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Entry version 139 (11 Dec 2019)
Sequence version 3 (21 Mar 2012)
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Protein

Serine incorporator 2

Gene

SERINC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-977347 Serine biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine incorporator 2
Alternative name(s):
Tumor differentially expressed protein 2-like
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SERINC2
Synonyms:TDE2L
ORF Names:FKSG84, UNQ263/PRO300
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000168528.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23231 SERINC2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614549 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96SA4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei5 – 27HelicalSequence analysisAdd BLAST23
Transmembranei40 – 57HelicalSequence analysisAdd BLAST18
Transmembranei96 – 118HelicalSequence analysisAdd BLAST23
Transmembranei131 – 150HelicalSequence analysisAdd BLAST20
Transmembranei160 – 182HelicalSequence analysisAdd BLAST23
Transmembranei202 – 224HelicalSequence analysisAdd BLAST23
Transmembranei239 – 256HelicalSequence analysisAdd BLAST18
Transmembranei268 – 290HelicalSequence analysisAdd BLAST23
Transmembranei317 – 339HelicalSequence analysisAdd BLAST23
Transmembranei385 – 407HelicalSequence analysisAdd BLAST23
Transmembranei422 – 444HelicalSequence analysisAdd BLAST23

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
347735

Open Targets

More...
OpenTargetsi
ENSG00000168528

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134933002

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96SA4 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SERINC2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
380865453

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002189681 – 455Serine incorporator 2Add BLAST455

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96SA4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96SA4

PeptideAtlas

More...
PeptideAtlasi
Q96SA4

PRoteomics IDEntifications database

More...
PRIDEi
Q96SA4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
18537
78094 [Q96SA4-1]
78095 [Q96SA4-2]
78096 [Q96SA4-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96SA4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96SA4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000168528 Expressed in 147 organ(s), highest expression level in mucosa of transverse colon

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96SA4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA005974

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
131485, 8 interactors

Protein interaction database and analysis system

More...
IntActi
Q96SA4, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000362814

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96SA4 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TDE1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2592 Eukaryota
ENOG410XP7K LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182793

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000165463

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96SA4

Identification of Orthologs from Complete Genome Data

More...
OMAi
KCWFAGL

Database of Orthologous Groups

More...
OrthoDBi
1276632at2759

TreeFam database of animal gene trees

More...
TreeFami
TF312881

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029554 SERINC2
IPR005016 TDE1/TMS

The PANTHER Classification System

More...
PANTHERi
PTHR10383 PTHR10383, 1 hit
PTHR10383:SF22 PTHR10383:SF22, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03348 Serinc, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q96SA4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGACLGACSL LSCASCLCGS APCILCSCCP ASRNSTVSRL IFTFFLFLGV
60 70 80 90 100
LVSIIMLSPG VESQLYKLPW VCEEGAGIPT VLQGHIDCGS LLGYRAVYRM
110 120 130 140 150
CFATAAFFFF FTLLMLCVSS SRDPRAAIQN GFWFFKFLIL VGLTVGAFYI
160 170 180 190 200
PDGSFTNIWF YFGVVGSFLF ILIQLVLLID FAHSWNQRWL GKAEECDSRA
210 220 230 240 250
WYAGLFFFTL LFYLLSIAAV ALMFMYYTEP SGCHEGKVFI SLNLTFCVCV
260 270 280 290 300
SIAAVLPKVQ DAQPNSGLLQ ASVITLYTMF VTWSALSSIP EQKCNPHLPT
310 320 330 340 350
QLGNETVVAG PEGYETQWWD APSIVGLIIF LLCTLFISLR SSDHRQVNSL
360 370 380 390 400
MQTEECPPML DATQQQQQVA ACEGRAFDNE QDGVTYSYSF FHFCLVLASL
410 420 430 440 450
HVMMTLTNWY KPGETRKMIS TWTAVWVKIC ASWAGLLLYL WTLVAPLLLR

NRDFS
Length:455
Mass (Da):50,742
Last modified:March 21, 2012 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD18D21B535C7A73C
GO
Isoform 2 (identifier: Q96SA4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     4-13: CLGACSLLSC → EGAPDFLSCPRVRR

Show »
Length:459
Mass (Da):51,376
Checksum:iC65C9FA7E5A3C538
GO
Isoform 3 (identifier: Q96SA4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MGACLGACSLLSC → MRSMRLREEESPGPSHT

Show »
Length:459
Mass (Da):51,514
Checksum:i49BD4F82611E3CFF
GO
Isoform 4 (identifier: Q96SA4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MGACLGACSLLSC → MDGRMMRSMRLREEESPGPSHT

Show »
Length:464
Mass (Da):52,105
Checksum:i15645E0FC8E3677D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti4C → L in AAK83284 (Ref. 1) Curated1
Sequence conflicti81V → A in BAH14728 (PubMed:14702039).Curated1
Sequence conflicti98Y → H in BAH14728 (PubMed:14702039).Curated1
Sequence conflicti111F → FF in AAQ88924 (PubMed:12975309).Curated1
Sequence conflicti368Q → QQ in AAK83284 (Ref. 1) Curated1
Sequence conflicti368Q → QQ in AAM22522 (Ref. 2) Curated1
Sequence conflicti368Q → QQ in AAQ88924 (PubMed:12975309).Curated1
Sequence conflicti368Q → QQ in BAH12803 (PubMed:14702039).Curated1
Sequence conflicti368Q → QQ in BAH14728 (PubMed:14702039).Curated1
Sequence conflicti368Q → QQ in AAH84580 (PubMed:15489334).Curated1
Sequence conflicti368Q → QQ in AAI26284 (PubMed:15489334).Curated1
Sequence conflicti368Q → QQ in AAI26286 (PubMed:15489334).Curated1
Sequence conflicti382D → G in BAH14728 (PubMed:14702039).Curated1
Sequence conflicti451N → K in AAK83284 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_061838303G → S. Corresponds to variant dbSNP:rs34728687Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0424631 – 13MGACL…SLLSC → MRSMRLREEESPGPSHT in isoform 3. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_0468401 – 13MGACL…SLLSC → MDGRMMRSMRLREEESPGPS HT in isoform 4. CuratedAdd BLAST13
Alternative sequenceiVSP_0424644 – 13CLGACSLLSC → EGAPDFLSCPRVRR in isoform 2. 1 Publication10

