UniProtKB - Q96SN7 (ORAI2_HUMAN)

BLAST

>sp|Q96SN7|ORAI2_HUMAN Protein orai-2 OS=Homo sapiens OX=9606 GN=ORAI2 PE=1 SV=1
MSAELNVPIDPSAPACPEPGHKGMDYRDWVRRSYLELVTSNHHSVQALSWRKLYLSRAKL
KASSRTSALLSGFAMVAMVEVQLETQYQYPRPLLIAFSACTTVLVAVHLFALLISTCILP
NVEAVSNIHNLNSISESPHERMHPYIELAWGFSTVLGILLFLAEVVLLCWIKFLPVDARR
QPGPPPGPGSHTGWQAALVSTIIMVPVGLIFVVFTIHFYRSLVRHKTERHNREIEELHKL
KVQLDGHERSLQVL

Align
Format
Add to basket Added to basket
History
Entry version 120 (12 Sep 2018)
Sequence version 1 (01 Dec 2001)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

Protein orai-2

Gene

ORAI2

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Ca²⁺ release-activated Ca²⁺-like (CRAC-like) channel subunit which mediates Ca²⁺ influx and increase in Ca²⁺-selective current by synergy with the Ca²⁺ sensor, STIM1.2 Publications

GO - Molecular functionⁱ

store-operated calcium channel activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

store-operated calcium entry
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-139853 Elevation of cytosolic Ca2+ levels R-HSA-5578775 Ion homeostasis R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Reactomeⁱ

R-HSA-139853 Elevation of cytosolic Ca2+ levels
R-HSA-5578775 Ion homeostasis
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein orai-2 Alternative name(s): CAP-binding protein complex-interacting protein 2 Transmembrane protein 142B
Gene namesⁱ	Name:ORAI2 Synonyms:C7orf19, CBCIP2, TMEM142B ORF Names:PP1729
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000160991.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:21667 ORAI2
MIMⁱ	610929 gene
neXtProtⁱ	NX_Q96SN7

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	66 – 83	HelicalSequence analysisAdd BLAST	18
Transmembraneⁱ	94 – 114	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	148 – 168	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	196 – 216	HelicalSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000160991
PharmGKBⁱ	PA162398454

Chemistry databases

ChEMBLⁱ	CHEMBL3038476

ChEMBLⁱ

CHEMBL3038476

Polymorphism and mutation databases

DMDMⁱ	74732728

DMDMⁱ

74732728

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000234391	1 – 254	Protein orai-2Add BLAST		254

Proteomic databases

EPDⁱ	Q96SN7
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96SN7
PaxDbⁱ	Q96SN7
PeptideAtlas More...PeptideAtlasⁱ	Q96SN7
PRIDEⁱ	Q96SN7
ProteomicsDBⁱ	78130

PTM databases

iPTMnetⁱ	Q96SN7
PhosphoSitePlusⁱ	Q96SN7

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000160991 Expressed in 229 organ(s), highest expression level in caecum
CleanExⁱ	HS_ORAI2
ExpressionAtlasⁱ	Q96SN7 baseline and differential
Genevisibleⁱ	Q96SN7 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA055137 HPA065937

HPAⁱ

HPA055137
HPA065937

Interactionⁱ

Subunit structureⁱ

Interacts with CRACR2A/EFCAB4B.1 Publication

Protein-protein interaction databases

BioGridⁱ	123192, 5 interactors
Database of interacting proteins More...DIPⁱ	DIP-48944N
IntActⁱ	Q96SN7, 9 interactors
STRINGⁱ	9606.ENSP00000348752

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96SN7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the Orai family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4298 Eukaryota ENOG4110DSB LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000015354
HOGENOMⁱ	HOG000246925
HOVERGENⁱ	HBG081343
InParanoidⁱ	Q96SN7
KEGG Orthology (KO) More...KOⁱ	K16057
OMAⁱ	PACCSEP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0E4P
PhylomeDBⁱ	Q96SN7
TreeFamⁱ	TF313576

