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Entry version 162 (08 May 2019)
Sequence version 2 (18 May 2010)
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Protein

Zinc finger protein 347

Gene

ZNF347

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri261 – 283C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri289 – 311C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 339C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri345 – 367C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri429 – 451C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri457 – 479C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri485 – 507C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri513 – 535C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri541 – 563C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri569 – 591C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri597 – 619C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri625 – 647C2H2-type 14; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri653 – 675C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri681 – 703C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri709 – 731C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri737 – 759C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri765 – 787C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri790 – 812C2H2-type 20; degeneratePROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436 Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 347
Alternative name(s):
Zinc finger protein 1111
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF347
Synonyms:ZNF1111
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16447 ZNF347

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96SE7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000197937

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38143

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF347

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296453051

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000475451 – 839Zinc finger protein 347Add BLAST839

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki253Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki827Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96SE7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96SE7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96SE7

PeptideAtlas

More...
PeptideAtlasi
Q96SE7

PRoteomics IDEntifications database

More...
PRIDEi
Q96SE7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
78108

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96SE7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96SE7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000197937 Expressed in 138 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96SE7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96SE7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA023448

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q96SE7, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000405218

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1839
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EMANMR-A312-344[»]
2EMPNMR-A536-568[»]
2EN4NMR-A284-316[»]
2ENENMR-A592-624[»]
2ENFNMR-A340-372[»]
2EOENMR-A508-540[»]
2EOWNMR-A368-400[»]
2EQ0NMR-A452-484[»]
2EQ1NMR-A480-512[»]
2EQ2NMR-A676-708[»]
2EQ3NMR-A704-736[»]
2YTINMR-A564-596[»]
2YTKNMR-A396-428[»]
2YTNNMR-A732-764[»]
2YTRNMR-A760-792[»]
2YU8NMR-A648-680[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96SE7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q96SE7

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 79KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri261 – 283C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri289 – 311C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 339C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri345 – 367C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri429 – 451C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri457 – 479C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri485 – 507C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri513 – 535C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri541 – 563C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri569 – 591C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri597 – 619C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri625 – 647C2H2-type 14; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri653 – 675C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri681 – 703C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri709 – 731C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri737 – 759C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri765 – 787C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri790 – 812C2H2-type 20; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000164205

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234617

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96SE7

KEGG Orthology (KO)

More...
KOi
K09228

Identification of Orthologs from Complete Genome Data

More...
OMAi
KSNGCGM

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96SE7

TreeFam database of animal gene trees

More...
TreeFami
TF341892

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 18 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 19 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 12 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 17 hits
PS50157 ZINC_FINGER_C2H2_2, 20 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96SE7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALTQGQVTF RDVAIEFSQE EWTCLDPAQR TLYRDVMLEN YRNLASLGIS
60 70 80 90 100
CFDLSIISML EQGKEPFTLE SQVQIAGNPD GWEWIKAVIT ALSSEFVMKD
110 120 130 140 150
LLHKGKSNTG EVFQTVMLER QESQDIEGCS FREVQKNTHG LEYQCRDAEG
160 170 180 190 200
NYKGVLLTQE GNLTHGRDEH DKRDARNKLI KNQLGLSLQS HLPELQLFQY
210 220 230 240 250
EGKIYECNQV EKSFNNNSSV SPPQQMPYNV KTHISKKYLK DFISSLLLTQ
260 270 280 290 300
GQKANNWGSP YKSNGCGMVF PQNSHLASHQ RSHTKEKPYK CYECGKAFRT
310 320 330 340 350
RSNLTTHQVI HTGEKRYKCN ECGKVFSRNS QLSQHQKIHT GEKPYKCNEC
360 370 380 390 400
GKVFTQNSHL VRHRGIHTGE KPYKCNECGK AFRARSSLAI HQATHSGEKP
410 420 430 440 450
YKCNECGKVF TQNSHLTNHW RIHTGEKPYK CNECGKAFGV RSSLAIHLVI
460 470 480 490 500
HTGEKPYKCH ECGKVFRRNS HLARHQLIHT GEKPYKCNEC GKAFRAHSNL
510 520 530 540 550
TTHQVIHTGE KPYKCNECGK VFTQNSHLAN HQRIHTGVKP YMCNECGKAF
560 570 580 590 600
SVYSSLTTHQ VIHTGEKPYK CNECGKVFTQ NSHLARHRGI HTGEKPYKCN
610 620 630 640 650
ECGKVFRHNS YLSRHQRIHT GEKPYKYNEY GKAFSEHSNL TTHQVIHTGE
660 670 680 690 700
KPYKCNECGK VFTQNSHLAR HRRVHTGGKP YQCNECGKAF SQTSKLARHQ
710 720 730 740 750
RVHTGEKPYE CNQCGKAFSV RSSLTTHQAI HTGKKPYKCN ECGKVFTQNS
760 770 780 790 800
HLARHRGIHT GEKPYKCNEC GKAFSQTSKL ARHQRIHTGE KPYECGKPFS
810 820 830
ICSSLTTHQT IHTGGKPYKC NVWKVLKSEF KPCKPSQNS
Length:839
Mass (Da):95,770
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC951647ECF4D644D
GO
Isoform 2 (identifier: Q96SE7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-47: L → LA

