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Entry version 159 (02 Dec 2020)
Sequence version 3 (16 Jun 2009)
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Protein

Zinc finger protein 607

Gene

ZNF607

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri114 – 136C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri142 – 164C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri170 – 192C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri197 – 219C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri225 – 247C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 275C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 8; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 387C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 415C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri421 – 443C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri449 – 471C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri477 – 499C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri505 – 527C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri533 – 555C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri561 – 583C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri589 – 611C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri617 – 639C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri645 – 667C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri673 – 695C2H2-type 20PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q96SK3

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436, Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 607
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF607
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

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EuPathDBi
HostDB:ENSG00000198182.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28192, ZNF607

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96SK3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000198182

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134938252

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96SK3, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF607

Domain mapping of disease mutations (DMDM)

More...
DMDMi
239938814

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000476891 – 696Zinc finger protein 607Add BLAST696

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96SK3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96SK3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96SK3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96SK3

PeptideAtlas

More...
PeptideAtlasi
Q96SK3

PRoteomics IDEntifications database

More...
PRIDEi
Q96SK3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
25534
78122 [Q96SK3-1]
78123 [Q96SK3-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96SK3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q96SK3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000198182, Expressed in prostate gland and 178 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96SK3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96SK3, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000198182, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
124252, 5 interactors

Protein interaction database and analysis system

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IntActi
Q96SK3, 5 interactors

Molecular INTeraction database

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MINTi
Q96SK3

STRING: functional protein association networks

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STRINGi
9606.ENSP00000347338

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96SK3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96SK3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 78KRABPROSITE-ProRule annotationAdd BLAST73

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri114 – 136C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri142 – 164C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri170 – 192C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri197 – 219C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri225 – 247C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 275C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 8; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 387C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 415C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri421 – 443C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri449 – 471C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri477 – 499C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri505 – 527C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri533 – 555C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri561 – 583C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri589 – 611C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri617 – 639C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri645 – 667C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri673 – 695C2H2-type 20PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163859

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002678_44_5_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96SK3

Identification of Orthologs from Complete Genome Data

More...
OMAi
AFSVHGR

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96SK3

TreeFam database of animal gene trees

More...
TreeFami
TF341817

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765, KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 15 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 19 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 12 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 18 hits
PS50157, ZINC_FINGER_C2H2_2, 20 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96SK3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSYGSITFGD VAIDFSHQEW EYLSLVQKTL YQEVMMENYD NLVSLAGHSV
60 70 80 90 100
SKPDLITLLE QGKEPWMIVR EETRGECTDL DSRCEIISDG KMQLYRKHSC
110 120 130 140 150
VTLHQRIHNG QKPYECKQCQ KSFSHLTELM VHQTIHTSEE PDQCEKFRKA
160 170 180 190 200
FSHLTDLRKH QKINAREKPY ECEECGKVFS YPANLAQHGK VHVEKPYECK
210 220 230 240 250
ECGEAFRTSR QLTVHHRFHY GEKPYECKEC GKAFSVYGRL SRHQSIHTGE
260 270 280 290 300
KPFECNKCGK SFRLKAGLKV HQSIHTGEKP HECKECGKAF RQFSHLVGHK
310 320 330 340 350
RIHTGEKPYE CKECGKGFTC RYQLTMHQRI YSGEKHYECK ENGEAFSSGH
360 370 380 390 400
QLTAPHTFES VEKPYKCEEC GKAFSVHGRL TRHQGIHSGK KPYECNKCGK
410 420 430 440 450
SFRLNSSLKI HQNIHTGEKP YKCKECGKAF SQRAHLAHHN RIHTGYKPFE
460 470 480 490 500
CKECGKSFRC ASYLVIHERI HTGEKPYVCQ ECGKGFSYSH KLTIHRRVHT
510 520 530 540 550
GEKPYECKEC GKAFSVSGQL TQHLSIHSGK KPFECNKCGK SFRFISVLKA
560 570 580 590 600
HQNIHSAEKP YECKECGKAF RHATSLIYHD RTHAGEKSYE CKECGETFSH
610 620 630 640 650
ASHLIIHERI HTSDKPYECK RCGKAFHCAS YLVRHESVHA DGNPYMCEEC
660 670 680 690
GKAFNSSHEL SIHHRVHTGE KPFKCNKCRR SFRLRSILEV HQRIHI
Length:696
Mass (Da):80,507
Last modified:June 16, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i62ABBBDA26A3F875
GO
Isoform 2 (identifier: Q96SK3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-325: Missing.

Show »
Length:371
Mass (Da):42,712
Checksum:i48EAAF78A7A7E350
GO
Isoform 3 (identifier: Q96SK3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     46-46: Missing.

