UniProtKB - Q96S97 (MYADM_HUMAN)
Protein
Myeloid-associated differentiation marker
Gene
MYADM
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- establishment of endothelial barrier Source: UniProtKB
- membrane raft organization Source: UniProtKB
- negative regulation of actin filament polymerization Source: UniProtKB
- negative regulation of gene expression Source: UniProtKB
- negative regulation of heterotypic cell-cell adhesion Source: UniProtKB
- negative regulation of protein kinase C signaling Source: UniProtKB
- negative regulation of protein phosphorylation Source: UniProtKB
- positive regulation of cell migration Source: UniProtKB
- positive regulation of substrate adhesion-dependent cell spreading Source: UniProtKB
- protein localization to plasma membrane Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q96S97 |
Protein family/group databases
TCDBi | 1.A.64.3.1, the plasmolipin (plasmolipin) family |
Names & Taxonomyi
Protein namesi | Recommended name: Myeloid-associated differentiation markerAlternative name(s): Protein SB135 |
Gene namesi | Name:MYADM ORF Names:UNQ553/PRO1110 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7544, MYADM |
MIMi | 609959, gene |
neXtProti | NX_Q96S97 |
VEuPathDBi | HostDB:ENSG00000179820.15 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Cytoskeleton
- cortical actin cytoskeleton Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- cell-cell junction Source: UniProtKB
- integral component of membrane Source: UniProtKB-KW
- membrane raft Source: UniProtKB
- ruffle Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 41 – 61 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 70 – 90 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 101 – 121 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 137 – 157 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 171 – 191 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 203 – 223 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 239 – 259 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 294 – 314 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 91663 |
OpenTargetsi | ENSG00000179820 |
PharmGKBi | PA31344 |
Miscellaneous databases
Pharosi | Q96S97, Tbio |
Genetic variation databases
BioMutai | MYADM |
DMDMi | 21263793 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000156816 | 1 – 322 | Myeloid-associated differentiation markerAdd BLAST | 322 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 22 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q96S97 |
jPOSTi | Q96S97 |
MassIVEi | Q96S97 |
MaxQBi | Q96S97 |
PaxDbi | Q96S97 |
PeptideAtlasi | Q96S97 |
PRIDEi | Q96S97 |
ProteomicsDBi | 78092 |
PTM databases
iPTMneti | Q96S97 |
PhosphoSitePlusi | Q96S97 |
SwissPalmi | Q96S97 |
Expressioni
Tissue specificityi
Widely expressed. Not detected in thymus.1 Publication
Gene expression databases
Bgeei | ENSG00000179820, Expressed in layer of synovial tissue and 226 other tissues |
ExpressionAtlasi | Q96S97, baseline and differential |
Genevisiblei | Q96S97, HS |
Organism-specific databases
HPAi | ENSG00000179820, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ96S97
Protein-protein interaction databases
BioGRIDi | 124862, 56 interactors |
IntActi | Q96S97, 32 interactors |
STRINGi | 9606.ENSP00000375649 |
Miscellaneous databases
