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Protein

Myeloid-associated differentiation marker

Gene

MYADM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Protein family/group databases

TCDBi1.A.64.3.1 the plasmolipin (plasmolipin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Myeloid-associated differentiation marker
Alternative name(s):
Protein SB135
Gene namesi
Name:MYADM
ORF Names:UNQ553/PRO1110
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000179820.15
HGNCiHGNC:7544 MYADM
MIMi609959 gene
neXtProtiNX_Q96S97

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei41 – 61HelicalSequence analysisAdd BLAST21
Transmembranei70 – 90HelicalSequence analysisAdd BLAST21
Transmembranei101 – 121HelicalSequence analysisAdd BLAST21
Transmembranei137 – 157HelicalSequence analysisAdd BLAST21
Transmembranei171 – 191HelicalSequence analysisAdd BLAST21
Transmembranei203 – 223HelicalSequence analysisAdd BLAST21
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21
Transmembranei294 – 314HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi91663
OpenTargetsiENSG00000179820
PharmGKBiPA31344

Polymorphism and mutation databases

BioMutaiMYADM
DMDMi21263793

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001568161 – 322Myeloid-associated differentiation markerAdd BLAST322

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei22PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96S97
MaxQBiQ96S97
PaxDbiQ96S97
PeptideAtlasiQ96S97
PRIDEiQ96S97
ProteomicsDBi78092

PTM databases

iPTMnetiQ96S97
PhosphoSitePlusiQ96S97
SwissPalmiQ96S97

Expressioni

Tissue specificityi

Widely expressed. Not detected in thymus.1 Publication

Gene expression databases

BgeeiENSG00000179820 Expressed in 211 organ(s), highest expression level in layer of synovial tissue
CleanExiHS_MYADM
ExpressionAtlasiQ96S97 baseline and differential
GenevisibleiQ96S97 HS

Organism-specific databases

HPAiHPA056301

Interactioni

Protein-protein interaction databases

BioGridi124862, 31 interactors
IntActiQ96S97, 10 interactors
STRINGi9606.ENSP00000337222

Structurei

3D structure databases

ProteinModelPortaliQ96S97
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 163MARVEL 1PROSITE-ProRule annotationAdd BLAST133
Domaini168 – 319MARVEL 2PROSITE-ProRule annotationAdd BLAST152

Sequence similaritiesi

Belongs to the MAL family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4788 Eukaryota
ENOG4111IAF LUCA
GeneTreeiENSGT00390000010832
HOVERGENiHBG052545
InParanoidiQ96S97
OMAiFPITYAC
OrthoDBiEOG091G0D9S
PhylomeDBiQ96S97
TreeFamiTF331088

Family and domain databases

InterProiView protein in InterPro
IPR008253 Marvel
PfamiView protein in Pfam
PF01284 MARVEL, 2 hits
PROSITEiView protein in PROSITE
PS51225 MARVEL, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q96S97-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPVTVTRTTI TTTTTSSSGL GSPMIVGSPR ALTQPLGLLR LLQLVSTCVA
60 70 80 90 100
FSLVASVGAW TGSMGNWSMF TWCFCFSVTL IILIVELCGL QARFPLSWRN
110 120 130 140 150
FPITFACYAA LFCLSASIIY PTTYVQFLSH GRSRDHAIAA TFFSCIACVA
160 170 180 190 200
YATEVAWTRA RPGEITGYMA TVPGLLKVLE TFVACIIFAF ISDPNLYQHQ
210 220 230 240 250
PALEWCVAVY AICFILAAIA ILLNLGECTN VLPIPFPSFL SGLALLSVLL
260 270 280 290 300
YATALVLWPL YQFDEKYGGQ PRRSRDVSCS RSHAYYVCAW DRRLAVAILT
310 320
AINLLAYVAD LVHSAHLVFV KV
Length:322
Mass (Da):35,274
Last modified:March 1, 2002 - v2
Checksum:iA92142CC63625A4E
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JZL8C9JZL8_HUMAN
Myeloid-associated differentiation ...
MYADM
188Annotation score:
C9J5M0C9J5M0_HUMAN
Myeloid-associated differentiation ...
MYADM
242Annotation score:
C9JJV6C9JJV6_HUMAN
Myeloid-associated differentiation ...
MYADM
146Annotation score:
C9JC07C9JC07_HUMAN
Myeloid-associated differentiation ...
MYADM
259Annotation score:

