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Protein

Spermatid perinuclear RNA-binding protein

Gene

STRBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA. Binds also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA PRM1 3'-UTR and adenovirus VA RNA (By similarity).By similarity

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • double-stranded RNA binding Source: GO_Central
  • microtubule binding Source: Ensembl
  • RNA binding Source: UniProtKB
  • single-stranded RNA binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, RNA-binding
Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatid perinuclear RNA-binding protein
Gene namesi
Name:STRBP
Synonyms:SPNR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000165209.18
HGNCiHGNC:16462 STRBP
MIMi611138 gene
neXtProtiNX_Q96SI9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000165209
PharmGKBiPA38145

Polymorphism and mutation databases

BioMutaiSTRBP
DMDMi74752134

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002749171 – 672Spermatid perinuclear RNA-binding proteinAdd BLAST672

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei612Asymmetric dimethylarginineBy similarity1
Modified residuei617Asymmetric dimethylarginineBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

EPDiQ96SI9
PaxDbiQ96SI9
PeptideAtlasiQ96SI9
PRIDEiQ96SI9
ProteomicsDBi78115
78116 [Q96SI9-2]

PTM databases

iPTMnetiQ96SI9
PhosphoSitePlusiQ96SI9
SwissPalmiQ96SI9

Expressioni

Gene expression databases

BgeeiENSG00000165209 Expressed in 200 organ(s), highest expression level in testis
CleanExiHS_STRBP
ExpressionAtlasiQ96SI9 baseline and differential
GenevisibleiQ96SI9 HS

Organism-specific databases

HPAiHPA020651

Interactioni

Subunit structurei

Interacts with EIF2AK2. Associates with microtubules; it is unsure whether such interaction is direct or indirect.By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120623, 106 interactors
IntActiQ96SI9, 34 interactors
MINTiQ96SI9
STRINGi9606.ENSP00000321347

Structurei

Secondary structure

1672
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ96SI9
SMRiQ96SI9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96SI9

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 363DZFPROSITE-ProRule annotationAdd BLAST359
Domaini387 – 453DRBM 1PROSITE-ProRule annotationAdd BLAST67
Domaini510 – 576DRBM 2PROSITE-ProRule annotationAdd BLAST67

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi584 – 587Poly-Lys4

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IN2U Eukaryota
ENOG410Z2M4 LUCA
GeneTreeiENSGT00550000074528
HOVERGENiHBG069915
InParanoidiQ96SI9
KOiK13200
OMAiGYITPGY
OrthoDBiEOG091G022L
PhylomeDBiQ96SI9
TreeFamiTF320194

