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Entry version 119 (13 Feb 2019)
Sequence version 2 (30 Nov 2010)
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Protein

T-complex protein 1 subunit theta-like 2

Gene

CCT8L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Possible molecular chaperone; assists the folding of proteins upon ATP hydrolysis.By similarity

Miscellaneous

Presence of two highly similar CCT8L genes (CCT8L1P and CCT8L2) in the genomes of human and chimp and of a single copy in other mammal genomes, including rhesus monkey, suggests that the duplication of this gene occurred in the ape lineage (Hominoidea) after its divergence from the old-world monkeys (Cercopithecidae).1 Publication
Expression of CCT8L2 is confirmed by many ESTs mostly identified from the testis.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • anion channel activity Source: ProtInc
  • ATP binding Source: UniProtKB-KW
  • calcium-activated potassium channel activity Source: ProtInc

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
T-complex protein 1 subunit theta-like 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCT8L2
Synonyms:CESK1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000198445.4

Human Gene Nomenclature Database

More...
HGNCi
HGNC:15553 CCT8L2

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96SF2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000198445

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162382100

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CCT8L2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
313104021

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003473391 – 557T-complex protein 1 subunit theta-like 2Add BLAST557

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96SF2

PeptideAtlas

More...
PeptideAtlasi
Q96SF2

PRoteomics IDEntifications database

More...
PRIDEi
Q96SF2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
78109

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96SF2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198445 Expressed in 7 organ(s), highest expression level in right testis

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96SF2 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q96SF2, 1 interactor

Molecular INTeraction database

More...
MINTi
Q96SF2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000353048

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q96SF2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96SF2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0362 Eukaryota
ENOG410XPXR LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163221

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000131368

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG098338

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96SF2

Identification of Orthologs from Complete Genome Data

More...
OMAi
YSVMNTH

Database of Orthologous Groups

More...
OrthoDBi
617040at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96SF2

TreeFam database of animal gene trees

More...
TreeFami
TF105699

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.560.10, 1 hit
3.30.260.10, 1 hit
3.50.7.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017998 Chaperone_TCP-1
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00118 Cpn60_TCP1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00304 TCOMPLEXTCP1

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48592 SSF48592, 1 hit
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q96SF2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSTVPSALE LPQRLALNPR ESPRSPEEEE PHLLSSLAAV QTLASVIRPC
60 70 80 90 100
YGPHGRQKFL VTMKGETVCT GCATAILRAL ELEHPAAWLL REAGQTQAEN
110 120 130 140 150
SGDGTAFVVL LTEALLEQAE QLLKAGLPRP QLREAYATAT AEVLATLPSL
160 170 180 190 200
AIQSLGPLED PSWALHSVMN THTLSPMDHL TKLVAHACWA IKELDGSFKP
210 220 230 240 250
ERVGVCALPG GTLEDSCLLP GLAISGKLCG QMATVLSGAR VALFACPFGP
260 270 280 290 300
AHPNAPATAR LSSPADLAQF SKGSDQLLEK QVGQLAAAGI NVAVVLGEVD
310 320 330 340 350
EETLTLADKY GIVVIQARSW MEIIYLSEVL DTPLLPRLLP PQRPGKCQRV
360 370 380 390 400
YRQELGDGLA VVFEWECTGT PALTVVLRGA TTQGLRSAEQ AVYHGIDAYF
410 420 430 440 450
QLCQDPRLIP GAGATEMALA KMLSDKGSRL EGPSGPAFLA FAWALKYLPK
460 470 480 490 500
TLAENAGLAV SDVMAEMSGV HQGGNLLMGV GTEGIINVAQ EGVWDTLIVK
510 520 530 540 550
AQGFRAVAEV VLQLVTVDEI VVAKKSPTHQ EIWNPDSKKT KKHPPPVETK

KILGLNN
Length:557
Mass (Da):59,388
Last modified:November 30, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF7D105C7324D5A30
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI39843 differs from that shown. Contaminating sequence. Sequence of unknown origin in the C-terminal part.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_046042320W → R4 PublicationsCorresponds to variant dbSNP:rs2236639Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AP000365 Genomic DNA Translation: BAA84680.1
AP003553 Genomic DNA Translation: BAB43952.1
CR456508 mRNA Translation: CAG30394.1
AP000547 Genomic DNA No translation available.
CH471193 Genomic DNA Translation: EAW57714.1
BC033797 mRNA Translation: AAH33797.1
BC100811 mRNA Translation: AAI00812.1
BC100812 mRNA Translation: AAI00813.1
BC100813 mRNA Translation: AAI00814.1
BC139842 mRNA Translation: AAI39843.2 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13738.1

NCBI Reference Sequences

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RefSeqi
NP_055221.1, NM_014406.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.128342

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000359963; ENSP00000353048; ENSG00000198445

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
150160

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:150160

UCSC genome browser

More...
UCSCi
uc002zlp.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000365 Genomic DNA Translation: BAA84680.1
AP003553 Genomic DNA Translation: BAB43952.1
CR456508 mRNA Translation: CAG30394.1
AP000547 Genomic DNA No translation available.
CH471193 Genomic DNA Translation: EAW57714.1
BC033797 mRNA Translation: AAH33797.1
BC100811 mRNA Translation: AAI00812.1
BC100812 mRNA Translation: AAI00813.1
BC100813 mRNA Translation: AAI00814.1
BC139842 mRNA Translation: AAI39843.2 Sequence problems.
CCDSiCCDS13738.1
RefSeqiNP_055221.1, NM_014406.4
UniGeneiHs.128342

3D structure databases

ProteinModelPortaliQ96SF2
SMRiQ96SF2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ96SF2, 1 interactor
MINTiQ96SF2
STRINGi9606.ENSP00000353048

PTM databases

PhosphoSitePlusiQ96SF2

Polymorphism and mutation databases

BioMutaiCCT8L2
DMDMi313104021

Proteomic databases

PaxDbiQ96SF2
PeptideAtlasiQ96SF2
PRIDEiQ96SF2
ProteomicsDBi78109

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
150160
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359963; ENSP00000353048; ENSG00000198445
GeneIDi150160
KEGGihsa:150160
UCSCiuc002zlp.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
150160
EuPathDBiHostDB:ENSG00000198445.4

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CCT8L2
HGNCiHGNC:15553 CCT8L2
neXtProtiNX_Q96SF2
OpenTargetsiENSG00000198445
PharmGKBiPA162382100

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0362 Eukaryota
ENOG410XPXR LUCA
GeneTreeiENSGT00940000163221
HOGENOMiHOG000131368
HOVERGENiHBG098338
InParanoidiQ96SF2
OMAiYSVMNTH
OrthoDBi617040at2759
PhylomeDBiQ96SF2
TreeFamiTF105699

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
150160

Protein Ontology

More...
PROi
PR:Q96SF2

Gene expression databases

BgeeiENSG00000198445 Expressed in 7 organ(s), highest expression level in right testis
GenevisibleiQ96SF2 HS

Family and domain databases

Gene3Di1.10.560.10, 1 hit
3.30.260.10, 1 hit
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR017998 Chaperone_TCP-1
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 1 hit
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTCPQM_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96SF2
Secondary accession number(s): A4QPH3, Q9UJS3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: November 30, 2010
Last modified: February 13, 2019
This is version 119 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
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