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Protein

Glutathione peroxidase 7

Gene

GPX7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks.1 Publication

Catalytic activityi

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei57By similarity1

GO - Molecular functioni

  • catalase activity Source: CACAO
  • glutathione peroxidase activity Source: UniProtKB-EC
  • peroxidase activity Source: Reactome

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase

Enzyme and pathway databases

BRENDAi1.11.1.9 2681
ReactomeiR-HSA-3299685 Detoxification of Reactive Oxygen Species

Protein family/group databases

PeroxiBasei3606 HsGPx07

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione peroxidase 7 (EC:1.11.1.9)
Short name:
GPx-7
Short name:
GSHPx-7
Alternative name(s):
CL683
Gene namesi
Name:GPX7
Synonyms:GPX6
ORF Names:UNQ469/PRO828
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116157.5
HGNCiHGNC:4559 GPX7
MIMi615784 gene
neXtProtiNX_Q96SL4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Barrett esophagus (BE)1 Publication
The disease is caused by mutations affecting the gene represented in this entry. The pathologic mechanisms leading to Barrett esophagus involve GPX7 dysfunction that results in higher levels of hydrogen peroxide and ROS-induced oxidative stress and DNA damage in esophageal cells.
Disease descriptionA condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes.
See also OMIM:614266

Organism-specific databases

DisGeNETi2882
MIMi614266 phenotype
OpenTargetsiENSG00000116157
PharmGKBiPA28955

Chemistry databases

DrugBankiDB00143 Glutathione

Polymorphism and mutation databases

BioMutaiGPX7
DMDMi33516901

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001308420 – 187Glutathione peroxidase 7Add BLAST168

Proteomic databases

EPDiQ96SL4
MaxQBiQ96SL4
PaxDbiQ96SL4
PeptideAtlasiQ96SL4
PRIDEiQ96SL4
ProteomicsDBi78126

PTM databases

iPTMnetiQ96SL4
PhosphoSitePlusiQ96SL4

Expressioni

Tissue specificityi

Expressed in esophageal epithelial cells; expression is up-regulated after exposure to acidic bile acids.1 Publication

Gene expression databases

BgeeiENSG00000116157 Expressed in 148 organ(s), highest expression level in kidney
CleanExiHS_GPX6
HS_GPX7
GenevisibleiQ96SL4 HS

Organism-specific databases

HPAiHPA025829

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi109139, 45 interactors
IntActiQ96SL4, 11 interactors
STRINGi9606.ENSP00000354677

Structurei

Secondary structure

1187
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ96SL4
SMRiQ96SL4
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96SL4

Family & Domainsi

Sequence similaritiesi

Belongs to the glutathione peroxidase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1651 Eukaryota
COG0386 LUCA
GeneTreeiENSGT00760000119230
HOGENOMiHOG000277054
HOVERGENiHBG004333
InParanoidiQ96SL4
KOiK00432
OMAiNQFGSQD
OrthoDBiEOG091G0OJG
PhylomeDBiQ96SL4
TreeFamiTF331942

Family and domain databases

CDDicd00340 GSH_Peroxidase, 1 hit
InterProiView protein in InterPro
IPR013376 Glut_perox_Gpx7
IPR000889 Glutathione_peroxidase
IPR029759 GPX_AS
IPR029760 GPX_CS
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR11592 PTHR11592, 1 hit
PfamiView protein in Pfam
PF00255 GSHPx, 1 hit
PIRSFiPIRSF000303 Glutathion_perox, 1 hit
PRINTSiPR01011 GLUTPROXDASE
SUPFAMiSSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR02540 gpx7, 1 hit
PROSITEiView protein in PROSITE
PS00460 GLUTATHIONE_PEROXID_1, 1 hit
PS00763 GLUTATHIONE_PEROXID_2, 1 hit
PS51355 GLUTATHIONE_PEROXID_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96SL4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVAATVAAAW LLLWAAACAQ QEQDFYDFKA VNIRGKLVSL EKYRGSVSLV
60 70 80 90 100
VNVASECGFT DQHYRALQQL QRDLGPHHFN VLAFPCNQFG QQEPDSNKEI
110 120 130 140 150
ESFARRTYSV SFPMFSKIAV TGTGAHPAFK YLAQTSGKEP TWNFWKYLVA
160 170 180
PDGKVVGAWD PTVSVEEVRP QITALVRKLI LLKREDL
Length:187
Mass (Da):20,996
Last modified:December 1, 2001 - v1
Checksum:i0ACB80AC2522EFCD
GO

