-2]
78133 [Q96SN8-3]
78134 [Q96SN8-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q96SN8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q96SN8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000136861 Expressed in 214 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96SN8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96SN8 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA035820
HPA046529

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CDK5R1 (p35 form) (By similarity). CDK5RAP1, CDK5RAP2 and CDK5RAP3 show competitive binding to CDK5R1. May form a complex with CDK5R1 and CDK5 (By similarity).

Interacts with pericentrin/PCNT; the interaction is leading to centrosomal and Golgi localization of CDK5RAP2 and PCNT (PubMed:20466722).

Interacts with AKAP9; the interaction targets CDK5RAP2 and AKAP9 to Golgi apparatus (PubMed:20466722).

Interacts with MAPRE1; the interaction is direct and targets CDK5RAP2 and EB1/MAPRE1 to microtubule plus ends (PubMed:19553473).

Interacts with TUBG1; the interaction is leading to the centrosomal localization of CDK5RAP2 and TUBG1 (PubMed:17959831).

Interacts with TUBGCP3 (PubMed:17959831).

Interacts with CALM1 (PubMed:20466722).

Interacts with CDC20 (PubMed:19282672).

Interacts with CEP68; degradation of CEP68 in early mitosis leads to removal of CDK5RAP2 from the centrosome which promotes centriole disengagement and subsequent centriole separation (PubMed:25503564).

Interacts with NCKAP5L (PubMed:26485573).

Forms a pericentrosomal complex with AKAP9, MAPRE1 and PDE4DIP isoform 13/MMG8/SMYLE; within this complex, MAPRE1 binding to CDK5RAP2 may be mediated by PDE4DIP (PubMed:29162697).

Interacts with LGALS3BP; this interaction may connect the pericentrosomal complex to the gamma-tubulin ring complex (gamma-TuRC) to promote microtubule assembly and acetylation (PubMed:29162697).

By similarity7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
120873, 106 interactors

Database of interacting proteins

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DIPi
DIP-31632N

Protein interaction database and analysis system

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IntActi
Q96SN8, 67 interactors

Molecular INTeraction database

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MINTi
Q96SN8

STRING: functional protein association networks

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STRINGi
9606.ENSP00000343818

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96SN8

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni58 – 196Interaction with NCKAP5L1 PublicationAdd BLAST139
Regioni926 – 1208Interaction with MAPRE11 PublicationAdd BLAST283
Regioni1726 – 1893Interaction with PCNT and AKAP91 PublicationAdd BLAST168
Regioni1726 – 1768Interaction with CDK5R1By similarityAdd BLAST43
Regioni1861 – 1870Required for centrosomal attachment, Golgi localization and CALM1 interaction10

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410J2NR Eukaryota
ENOG411281S LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00950000183190

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96SN8

KEGG Orthology (KO)

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KOi
K16542

Identification of Orthologs from Complete Genome Data

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OMAi
RICLAEQ

Database of Orthologous Groups

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OrthoDBi
1249457at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q96SN8

