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UniProtKB - Q96SN7 (ORAI2_HUMAN)

Entry version 135 (02 Jun 2021)
Sequence version 1 (01 Dec 2001)
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Protein

Protein orai-2

Gene

ORAI2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ca2+ release-activated Ca2+-like (CRAC-like) channel subunit which mediates Ca2+ influx and increase in Ca2+-selective current by synergy with the Ca2+ sensor, STIM1.

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96SN7

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-139853, Elevation of cytosolic Ca2+ levels
R-HSA-5578775, Ion homeostasis
R-HSA-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein orai-2
Alternative name(s):
CAP-binding protein complex-interacting protein 2
Transmembrane protein 142B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ORAI2
Synonyms:C7orf19, CBCIP2, TMEM142B
ORF Names:PP1729
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:21667, ORAI2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		610929, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96SN7

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000160991.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei66 – 83HelicalSequence analysisAdd BLAST18
Transmembranei94 – 114HelicalSequence analysisAdd BLAST21
Transmembranei148 – 168HelicalSequence analysisAdd BLAST21
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		80228

Open Targets

More...OpenTargetsi		ENSG00000160991

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162398454

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96SN7, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3038476

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		2965

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ORAI2

Domain mapping of disease mutations (DMDM)

More...DMDMi		74732728

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002343911 – 254Protein orai-2Add BLAST254

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96SN7

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96SN7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96SN7

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96SN7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96SN7

PeptideAtlas

More...PeptideAtlasi		Q96SN7

PRoteomics IDEntifications database

More...PRIDEi		Q96SN7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		78130

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96SN7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96SN7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000160991, Expressed in caecum and 240 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96SN7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96SN7, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000160991, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CRACR2A/EFCAB4B.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		123192, 6 interactors

Database of interacting proteins

More...DIPi		DIP-48944N

Protein interaction database and analysis system

More...IntActi		Q96SN7, 9 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000348752

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96SN7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Orai family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4298, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000015354

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96SN7

Identification of Orthologs from Complete Genome Data

More...OMAi		VDARHQP

Database of Orthologous Groups

More...OrthoDBi		1197243at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96SN7

TreeFam database of animal gene trees

More...TreeFami		TF313576

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.140.140, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR012446, CRAC_channel
IPR030034, Orai-2
IPR038350, Orai_sf

The PANTHER Classification System

More...PANTHERi		PTHR31501, PTHR31501, 1 hit
PTHR31501:SF5, PTHR31501:SF5, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07856, Orai-1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q96SN7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAELNVPID PSAPACPEPG HKGMDYRDWV RRSYLELVTS NHHSVQALSW 
        60         70         80         90        100
RKLYLSRAKL KASSRTSALL SGFAMVAMVE VQLETQYQYP RPLLIAFSAC 
       110        120        130        140        150
TTVLVAVHLF ALLISTCILP NVEAVSNIHN LNSISESPHE RMHPYIELAW 
       160        170        180        190        200
GFSTVLGILL FLAEVVLLCW IKFLPVDARR QPGPPPGPGS HTGWQAALVS 
       210        220        230        240        250
TIIMVPVGLI FVVFTIHFYR SLVRHKTERH NREIEELHKL KVQLDGHERS 

LQVL
Length:254
Mass (Da):28,570
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD53CD2376F48E23C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JQR7C9JQR7_HUMAN
Protein orai-2
ORAI2
229Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J2H9C9J2H9_HUMAN
Protein orai-2
ORAI2
212Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J5L2C9J5L2_HUMAN
Protein orai-2
ORAI2
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JUY6C9JUY6_HUMAN
Protein orai-2
ORAI2
30Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG23755 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence AAP22352 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAG33568 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05354315A → P. Corresponds to variant dbSNP:rs34947403Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK027639 mRNA Translation: BAB55256.1
AC093668 Genomic DNA Translation: AAP22351.1
AC093668 Genomic DNA Translation: AAP22352.1 Sequence problems.
BC069270 mRNA Translation: AAH69270.1
AF258552 mRNA Translation: AAG23755.1 Sequence problems.
CR457287 mRNA Translation: CAG33568.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS5722.1