Show »
Length:695
Mass (Da):80,435
Checksum:i141542D11FD6018A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ELX6K7ELX6_HUMAN
Zinc finger protein 607
ZNF607
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ESQ1K7ESQ1_HUMAN
Zinc finger protein 607
ZNF607
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EN48K7EN48_HUMAN
Zinc finger protein 607
ZNF607
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti653 – 654AF → GL in AAH14850 (PubMed:15489334).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0579742S → A1 PublicationCorresponds to variant dbSNP:rs2909097Ensembl.1
Natural variantiVAR_05797570R → H. Corresponds to variant dbSNP:rs2385006EnsemblClinVar.1
Natural variantiVAR_057976123F → L. Corresponds to variant dbSNP:rs35735839Ensembl.1
Natural variantiVAR_057977375S → T. Corresponds to variant dbSNP:rs960689Ensembl.1
Natural variantiVAR_058306433R → H. Corresponds to variant dbSNP:rs2385006EnsemblClinVar.1
Natural variantiVAR_058307531K → R2 PublicationsCorresponds to variant dbSNP:rs958305Ensembl.1
Natural variantiVAR_057978653A → P. Corresponds to variant dbSNP:rs17856468Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0375031 – 325Missing in isoform 2. 2 PublicationsAdd BLAST325
Alternative sequenceiVSP_04684346Missing in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK131557 mRNA Translation: BAD18691.1
AK131559 mRNA Translation: BAD18693.1
AK027708 mRNA Translation: BAB55313.1
AC093227 Genomic DNA No translation available.
BC014850 mRNA Translation: AAH14850.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33006.1 [Q96SK3-1]
CCDS54259.1 [Q96SK3-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001166148.1, NM_001172677.1 [Q96SK3-3]
NP_116078.4, NM_032689.4 [Q96SK3-1]
XP_006723498.1, XM_006723435.3 [Q96SK3-1]
XP_006723499.1, XM_006723436.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000355202; ENSP00000347338; ENSG00000198182 [Q96SK3-1]
ENST00000395835; ENSP00000438015; ENSG00000198182 [Q96SK3-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
84775

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:84775

UCSC genome browser

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UCSCi
uc002ohb.3, human [Q96SK3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131557 mRNA Translation: BAD18691.1
AK131559 mRNA Translation: BAD18693.1
AK027708 mRNA Translation: BAB55313.1
AC093227 Genomic DNA No translation available.
BC014850 mRNA Translation: AAH14850.1
CCDSiCCDS33006.1 [Q96SK3-1]
CCDS54259.1 [Q96SK3-3]
RefSeqiNP_001166148.1, NM_001172677.1 [Q96SK3-3]
NP_116078.4, NM_032689.4 [Q96SK3-1]
XP_006723498.1, XM_006723435.3 [Q96SK3-1]
XP_006723499.1, XM_006723436.2

3D structure databases

SMRiQ96SK3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124252, 5 interactors
IntActiQ96SK3, 5 interactors
MINTiQ96SK3
STRINGi9606.ENSP00000347338

PTM databases

iPTMnetiQ96SK3
PhosphoSitePlusiQ96SK3

Polymorphism and mutation databases

BioMutaiZNF607
DMDMi239938814

Proteomic databases

jPOSTiQ96SK3
MassIVEiQ96SK3
MaxQBiQ96SK3
PaxDbiQ96SK3
PeptideAtlasiQ96SK3
PRIDEiQ96SK3
ProteomicsDBi25534
78122 [Q96SK3-1]
78123 [Q96SK3-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
16401, 87 antibodies

Genome annotation databases

EnsembliENST00000355202; ENSP00000347338; ENSG00000198182 [Q96SK3-1]
ENST00000395835; ENSP00000438015; ENSG00000198182 [Q96SK3-3]
GeneIDi84775
KEGGihsa:84775
UCSCiuc002ohb.3, human [Q96SK3-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
84775
EuPathDBiHostDB:ENSG00000198182.12

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF607
HGNCiHGNC:28192, ZNF607
HPAiENSG00000198182, Low tissue specificity
neXtProtiNX_Q96SK3
OpenTargetsiENSG00000198182
PharmGKBiPA134938252

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000163859
HOGENOMiCLU_002678_44_5_1
InParanoidiQ96SK3
OMAiAFSVHGR
OrthoDBi1318335at2759
PhylomeDBiQ96SK3
TreeFamiTF341817

Enzyme and pathway databases

PathwayCommonsiQ96SK3
ReactomeiR-HSA-212436, Generic Transcription Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
84775, 4 hits in 866 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84775
PharosiQ96SK3, Tdark

Protein Ontology

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PROi
PR:Q96SK3
RNActiQ96SK3, protein

Gene expression databases

BgeeiENSG00000198182, Expressed in prostate gland and 178 other tissues
ExpressionAtlasiQ96SK3, baseline and differential
GenevisibleiQ96SK3, HS

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 15 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 19 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 12 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 18 hits
PS50157, ZINC_FINGER_C2H2_2, 20 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN607_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96SK3
Secondary accession number(s): F5H141
, Q6ZMN2, Q6ZMN4, Q96C40
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 16, 2009
Last modified: December 2, 2020
This is version 159 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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