GPX7

Functionⁱ

It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks.1 Publication

Catalytic activityⁱ

2 glutathione + H₂O₂ = glutathione disulfide + 2 H₂O.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	57	By similarity		1

GO - Molecular functionⁱ

catalase activity
Source: CACAO
Inferred from direct assayⁱ
- 22157330
glutathione peroxidase activity Source: UniProtKB-EC
peroxidase activity
Source: Reactome
Inferred from experimentⁱ
- 21215271

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to oxidative stress Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase, Peroxidase

Molecular function

Oxidoreductase, Peroxidase

Enzyme and pathway databases

BRENDAⁱ	1.11.1.9 2681
Reactomeⁱ	R-HSA-3299685 Detoxification of Reactive Oxygen Species

Protein family/group databases

PeroxiBaseⁱ	3606 HsGPx07

PeroxiBaseⁱ

3606 HsGPx07

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Glutathione peroxidase 7 (EC:1.11.1.9) Short name: GPx-7 Short name: GSHPx-7 Alternative name(s): CL683
Gene namesⁱ	Name:GPX7 Synonyms:GPX6 ORF Names:UNQ469/PRO828
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000116157.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4559 GPX7
MIMⁱ	615784 gene
neXtProtⁱ	NX_Q96SL4

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Barrett esophagus (BE)1 Publication

The disease is caused by mutations affecting the gene represented in this entry. The pathologic mechanisms leading to Barrett esophagus involve GPX7 dysfunction that results in higher levels of hydrogen peroxide and ROS-induced oxidative stress and DNA damage in esophageal cells.

Disease descriptionA condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes.

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2882
MIMⁱ	614266 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000116157
PharmGKBⁱ	PA28955

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB00143 Glutathione

DrugBankⁱ

DB00143 Glutathione

Polymorphism and mutation databases

BioMutaⁱ	GPX7
DMDMⁱ	33516901

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 19	Sequence analysisAdd BLAST		19
ChainⁱPRO_0000013084	20 – 187	Glutathione peroxidase 7Add BLAST		168

Proteomic databases

EPDⁱ	Q96SL4
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96SL4
PaxDbⁱ	Q96SL4
PeptideAtlas More...PeptideAtlasⁱ	Q96SL4
PRIDEⁱ	Q96SL4
ProteomicsDBⁱ	78126

PTM databases

iPTMnetⁱ	Q96SL4
PhosphoSitePlusⁱ	Q96SL4

Expressionⁱ

Tissue specificityⁱ

Expressed in esophageal epithelial cells; expression is up-regulated after exposure to acidic bile acids.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000116157 Expressed in 148 organ(s), highest expression level in kidney
CleanExⁱ	HS_GPX6 HS_GPX7
Genevisibleⁱ	Q96SL4 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA025829

HPAⁱ

HPA025829

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
ASNA1	O43681	5	EBI-749411,EBI-2515857
CEP70	Q8NHQ1	3	EBI-749411,EBI-739624
SGTA	O43765	3	EBI-749411,EBI-347996

Protein-protein interaction databases

BioGridⁱ	109139, 45 interactors
IntActⁱ	Q96SL4, 11 interactors
STRINGⁱ	9606.ENSP00000354677

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	25 – 27	Combined sources	3
Beta strandⁱ	29 – 32	Combined sources	4
Beta strandⁱ	37 – 39	Combined sources	3
Helixⁱ	40 – 43	Combined sources	4
Beta strandⁱ	46 – 53	Combined sources	8
Beta strandⁱ	55 – 57	Combined sources	3
Helixⁱ	60 – 74	Combined sources	15
Helixⁱ	75 – 77	Combined sources	3
Beta strandⁱ	79 – 85	Combined sources	7
Helixⁱ	97 – 108	Combined sources	12
Helixⁱ	127 – 136	Combined sources	10
Beta strandⁱ	146 – 149	Combined sources	4
Beta strandⁱ	155 – 159	Combined sources	5
Helixⁱ	165 – 173	Combined sources	9

Show more details

3D structure databases

ProteinModelPortalⁱ	Q96SL4
SMRⁱ	Q96SL4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q96SL4