Sequence cautioni

The sequence AAP97182 differs from that shown. Reason: Frameshift at positions 228, 277 and 278.Curated
The sequence BAB55302 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti77 – 94Missing in BAC04265 (PubMed:14702039).CuratedAdd BLAST18
Sequence conflicti279C → G (PubMed:12075932).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087882 mRNA Translation: AAP97182.1 Frameshift.
AY037147 mRNA Translation: AAK67628.2
AY358582 mRNA Translation: AAQ88945.1
AK027693 mRNA Translation: BAB55302.1 Different initiation.
AK093999 mRNA Translation: BAC04265.1
AK075276 mRNA Translation: BAC11513.1
AK316566 mRNA Translation: BAG38155.1
CH471135 Genomic DNA Translation: EAW72159.1
BC013995 mRNA Translation: AAH13995.1
BC095412 mRNA Translation: AAH95412.1
CCDSiCCDS12866.1
RefSeqiNP_001018654.1, NM_001020818.2
NP_001018655.1, NM_001020819.2
NP_001018656.1, NM_001020820.2
NP_001018657.1, NM_001020821.2
NP_001277117.1, NM_001290188.1
NP_001277118.1, NM_001290189.1
NP_001277119.1, NM_001290190.1
NP_001277120.1, NM_001290191.1
NP_001277121.1, NM_001290192.1
NP_001277122.1, NM_001290193.1
NP_001277123.1, NM_001290194.1
NP_612382.1, NM_138373.4
UniGeneiHs.380906

Genome annotation databases

EnsembliENST00000336967; ENSP00000337222; ENSG00000179820
ENST00000391768; ENSP00000375648; ENSG00000179820
ENST00000391769; ENSP00000375649; ENSG00000179820
ENST00000391770; ENSP00000375650; ENSG00000179820
ENST00000391771; ENSP00000375651; ENSG00000179820
GeneIDi91663
KEGGihsa:91663
UCSCiuc002qcl.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087882 mRNA Translation: AAP97182.1 Frameshift.
AY037147 mRNA Translation: AAK67628.2
AY358582 mRNA Translation: AAQ88945.1
AK027693 mRNA Translation: BAB55302.1 Different initiation.
AK093999 mRNA Translation: BAC04265.1
AK075276 mRNA Translation: BAC11513.1
AK316566 mRNA Translation: BAG38155.1
CH471135 Genomic DNA Translation: EAW72159.1
BC013995 mRNA Translation: AAH13995.1
BC095412 mRNA Translation: AAH95412.1
CCDSiCCDS12866.1
RefSeqiNP_001018654.1, NM_001020818.2
NP_001018655.1, NM_001020819.2
NP_001018656.1, NM_001020820.2
NP_001018657.1, NM_001020821.2
NP_001277117.1, NM_001290188.1
NP_001277118.1, NM_001290189.1
NP_001277119.1, NM_001290190.1
NP_001277120.1, NM_001290191.1
NP_001277121.1, NM_001290192.1
NP_001277122.1, NM_001290193.1
NP_001277123.1, NM_001290194.1
NP_612382.1, NM_138373.4
UniGeneiHs.380906

3D structure databases

ProteinModelPortaliQ96S97
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124862, 31 interactors
IntActiQ96S97, 10 interactors
STRINGi9606.ENSP00000337222

Protein family/group databases

TCDBi1.A.64.3.1 the plasmolipin (plasmolipin) family

PTM databases

iPTMnetiQ96S97
PhosphoSitePlusiQ96S97
SwissPalmiQ96S97

Polymorphism and mutation databases

BioMutaiMYADM
DMDMi21263793

Proteomic databases

EPDiQ96S97
MaxQBiQ96S97
PaxDbiQ96S97
PeptideAtlasiQ96S97
PRIDEiQ96S97
ProteomicsDBi78092

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336967; ENSP00000337222; ENSG00000179820
ENST00000391768; ENSP00000375648; ENSG00000179820
ENST00000391769; ENSP00000375649; ENSG00000179820
ENST00000391770; ENSP00000375650; ENSG00000179820
ENST00000391771; ENSP00000375651; ENSG00000179820
GeneIDi91663
KEGGihsa:91663
UCSCiuc002qcl.4 human

Organism-specific databases

CTDi91663
DisGeNETi91663
EuPathDBiHostDB:ENSG00000179820.15
GeneCardsiMYADM
HGNCiHGNC:7544 MYADM
HPAiHPA056301
MIMi609959 gene
neXtProtiNX_Q96S97
OpenTargetsiENSG00000179820
PharmGKBiPA31344
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4788 Eukaryota
ENOG4111IAF LUCA
GeneTreeiENSGT00390000010832
HOVERGENiHBG052545
InParanoidiQ96S97
OMAiFPITYAC
OrthoDBiEOG091G0D9S
PhylomeDBiQ96S97
TreeFamiTF331088

Miscellaneous databases

ChiTaRSiMYADM human
GeneWikiiMYADM
GenomeRNAii91663
PROiPR:Q96S97
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000179820 Expressed in 211 organ(s), highest expression level in layer of synovial tissue
CleanExiHS_MYADM
ExpressionAtlasiQ96S97 baseline and differential
GenevisibleiQ96S97 HS

Family and domain databases

InterProiView protein in InterPro
IPR008253 Marvel
PfamiView protein in Pfam
PF01284 MARVEL, 2 hits
PROSITEiView protein in PROSITE
PS51225 MARVEL, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMYADM_HUMAN
AccessioniPrimary (citable) accession number: Q96S97
Secondary accession number(s): B2RE58
, Q542Z1, Q7Z507, Q8N9R4, Q96CS6, Q96SK9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: March 1, 2002
Last modified: September 12, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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