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Entry version 155 (07 Apr 2021)
Sequence version 3 (03 Oct 2006)
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Protein

Pleckstrin homology domain-containing family F member 1

Gene

PLEKHF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri152 – 212FYVE-typePROSITE-ProRule annotationAdd BLAST61

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q96S99

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pleckstrin homology domain-containing family F member 1
Short name:
PH domain-containing family F member 1
Alternative name(s):
Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains
Short name:
Apoptosis-inducing protein
PH and FYVE domain-containing protein 1
Phafin-1
Zinc finger FYVE domain-containing protein 15
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLEKHF1
Synonyms:APPD, LAPF, ZFYVE15
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20764, PLEKHF1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615200, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96S99

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000166289.5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Lysosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
79156

Open Targets

More...
OpenTargetsi
ENSG00000166289

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134928547

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96S99, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PLEKHF1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
115502559

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002515971 – 279Pleckstrin homology domain-containing family F member 1Add BLAST279

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96S99

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96S99

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96S99

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96S99

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96S99

PeptideAtlas

More...
PeptideAtlasi
Q96S99

PRoteomics IDEntifications database

More...
PRIDEi
Q96S99

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
78093

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96S99

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96S99

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in heart and skeletal muscle. Weakly expressed in brain, thymus, spleen, kidney, liver, small intestine, placenta and lung.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000166289, Expressed in gastrocnemius and 202 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96S99, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96S99, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000166289, Tissue enhanced (blood, skeletal muscle)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
122574, 8 interactors

Protein interaction database and analysis system

More...
IntActi
Q96S99, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000389787

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96S99, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96S99

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 131PHPROSITE-ProRule annotationAdd BLAST97

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

PH and FYVE-type zinc finger domains are required for lysosomal location.

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri152 – 212FYVE-typePROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1729, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160728

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_064864_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96S99

Identification of Orthologs from Complete Genome Data

More...
OMAi
VSWSAFH

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96S99

TreeFam database of animal gene trees

More...
TreeFami
TF315235

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15754, FYVE_PKHF1, 1 hit
cd01218, PH_Phafin2-like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR037871, PH_Phafin
IPR042762, PKHF1_FYVE
IPR000306, Znf_FYVE
IPR017455, Znf_FYVE-rel
IPR011011, Znf_FYVE_PHD
IPR013083, Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01363, FYVE, 1 hit
PF00169, PH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00064, FYVE, 1 hit
SM00233, PH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57903, SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50003, PH_DOMAIN, 1 hit
PS50178, ZF_FYVE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q96S99-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVDHLANTEI NSQRIAAVES CFGASGQPLA LPGRVLLGEG VLTKECRKKA
60 70 80 90 100
KPRIFFLFND ILVYGSIVLN KRKYRSQHII PLEEVTLELL PETLQAKNRW
110 120 130 140 150
MIKTAKKSFV VSAASATERQ EWISHIEECV RRQLRATGRP PSTEHAAPWI
160 170 180 190 200
PDKATDICMR CTQTRFSALT RRHHCRKCGF VVCAECSRQR FLLPRLSPKP
210 220 230 240 250
VRVCSLCYRE LAAQQRQEEA EEQGAGSPGQ PAHLARPICG ASSGDDDDSD
260 270
EDKEGSRDGD WPSSVEFYAS GVAWSAFHS
Length:279
Mass (Da):31,195
Last modified:October 3, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iED2ADEBDE6BCF3BF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ELB8K7ELB8_HUMAN
Pleckstrin homology domain-containi...
PLEKHF1
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EIX0K7EIX0_HUMAN
Pleckstrin homology domain-containi...
PLEKHF1
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti55F → L in AAL30773 (Ref. 2) Curated1
Sequence conflicti55F → L in BAB55349 (PubMed:14702039).Curated1
Sequence conflicti135R → K in AAK67626 (PubMed:16188880).Curated1
Sequence conflicti229G → R in AAK67626 (PubMed:16188880).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY037145 mRNA Translation: AAK67626.2
AF434818 mRNA Translation: AAL30773.1
AK027758 mRNA Translation: BAB55349.1
BC002744 mRNA Translation: AAH02744.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12417.1

NCBI Reference Sequences

More...
RefSeqi
NP_077286.3, NM_024310.4
XP_011525611.1, XM_011527309.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000436066; ENSP00000389787; ENSG00000166289
ENST00000592810; ENSP00000466292; ENSG00000166289

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
79156

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79156

UCSC genome browser

More...
UCSCi
uc002nsh.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY037145 mRNA Translation: AAK67626.2
AF434818 mRNA Translation: AAL30773.1
AK027758 mRNA Translation: BAB55349.1
BC002744 mRNA Translation: AAH02744.1
CCDSiCCDS12417.1
RefSeqiNP_077286.3, NM_024310.4
XP_011525611.1, XM_011527309.2

3D structure databases

SMRiQ96S99
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi122574, 8 interactors
IntActiQ96S99, 7 interactors
STRINGi9606.ENSP00000389787

PTM databases

iPTMnetiQ96S99
PhosphoSitePlusiQ96S99

Genetic variation databases

BioMutaiPLEKHF1
DMDMi115502559

Proteomic databases

EPDiQ96S99
jPOSTiQ96S99
MassIVEiQ96S99
MaxQBiQ96S99
PaxDbiQ96S99
PeptideAtlasiQ96S99
PRIDEiQ96S99
ProteomicsDBi78093

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
15545, 125 antibodies

Genome annotation databases

EnsembliENST00000436066; ENSP00000389787; ENSG00000166289
ENST00000592810; ENSP00000466292; ENSG00000166289
GeneIDi79156
KEGGihsa:79156
UCSCiuc002nsh.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79156
DisGeNETi79156

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PLEKHF1
HGNCiHGNC:20764, PLEKHF1
HPAiENSG00000166289, Tissue enhanced (blood, skeletal muscle)
MIMi615200, gene
neXtProtiNX_Q96S99
OpenTargetsiENSG00000166289
PharmGKBiPA134928547
VEuPathDBiHostDB:ENSG00000166289.5

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1729, Eukaryota
GeneTreeiENSGT00940000160728
HOGENOMiCLU_064864_2_0_1
InParanoidiQ96S99
OMAiVSWSAFH
PhylomeDBiQ96S99
TreeFamiTF315235

Enzyme and pathway databases

PathwayCommonsiQ96S99

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
79156, 7 hits in 1000 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PLEKHF1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
79156
PharosiQ96S99, Tbio

Protein Ontology

More...
PROi
PR:Q96S99
RNActiQ96S99, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000166289, Expressed in gastrocnemius and 202 other tissues
ExpressionAtlasiQ96S99, baseline and differential
GenevisibleiQ96S99, HS

Family and domain databases

CDDicd15754, FYVE_PKHF1, 1 hit
cd01218, PH_Phafin2-like, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR037871, PH_Phafin
IPR042762, PKHF1_FYVE
IPR000306, Znf_FYVE
IPR017455, Znf_FYVE-rel
IPR011011, Znf_FYVE_PHD
IPR013083, Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF01363, FYVE, 1 hit
PF00169, PH, 1 hit
SMARTiView protein in SMART
SM00064, FYVE, 1 hit
SM00233, PH, 1 hit
SUPFAMiSSF57903, SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50003, PH_DOMAIN, 1 hit
PS50178, ZF_FYVE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPKHF1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96S99
Secondary accession number(s): Q96K11, Q9BUB9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: April 7, 2021
This is version 155 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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