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Protein

BTB/POZ domain-containing protein KCTD15

Gene

KCTD15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

During embryonic development, interferes with neural crest formation (By similarity). Inhibits AP2 transcriptional activity by interaction with its activation domain.By similarity1 Publication

GO - Molecular functioni

  • identical protein binding Source: IntAct

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein

Enzyme and pathway databases

ReactomeiR-HSA-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD15
Alternative name(s):
Potassium channel tetramerization domain-containing protein 15
Gene namesi
Name:KCTD15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000153885.14
HGNCiHGNC:23297 KCTD15
MIMi615240 gene
neXtProtiNX_Q96SI1

Pathology & Biotechi

Organism-specific databases

DisGeNETi79047
OpenTargetsiENSG00000153885
PharmGKBiPA134916319

Polymorphism and mutation databases

BioMutaiKCTD15
DMDMi74732704

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002472511 – 283BTB/POZ domain-containing protein KCTD15Add BLAST283

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei31PhosphoserineCombined sources1
Modified residuei35PhosphoserineCombined sources1
Modified residuei38PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96SI1
MaxQBiQ96SI1
PaxDbiQ96SI1
PeptideAtlasiQ96SI1
PRIDEiQ96SI1
ProteomicsDBi78113
78114 [Q96SI1-2]

PTM databases

iPTMnetiQ96SI1
PhosphoSitePlusiQ96SI1

Expressioni

Gene expression databases

BgeeiENSG00000153885 Expressed in 196 organ(s), highest expression level in ectocervix
CleanExiHS_KCTD15
ExpressionAtlasiQ96SI1 baseline and differential
GenevisibleiQ96SI1 HS

Organism-specific databases

HPAiHPA050822

Interactioni

Subunit structurei

Interacts with TFAP2A; this interaction inhibits TFAP2A transcriptional activation.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122506, 16 interactors
IntActiQ96SI1, 12 interactors
MINTiQ96SI1
STRINGi9606.ENSP00000394390

Structurei

3D structure databases

ProteinModelPortaliQ96SI1
SMRiQ96SI1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 126BTBAdd BLAST71

Phylogenomic databases

eggNOGiKOG2723 Eukaryota
ENOG410Z155 LUCA
GeneTreeiENSGT00760000119013
HOGENOMiHOG000232179
HOVERGENiHBG055358
InParanoidiQ96SI1
KOiK21754
OMAiLAQPCDC
OrthoDBiEOG091G0SU5
PhylomeDBiQ96SI1

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96SI1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPHRKERPSG SSLHTHGSTG TAEGGNMSRL SLTRSPVSPL AAQGIPLPAQ
60 70 80 90 100
LTKSNAPVHI DVGGHMYTSS LATLTKYPDS RISRLFNGTE PIVLDSLKQH
110 120 130 140 150
YFIDRDGEIF RYVLSFLRTS KLLLPDDFKD FSLLYEEARY YQLQPMVREL
160 170 180 190 200
ERWQQEQEQR RRSRACDCLV VRVTPDLGER IALSGEKALI EEVFPETGDV
210 220 230 240 250
MCNSVNAGWN QDPTHVIRFP LNGYCRLNSV QVLERLFQRG FSVAASCGGG
260 270 280
VDSSQFSEYV LCREERRPQP TPTAVRIKQE PLD
Length:283
Mass (Da):31,942
Last modified:December 1, 2001 - v1
Checksum:i29E2ED079DB4E5CC
GO
Isoform 2 (identifier: Q96SI1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     232-234: VLE → DVL
     235-283: Missing.

Note: No experimental confirmation available.
Show »
Length:234
Mass (Da):26,476
Checksum:i7D1A451215804C87
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EN63K7EN63_HUMAN
BTB/POZ domain-containing protein K...
KCTD15
128Annotation score:
V9GYY8V9GYY8_HUMAN
BTB/POZ domain-containing protein K...
KCTD15
163Annotation score:
K7EM48K7EM48_HUMAN
BTB/POZ domain-containing protein K...
KCTD15
112Annotation score:
K7EQS3K7EQS3_HUMAN
BTB/POZ domain-containing protein K...
KCTD15
82Annotation score:
K7EPF0K7EPF0_HUMAN
BTB/POZ domain-containing protein K...
KCTD15
77Annotation score:
K7EIF1K7EIF1_HUMAN
BTB/POZ domain-containing protein K...
KCTD15
61Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02709064G → S1 PublicationCorresponds to variant dbSNP:rs17849437Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019958232 – 234VLE → DVL in isoform 2. 1 Publication3
Alternative sequenceiVSP_019959235 – 283Missing in isoform 2. 1 PublicationAdd BLAST49