Family and domain databases

CDDicd00048 DSRM, 2 hits
InterProiView protein in InterPro
IPR014720 dsRBD_dom
IPR006561 DZF_dom
IPR030446 STRBP
PANTHERiPTHR10910:SF27 PTHR10910:SF27, 1 hit
PfamiView protein in Pfam
PF00035 dsrm, 2 hits
PF07528 DZF, 1 hit
SMARTiView protein in SMART
SM00358 DSRM, 2 hits
SM00572 DZF, 1 hit
PROSITEiView protein in PROSITE
PS50137 DS_RBD, 2 hits
PS51703 DZF, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96SI9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRSIRSFAND DRHVMVKHST IYPSPEELEA VQNMVSTVEC ALKHVSDWLD
60 70 80 90 100
ETNKGTKTEG ETEVKKDEAG ENYSKDQGGR TLCGVMRIGL VAKGLLIKDD
110 120 130 140 150
MDLELVLMCK DKPTETLLNT VKDNLPIQIQ KLTEEKYQVE QCVNEASIII
160 170 180 190 200
RNTKEPTLTL KVILTSPLIR DELEKKDGEN VSMKDPPDLL DRQKCLNALA
210 220 230 240 250
SLRHAKWFQA RANGLKSCVI VLRILRDLCN RVPTWAPLKG WPLELICEKS
260 270 280 290 300
IGTCNRPLGA GEALRRVMEC LASGILLPGG PGLHDPCERD PTDALSYMTI
310 320 330 340 350
QQKEDITHSA QHALRLSAFG QIYKVLEMDP LPSSKPFQKY SWSVTDKEGA
360 370 380 390 400
GSSALKRPFE DGLGDDKDPN KKMKRNLRKI LDSKAIDLMN ALMRLNQIRP
410 420 430 440 450
GLQYKLLSQS GPVHAPVFTM SVDVDGTTYE ASGPSKKTAK LHVAVKVLQA
460 470 480 490 500
MGYPTGFDAD IECMSSDEKS DNESKNETVS SNSSNNTGNS TTETSSTLEV
510 520 530 540 550
RTQGPILTAS GKNPVMELNE KRRGLKYELI SETGGSHDKR FVMEVEVDGQ
560 570 580 590 600
KFRGAGPNKK VAKASAALAA LEKLFSGPNA ANNKKKKIIP QAKGVVNTAV
610 620 630 640 650
SAAVQAVRGR GRGTLTRGAF VGATAAPGYI APGYGTPYGY STAAPAYGLP
660 670
KRMVLLPVMK FPTYPVPHYS FF
Length:672
Mass (Da):73,653
Last modified:December 1, 2001 - v1
Checksum:i26465F4D3A429FBC
GO
Isoform 2 (identifier: Q96SI9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: Missing.

Show »
Length:658
Mass (Da):71,967
Checksum:i131F93237EEF70B1
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5JPA5Q5JPA5_HUMAN
Spermatid perinuclear RNA-binding p...
STRBP DKFZp434G151, DKFZp434P151
94Annotation score:
H0YC91H0YC91_HUMAN
Spermatid perinuclear RNA-binding p...
STRBP
89Annotation score:
H0YD70H0YD70_HUMAN
Spermatid perinuclear RNA-binding p...
STRBP
84Annotation score:
H0YD00H0YD00_HUMAN
Spermatid perinuclear RNA-binding p...
STRBP
57Annotation score:
E9PKQ0E9PKQ0_HUMAN
Spermatid perinuclear RNA-binding p...
STRBP
74Annotation score:

Sequence cautioni

The sequence AAI08732 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA92120 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB14873 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti173 – 175LEK → IGRR in AAK20832 (Ref. 1) Curated3
Sequence conflicti196L → P in BAA92120 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035662280G → R in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0229371 – 14Missing in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF333337 mRNA Translation: AAK20832.1
AL136866 mRNA Translation: CAB66800.1
AK002169 mRNA Translation: BAA92120.1 Different initiation.
AK024285 mRNA Translation: BAB14873.1 Different initiation.
AK027890 mRNA Translation: BAB55434.1
AL365338 Genomic DNA No translation available.
BC002693 mRNA Translation: AAH02693.2
BC017732 mRNA Translation: AAH17732.1
BC108731 mRNA Translation: AAI08732.1 Sequence problems.
CCDSiCCDS55337.1 [Q96SI9-2]
CCDS6851.1 [Q96SI9-1]
RefSeqiNP_001164608.1, NM_001171137.1 [Q96SI9-2]
NP_060857.2, NM_018387.4 [Q96SI9-1]
XP_016870383.1, XM_017014894.1
XP_016870384.1, XM_017014895.1
XP_016870385.1, XM_017014896.1 [Q96SI9-1]
UniGeneiHs.287659
Hs.694157