TreeFam database of animal gene trees

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TreeFami
TF329233

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR012943 Cnn_1N

Pfam protein domain database

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Pfami
View protein in Pfam
PF07989 Cnn_1N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96SN8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMDLVLEEDV TVPGTLSGCS GLVPSVPDDL DGINPNAGLG NGLLPNVSEE
60 70 80 90 100
TVSPTRARNM KDFENQITEL KKENFNLKLR IYFLEERMQQ EFHGPTEHIY
110 120 130 140 150
KTNIELKVEV ESLKRELQER EQLLIKASKA VESLAEAGGS EIQRVKEDAR
160 170 180 190 200
KKVQQVEDLL TKRILLLEKD VTAAQAELEK AFAGTETEKA LRLRLESKLS
210 220 230 240 250
EMKKMHEGDL AMALVLDEKD RLIEELKLSL KSKEALIQCL KEEKSQMACP
260 270 280 290 300
DENVSSGELR GLCAAPREEK ERETEAAQME HQKERNSFEE RIQALEEDLR
310 320 330 340 350
EKEREIATEK KNSLKRDKAI QGLTMALKSK EKKVEELNSE IEKLSAAFAK
360 370 380 390 400
AREALQKAQT QEFQGSEDYE TALSGKEALS AALRSQNLTK STENHRLRRS
410 420 430 440 450
IKKITQELSD LQQERERLEK DLEEAHREKS KGDCTIRDLR NEVEKLRNEV
460 470 480 490 500
NEREKAMENR YKSLLSESNK KLHNQEQVIK HLTESTNQKD VLLQKFNEKD
510 520 530 540 550
LEVIQQNCYL MAAEDLELRS EGLITEKCSS QQPPGSKTIF SKEKKQSSDY
560 570 580 590 600
EELIQVLKKE QDIYTHLVKS LQESDSINNL QAELNKIFAL RKQLEQDVLS
610 620 630 640 650
YQNLRKTLEE QISEIRRREE ESFSLYSDQT SYLSICLEEN NRFQVEHFSQ
660 670 680 690 700
EELKKKVSDL IQLVKELYTD NQHLKKTIFD LSCMGFQGNG FPDRLASTEQ
710 720 730 740 750
TELLASKEDE DTIKIGEDDE INFLSDQHLQ QSNEIMKDLS KGGCKNGYLR
760 770 780 790 800
HTESKISDCD GAHAPGCLEE GAFINLLAPL FNEKATLLLE SRPDLLKVVR
810 820 830 840 850
ELLLGQLFLT EQEVSGEHLD GKTEKTPKQK GELVHFVQTN SFSKPHDELK
860 870 880 890 900
LSCEAQLVKA GEVPKVGLKD ASVQTVATEG DLLRFKHEAT REAWEEKPIN
910 920 930 940 950
TALSAEHRPE NLHGVPGWQA ALLSLPGITN REAKKSRLPI LIKPSRSLGN
960 970 980 990 1000
MYRLPATQEV VTQLQSQILE LQGELKEFKT CNKQLHQKLI LAEAVMEGRP
1010 1020 1030 1040 1050
TPDKTLLNAQ PPVGAAYQDS PGEQKGIKTT SSVWRDKEMD SDQQRSYEID
1060 1070 1080 1090 1100
SEICPPDDLA SLPSCKENPE DVLSPTSVAT YLSSKSQPSA KVSVMGTDQS
1110 1120 1130 1140 1150
ESINTSNETE YLKQKIHDLE TELEGYQNFI FQLQKHSQCS EAIITVLCGT
1160 1170 1180 1190 1200
EGAQDGLSKP KNGSDGEEMT FSSLHQVRYV KHVKILGPLA PEMIDSRVLE
1210 1220 1230 1240 1250
NLKQQLEEQE YKLQKEQNLN MQLFSEIHNL QNKFRDLSPP RYDSLVQSQA
1260 1270 1280 1290 1300
RELSLQRQQI KDGHGICVIS RQHMNTMIKA FEELLQASDV DYCVAEGFQE
1310 1320 1330 1340 1350
QLNQCAELLE KLEKLFLNGK SVGVEMNTQN ELMERIEEDN LTYQHLLPES
1360 1370 1380 1390 1400
PEPSASHALS DYETSEKSFF SRDQKQDNET EKTSVMVNSF SQDLLMEHIQ
1410 1420 1430 1440 1450
EIRTLRKRLE ESIKTNEKLR KQLERQGSEF VQGSTSIFAS GSELHSSLTS
1460 1470 1480 1490 1500
EIHFLRKQNQ ALNAMLIKGS RDKQKENDKL RESLSRKTVS LEHLQREYAS
1510 1520 1530 1540 1550
VKEENERLQK EGSEKERHNQ QLIQEVRCSG QELSRVQEEV KLRQQLLSQN
1560 1570 1580 1590 1600
DKLLQSLRVE LKAYEKLDEE HRRLREASGE GWKGQDPFRD LHSLLMEIQA
1610 1620 1630 1640 1650
LRLQLERSIE TSSTLQSRLK EQLARGAEKA QEGALTLAVQ AVSIPEVPLQ
1660 1670 1680 1690 1700
PDKHDGDKYP MESDNSFDLF DSSQAVTPKS VSETPPLSGN DTDSLSCDSG
1710 1720 1730 1740 1750
SSATSTPCVS RLVTGHHLWA SKNGRHVLGL IEDYEALLKQ ISQGQRLLAE
1760 1770 1780 1790 1800
MDIQTQEAPS STSQELGTKG PHPAPLSKFV SSVSTAKLTL EEAYRRLKLL
1810 1820 1830 1840 1850
WRVSLPEDGQ CPLHCEQIGE MKAEVTKLHK KLFEQEKKLQ NTMKLLQLSK
1860 1870 1880 1890
RQEKVIFDQL VVTHKILRKA RGNLELRPGG AHPGTCSPSR PGS
Note: No experimental confirmation available.
Length:1,893
Mass (Da):215,038
Last modified:May 18, 2010 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i833B9F9EF3CE8D07
GO
Isoform 2 (identifier: Q96SN8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     702-733: Missing.