RNActi | Q96S97, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 31 – 163 | MARVEL 1PROSITE-ProRule annotationAdd BLAST | 133 | |
Domaini | 168 – 319 | MARVEL 2PROSITE-ProRule annotationAdd BLAST | 152 |
Sequence similaritiesi
Belongs to the MAL family.Curated
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4788, Eukaryota |
GeneTreei | ENSGT00950000182933 |
InParanoidi | Q96S97 |
OMAi | TTYVQFM |
OrthoDBi | 1056604at2759 |
PhylomeDBi | Q96S97 |
TreeFami | TF331088 |
Family and domain databases
InterProi | View protein in InterPro IPR008253, Marvel |
Pfami | View protein in Pfam PF01284, MARVEL, 2 hits |
PROSITEi | View protein in PROSITE PS51225, MARVEL, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
Q96S97-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPVTVTRTTI TTTTTSSSGL GSPMIVGSPR ALTQPLGLLR LLQLVSTCVA
60 70 80 90 100
FSLVASVGAW TGSMGNWSMF TWCFCFSVTL IILIVELCGL QARFPLSWRN
110 120 130 140 150
FPITFACYAA LFCLSASIIY PTTYVQFLSH GRSRDHAIAA TFFSCIACVA
160 170 180 190 200
YATEVAWTRA RPGEITGYMA TVPGLLKVLE TFVACIIFAF ISDPNLYQHQ
210 220 230 240 250
PALEWCVAVY AICFILAAIA ILLNLGECTN VLPIPFPSFL SGLALLSVLL
260 270 280 290 300
YATALVLWPL YQFDEKYGGQ PRRSRDVSCS RSHAYYVCAW DRRLAVAILT
310 320
AINLLAYVAD LVHSAHLVFV KV
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JC07 | C9JC07_HUMAN | Myeloid-associated differentiation ... | MYADM | 259 | Annotation score: | ||
C9JJV6 | C9JJV6_HUMAN | Myeloid-associated differentiation ... | MYADM | 146 | Annotation score: | ||
C9JZL8 | C9JZL8_HUMAN | Myeloid-associated differentiation ... | MYADM | 188 | Annotation score: | ||
A0A494C017 | A0A494C017_HUMAN | Myeloid-associated differentiation ... | MYADM | 122 | Annotation score: | ||
A0A499FIY8 | A0A499FIY8_HUMAN | Myeloid-associated differentiation ... | MYADM | 203 | Annotation score: |
Sequence cautioni
The sequence AAP97182 differs from that shown. Reason: Frameshift.Curated
The sequence BAB55302 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 77 – 94 | Missing in BAC04265 (PubMed:14702039).CuratedAdd BLAST | 18 | |
Sequence conflicti | 279 | C → G (PubMed:12075932).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF087882 mRNA Translation: AAP97182.1 Frameshift. AY037147 mRNA Translation: AAK67628.2 AY358582 mRNA Translation: AAQ88945.1 AK027693 mRNA Translation: BAB55302.1 Different initiation. AK093999 mRNA Translation: BAC04265.1 AK075276 mRNA Translation: BAC11513.1 AK316566 mRNA Translation: BAG38155.1 CH471135 Genomic DNA Translation: EAW72159.1 BC013995 mRNA Translation: AAH13995.1 BC095412 mRNA Translation: AAH95412.1 |
CCDSi | CCDS12866.1 |
RefSeqi | NP_001018654.1, NM_001020818.2 NP_001018655.1, NM_001020819.2 NP_001018656.1, NM_001020820.2 NP_001018657.1, NM_001020821.2 NP_001277117.1, NM_001290188.1 NP_001277118.1, NM_001290189.1 NP_001277119.1, NM_001290190.1 NP_001277120.1, NM_001290191.1 NP_001277121.1, NM_001290192.1 NP_001277122.1, NM_001290193.1 NP_001277123.1, NM_001290194.1 NP_612382.1, NM_138373.4 |
Genome annotation databases
Ensembli | ENST00000391768; ENSP00000375648; ENSG00000179820 ENST00000391769; ENSP00000375649; ENSG00000179820 ENST00000391770; ENSP00000375650; ENSG00000179820 ENST00000391771; ENSP00000375651; ENSG00000179820 ENST00000421337; ENSP00000398269; ENSG00000179820 |
GeneIDi | 91663 |
KEGGi | hsa:91663 |