Genome annotation databases

EnsembliENST00000348403; ENSP00000321347; ENSG00000165209 [Q96SI9-1]
ENST00000360998; ENSP00000354271; ENSG00000165209 [Q96SI9-2]
ENST00000447404; ENSP00000415968; ENSG00000165209 [Q96SI9-1]
GeneIDi55342
KEGGihsa:55342
UCSCiuc004bnu.4 human [Q96SI9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF333337 mRNA Translation: AAK20832.1
AL136866 mRNA Translation: CAB66800.1
AK002169 mRNA Translation: BAA92120.1 Different initiation.
AK024285 mRNA Translation: BAB14873.1 Different initiation.
AK027890 mRNA Translation: BAB55434.1
AL365338 Genomic DNA No translation available.
BC002693 mRNA Translation: AAH02693.2
BC017732 mRNA Translation: AAH17732.1
BC108731 mRNA Translation: AAI08732.1 Sequence problems.
CCDSiCCDS55337.1 [Q96SI9-2]
CCDS6851.1 [Q96SI9-1]
RefSeqiNP_001164608.1, NM_001171137.1 [Q96SI9-2]
NP_060857.2, NM_018387.4 [Q96SI9-1]
XP_016870383.1, XM_017014894.1
XP_016870384.1, XM_017014895.1
XP_016870385.1, XM_017014896.1 [Q96SI9-1]
UniGeneiHs.287659
Hs.694157

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DMYNMR-A378-461[»]
ProteinModelPortaliQ96SI9
SMRiQ96SI9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120623, 106 interactors
IntActiQ96SI9, 34 interactors
MINTiQ96SI9
STRINGi9606.ENSP00000321347

PTM databases

iPTMnetiQ96SI9
PhosphoSitePlusiQ96SI9
SwissPalmiQ96SI9

Polymorphism and mutation databases

BioMutaiSTRBP
DMDMi74752134

Proteomic databases

EPDiQ96SI9
PaxDbiQ96SI9
PeptideAtlasiQ96SI9
PRIDEiQ96SI9
ProteomicsDBi78115
78116 [Q96SI9-2]

Protocols and materials databases

DNASUi55342
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000348403; ENSP00000321347; ENSG00000165209 [Q96SI9-1]
ENST00000360998; ENSP00000354271; ENSG00000165209 [Q96SI9-2]
ENST00000447404; ENSP00000415968; ENSG00000165209 [Q96SI9-1]
GeneIDi55342
KEGGihsa:55342
UCSCiuc004bnu.4 human [Q96SI9-1]

Organism-specific databases

CTDi55342
EuPathDBiHostDB:ENSG00000165209.18
GeneCardsiSTRBP
HGNCiHGNC:16462 STRBP
HPAiHPA020651
MIMi611138 gene
neXtProtiNX_Q96SI9
OpenTargetsiENSG00000165209
PharmGKBiPA38145
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IN2U Eukaryota
ENOG410Z2M4 LUCA
GeneTreeiENSGT00550000074528
HOVERGENiHBG069915
InParanoidiQ96SI9
KOiK13200
OMAiGYITPGY
OrthoDBiEOG091G022L
PhylomeDBiQ96SI9
TreeFamiTF320194

Miscellaneous databases

ChiTaRSiSTRBP human
EvolutionaryTraceiQ96SI9
GeneWikiiSTRBP
GenomeRNAii55342
PROiPR:Q96SI9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000165209 Expressed in 200 organ(s), highest expression level in testis
CleanExiHS_STRBP
ExpressionAtlasiQ96SI9 baseline and differential
GenevisibleiQ96SI9 HS

Family and domain databases

CDDicd00048 DSRM, 2 hits
InterProiView protein in InterPro
IPR014720 dsRBD_dom
IPR006561 DZF_dom
IPR030446 STRBP
PANTHERiPTHR10910:SF27 PTHR10910:SF27, 1 hit
PfamiView protein in Pfam
PF00035 dsrm, 2 hits
PF07528 DZF, 1 hit
SMARTiView protein in SMART
SM00358 DSRM, 2 hits
SM00572 DZF, 1 hit
PROSITEiView protein in PROSITE
PS50137 DS_RBD, 2 hits
PS51703 DZF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTRBP_HUMAN
AccessioniPrimary (citable) accession number: Q96SI9
Secondary accession number(s): Q32NB9
, Q9BUE1, Q9BXG4, Q9H0B4, Q9H7V1, Q9NUK4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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