Family and domain databases

Gene3Dⁱ	1.20.140.140, 1 hit
InterProⁱ	View protein in InterPro IPR012446 CRAC_channel IPR030034 Orai-2 IPR038350 Orai_sf
PANTHERⁱ	PTHR31501 PTHR31501, 1 hit PTHR31501:SF5 PTHR31501:SF5, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07856 Orai-1, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show all Align All

Q96SN7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSAELNVPID PSAPACPEPG HKGMDYRDWV RRSYLELVTS NHHSVQALSW 
        60         70         80         90        100
RKLYLSRAKL KASSRTSALL SGFAMVAMVE VQLETQYQYP RPLLIAFSAC 
       110        120        130        140        150
TTVLVAVHLF ALLISTCILP NVEAVSNIHN LNSISESPHE RMHPYIELAW 
       160        170        180        190        200
GFSTVLGILL FLAEVVLLCW IKFLPVDARR QPGPPPGPGS HTGWQAALVS 
       210        220        230        240        250
TIIMVPVGLI FVVFTIHFYR SLVRHKTERH NREIEELHKL KVQLDGHERS 

LQVL

Length:254

Mass (Da):28,570

Last modified:December 1, 2001 - v1

Checksum:ⁱD53CD2376F48E23C

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9JQR7	C9JQR7_HUMAN	Protein orai-2 Protein orai-2	ORAI2	229	Annotation score:
C9J2H9	C9J2H9_HUMAN	Protein orai-2 Protein orai-2	ORAI2	212	Annotation score:
C9J5L2	C9J5L2_HUMAN	Protein orai-2 Protein orai-2	ORAI2	97	Annotation score:
C9JUY6	C9JUY6_HUMAN	Protein orai-2 Protein orai-2	ORAI2	30	Annotation score:

Sequence cautionⁱ

The sequence AAG23755 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

The sequence AAP22352 differs from that shown. Reason: Erroneous gene model prediction.Curated

The sequence CAG33568 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_053543	15	A → P. Corresponds to variant dbSNP:rs34947403Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK027639 mRNA Translation: BAB55256.1 AC093668 Genomic DNA Translation: AAP22351.1 AC093668 Genomic DNA Translation: AAP22352.1 Sequence problems. BC069270 mRNA Translation: AAH69270.1 AF258552 mRNA Translation: AAG23755.1 Sequence problems. CR457287 mRNA Translation: CAG33568.1 Sequence problems.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5722.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001119812.1, NM_001126340.2 NP_001258747.1, NM_001271818.1 NP_116220.1, NM_032831.3
UniGeneⁱ	Hs.363308 Hs.736659

Genome annotation databases

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96SN7	ORAI calcium release-activated calcium modulator 2		PANTR		262	UniRef100_Q96SN7
Uncharacterized protein		PANPA		262
ORAI calcium release-activated calcium modulator 2		GORGO		254
Protein orai-2 (Fragment)		HUMAN		212
ORAI2 isoform 8 (Fragment)		PONAB		212
+13

Protein	Similar proteins		Species	Score	Length	Source
Q96SN7	Protein orai-2		MOUSE		250	UniRef90_Q96SN7
ORAI calcium release-activated calcium modulator 2		PANTR		262
Uncharacterized protein		PANPA		262
ORAI calcium release-activated calcium modulator 2		GORGO		254
Protein orai-2 (Fragment)		HUMAN		212
+98

Protein	Similar proteins		Species	Score	Length	Source
Q96SN7	Calcium release-activated calcium channel protein 1		MOUSE		304	UniRef50_Q8BWG9
Calcium release-activated calcium channel protein 1		RAT		304
Protein orai-2		XENLA		257
calcium release-activated calcium channel protein 1		MESAU		302
Calcium release-activated calcium channel protein 1		CRIGR		301
+421

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK027639 mRNA Translation: BAB55256.1 AC093668 Genomic DNA Translation: AAP22351.1 AC093668 Genomic DNA Translation: AAP22352.1 Sequence problems. BC069270 mRNA Translation: AAH69270.1 AF258552 mRNA Translation: AAG23755.1 Sequence problems. CR457287 mRNA Translation: CAG33568.1 Sequence problems.
CCDSⁱ	CCDS5722.1
RefSeqⁱ	NP_001119812.1, NM_001126340.2 NP_001258747.1, NM_001271818.1 NP_116220.1, NM_032831.3
UniGeneⁱ	Hs.363308 Hs.736659