Note: No experimental confirmation available.
Show »
Length:840
Mass (Da):95,841
Checksum:i22CAD154FA4607FB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R1E9M0R1E9_HUMAN
Zinc finger protein 347
ZNF347
34Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZE2M0QZE2_HUMAN
Zinc finger protein 347
ZNF347
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QXR8M0QXR8_HUMAN
Zinc finger protein 347
ZNF347
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZJ6M0QZJ6_HUMAN
Zinc finger protein 347
ZNF347
34Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti215N → D in BAG53339 (PubMed:14702039).Curated1
Sequence conflicti253K → R in BAG53339 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052815117M → V. Corresponds to variant dbSNP:rs34656962Ensembl.1
Natural variantiVAR_059913264N → D3 PublicationsCorresponds to variant dbSNP:rs2195310Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04684147L → LA in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY029765 mRNA Translation: AAK37403.1
AK096623 mRNA Translation: BAG53339.1
AC010328 Genomic DNA No translation available.
AC092070 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72119.1
BC136255 mRNA Translation: AAI36256.1
AL713691 mRNA Translation: CAD28491.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33097.1 [Q96SE7-1]
CCDS54314.1 [Q96SE7-2]

NCBI Reference Sequences

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RefSeqi
NP_001166145.1, NM_001172674.1 [Q96SE7-2]
NP_001166146.1, NM_001172675.1 [Q96SE7-2]
NP_115973.2, NM_032584.2 [Q96SE7-1]
XP_005259392.1, XM_005259335.4 [Q96SE7-1]
XP_016882873.1, XM_017027384.1 [Q96SE7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000334197; ENSP00000334146; ENSG00000197937 [Q96SE7-1]
ENST00000452676; ENSP00000405218; ENSG00000197937 [Q96SE7-2]
ENST00000601469; ENSP00000471712; ENSG00000197937 [Q96SE7-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
84671

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:84671

UCSC genome browser

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UCSCi
uc002qbb.3 human [Q96SE7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029765 mRNA Translation: AAK37403.1
AK096623 mRNA Translation: BAG53339.1
AC010328 Genomic DNA No translation available.
AC092070 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72119.1
BC136255 mRNA Translation: AAI36256.1
AL713691 mRNA Translation: CAD28491.1
CCDSiCCDS33097.1 [Q96SE7-1]
CCDS54314.1 [Q96SE7-2]
RefSeqiNP_001166145.1, NM_001172674.1 [Q96SE7-2]
NP_001166146.1, NM_001172675.1 [Q96SE7-2]
NP_115973.2, NM_032584.2 [Q96SE7-1]
XP_005259392.1, XM_005259335.4 [Q96SE7-1]
XP_016882873.1, XM_017027384.1 [Q96SE7-1]

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EMANMR-A312-344[»]
2EMPNMR-A536-568[»]
2EN4NMR-A284-316[»]
2ENENMR-A592-624[»]
2ENFNMR-A340-372[»]
2EOENMR-A508-540[»]
2EOWNMR-A368-400[»]
2EQ0NMR-A452-484[»]
2EQ1NMR-A480-512[»]
2EQ2NMR-A676-708[»]
2EQ3NMR-A704-736[»]
2YTINMR-A564-596[»]
2YTKNMR-A396-428[»]
2YTNNMR-A732-764[»]
2YTRNMR-A760-792[»]
2YU8NMR-A648-680[»]
SMRiQ96SE7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ96SE7, 1 interactor
STRINGi9606.ENSP00000405218

PTM databases

iPTMnetiQ96SE7
PhosphoSitePlusiQ96SE7

Polymorphism and mutation databases

BioMutaiZNF347
DMDMi296453051

Proteomic databases

jPOSTiQ96SE7
MaxQBiQ96SE7
PaxDbiQ96SE7
PeptideAtlasiQ96SE7
PRIDEiQ96SE7
ProteomicsDBi78108

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334197; ENSP00000334146; ENSG00000197937 [Q96SE7-1]
ENST00000452676; ENSP00000405218; ENSG00000197937 [Q96SE7-2]
ENST00000601469; ENSP00000471712; ENSG00000197937 [Q96SE7-2]
GeneIDi84671
KEGGihsa:84671
UCSCiuc002qbb.3 human [Q96SE7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
84671

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF347
HGNCiHGNC:16447 ZNF347
HPAiHPA023448
neXtProtiNX_Q96SE7
OpenTargetsiENSG00000197937
PharmGKBiPA38143

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000164205
HOGENOMiHOG000234617
InParanoidiQ96SE7
KOiK09228
OMAiKSNGCGM
OrthoDBi1318335at2759
PhylomeDBiQ96SE7
TreeFamiTF341892

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF347 human
EvolutionaryTraceiQ96SE7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84671

Protein Ontology

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PROi
PR:Q96SE7

Gene expression databases

BgeeiENSG00000197937 Expressed in 138 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ96SE7 baseline and differential
GenevisibleiQ96SE7 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 18 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 19 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 12 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 17 hits
PS50157 ZINC_FINGER_C2H2_2, 20 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN347_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96SE7
Secondary accession number(s): B3KU77
, B9EG59, G5E9N4, Q8TCN1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: May 18, 2010
Last modified: May 8, 2019
This is version 162 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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