Sequence cautioni

The sequence AAC72961 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti75 – 77GPH → HED (Ref. 7) Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF320068 mRNA Translation: AAN76501.1
AY358402 mRNA Translation: AAQ88768.1
AK027683 mRNA Translation: BAB55294.1
DQ096732 Genomic DNA Translation: AAY88741.1
AL356976 Genomic DNA No translation available.
BC032788 mRNA Translation: AAH32788.1
AF091092 mRNA Translation: AAC72961.1 Sequence problems.
CCDSiCCDS569.1
RefSeqiNP_056511.2, NM_015696.4
UniGeneiHs.43728

Genome annotation databases

EnsembliENST00000361314; ENSP00000354677; ENSG00000116157
GeneIDi2882
KEGGihsa:2882
UCSCiuc001cue.4 human

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF320068 mRNA Translation: AAN76501.1
AY358402 mRNA Translation: AAQ88768.1
AK027683 mRNA Translation: BAB55294.1
DQ096732 Genomic DNA Translation: AAY88741.1
AL356976 Genomic DNA No translation available.
BC032788 mRNA Translation: AAH32788.1
AF091092 mRNA Translation: AAC72961.1 Sequence problems.
CCDSiCCDS569.1
RefSeqiNP_056511.2, NM_015696.4
UniGeneiHs.43728

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2P31X-ray2.00A/B20-177[»]
ProteinModelPortaliQ96SL4
SMRiQ96SL4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109139, 45 interactors
IntActiQ96SL4, 11 interactors
STRINGi9606.ENSP00000354677

Chemistry databases

DrugBankiDB00143 Glutathione

Protein family/group databases

PeroxiBasei3606 HsGPx07

PTM databases

iPTMnetiQ96SL4
PhosphoSitePlusiQ96SL4

Polymorphism and mutation databases

BioMutaiGPX7
DMDMi33516901

Proteomic databases

EPDiQ96SL4
MaxQBiQ96SL4
PaxDbiQ96SL4
PeptideAtlasiQ96SL4
PRIDEiQ96SL4
ProteomicsDBi78126

Protocols and materials databases

DNASUi2882
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361314; ENSP00000354677; ENSG00000116157
GeneIDi2882
KEGGihsa:2882
UCSCiuc001cue.4 human

Organism-specific databases

CTDi2882
DisGeNETi2882
EuPathDBiHostDB:ENSG00000116157.5
GeneCardsiGPX7
HGNCiHGNC:4559 GPX7
HPAiHPA025829
MIMi614266 phenotype
615784 gene
neXtProtiNX_Q96SL4
OpenTargetsiENSG00000116157
PharmGKBiPA28955
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1651 Eukaryota
COG0386 LUCA
GeneTreeiENSGT00760000119230
HOGENOMiHOG000277054
HOVERGENiHBG004333
InParanoidiQ96SL4
KOiK00432
OMAiNQFGSQD
OrthoDBiEOG091G0OJG
PhylomeDBiQ96SL4
TreeFamiTF331942

Enzyme and pathway databases

BRENDAi1.11.1.9 2681
ReactomeiR-HSA-3299685 Detoxification of Reactive Oxygen Species

Miscellaneous databases

ChiTaRSiGPX7 human
EvolutionaryTraceiQ96SL4
GeneWikiiGPX7
GenomeRNAii2882
PROiPR:Q96SL4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000116157 Expressed in 148 organ(s), highest expression level in kidney
CleanExiHS_GPX6
HS_GPX7
GenevisibleiQ96SL4 HS

Family and domain databases

CDDicd00340 GSH_Peroxidase, 1 hit
InterProiView protein in InterPro
IPR013376 Glut_perox_Gpx7
IPR000889 Glutathione_peroxidase
IPR029759 GPX_AS
IPR029760 GPX_CS
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR11592 PTHR11592, 1 hit
PfamiView protein in Pfam
PF00255 GSHPx, 1 hit
PIRSFiPIRSF000303 Glutathion_perox, 1 hit
PRINTSiPR01011 GLUTPROXDASE
SUPFAMiSSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR02540 gpx7, 1 hit
PROSITEiView protein in PROSITE
PS00460 GLUTATHIONE_PEROXID_1, 1 hit
PS00763 GLUTATHIONE_PEROXID_2, 1 hit
PS51355 GLUTATHIONE_PEROXID_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGPX7_HUMAN
AccessioniPrimary (citable) accession number: Q96SL4
Secondary accession number(s): O95337, Q5T501
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 4, 2003
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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