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UniProtKB - Q96SN7 (ORAI2_HUMAN)
Protein
Protein orai-2
Gene
ORAI2
Organism
Homo sapiens (Human)
Status
Functioni
Ca2+ release-activated Ca2+-like (CRAC-like) channel subunit which mediates Ca2+ influx and increase in Ca2+-selective current by synergy with the Ca2+ sensor, STIM1.
2 PublicationsGO - Molecular functioni
- store-operated calcium channel activity Source: GO_Central
GO - Biological processi
- store-operated calcium entry Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q96SN7 |
Reactomei | R-HSA-139853, Elevation of cytosolic Ca2+ levels R-HSA-5578775, Ion homeostasis R-HSA-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
SignaLinki | Q96SN7 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein orai-2Alternative name(s): CAP-binding protein complex-interacting protein 2 Transmembrane protein 142B |
Gene namesi | Name:ORAI2 Synonyms:C7orf19, CBCIP2, TMEM142B ORF Names:PP1729 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:21667, ORAI2 |
MIMi | 610929, gene |
neXtProti | NX_Q96SN7 |
VEuPathDBi | HostDB:ENSG00000160991 |
Subcellular locationi
Other locations
- Membrane By similarity; Multi-pass membrane protein By similarity
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 66 – 83 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 94 – 114 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 148 – 168 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 196 – 216 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 80228 |
OpenTargetsi | ENSG00000160991 |
PharmGKBi | PA162398454 |
Miscellaneous databases
Pharosi | Q96SN7, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3038476 |
GuidetoPHARMACOLOGYi | 2965 |
Genetic variation databases
BioMutai | ORAI2 |
DMDMi | 74732728 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000234391 | 1 – 254 | Protein orai-2Add BLAST | 254 |
Proteomic databases
EPDi | Q96SN7 |
jPOSTi | Q96SN7 |
MassIVEi | Q96SN7 |
MaxQBi | Q96SN7 |
PaxDbi | Q96SN7 |
PeptideAtlasi | Q96SN7 |
PRIDEi | Q96SN7 |
ProteomicsDBi | 78130 |
PTM databases
iPTMneti | Q96SN7 |
PhosphoSitePlusi | Q96SN7 |
Expressioni
Gene expression databases
Bgeei | ENSG00000160991, Expressed in caecum and 240 other tissues |
ExpressionAtlasi | Q96SN7, baseline and differential |
Genevisiblei | Q96SN7, HS |
Organism-specific databases
HPAi | ENSG00000160991, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with CRACR2A/EFCAB4B.
1 PublicationProtein-protein interaction databases
BioGRIDi | 123192, 6 interactors |
DIPi | DIP-48944N |
IntActi | Q96SN7, 9 interactors |
STRINGi | 9606.ENSP00000348752 |
Miscellaneous databases
RNActi | Q96SN7, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the Orai family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4298, Eukaryota |
GeneTreei | ENSGT00390000015354 |
InParanoidi | Q96SN7 |
OMAi | LEMQYQY |
OrthoDBi | 1197243at2759 |
PhylomeDBi | Q96SN7 |
TreeFami | TF313576 |
Family and domain databases
Gene3Di | 1.20.140.140, 1 hit |
InterProi | View protein in InterPro IPR012446, CRAC_channel IPR030034, Orai-2 IPR038350, Orai_sf |
PANTHERi | PTHR31501, PTHR31501, 1 hit PTHR31501:SF5, PTHR31501:SF5, 1 hit |
Pfami | View protein in Pfam PF07856, Orai-1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q96SN7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSAELNVPID PSAPACPEPG HKGMDYRDWV RRSYLELVTS NHHSVQALSW
60 70 80 90 100
RKLYLSRAKL KASSRTSALL SGFAMVAMVE VQLETQYQYP RPLLIAFSAC
110 120 130 140 150
TTVLVAVHLF ALLISTCILP NVEAVSNIHN LNSISESPHE RMHPYIELAW
160 170 180 190 200
GFSTVLGILL FLAEVVLLCW IKFLPVDARR QPGPPPGPGS HTGWQAALVS
210 220 230 240 250
TIIMVPVGLI FVVFTIHFYR SLVRHKTERH NREIEELHKL KVQLDGHERS
LQVL
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JQR7 | C9JQR7_HUMAN | Protein orai-2 | ORAI2 | 229 | Annotation score: | ||