NCBI Reference Sequences

More...RefSeqi		NP_001119812.1, NM_001126340.2
NP_001258747.1, NM_001271818.1
NP_116220.1, NM_032831.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000356387; ENSP00000348752; ENSG00000160991
ENST00000403646; ENSP00000385489; ENSG00000160991
ENST00000473939; ENSP00000417928; ENSG00000160991
ENST00000478730; ENSP00000418140; ENSG00000160991
ENST00000611770; ENSP00000478113; ENSG00000160991

Database of genes from NCBI RefSeq genomes

More...GeneIDi		80228

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:80228

UCSC genome browser

More...UCSCi		uc003uzj.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027639 mRNA Translation: BAB55256.1
AC093668 Genomic DNA Translation: AAP22351.1
AC093668 Genomic DNA Translation: AAP22352.1 Sequence problems.
BC069270 mRNA Translation: AAH69270.1
AF258552 mRNA Translation: AAG23755.1 Sequence problems.
CR457287 mRNA Translation: CAG33568.1 Sequence problems.
CCDSiCCDS5722.1
RefSeqiNP_001119812.1, NM_001126340.2
NP_001258747.1, NM_001271818.1
NP_116220.1, NM_032831.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi123192, 6 interactors
DIPiDIP-48944N
IntActiQ96SN7, 9 interactors
STRINGi9606.ENSP00000348752

Chemistry databases

ChEMBLiCHEMBL3038476
GuidetoPHARMACOLOGYi2965

PTM databases

iPTMnetiQ96SN7
PhosphoSitePlusiQ96SN7

Genetic variation databases

BioMutaiORAI2
DMDMi74732728

Proteomic databases

EPDiQ96SN7
jPOSTiQ96SN7
MassIVEiQ96SN7
MaxQBiQ96SN7
PaxDbiQ96SN7
PeptideAtlasiQ96SN7
PRIDEiQ96SN7
ProteomicsDBi78130

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		31061, 160 antibodies

The DNASU plasmid repository

More...DNASUi		80228

Genome annotation databases

EnsembliENST00000356387; ENSP00000348752; ENSG00000160991
ENST00000403646; ENSP00000385489; ENSG00000160991
ENST00000473939; ENSP00000417928; ENSG00000160991
ENST00000478730; ENSP00000418140; ENSG00000160991
ENST00000611770; ENSP00000478113; ENSG00000160991
GeneIDi80228
KEGGihsa:80228
UCSCiuc003uzj.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		80228
DisGeNETi80228

GeneCards: human genes, protein and diseases

More...GeneCardsi		ORAI2
HGNCiHGNC:21667, ORAI2
HPAiENSG00000160991, Low tissue specificity
MIMi610929, gene
neXtProtiNX_Q96SN7
OpenTargetsiENSG00000160991
PharmGKBiPA162398454
VEuPathDBiHostDB:ENSG00000160991.15

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4298, Eukaryota
GeneTreeiENSGT00390000015354
InParanoidiQ96SN7
OMAiVDARHQP
OrthoDBi1197243at2759
PhylomeDBiQ96SN7
TreeFamiTF313576

Enzyme and pathway databases

PathwayCommonsiQ96SN7
ReactomeiR-HSA-139853, Elevation of cytosolic Ca2+ levels
R-HSA-5578775, Ion homeostasis
R-HSA-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		80228, 6 hits in 989 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ORAI2, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ORAI2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		80228
PharosiQ96SN7, Tbio

Protein Ontology

More...PROi		PR:Q96SN7
RNActiQ96SN7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000160991, Expressed in caecum and 240 other tissues
ExpressionAtlasiQ96SN7, baseline and differential
GenevisibleiQ96SN7, HS

Family and domain databases

Gene3Di1.20.140.140, 1 hit
InterProiView protein in InterPro
IPR012446, CRAC_channel
IPR030034, Orai-2
IPR038350, Orai_sf
PANTHERiPTHR31501, PTHR31501, 1 hit
PTHR31501:SF5, PTHR31501:SF5, 1 hit
PfamiView protein in Pfam
PF07856, Orai-1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiORAI2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96SN7
Secondary accession number(s): Q6IA68, Q8WY94, Q9H9Y3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 1, 2001
Last modified: June 2, 2021
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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