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Entry version 116 (31 Jul 2019)
Sequence version 2 (20 May 2008)
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Protein

Doublesex- and mab-3-related transcription factor A2

Gene

DMRTA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in sexual development.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi70 – 117DMPROSITE-ProRule annotationAdd BLAST48

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Doublesex- and mab-3-related transcription factor A2
Alternative name(s):
Doublesex- and mab-3-related transcription factor 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DMRTA2
Synonyms:DMRT5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13908 DMRTA2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614804 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96SC8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
63950

Open Targets

More...
OpenTargetsi
ENSG00000142700

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27385

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DMRTA2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
189044724

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003337721 – 542Doublesex- and mab-3-related transcription factor A2Add BLAST542

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96SC8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96SC8

PeptideAtlas

More...
PeptideAtlasi
Q96SC8

PRoteomics IDEntifications database

More...
PRIDEi
Q96SC8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
78102

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96SC8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96SC8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000142700 Expressed in 53 organ(s), highest expression level in buccal mucosa cell

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96SC8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043098
HPA062958

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000383909

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96SC8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi13 – 40Ala-richAdd BLAST28
Compositional biasi165 – 363Gly-richAdd BLAST199
Compositional biasi359 – 519Ala-richAdd BLAST161

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DMRT family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3815 Eukaryota
ENOG410XSK9 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161649

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231615

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96SC8

KEGG Orthology (KO)

More...
KOi
K19491

Identification of Orthologs from Complete Genome Data

More...
OMAi
DDAWPGR

Database of Orthologous Groups

More...
OrthoDBi
1573364at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96SC8

TreeFam database of animal gene trees

More...
TreeFami
TF317837

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.1040.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001275 DM_DNA-bd
IPR036407 DM_DNA-bd_sf
IPR005173 DMA
IPR026607 DMRT/dsx/mab-3
IPR009060 UBA-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12322 PTHR12322, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00751 DM, 1 hit
PF03474 DMA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00301 DM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46934 SSF46934, 1 hit
SSF82927 SSF82927, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS40000 DM_1, 1 hit
PS50809 DM_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q96SC8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELRSELPSV PGAATAAAAT ATGPPVASVA SVAAAAAAAA SLPVSVAGGL
60 70 80 90 100
LRGPPLLLRA AEKYPRTPKC ARCRNHGVVS ALKGHKRYCR WKDCLCAKCT
110 120 130 140 150
LIAERQRVMA AQVALRRQQA QEENEARELQ LLYGTAEGLA LAAANGIIPP
160 170 180 190 200
RPAYEVFGSV CAADGGGPGA GAPAGTGGGA AGAGGSEAKL QKFDLFPKTL
210 220 230 240 250
LQAGRPGSPL PPPVKPLSPD GADSGPGTSS PEVRPGSGSE NGDGESFSGS
260 270 280 290 300
PLARASKEAG GSCPGSAGPG GGGEEDSPGS ASPLGSESGS EADKEEGEAA
310 320 330 340 350
PAPGLGGGSG PRQRTPLDIL TRVFPGHRRG VLELVLQGCG GDVVQAIEQV
360 370 380 390 400
LNHHRGGLAA GLGPAAPPDK AAVGAAAAAD DAWPSRVDAA AAAAAAAGGP
410 420 430 440 450
GLPAPLQAGP AAPPHHRPLL AGAMAPGALG SLSSRSAFSP LQPNASHFGA
460 470 480 490 500
DAGAYPLGAP LGLSPLRLAY SAAAAHSRGL AFMAPYSTAG LVPTLGFRPP
510 520 530 540
MDYAFSDLMR DRSAAAAAAV HKEPTYGGGL YGPMVNGAPE KQ
Length:542
Mass (Da):53,356
Last modified:May 20, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1ADA8CE1D2D9C76B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL049637 Genomic DNA No translation available.
AJ301580 mRNA Translation: CAC37946.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44141.1

NCBI Reference Sequences

More...
RefSeqi
NP_115486.1, NM_032110.2
XP_011540239.1, XM_011541937.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000404795; ENSP00000383909; ENSG00000142700
ENST00000418121; ENSP00000399370; ENSG00000142700

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
63950

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:63950

UCSC genome browser

More...
UCSCi
uc010ona.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049637 Genomic DNA No translation available.
AJ301580 mRNA Translation: CAC37946.1
CCDSiCCDS44141.1
RefSeqiNP_115486.1, NM_032110.2
XP_011540239.1, XM_011541937.2

3D structure databases

SMRiQ96SC8
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000383909

PTM databases

iPTMnetiQ96SC8
PhosphoSitePlusiQ96SC8

Polymorphism and mutation databases

BioMutaiDMRTA2
DMDMi189044724

Proteomic databases

jPOSTiQ96SC8
PaxDbiQ96SC8
PeptideAtlasiQ96SC8
PRIDEiQ96SC8
ProteomicsDBi78102

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000404795; ENSP00000383909; ENSG00000142700
ENST00000418121; ENSP00000399370; ENSG00000142700
GeneIDi63950
KEGGihsa:63950
UCSCiuc010ona.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
63950
DisGeNETi63950

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DMRTA2
HGNCiHGNC:13908 DMRTA2
HPAiHPA043098
HPA062958
MIMi614804 gene
neXtProtiNX_Q96SC8
OpenTargetsiENSG00000142700
PharmGKBiPA27385

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3815 Eukaryota
ENOG410XSK9 LUCA
GeneTreeiENSGT00940000161649
HOGENOMiHOG000231615
InParanoidiQ96SC8
KOiK19491
OMAiDDAWPGR
OrthoDBi1573364at2759
PhylomeDBiQ96SC8
TreeFamiTF317837

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
63950

Protein Ontology

More...
PROi
PR:Q96SC8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000142700 Expressed in 53 organ(s), highest expression level in buccal mucosa cell
GenevisibleiQ96SC8 HS

Family and domain databases

Gene3Di4.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR001275 DM_DNA-bd
IPR036407 DM_DNA-bd_sf
IPR005173 DMA
IPR026607 DMRT/dsx/mab-3
IPR009060 UBA-like_sf
PANTHERiPTHR12322 PTHR12322, 1 hit
PfamiView protein in Pfam
PF00751 DM, 1 hit
PF03474 DMA, 1 hit
SMARTiView protein in SMART
SM00301 DM, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
SSF82927 SSF82927, 1 hit
PROSITEiView protein in PROSITE
PS40000 DM_1, 1 hit
PS50809 DM_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDMTA2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96SC8
Secondary accession number(s): Q5TFQ3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: July 31, 2019
This is version 116 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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