C9J5L2 | C9J5L2_HUMAN | Protein orai-2 | ORAI2 | 97 | Annotation score: | ||
C9JUY6 | C9JUY6_HUMAN | Protein orai-2 | ORAI2 | 30 | Annotation score: |
Sequence cautioni
The sequence AAG23755 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence AAP22352 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAG33568 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_053543 | 15 | A → P. Corresponds to variant dbSNP:rs34947403Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK027639 mRNA Translation: BAB55256.1 AC093668 Genomic DNA Translation: AAP22351.1 AC093668 Genomic DNA Translation: AAP22352.1 Sequence problems. BC069270 mRNA Translation: AAH69270.1 AF258552 mRNA Translation: AAG23755.1 Sequence problems. CR457287 mRNA Translation: CAG33568.1 Sequence problems. |
CCDSi | CCDS5722.1 |
RefSeqi | NP_001119812.1, NM_001126340.2 NP_001258747.1, NM_001271818.1 NP_116220.1, NM_032831.3 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK027639 mRNA Translation: BAB55256.1 AC093668 Genomic DNA Translation: AAP22351.1 AC093668 Genomic DNA Translation: AAP22352.1 Sequence problems. BC069270 mRNA Translation: AAH69270.1 AF258552 mRNA Translation: AAG23755.1 Sequence problems. CR457287 mRNA Translation: CAG33568.1 Sequence problems. |
CCDSi | CCDS5722.1 |
RefSeqi | NP_001119812.1, NM_001126340.2 NP_001258747.1, NM_001271818.1 NP_116220.1, NM_032831.3 |
3D structure databases
SMRi | Q96SN7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 123192, 6 interactors |
DIPi | DIP-48944N |
IntActi | Q96SN7, 9 interactors |
STRINGi | 9606.ENSP00000348752 |
Chemistry databases
ChEMBLi | CHEMBL3038476 |
GuidetoPHARMACOLOGYi | 2965 |
PTM databases
iPTMneti | Q96SN7 |
PhosphoSitePlusi | Q96SN7 |
Genetic variation databases
BioMutai | ORAI2 |
DMDMi | 74732728 |
Proteomic databases
EPDi | Q96SN7 |
jPOSTi | Q96SN7 |
MassIVEi | Q96SN7 |
MaxQBi | Q96SN7 |
PaxDbi | Q96SN7 |
PeptideAtlasi | Q96SN7 |
PRIDEi | Q96SN7 |
ProteomicsDBi | 78130 |
Protocols and materials databases
Antibodypediai | 31061, 162 antibodies from 27 providers |
DNASUi | 80228 |
Genome annotation databases
Organism-specific databases
CTDi | 80228 |
DisGeNETi | 80228 |
GeneCardsi | ORAI2 |
HGNCi | HGNC:21667, ORAI2 |
HPAi | ENSG00000160991, Low tissue specificity |
MIMi | 610929, gene |
neXtProti | NX_Q96SN7 |
OpenTargetsi | ENSG00000160991 |
PharmGKBi | PA162398454 |
VEuPathDBi | HostDB:ENSG00000160991 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4298, Eukaryota |
GeneTreei | ENSGT00390000015354 |
InParanoidi | Q96SN7 |
OMAi | LEMQYQY |
OrthoDBi | 1197243at2759 |
PhylomeDBi | Q96SN7 |
TreeFami | TF313576 |
Enzyme and pathway databases
PathwayCommonsi | Q96SN7 |
Reactomei | R-HSA-139853, Elevation of cytosolic Ca2+ levels R-HSA-5578775, Ion homeostasis R-HSA-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
SignaLinki | Q96SN7 |
Miscellaneous databases
BioGRID-ORCSi | 80228, 7 hits in 1039 CRISPR screens |
ChiTaRSi | ORAI2, human |
GeneWikii | ORAI2 |
GenomeRNAii | 80228 |
Pharosi | Q96SN7, Tchem |
PROi | PR:Q96SN7 |
RNActi | Q96SN7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000160991, Expressed in caecum and 240 other tissues |
ExpressionAtlasi | Q96SN7, baseline and differential |
Genevisiblei | Q96SN7, HS |
Family and domain databases
Gene3Di | 1.20.140.140, 1 hit |
InterProi | View protein in InterPro IPR012446, CRAC_channel IPR030034, Orai-2 IPR038350, Orai_sf |
PANTHERi | PTHR31501, PTHR31501, 1 hit PTHR31501:SF5, PTHR31501:SF5, 1 hit |
Pfami | View protein in Pfam PF07856, Orai-1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ORAI2_HUMAN | |
Accessioni | Q96SN7Primary (citable) accession number: Q96SN7 Secondary accession number(s): Q6IA68, Q8WY94, Q9H9Y3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 16, 2006 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 137 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families