UCSCi | uc002qcl.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF087882 mRNA Translation: AAP97182.1 Frameshift. AY037147 mRNA Translation: AAK67628.2 AY358582 mRNA Translation: AAQ88945.1 AK027693 mRNA Translation: BAB55302.1 Different initiation. AK093999 mRNA Translation: BAC04265.1 AK075276 mRNA Translation: BAC11513.1 AK316566 mRNA Translation: BAG38155.1 CH471135 Genomic DNA Translation: EAW72159.1 BC013995 mRNA Translation: AAH13995.1 BC095412 mRNA Translation: AAH95412.1 |
CCDSi | CCDS12866.1 |
RefSeqi | NP_001018654.1, NM_001020818.2 NP_001018655.1, NM_001020819.2 NP_001018656.1, NM_001020820.2 NP_001018657.1, NM_001020821.2 NP_001277117.1, NM_001290188.1 NP_001277118.1, NM_001290189.1 NP_001277119.1, NM_001290190.1 NP_001277120.1, NM_001290191.1 NP_001277121.1, NM_001290192.1 NP_001277122.1, NM_001290193.1 NP_001277123.1, NM_001290194.1 NP_612382.1, NM_138373.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 124862, 56 interactors |
IntActi | Q96S97, 32 interactors |
STRINGi | 9606.ENSP00000375649 |
Protein family/group databases
TCDBi | 1.A.64.3.1, the plasmolipin (plasmolipin) family |
PTM databases
iPTMneti | Q96S97 |
PhosphoSitePlusi | Q96S97 |
SwissPalmi | Q96S97 |
Genetic variation databases
BioMutai | MYADM |
DMDMi | 21263793 |
Proteomic databases
EPDi | Q96S97 |
jPOSTi | Q96S97 |
MassIVEi | Q96S97 |
MaxQBi | Q96S97 |
PaxDbi | Q96S97 |
PeptideAtlasi | Q96S97 |
PRIDEi | Q96S97 |
ProteomicsDBi | 78092 |
Protocols and materials databases
Antibodypediai | 19206, 215 antibodies |
Genome annotation databases
Ensembli | ENST00000391768; ENSP00000375648; ENSG00000179820 ENST00000391769; ENSP00000375649; ENSG00000179820 ENST00000391770; ENSP00000375650; ENSG00000179820 ENST00000391771; ENSP00000375651; ENSG00000179820 ENST00000421337; ENSP00000398269; ENSG00000179820 |
GeneIDi | 91663 |
KEGGi | hsa:91663 |
UCSCi | uc002qcl.4, human |
Organism-specific databases
CTDi | 91663 |
DisGeNETi | 91663 |
GeneCardsi | MYADM |
HGNCi | HGNC:7544, MYADM |
HPAi | ENSG00000179820, Low tissue specificity |
MIMi | 609959, gene |
neXtProti | NX_Q96S97 |
OpenTargetsi | ENSG00000179820 |
PharmGKBi | PA31344 |
VEuPathDBi | HostDB:ENSG00000179820.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4788, Eukaryota |
GeneTreei | ENSGT00950000182933 |
InParanoidi | Q96S97 |
OMAi | TTYVQFM |
OrthoDBi | 1056604at2759 |
PhylomeDBi | Q96S97 |
TreeFami | TF331088 |
Enzyme and pathway databases
PathwayCommonsi | Q96S97 |
Miscellaneous databases
BioGRID-ORCSi | 91663, 185 hits in 872 CRISPR screens |
ChiTaRSi | MYADM, human |
GeneWikii | MYADM |
GenomeRNAii | 91663 |
Pharosi | Q96S97, Tbio |
PROi | PR:Q96S97 |
RNActi | Q96S97, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000179820, Expressed in layer of synovial tissue and 226 other tissues |
ExpressionAtlasi | Q96S97, baseline and differential |
Genevisiblei | Q96S97, HS |
Family and domain databases
InterProi | View protein in InterPro IPR008253, Marvel |
Pfami | View protein in Pfam PF01284, MARVEL, 2 hits |
PROSITEi | View protein in PROSITE PS51225, MARVEL, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MYADM_HUMAN | |
Accessioni | Q96S97Primary (citable) accession number: Q96S97 Secondary accession number(s): B2RE58 Q96SK9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 27, 2002 |
Last sequence update: | March 1, 2002 | |
Last modified: | February 10, 2021 | |
This is version 150 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families