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027901 mRNA Translation: BAB55443.1
AK291465 mRNA Translation: BAF84154.1
BC001185 mRNA Translation: AAH01185.1
BC009335 mRNA Translation: AAH09335.1
CCDSiCCDS12434.1 [Q96SI1-2]
CCDS46039.1 [Q96SI1-1]
RefSeqiNP_001123466.1, NM_001129994.1 [Q96SI1-1]
NP_001123467.1, NM_001129995.1 [Q96SI1-1]
NP_076981.2, NM_024076.2 [Q96SI1-2]
XP_011525598.1, XM_011527296.1 [Q96SI1-1]
XP_011525599.1, XM_011527297.2 [Q96SI1-1]
XP_011525600.1, XM_011527298.2 [Q96SI1-1]
XP_016882772.1, XM_017027283.1 [Q96SI1-1]
UniGeneiHs.221873
Hs.606506

Genome annotation databases

EnsembliENST00000284006; ENSP00000284006; ENSG00000153885 [Q96SI1-2]
ENST00000430256; ENSP00000394390; ENSG00000153885 [Q96SI1-1]
ENST00000588881; ENSP00000464812; ENSG00000153885 [Q96SI1-1]
ENST00000589786; ENSP00000467612; ENSG00000153885 [Q96SI1-1]
GeneIDi79047
KEGGihsa:79047
UCSCiuc002nuv.4 human [Q96SI1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027901 mRNA Translation: BAB55443.1
AK291465 mRNA Translation: BAF84154.1
BC001185 mRNA Translation: AAH01185.1
BC009335 mRNA Translation: AAH09335.1
CCDSiCCDS12434.1 [Q96SI1-2]
CCDS46039.1 [Q96SI1-1]
RefSeqiNP_001123466.1, NM_001129994.1 [Q96SI1-1]
NP_001123467.1, NM_001129995.1 [Q96SI1-1]
NP_076981.2, NM_024076.2 [Q96SI1-2]
XP_011525598.1, XM_011527296.1 [Q96SI1-1]
XP_011525599.1, XM_011527297.2 [Q96SI1-1]
XP_011525600.1, XM_011527298.2 [Q96SI1-1]
XP_016882772.1, XM_017027283.1 [Q96SI1-1]
UniGeneiHs.221873
Hs.606506

3D structure databases

ProteinModelPortaliQ96SI1
SMRiQ96SI1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122506, 16 interactors
IntActiQ96SI1, 12 interactors
MINTiQ96SI1
STRINGi9606.ENSP00000394390

PTM databases

iPTMnetiQ96SI1
PhosphoSitePlusiQ96SI1

Polymorphism and mutation databases

BioMutaiKCTD15
DMDMi74732704

Proteomic databases

EPDiQ96SI1
MaxQBiQ96SI1
PaxDbiQ96SI1
PeptideAtlasiQ96SI1
PRIDEiQ96SI1
ProteomicsDBi78113
78114 [Q96SI1-2]

Protocols and materials databases

DNASUi79047
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000284006; ENSP00000284006; ENSG00000153885 [Q96SI1-2]
ENST00000430256; ENSP00000394390; ENSG00000153885 [Q96SI1-1]
ENST00000588881; ENSP00000464812; ENSG00000153885 [Q96SI1-1]
ENST00000589786; ENSP00000467612; ENSG00000153885 [Q96SI1-1]
GeneIDi79047
KEGGihsa:79047
UCSCiuc002nuv.4 human [Q96SI1-1]

Organism-specific databases

CTDi79047
DisGeNETi79047
EuPathDBiHostDB:ENSG00000153885.14
GeneCardsiKCTD15
HGNCiHGNC:23297 KCTD15
HPAiHPA050822
MIMi615240 gene
neXtProtiNX_Q96SI1
OpenTargetsiENSG00000153885
PharmGKBiPA134916319
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2723 Eukaryota
ENOG410Z155 LUCA
GeneTreeiENSGT00760000119013
HOGENOMiHOG000232179
HOVERGENiHBG055358
InParanoidiQ96SI1
KOiK21754
OMAiLAQPCDC
OrthoDBiEOG091G0SU5
PhylomeDBiQ96SI1

Enzyme and pathway databases

ReactomeiR-HSA-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors

Miscellaneous databases

ChiTaRSiKCTD15 human
GeneWikiiKCTD15
GenomeRNAii79047
PROiPR:Q96SI1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000153885 Expressed in 196 organ(s), highest expression level in ectocervix
CleanExiHS_KCTD15
ExpressionAtlasiQ96SI1 baseline and differential
GenevisibleiQ96SI1 HS

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKCD15_HUMAN
AccessioniPrimary (citable) accession number: Q96SI1
Secondary accession number(s): A8K600, Q9BVI6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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