3D structure databases

ProteinModelPortalⁱ	Q96SN7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	123192, 5 interactors
DIPⁱ	DIP-48944N
IntActⁱ	Q96SN7, 9 interactors
STRINGⁱ	9606.ENSP00000348752

Chemistry databases

ChEMBLⁱ	CHEMBL3038476

ChEMBLⁱ

CHEMBL3038476

PTM databases

iPTMnetⁱ	Q96SN7
PhosphoSitePlusⁱ	Q96SN7

Polymorphism and mutation databases

DMDMⁱ	74732728

DMDMⁱ

74732728

Proteomic databases

EPDⁱ	Q96SN7
MaxQBⁱ	Q96SN7
PaxDbⁱ	Q96SN7
PeptideAtlasⁱ	Q96SN7
PRIDEⁱ	Q96SN7
ProteomicsDBⁱ	78130

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000356387; ENSP00000348752; ENSG00000160991 ENST00000403646; ENSP00000385489; ENSG00000160991 ENST00000473939; ENSP00000417928; ENSG00000160991 ENST00000478730; ENSP00000418140; ENSG00000160991 ENST00000611770; ENSP00000478113; ENSG00000160991
GeneIDⁱ	80228
KEGGⁱ	hsa:80228
UCSCⁱ	uc003uzj.3 human

Organism-specific databases

CTDⁱ	80228
EuPathDBⁱ	HostDB:ENSG00000160991.15
GeneCardsⁱ	ORAI2
HGNCⁱ	HGNC:21667 ORAI2
HPAⁱ	HPA055137 HPA065937
MIMⁱ	610929 gene
neXtProtⁱ	NX_Q96SN7
OpenTargetsⁱ	ENSG00000160991
PharmGKBⁱ	PA162398454
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4298 Eukaryota ENOG4110DSB LUCA
GeneTreeⁱ	ENSGT00390000015354
HOGENOMⁱ	HOG000246925
HOVERGENⁱ	HBG081343
InParanoidⁱ	Q96SN7
KOⁱ	K16057
OMAⁱ	PACCSEP
OrthoDBⁱ	EOG091G0E4P
PhylomeDBⁱ	Q96SN7
TreeFamⁱ	TF313576

Enzyme and pathway databases

Reactomeⁱ	R-HSA-139853 Elevation of cytosolic Ca2+ levels R-HSA-5578775 Ion homeostasis R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Reactomeⁱ

R-HSA-139853 Elevation of cytosolic Ca2+ levels
R-HSA-5578775 Ion homeostasis
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Miscellaneous databases

ChiTaRSⁱ	ORAI2 human
GeneWikiⁱ	ORAI2
GenomeRNAiⁱ	80228
Protein Ontology More...PROⁱ	PR:Q96SN7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000160991 Expressed in 229 organ(s), highest expression level in caecum
CleanExⁱ	HS_ORAI2
ExpressionAtlasⁱ	Q96SN7 baseline and differential
Genevisibleⁱ	Q96SN7 HS

Family and domain databases

Gene3Dⁱ	1.20.140.140, 1 hit
InterProⁱ	View protein in InterPro IPR012446 CRAC_channel IPR030034 Orai-2 IPR038350 Orai_sf
PANTHERⁱ	PTHR31501 PTHR31501, 1 hit PTHR31501:SF5 PTHR31501:SF5, 1 hit
Pfamⁱ	View protein in Pfam PF07856 Orai-1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ORAI2_HUMAN
Accessionⁱ	Q96SN7Primary (citable) accession number: Q96SN7 Secondary accession number(s): Q6IA68, Q8WY94, Q9H9Y3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
	Last sequence update:	December 1, 2001
	Last modified:	September 12, 2018
	This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q96SN7 (ORAI2_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Protein orai-2

ORAI2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