Note: No experimental confirmation available.
Show »
Length:1,861
Mass (Da):211,381
Checksum:iC56C74BE444511C8
GO
Isoform 3 (identifier: Q96SN8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1009-1049: Missing.

Note: No experimental confirmation available.
Show »
Length:1,852
Mass (Da):210,471
Checksum:iD34C2C2D6EABDE08
GO
Isoform 4 (identifier: Q96SN8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1576-1654: Missing.

Show »
Length:1,814
Mass (Da):206,323
Checksum:iC28575B525292309
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MRG9A0A0A0MRG9_HUMAN
CDK5 regulatory subunit-associated ...
CDK5RAP2
1,663Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AMJ5B1AMJ5_HUMAN
CDK5 regulatory subunit-associated ...
CDK5RAP2
1,287Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JTU8Q5JTU8_HUMAN
CDK5 regulatory subunit-associated ...
CDK5RAP2
903Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WCI3F8WCI3_HUMAN
CDK5 regulatory subunit-associated ...
CDK5RAP2
749Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WBJ0F8WBJ0_HUMAN
CDK5 regulatory subunit-associated ...
CDK5RAP2
275Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WF55F8WF55_HUMAN
CDK5 regulatory subunit-associated ...
CDK5RAP2
460Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9K0C9C9K0C9_HUMAN
CDK5 regulatory subunit-associated ...
CDK5RAP2
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH04526 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAA91865 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB13459 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAB15263 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB55253 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAD97663 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated
The sequence CAD97828 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti27P → S in CAD97663 (PubMed:17974005).Curated1
Sequence conflicti43L → V in AAP41926 (Ref. 3) Curated1
Sequence conflicti292I → F in CAD97828 (PubMed:17974005).Curated1
Sequence conflicti414E → K in CAD97828 (PubMed:17974005).Curated1
Sequence conflicti1254S → F in CAD97663 (PubMed:17974005).Curated1
Sequence conflicti1458Q → R in BAA91865 (PubMed:14702039).Curated1
Sequence conflicti1483S → P in CAD97663 (PubMed:17974005).Curated1
Sequence conflicti1550N → D in BAB55253 (PubMed:14702039).Curated1
Sequence conflicti1838K → R in BAA91865 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_056831183A → P. Corresponds to variant dbSNP:rs13287734EnsemblClinVar.1
Natural variantiVAR_017443289E → Q2 PublicationsCorresponds to variant dbSNP:rs4836822EnsemblClinVar.1
Natural variantiVAR_0324261045R → T. Corresponds to variant dbSNP:rs3780679EnsemblClinVar.1
Natural variantiVAR_0596161330N → I. Corresponds to variant dbSNP:rs7875294EnsemblClinVar.1
Natural variantiVAR_0174441540V → L2 PublicationsCorresponds to variant dbSNP:rs4837768EnsemblClinVar.1
Natural variantiVAR_0568321607R → S. Corresponds to variant dbSNP:rs16909747EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_007563702 – 733Missing in isoform 2. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_0075641009 – 1049Missing in isoform 3. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_0075651576 – 1654Missing in isoform 4. 3 PublicationsAdd BLAST79

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB046853 mRNA Translation: BAB13459.2 Different initiation.
AF448860 mRNA Translation: AAP41926.1
AL133161 mRNA Translation: CAB61487.1
BX537421 mRNA Translation: CAD97663.1 Sequence problems.
BX537759 mRNA Translation: CAD97828.1 Frameshift.
AL138836 Genomic DNA No translation available.
AL353736 Genomic DNA No translation available.
AL391870 Genomic DNA No translation available.
AL590642 Genomic DNA No translation available.
AK001729 mRNA Translation: BAA91865.1 Different initiation.
AK025867 mRNA Translation: BAB15263.1 Different initiation.
AK027636 mRNA Translation: BAB55253.1 Different initiation.
BC004526 mRNA Translation: AAH04526.2 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43871.1 [Q96SN8-4]
CCDS6823.1 [Q96SN8-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
T42658