EvolutionaryTraceⁱ

Q96SL4

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the glutathione peroxidase family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG1651 Eukaryota COG0386 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119230
HOGENOMⁱ	HOG000277054
HOVERGENⁱ	HBG004333
InParanoidⁱ	Q96SL4
KEGG Orthology (KO) More...KOⁱ	K00432
OMAⁱ	NQFGSQD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0OJG
PhylomeDBⁱ	Q96SL4
TreeFamⁱ	TF331942

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00340 GSH_Peroxidase, 1 hit
InterProⁱ	View protein in InterPro IPR013376 Glut_perox_Gpx7 IPR000889 Glutathione_peroxidase IPR029759 GPX_AS IPR029760 GPX_CS IPR036249 Thioredoxin-like_sf
PANTHERⁱ	PTHR11592 PTHR11592, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00255 GSHPx, 1 hit
PIRSFⁱ	PIRSF000303 Glutathion_perox, 1 hit
PRINTSⁱ	PR01011 GLUTPROXDASE
SUPFAMⁱ	SSF52833 SSF52833, 1 hit
TIGRFAMsⁱ	TIGR02540 gpx7, 1 hit
PROSITEⁱ	View protein in PROSITE PS00460 GLUTATHIONE_PEROXID_1, 1 hit PS00763 GLUTATHIONE_PEROXID_2, 1 hit PS51355 GLUTATHIONE_PEROXID_3, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q96SL4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVAATVAAAW LLLWAAACAQ QEQDFYDFKA VNIRGKLVSL EKYRGSVSLV 
        60         70         80         90        100
VNVASECGFT DQHYRALQQL QRDLGPHHFN VLAFPCNQFG QQEPDSNKEI 
       110        120        130        140        150
ESFARRTYSV SFPMFSKIAV TGTGAHPAFK YLAQTSGKEP TWNFWKYLVA 
       160        170        180 
PDGKVVGAWD PTVSVEEVRP QITALVRKLI LLKREDL

Length:187

Mass (Da):20,996

Last modified:December 1, 2001 - v1

Checksum:ⁱ0ACB80AC2522EFCD

GO

Sequence cautionⁱ

The sequence AAC72961 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	75 – 77	GPH → HED (Ref. 7) Curated		3

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF320068 mRNA Translation: AAN76501.1 AY358402 mRNA Translation: AAQ88768.1 AK027683 mRNA Translation: BAB55294.1 DQ096732 Genomic DNA Translation: AAY88741.1 AL356976 Genomic DNA No translation available. BC032788 mRNA Translation: AAH32788.1 AF091092 mRNA Translation: AAC72961.1 Sequence problems.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS569.1
NCBI Reference Sequences More...RefSeqⁱ	NP_056511.2, NM_015696.4
UniGeneⁱ	Hs.43728

Genome annotation databases

Ensemblⁱ	ENST00000361314; ENSP00000354677; ENSG00000116157
GeneIDⁱ	2882
KEGGⁱ	hsa:2882
UCSC genome browser More...UCSCⁱ	uc001cue.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96SL4	Glutathione peroxidase		PANTR		187	UniRef100_Q96SL4
Glutathione peroxidase		PONAB		187

Protein	Similar proteins		Species	Score	Length	Source
Q96SL4	Glutathione peroxidase 7		BOVIN		186	UniRef90_Q96SL4
Glutathione peroxidase 7		MOUSE		186
Glutathione peroxidase		PANTR		187
Glutathione peroxidase		PONAB		187
Glutathione peroxidase		RHIRO		193
+65

Protein	Similar proteins		Species	Score	Length	Source
Q96SL4	Glutathione peroxidase 7		BOVIN		186	UniRef50_Q96SL4
Glutathione peroxidase 7		MOUSE		186
Glutathione peroxidase		PANTR		187
Glutathione peroxidase		PONAB		187
Glutathione peroxidase		RHIRO		193
+108

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF320068 mRNA Translation: AAN76501.1 AY358402 mRNA Translation: AAQ88768.1 AK027683 mRNA Translation: BAB55294.1 DQ096732 Genomic DNA Translation: AAY88741.1 AL356976 Genomic DNA No translation available. BC032788 mRNA Translation: AAH32788.1 AF091092 mRNA Translation: AAC72961.1 Sequence problems.
CCDSⁱ	CCDS569.1
RefSeqⁱ	NP_056511.2, NM_015696.4
UniGeneⁱ	Hs.43728