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF352325 mRNA Translation: AAK83284.1
AY094595 mRNA Translation: AAM22522.1
AY358560 mRNA Translation: AAQ88924.1
AK298512 mRNA Translation: BAH12803.1
AK316357 mRNA Translation: BAH14728.1
AK296118 mRNA Translation: BAG58867.1
AC114494 Genomic DNA No translation available.
BC084580 mRNA Translation: AAH84580.1
BC126283 mRNA Translation: AAI26284.1
BC126285 mRNA Translation: AAI26286.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS30662.1 [Q96SA4-1]
CCDS55583.1 [Q96SA4-4]
CCDS55584.1 [Q96SA4-3]
CCDS55585.1 [Q96SA4-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001185966.1, NM_001199037.1 [Q96SA4-3]
NP_001185967.1, NM_001199038.1 [Q96SA4-4]
NP_001185968.1, NM_001199039.1
NP_061035.2, NM_018565.3 [Q96SA4-2]
NP_849196.2, NM_178865.4 [Q96SA4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000373709; ENSP00000362813; ENSG00000168528 [Q96SA4-1]
ENST00000373710; ENSP00000362814; ENSG00000168528 [Q96SA4-4]
ENST00000536384; ENSP00000439048; ENSG00000168528 [Q96SA4-2]
ENST00000536859; ENSP00000444307; ENSG00000168528 [Q96SA4-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
347735

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:347735

UCSC genome browser

More...
UCSCi
uc001bst.4 human [Q96SA4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF352325 mRNA Translation: AAK83284.1
AY094595 mRNA Translation: AAM22522.1
AY358560 mRNA Translation: AAQ88924.1
AK298512 mRNA Translation: BAH12803.1
AK316357 mRNA Translation: BAH14728.1
AK296118 mRNA Translation: BAG58867.1
AC114494 Genomic DNA No translation available.
BC084580 mRNA Translation: AAH84580.1
BC126283 mRNA Translation: AAI26284.1
BC126285 mRNA Translation: AAI26286.1
CCDSiCCDS30662.1 [Q96SA4-1]
CCDS55583.1 [Q96SA4-4]
CCDS55584.1 [Q96SA4-3]
CCDS55585.1 [Q96SA4-2]
RefSeqiNP_001185966.1, NM_001199037.1 [Q96SA4-3]
NP_001185967.1, NM_001199038.1 [Q96SA4-4]
NP_001185968.1, NM_001199039.1
NP_061035.2, NM_018565.3 [Q96SA4-2]
NP_849196.2, NM_178865.4 [Q96SA4-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi131485, 8 interactors
IntActiQ96SA4, 5 interactors
STRINGi9606.ENSP00000362814

PTM databases

iPTMnetiQ96SA4
PhosphoSitePlusiQ96SA4

Polymorphism and mutation databases

BioMutaiSERINC2
DMDMi380865453

Proteomic databases

MassIVEiQ96SA4
PaxDbiQ96SA4
PeptideAtlasiQ96SA4
PRIDEiQ96SA4
ProteomicsDBi18537
78094 [Q96SA4-1]
78095 [Q96SA4-2]
78096 [Q96SA4-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
347735

Genome annotation databases

EnsembliENST00000373709; ENSP00000362813; ENSG00000168528 [Q96SA4-1]
ENST00000373710; ENSP00000362814; ENSG00000168528 [Q96SA4-4]
ENST00000536384; ENSP00000439048; ENSG00000168528 [Q96SA4-2]
ENST00000536859; ENSP00000444307; ENSG00000168528 [Q96SA4-3]
GeneIDi347735
KEGGihsa:347735
UCSCiuc001bst.4 human [Q96SA4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
347735
DisGeNETi347735
EuPathDBiHostDB:ENSG00000168528.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SERINC2
HGNCiHGNC:23231 SERINC2
HPAiHPA005974
MIMi614549 gene
neXtProtiNX_Q96SA4
OpenTargetsiENSG00000168528
PharmGKBiPA134933002

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2592 Eukaryota
ENOG410XP7K LUCA
GeneTreeiENSGT00950000182793
HOGENOMiHOG000165463
InParanoidiQ96SA4
OMAiKCWFAGL
OrthoDBi1276632at2759
TreeFamiTF312881

Enzyme and pathway databases

ReactomeiR-HSA-977347 Serine biosynthesis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SERINC2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
347735
PharosiQ96SA4 Tbio

Protein Ontology

More...
PROi
PR:Q96SA4
RNActiQ96SA4 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000168528 Expressed in 147 organ(s), highest expression level in mucosa of transverse colon
GenevisibleiQ96SA4 HS

Family and domain databases

InterProiView protein in InterPro
IPR029554 SERINC2
IPR005016 TDE1/TMS
PANTHERiPTHR10383 PTHR10383, 1 hit
PTHR10383:SF22 PTHR10383:SF22, 1 hit
PfamiView protein in Pfam
PF03348 Serinc, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSERC2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96SA4
Secondary accession number(s): A0AVB4
, B4DJK5, B7Z567, B7ZAP2, E7EUZ9, Q86Y23
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: March 21, 2012
Last modified: December 11, 2019
This is version 139 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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