NCBI Reference Sequences

More...
RefSeqi
NP_001011649.1, NM_001011649.2 [Q96SN8-4]
NP_001258968.1, NM_001272039.1
NP_060719.4, NM_018249.5 [Q96SN8-1]
XP_006717245.1, XM_006717182.1 [Q96SN8-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000349780; ENSP00000343818; ENSG00000136861 [Q96SN8-1]
ENST00000360190; ENSP00000353317; ENSG00000136861 [Q96SN8-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55755

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55755

UCSC genome browser

More...
UCSCi
uc004bkf.5 human [Q96SN8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046853 mRNA Translation: BAB13459.2 Different initiation.
AF448860 mRNA Translation: AAP41926.1
AL133161 mRNA Translation: CAB61487.1
BX537421 mRNA Translation: CAD97663.1 Sequence problems.
BX537759 mRNA Translation: CAD97828.1 Frameshift.
AL138836 Genomic DNA No translation available.
AL353736 Genomic DNA No translation available.
AL391870 Genomic DNA No translation available.
AL590642 Genomic DNA No translation available.
AK001729 mRNA Translation: BAA91865.1 Different initiation.
AK025867 mRNA Translation: BAB15263.1 Different initiation.
AK027636 mRNA Translation: BAB55253.1 Different initiation.
BC004526 mRNA Translation: AAH04526.2 Different initiation.
CCDSiCCDS43871.1 [Q96SN8-4]
CCDS6823.1 [Q96SN8-1]
PIRiT42658
RefSeqiNP_001011649.1, NM_001011649.2 [Q96SN8-4]
NP_001258968.1, NM_001272039.1
NP_060719.4, NM_018249.5 [Q96SN8-1]
XP_006717245.1, XM_006717182.1 [Q96SN8-2]

3D structure databases

SMRiQ96SN8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi120873, 106 interactors
DIPiDIP-31632N
IntActiQ96SN8, 67 interactors
MINTiQ96SN8
STRINGi9606.ENSP00000343818

PTM databases

iPTMnetiQ96SN8
PhosphoSitePlusiQ96SN8

Polymorphism and mutation databases

BioMutaiCDK5RAP2
DMDMi296439505

Proteomic databases

EPDiQ96SN8
jPOSTiQ96SN8
MassIVEiQ96SN8
MaxQBiQ96SN8
PaxDbiQ96SN8
PeptideAtlasiQ96SN8
PRIDEiQ96SN8
ProteomicsDBi78131 [Q96SN8-1]
78132 [Q96SN8-2]
78133 [Q96SN8-3]
78134 [Q96SN8-4]

Genome annotation databases

EnsembliENST00000349780; ENSP00000343818; ENSG00000136861 [Q96SN8-1]
ENST00000360190; ENSP00000353317; ENSG00000136861 [Q96SN8-4]
GeneIDi55755
KEGGihsa:55755
UCSCiuc004bkf.5 human [Q96SN8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55755
DisGeNETi55755

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CDK5RAP2
HGNCiHGNC:18672 CDK5RAP2
HPAiHPA035820
HPA046529
MalaCardsiCDK5RAP2
MIMi604804 phenotype
608201 gene
neXtProtiNX_Q96SN8
OpenTargetsiENSG00000136861
Orphaneti2512 Autosomal recessive primary microcephaly
PharmGKBiPA38632

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J2NR Eukaryota
ENOG411281S LUCA
GeneTreeiENSGT00950000183190
InParanoidiQ96SN8
KOiK16542
OMAiRICLAEQ
OrthoDBi1249457at2759
PhylomeDBiQ96SN8
TreeFamiTF329233

Enzyme and pathway databases

ReactomeiR-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-8854518 AURKA Activation by TPX2

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CDK5RAP2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CDK5RAP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55755
PharosiQ96SN8

Protein Ontology

More...
PROi
PR:Q96SN8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000136861 Expressed in 214 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ96SN8 baseline and differential
GenevisibleiQ96SN8 HS

Family and domain databases

InterProiView protein in InterPro
IPR012943 Cnn_1N
PfamiView protein in Pfam
PF07989 Cnn_1N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCK5P2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96SN8
Secondary accession number(s): Q5JV18
, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: May 18, 2010
Last modified: October 16, 2019
This is version 174 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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