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Protein

Protein orai-2

Gene

ORAI2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ca2+ release-activated Ca2+-like (CRAC-like) channel subunit which mediates Ca2+ influx and increase in Ca2+-selective current by synergy with the Ca2+ sensor, STIM1.2 Publications

GO - Molecular functioni

  • store-operated calcium channel activity Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-139853 Elevation of cytosolic Ca2+ levels
R-HSA-5578775 Ion homeostasis
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Names & Taxonomyi

Protein namesi
Recommended name:
Protein orai-2
Alternative name(s):
CAP-binding protein complex-interacting protein 2
Transmembrane protein 142B
Gene namesi
Name:ORAI2
Synonyms:C7orf19, CBCIP2, TMEM142B
ORF Names:PP1729
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000160991.15
HGNCiHGNC:21667 ORAI2
MIMi610929 gene
neXtProtiNX_Q96SN7

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei66 – 83HelicalSequence analysisAdd BLAST18
Transmembranei94 – 114HelicalSequence analysisAdd BLAST21
Transmembranei148 – 168HelicalSequence analysisAdd BLAST21
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000160991
PharmGKBiPA162398454

Chemistry databases

ChEMBLiCHEMBL3038476

Polymorphism and mutation databases

DMDMi74732728

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002343911 – 254Protein orai-2Add BLAST254

Proteomic databases

EPDiQ96SN7
MaxQBiQ96SN7
PaxDbiQ96SN7
PeptideAtlasiQ96SN7
PRIDEiQ96SN7
ProteomicsDBi78130

PTM databases

iPTMnetiQ96SN7
PhosphoSitePlusiQ96SN7

Expressioni

Gene expression databases

BgeeiENSG00000160991 Expressed in 229 organ(s), highest expression level in caecum
CleanExiHS_ORAI2
ExpressionAtlasiQ96SN7 baseline and differential
GenevisibleiQ96SN7 HS

Organism-specific databases

HPAiHPA055137
HPA065937

Interactioni

Subunit structurei

Interacts with CRACR2A/EFCAB4B.1 Publication

Protein-protein interaction databases

BioGridi123192, 5 interactors
DIPiDIP-48944N
IntActiQ96SN7, 9 interactors
STRINGi9606.ENSP00000348752

Structurei

3D structure databases

ProteinModelPortaliQ96SN7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Orai family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4298 Eukaryota
ENOG4110DSB LUCA
GeneTreeiENSGT00390000015354
HOGENOMiHOG000246925
HOVERGENiHBG081343
InParanoidiQ96SN7
KOiK16057
OMAiPACCSEP
OrthoDBiEOG091G0E4P
PhylomeDBiQ96SN7
TreeFamiTF313576

Family and domain databases

Gene3Di1.20.140.140, 1 hit
InterProiView protein in InterPro
IPR012446 CRAC_channel
IPR030034 Orai-2
IPR038350 Orai_sf
PANTHERiPTHR31501 PTHR31501, 1 hit
PTHR31501:SF5 PTHR31501:SF5, 1 hit
PfamiView protein in Pfam
PF07856 Orai-1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q96SN7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAELNVPID PSAPACPEPG HKGMDYRDWV RRSYLELVTS NHHSVQALSW
60 70 80 90 100
RKLYLSRAKL KASSRTSALL SGFAMVAMVE VQLETQYQYP RPLLIAFSAC
110 120 130 140 150
TTVLVAVHLF ALLISTCILP NVEAVSNIHN LNSISESPHE RMHPYIELAW
160 170 180 190 200
GFSTVLGILL FLAEVVLLCW IKFLPVDARR QPGPPPGPGS HTGWQAALVS
210 220 230 240 250
TIIMVPVGLI FVVFTIHFYR SLVRHKTERH NREIEELHKL KVQLDGHERS

LQVL
Length:254
Mass (Da):28,570
Last modified:December 1, 2001 - v1
Checksum:iD53CD2376F48E23C
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JQR7C9JQR7_HUMAN
Protein orai-2
ORAI2
229Annotation score:
C9J2H9C9J2H9_HUMAN
Protein orai-2
ORAI2
212Annotation score:
C9J5L2C9J5L2_HUMAN
Protein orai-2
ORAI2
97Annotation score:
C9JUY6C9JUY6_HUMAN
Protein orai-2
ORAI2
30Annotation score:

