UniProtKB - Q96SL4 (GPX7_HUMAN)
Protein
Glutathione peroxidase 7
Gene
GPX7
Organism
Homo sapiens (Human)
Status
Functioni
It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks.1 Publication
Catalytic activityi
- EC:1.11.1.9
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 57 | By similarity | 1 |
GO - Molecular functioni
- catalase activity Source: CACAO
- glutathione peroxidase activity Source: UniProtKB-EC
- peroxidase activity Source: Reactome
GO - Biological processi
- cellular response to oxidative stress Source: Reactome
Keywordsi
Molecular function | Oxidoreductase, Peroxidase |
Enzyme and pathway databases
BRENDAi | 1.11.1.9, 2681 |
PathwayCommonsi | Q96SL4 |
Reactomei | R-HSA-3299685, Detoxification of Reactive Oxygen Species |
Protein family/group databases
PeroxiBasei | 3606, HsGPx07 |
Names & Taxonomyi
Protein namesi | Recommended name: Glutathione peroxidase 7 (EC:1.11.1.9)Short name: GPx-7 Short name: GSHPx-7 Alternative name(s): CL683 |
Gene namesi | Name:GPX7 Synonyms:GPX6 ORF Names:UNQ469/PRO828 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4559, GPX7 |
MIMi | 615784, gene |
neXtProti | NX_Q96SL4 |
VEuPathDBi | HostDB:ENSG00000116157.5 |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
- endoplasmic reticulum lumen Source: Reactome
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPathology & Biotechi
Involvement in diseasei
Barrett esophagus (BE)1 Publication
The disease is caused by variants affecting the gene represented in this entry. The pathologic mechanisms leading to Barrett esophagus involve GPX7 dysfunction that results in higher levels of hydrogen peroxide and ROS-induced oxidative stress and DNA damage in esophageal cells.
Disease descriptionA condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes.
Related information in OMIMOrganism-specific databases
DisGeNETi | 2882 |
MIMi | 614266, phenotype |
OpenTargetsi | ENSG00000116157 |
PharmGKBi | PA28955 |
Miscellaneous databases
Pharosi | Q96SL4, Tbio |
Chemistry databases
DrugBanki | DB00143, Glutathione DB03310, Glutathione disulfide |
Genetic variation databases
BioMutai | GPX7 |
DMDMi | 33516901 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000013084 | 20 – 187 | Glutathione peroxidase 7Add BLAST | 168 |
Proteomic databases
EPDi | Q96SL4 |
jPOSTi | Q96SL4 |
MassIVEi | Q96SL4 |
MaxQBi | Q96SL4 |
PaxDbi | Q96SL4 |
PeptideAtlasi | Q96SL4 |
PRIDEi | Q96SL4 |
ProteomicsDBi | 78126 |
PTM databases
iPTMneti | Q96SL4 |
PhosphoSitePlusi | Q96SL4 |
Expressioni
Tissue specificityi
Expressed in esophageal epithelial cells; expression is up-regulated after exposure to acidic bile acids.1 Publication
Gene expression databases
Bgeei | ENSG00000116157, Expressed in colon and 167 other tissues |
Genevisiblei | Q96SL4, HS |
Organism-specific databases
HPAi | ENSG00000116157, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ96SL4
Protein-protein interaction databases
BioGRIDi | 109139, 53 interactors |
IntActi | Q96SL4, 40 interactors |
STRINGi | 9606.ENSP00000354677 |
Miscellaneous databases
RNActi | Q96SL4, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q96SL4 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q96SL4 |
Family & Domainsi
Sequence similaritiesi
Belongs to the glutathione peroxidase family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG1651, Eukaryota |
GeneTreei | ENSGT00940000159127 |
HOGENOMi | CLU_029507_0_1_1 |
InParanoidi | Q96SL4 |
OMAi | LAPFKGQ |
OrthoDBi | 1483113at2759 |
PhylomeDBi | Q96SL4 |
TreeFami | TF331942 |
Family and domain databases
CDDi | cd00340, GSH_Peroxidase, 1 hit |
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR013376, Glut_perox_Gpx7 IPR000889, Glutathione_peroxidase IPR029759, GPX_AS IPR029760, GPX_CS IPR036249, Thioredoxin-like_sf |
PANTHERi | PTHR11592, PTHR11592, 1 hit |
Pfami | View protein in Pfam PF00255, GSHPx, 1 hit |
PIRSFi | PIRSF000303, Glutathion_perox, 1 hit |
PRINTSi | PR01011, GLUTPROXDASE |
SUPFAMi | SSF52833, SSF52833, 1 hit |
TIGRFAMsi | TIGR02540, gpx7, 1 hit |
PROSITEi | View protein in PROSITE PS00460, GLUTATHIONE_PEROXID_1, 1 hit PS00763, GLUTATHIONE_PEROXID_2, 1 hit PS51355, GLUTATHIONE_PEROXID_3, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q96SL4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVAATVAAAW LLLWAAACAQ QEQDFYDFKA VNIRGKLVSL EKYRGSVSLV