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2P31	X-ray	2.00	A/B	20-177	[»]
ProteinModelPortalⁱ	Q96SL4
SMRⁱ	Q96SL4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109139, 45 interactors
IntActⁱ	Q96SL4, 11 interactors
STRINGⁱ	9606.ENSP00000354677

Chemistry databases

DrugBankⁱ	DB00143 Glutathione

DrugBankⁱ

DB00143 Glutathione

Protein family/group databases

PeroxiBaseⁱ	3606 HsGPx07

PeroxiBaseⁱ

3606 HsGPx07

PTM databases

iPTMnetⁱ	Q96SL4
PhosphoSitePlusⁱ	Q96SL4

Polymorphism and mutation databases

BioMutaⁱ	GPX7
DMDMⁱ	33516901

Proteomic databases

EPDⁱ	Q96SL4
MaxQBⁱ	Q96SL4
PaxDbⁱ	Q96SL4
PeptideAtlasⁱ	Q96SL4
PRIDEⁱ	Q96SL4
ProteomicsDBⁱ	78126

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	2882
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000361314; ENSP00000354677; ENSG00000116157
GeneIDⁱ	2882
KEGGⁱ	hsa:2882
UCSCⁱ	uc001cue.4 human

Organism-specific databases

CTDⁱ	2882
DisGeNETⁱ	2882
EuPathDBⁱ	HostDB:ENSG00000116157.5
GeneCardsⁱ	GPX7
HGNCⁱ	HGNC:4559 GPX7
HPAⁱ	HPA025829
MIMⁱ	614266 phenotype 615784 gene
neXtProtⁱ	NX_Q96SL4
OpenTargetsⁱ	ENSG00000116157
PharmGKBⁱ	PA28955
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1651 Eukaryota COG0386 LUCA
GeneTreeⁱ	ENSGT00760000119230
HOGENOMⁱ	HOG000277054
HOVERGENⁱ	HBG004333
InParanoidⁱ	Q96SL4
KOⁱ	K00432
OMAⁱ	NQFGSQD
OrthoDBⁱ	EOG091G0OJG
PhylomeDBⁱ	Q96SL4
TreeFamⁱ	TF331942

Enzyme and pathway databases

BRENDAⁱ	1.11.1.9 2681
Reactomeⁱ	R-HSA-3299685 Detoxification of Reactive Oxygen Species

Miscellaneous databases

ChiTaRSⁱ	GPX7 human
EvolutionaryTraceⁱ	Q96SL4
GeneWikiⁱ	GPX7
GenomeRNAiⁱ	2882
Protein Ontology More...PROⁱ	PR:Q96SL4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000116157 Expressed in 148 organ(s), highest expression level in kidney
CleanExⁱ	HS_GPX6 HS_GPX7
Genevisibleⁱ	Q96SL4 HS

Family and domain databases

CDDⁱ	cd00340 GSH_Peroxidase, 1 hit
InterProⁱ	View protein in InterPro IPR013376 Glut_perox_Gpx7 IPR000889 Glutathione_peroxidase IPR029759 GPX_AS IPR029760 GPX_CS IPR036249 Thioredoxin-like_sf
PANTHERⁱ	PTHR11592 PTHR11592, 1 hit
Pfamⁱ	View protein in Pfam PF00255 GSHPx, 1 hit
PIRSFⁱ	PIRSF000303 Glutathion_perox, 1 hit
PRINTSⁱ	PR01011 GLUTPROXDASE
SUPFAMⁱ	SSF52833 SSF52833, 1 hit
TIGRFAMsⁱ	TIGR02540 gpx7, 1 hit
PROSITEⁱ	View protein in PROSITE PS00460 GLUTATHIONE_PEROXID_1, 1 hit PS00763 GLUTATHIONE_PEROXID_2, 1 hit PS51355 GLUTATHIONE_PEROXID_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GPX7_HUMAN
Accessionⁱ	Q96SL4Primary (citable) accession number: Q96SL4 Secondary accession number(s): O95337, Q5T501
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 4, 2003
	Last sequence update:	December 1, 2001
	Last modified:	November 7, 2018
	This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q96SL4 (GPX7_HUMAN)

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Glutathione peroxidase 7

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Endoplasmic reticulum

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