Sequence cautioni

The sequence AAG23755 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence AAP22352 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAG33568 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05354315A → P. Corresponds to variant dbSNP:rs34947403Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027639 mRNA Translation: BAB55256.1
AC093668 Genomic DNA Translation: AAP22351.1
AC093668 Genomic DNA Translation: AAP22352.1 Sequence problems.
BC069270 mRNA Translation: AAH69270.1
AF258552 mRNA Translation: AAG23755.1 Sequence problems.
CR457287 mRNA Translation: CAG33568.1 Sequence problems.
CCDSiCCDS5722.1
RefSeqiNP_001119812.1, NM_001126340.2
NP_001258747.1, NM_001271818.1
NP_116220.1, NM_032831.3
UniGeneiHs.363308
Hs.736659

Genome annotation databases

EnsembliENST00000356387; ENSP00000348752; ENSG00000160991
ENST00000403646; ENSP00000385489; ENSG00000160991
ENST00000473939; ENSP00000417928; ENSG00000160991
ENST00000478730; ENSP00000418140; ENSG00000160991
ENST00000611770; ENSP00000478113; ENSG00000160991
GeneIDi80228
KEGGihsa:80228
UCSCiuc003uzj.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027639 mRNA Translation: BAB55256.1
AC093668 Genomic DNA Translation: AAP22351.1
AC093668 Genomic DNA Translation: AAP22352.1 Sequence problems.
BC069270 mRNA Translation: AAH69270.1
AF258552 mRNA Translation: AAG23755.1 Sequence problems.
CR457287 mRNA Translation: CAG33568.1 Sequence problems.
CCDSiCCDS5722.1
RefSeqiNP_001119812.1, NM_001126340.2
NP_001258747.1, NM_001271818.1
NP_116220.1, NM_032831.3
UniGeneiHs.363308
Hs.736659

3D structure databases

ProteinModelPortaliQ96SN7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123192, 5 interactors
DIPiDIP-48944N
IntActiQ96SN7, 9 interactors
STRINGi9606.ENSP00000348752

Chemistry databases

ChEMBLiCHEMBL3038476

PTM databases

iPTMnetiQ96SN7
PhosphoSitePlusiQ96SN7

Polymorphism and mutation databases

DMDMi74732728

Proteomic databases

EPDiQ96SN7
MaxQBiQ96SN7
PaxDbiQ96SN7
PeptideAtlasiQ96SN7
PRIDEiQ96SN7
ProteomicsDBi78130

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356387; ENSP00000348752; ENSG00000160991
ENST00000403646; ENSP00000385489; ENSG00000160991
ENST00000473939; ENSP00000417928; ENSG00000160991
ENST00000478730; ENSP00000418140; ENSG00000160991
ENST00000611770; ENSP00000478113; ENSG00000160991
GeneIDi80228
KEGGihsa:80228
UCSCiuc003uzj.3 human

Organism-specific databases

CTDi80228
EuPathDBiHostDB:ENSG00000160991.15
GeneCardsiORAI2
HGNCiHGNC:21667 ORAI2
HPAiHPA055137
HPA065937
MIMi610929 gene
neXtProtiNX_Q96SN7
OpenTargetsiENSG00000160991
PharmGKBiPA162398454
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4298 Eukaryota
ENOG4110DSB LUCA
GeneTreeiENSGT00390000015354
HOGENOMiHOG000246925
HOVERGENiHBG081343
InParanoidiQ96SN7
KOiK16057
OMAiPACCSEP
OrthoDBiEOG091G0E4P
PhylomeDBiQ96SN7
TreeFamiTF313576

Enzyme and pathway databases

ReactomeiR-HSA-139853 Elevation of cytosolic Ca2+ levels
R-HSA-5578775 Ion homeostasis
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Miscellaneous databases

ChiTaRSiORAI2 human
GeneWikiiORAI2
GenomeRNAii80228
PROiPR:Q96SN7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000160991 Expressed in 229 organ(s), highest expression level in caecum
CleanExiHS_ORAI2
ExpressionAtlasiQ96SN7 baseline and differential
GenevisibleiQ96SN7 HS

Family and domain databases

Gene3Di1.20.140.140, 1 hit
InterProiView protein in InterPro
IPR012446 CRAC_channel
IPR030034 Orai-2
IPR038350 Orai_sf
PANTHERiPTHR31501 PTHR31501, 1 hit
PTHR31501:SF5 PTHR31501:SF5, 1 hit
PfamiView protein in Pfam
PF07856 Orai-1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiORAI2_HUMAN
AccessioniPrimary (citable) accession number: Q96SN7
Secondary accession number(s): Q6IA68, Q8WY94, Q9H9Y3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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