60 70 80 90 100
VNVASECGFT DQHYRALQQL QRDLGPHHFN VLAFPCNQFG QQEPDSNKEI
110 120 130 140 150
ESFARRTYSV SFPMFSKIAV TGTGAHPAFK YLAQTSGKEP TWNFWKYLVA
160 170 180
PDGKVVGAWD PTVSVEEVRP QITALVRKLI LLKREDL
Sequence cautioni
The sequence AAC72961 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 75 – 77 | GPH → HED (Ref. 7) Curated | 3 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF320068 mRNA Translation: AAN76501.1 AY358402 mRNA Translation: AAQ88768.1 AK027683 mRNA Translation: BAB55294.1 DQ096732 Genomic DNA Translation: AAY88741.1 AL356976 Genomic DNA No translation available. BC032788 mRNA Translation: AAH32788.1 AF091092 mRNA Translation: AAC72961.1 Sequence problems. |
CCDSi | CCDS569.1 |
RefSeqi | NP_056511.2, NM_015696.4 |
Genome annotation databases
Ensembli | ENST00000361314; ENSP00000354677; ENSG00000116157 |
GeneIDi | 2882 |
KEGGi | hsa:2882 |
UCSCi | uc001cue.4, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF320068 mRNA Translation: AAN76501.1 AY358402 mRNA Translation: AAQ88768.1 AK027683 mRNA Translation: BAB55294.1 DQ096732 Genomic DNA Translation: AAY88741.1 AL356976 Genomic DNA No translation available. BC032788 mRNA Translation: AAH32788.1 AF091092 mRNA Translation: AAC72961.1 Sequence problems. |
CCDSi | CCDS569.1 |
RefSeqi | NP_056511.2, NM_015696.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2P31 | X-ray | 2.00 | A/B | 20-177 | [»] | |
SMRi | Q96SL4 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109139, 53 interactors |
IntActi | Q96SL4, 40 interactors |
STRINGi | 9606.ENSP00000354677 |
Chemistry databases
DrugBanki | DB00143, Glutathione DB03310, Glutathione disulfide |
Protein family/group databases
PeroxiBasei | 3606, HsGPx07 |
PTM databases
iPTMneti | Q96SL4 |
PhosphoSitePlusi | Q96SL4 |
Genetic variation databases
BioMutai | GPX7 |
DMDMi | 33516901 |
Proteomic databases
EPDi | Q96SL4 |
jPOSTi | Q96SL4 |
MassIVEi | Q96SL4 |
MaxQBi | Q96SL4 |
PaxDbi | Q96SL4 |
PeptideAtlasi | Q96SL4 |
PRIDEi | Q96SL4 |
ProteomicsDBi | 78126 |
Protocols and materials databases
Antibodypediai | 19147, 220 antibodies |
DNASUi | 2882 |
Genome annotation databases
Ensembli | ENST00000361314; ENSP00000354677; ENSG00000116157 |
GeneIDi | 2882 |
KEGGi | hsa:2882 |
UCSCi | uc001cue.4, human |
Organism-specific databases
CTDi | 2882 |
DisGeNETi | 2882 |
GeneCardsi | GPX7 |
HGNCi | HGNC:4559, GPX7 |
HPAi | ENSG00000116157, Low tissue specificity |
MIMi | 614266, phenotype 615784, gene |
neXtProti | NX_Q96SL4 |
OpenTargetsi | ENSG00000116157 |
PharmGKBi | PA28955 |
VEuPathDBi | HostDB:ENSG00000116157.5 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1651, Eukaryota |
GeneTreei | ENSGT00940000159127 |
HOGENOMi | CLU_029507_0_1_1 |
InParanoidi | Q96SL4 |
OMAi | LAPFKGQ |
OrthoDBi | 1483113at2759 |
PhylomeDBi | Q96SL4 |
TreeFami | TF331942 |
Enzyme and pathway databases
BRENDAi | 1.11.1.9, 2681 |
PathwayCommonsi | Q96SL4 |
Reactomei | R-HSA-3299685, Detoxification of Reactive Oxygen Species |
Miscellaneous databases
BioGRID-ORCSi | 2882, 5 hits in 875 CRISPR screens |
ChiTaRSi | GPX7, human |
EvolutionaryTracei | Q96SL4 |
GeneWikii | GPX7 |
GenomeRNAii | 2882 |
Pharosi | Q96SL4, Tbio |
PROi | PR:Q96SL4 |
RNActi | Q96SL4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000116157, Expressed in colon and 167 other tissues |
Genevisiblei | Q96SL4, HS |
Family and domain databases
CDDi | cd00340, GSH_Peroxidase, 1 hit |
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR013376, Glut_perox_Gpx7 IPR000889, Glutathione_peroxidase IPR029759, GPX_AS IPR029760, GPX_CS IPR036249, Thioredoxin-like_sf |
PANTHERi | PTHR11592, PTHR11592, 1 hit |
Pfami | View protein in Pfam PF00255, GSHPx, 1 hit |
PIRSFi | PIRSF000303, Glutathion_perox, 1 hit |
PRINTSi | PR01011, GLUTPROXDASE |
SUPFAMi | SSF52833, SSF52833, 1 hit |
TIGRFAMsi | TIGR02540, gpx7, 1 hit |
PROSITEi | View protein in PROSITE PS00460, GLUTATHIONE_PEROXID_1, 1 hit PS00763, GLUTATHIONE_PEROXID_2, 1 hit PS51355, GLUTATHIONE_PEROXID_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GPX7_HUMAN | |
Accessioni | Q96SL4Primary (citable) accession number: Q96SL4 Secondary accession number(s): O95337, Q5T501 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 4, 2003 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 168 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM