UniProtKB - Q96S97 (MYADM_HUMAN)

BLAST

>sp|Q96S97|MYADM_HUMAN Myeloid-associated differentiation marker OS=Homo sapiens OX=9606 GN=MYADM PE=1 SV=2
MPVTVTRTTITTTTTSSSGLGSPMIVGSPRALTQPLGLLRLLQLVSTCVAFSLVASVGAW
TGSMGNWSMFTWCFCFSVTLIILIVELCGLQARFPLSWRNFPITFACYAALFCLSASIIY
PTTYVQFLSHGRSRDHAIAATFFSCIACVAYATEVAWTRARPGEITGYMATVPGLLKVLE
TFVACIIFAFISDPNLYQHQPALEWCVAVYAICFILAAIAILLNLGECTNVLPIPFPSFL
SGLALLSVLLYATALVLWPLYQFDEKYGGQPRRSRDVSCSRSHAYYVCAWDRRLAVAILT
AINLLAYVADLVHSAHLVFVKV

Align
Format
Add to basket Added to basket
History
Entry version 134 (12 Sep 2018)
Sequence version 2 (01 Mar 2002)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

Myeloid-associated differentiation marker

Gene

MYADM

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

GO - Biological processⁱ

establishment of endothelial barrier
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23264465
membrane raft organization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21325632
negative regulation of actin filament polymerization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23264465
negative regulation of gene expression
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23264465
negative regulation of heterotypic cell-cell adhesion
Source: UniProtKB
Inferred from direct assayⁱ
- 23264465
negative regulation of protein kinase C signaling
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23264465
negative regulation of protein phosphorylation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23264465
positive regulation of cell migration
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21325632
positive regulation of substrate adhesion-dependent cell spreading
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21325632
protein localization to plasma membrane
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21325632

View the complete GO annotation on QuickGO ...

Protein family/group databases

TCDBⁱ	1.A.64.3.1 the plasmolipin (plasmolipin) family

TCDBⁱ

1.A.64.3.1 the plasmolipin (plasmolipin) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Myeloid-associated differentiation marker Alternative name(s): Protein SB135
Gene namesⁱ	Name:MYADM ORF Names:UNQ553/PRO1110
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000179820.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7544 MYADM
MIMⁱ	609959 gene
neXtProtⁱ	NX_Q96S97

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	41 – 61	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	70 – 90	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	101 – 121	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	137 – 157	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	171 – 191	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	203 – 223	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	239 – 259	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	294 – 314	HelicalSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	91663
Open Targets More...OpenTargetsⁱ	ENSG00000179820
PharmGKBⁱ	PA31344

Polymorphism and mutation databases

BioMutaⁱ	MYADM
DMDMⁱ	21263793

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000156816	1 – 322	Myeloid-associated differentiation markerAdd BLAST		322

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	22	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q96S97
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96S97
PaxDbⁱ	Q96S97
PeptideAtlas More...PeptideAtlasⁱ	Q96S97
PRIDEⁱ	Q96S97
ProteomicsDBⁱ	78092

PTM databases

iPTMnetⁱ	Q96S97
PhosphoSitePlusⁱ	Q96S97
SwissPalmⁱ	Q96S97

Expressionⁱ

Tissue specificityⁱ

Widely expressed. Not detected in thymus.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000179820 Expressed in 211 organ(s), highest expression level in layer of synovial tissue
CleanExⁱ	HS_MYADM
ExpressionAtlasⁱ	Q96S97 baseline and differential
Genevisibleⁱ	Q96S97 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA056301

HPAⁱ

HPA056301

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	124862, 31 interactors
IntActⁱ	Q96S97, 10 interactors
STRINGⁱ	9606.ENSP00000337222

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96S97
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	31 – 163	MARVEL 1PROSITE-ProRule annotationAdd BLAST		133
Domainⁱ	168 – 319	MARVEL 2PROSITE-ProRule annotationAdd BLAST		152

Sequence similaritiesⁱ

Belongs to the MAL family.Curated

Keywords - Domainⁱ

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4788 Eukaryota ENOG4111IAF LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000010832
HOVERGENⁱ	HBG052545
InParanoidⁱ	Q96S97
OMAⁱ	FPITYAC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0D9S
PhylomeDBⁱ	Q96S97
TreeFamⁱ	TF331088

Family and domain databases

InterProⁱ	View protein in InterPro IPR008253 Marvel
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01284 MARVEL, 2 hits
PROSITEⁱ	View protein in PROSITE PS51225 MARVEL, 2 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show all Align All

Q96S97-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPVTVTRTTI TTTTTSSSGL GSPMIVGSPR ALTQPLGLLR LLQLVSTCVA 
        60         70         80         90        100
FSLVASVGAW TGSMGNWSMF TWCFCFSVTL IILIVELCGL QARFPLSWRN 
       110        120        130        140        150
FPITFACYAA LFCLSASIIY PTTYVQFLSH GRSRDHAIAA TFFSCIACVA 
       160        170        180        190        200
YATEVAWTRA RPGEITGYMA TVPGLLKVLE TFVACIIFAF ISDPNLYQHQ 
       210        220        230        240        250
PALEWCVAVY AICFILAAIA ILLNLGECTN VLPIPFPSFL SGLALLSVLL 
       260        270        280        290        300
YATALVLWPL YQFDEKYGGQ PRRSRDVSCS RSHAYYVCAW DRRLAVAILT 
       310        320 
AINLLAYVAD LVHSAHLVFV KV

Length:322

Mass (Da):35,274

Last modified:March 1, 2002 - v2

Checksum:ⁱA92142CC63625A4E

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9JZL8	C9JZL8_HUMAN	Myeloid-associated differentiation ... Myeloid-associated differentiation marker	MYADM	188	Annotation score:
C9J5M0	C9J5M0_HUMAN	Myeloid-associated differentiation ... Myeloid-associated differentiation marker	MYADM	242	Annotation score:
C9JJV6	C9JJV6_HUMAN	Myeloid-associated differentiation ... Myeloid-associated differentiation marker	MYADM	146	Annotation score:
C9JC07	C9JC07_HUMAN	Myeloid-associated differentiation ... Myeloid-associated differentiation marker	MYADM	259	Annotation score:

Sequence cautionⁱ

The sequence AAP97182 differs from that shown. Reason: Frameshift at positions 228, 277 and 278.Curated

The sequence BAB55302 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	77 – 94	Missing in BAC04265 (PubMed:14702039).CuratedAdd BLAST		18
Sequence conflictⁱ	279	C → G (PubMed:12075932).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF087882 mRNA Translation: AAP97182.1 Frameshift. AY037147 mRNA Translation: AAK67628.2 AY358582 mRNA Translation: AAQ88945.1 AK027693 mRNA Translation: BAB55302.1 Different initiation. AK093999 mRNA Translation: BAC04265.1 AK075276 mRNA Translation: BAC11513.1 AK316566 mRNA Translation: BAG38155.1 CH471135 Genomic DNA Translation: EAW72159.1 BC013995 mRNA Translation: AAH13995.1 BC095412 mRNA Translation: AAH95412.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12866.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001018654.1, NM_001020818.2 NP_001018655.1, NM_001020819.2 NP_001018656.1, NM_001020820.2 NP_001018657.1, NM_001020821.2 NP_001277117.1, NM_001290188.1 NP_001277118.1, NM_001290189.1 NP_001277119.1, NM_001290190.1 NP_001277120.1, NM_001290191.1 NP_001277121.1, NM_001290192.1 NP_001277122.1, NM_001290193.1 NP_001277123.1, NM_001290194.1 NP_612382.1, NM_138373.4
UniGeneⁱ	Hs.380906

Genome annotation databases

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96S97	HCG1640809, isoform CRA_b		HUMAN		322	UniRef100_Q96S97
Myeloid associated differentiation marker		GORGO		322
Myeloid-associated differentiation marker (Fragment)		HUMAN		259
Myeloid-associated differentiation marker (Fragment)		HUMAN		146
Myeloid-associated differentiation marker (Fragment)		HUMAN		188
+1

Protein	Similar proteins		Species	Score	Length	Source
Q96S97	Myeloid-associated differentiation marker		PONAB		322	UniRef90_Q96S97
HCG1640809, isoform CRA_b		HUMAN		322
Myeloid associated differentiation marker		GORGO		322
Uncharacterized protein		CERAT		325
Uncharacterized protein (Fragment)		AILME		322
+64

Protein	Similar proteins		Species	Score	Length	Source
Q96S97	Myeloid-associated differentiation marker		PONAB		322	UniRef50_Q96S97
Myeloid-associated differentiation marker		MOUSE		320
Myeloid-associated differentiation marker		RAT		318
HCG1640809, isoform CRA_b		HUMAN		322
Myeloid associated differentiation marker		GORGO		322
+209

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF087882 mRNA Translation: AAP97182.1 Frameshift. AY037147 mRNA Translation: AAK67628.2 AY358582 mRNA Translation: AAQ88945.1 AK027693 mRNA Translation: BAB55302.1 Different initiation. AK093999 mRNA Translation: BAC04265.1 AK075276 mRNA Translation: BAC11513.1 AK316566 mRNA Translation: BAG38155.1 CH471135 Genomic DNA Translation: EAW72159.1 BC013995 mRNA Translation: AAH13995.1 BC095412 mRNA Translation: AAH95412.1
CCDSⁱ	CCDS12866.1
RefSeqⁱ	NP_001018654.1, NM_001020818.2 NP_001018655.1, NM_001020819.2 NP_001018656.1, NM_001020820.2 NP_001018657.1, NM_001020821.2 NP_001277117.1, NM_001290188.1 NP_001277118.1, NM_001290189.1 NP_001277119.1, NM_001290190.1 NP_001277120.1, NM_001290191.1 NP_001277121.1, NM_001290192.1 NP_001277122.1, NM_001290193.1 NP_001277123.1, NM_001290194.1 NP_612382.1, NM_138373.4
UniGeneⁱ	Hs.380906

3D structure databases

ProteinModelPortalⁱ	Q96S97
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	124862, 31 interactors
IntActⁱ	Q96S97, 10 interactors
STRINGⁱ	9606.ENSP00000337222

Protein family/group databases

TCDBⁱ	1.A.64.3.1 the plasmolipin (plasmolipin) family

TCDBⁱ

1.A.64.3.1 the plasmolipin (plasmolipin) family

PTM databases

iPTMnetⁱ	Q96S97
PhosphoSitePlusⁱ	Q96S97
SwissPalmⁱ	Q96S97

Polymorphism and mutation databases

BioMutaⁱ	MYADM
DMDMⁱ	21263793

Proteomic databases

EPDⁱ	Q96S97
MaxQBⁱ	Q96S97
PaxDbⁱ	Q96S97
PeptideAtlasⁱ	Q96S97
PRIDEⁱ	Q96S97
ProteomicsDBⁱ	78092

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000336967; ENSP00000337222; ENSG00000179820 ENST00000391768; ENSP00000375648; ENSG00000179820 ENST00000391769; ENSP00000375649; ENSG00000179820 ENST00000391770; ENSP00000375650; ENSG00000179820 ENST00000391771; ENSP00000375651; ENSG00000179820
GeneIDⁱ	91663
KEGGⁱ	hsa:91663
UCSCⁱ	uc002qcl.4 human

Organism-specific databases

CTDⁱ	91663
DisGeNETⁱ	91663
EuPathDBⁱ	HostDB:ENSG00000179820.15
GeneCardsⁱ	MYADM
HGNCⁱ	HGNC:7544 MYADM
HPAⁱ	HPA056301
MIMⁱ	609959 gene
neXtProtⁱ	NX_Q96S97
OpenTargetsⁱ	ENSG00000179820
PharmGKBⁱ	PA31344
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4788 Eukaryota ENOG4111IAF LUCA
GeneTreeⁱ	ENSGT00390000010832
HOVERGENⁱ	HBG052545
InParanoidⁱ	Q96S97
OMAⁱ	FPITYAC
OrthoDBⁱ	EOG091G0D9S
PhylomeDBⁱ	Q96S97
TreeFamⁱ	TF331088

Miscellaneous databases

ChiTaRSⁱ	MYADM human
GeneWikiⁱ	MYADM
GenomeRNAiⁱ	91663
Protein Ontology More...PROⁱ	PR:Q96S97
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000179820 Expressed in 211 organ(s), highest expression level in layer of synovial tissue
CleanExⁱ	HS_MYADM
ExpressionAtlasⁱ	Q96S97 baseline and differential
Genevisibleⁱ	Q96S97 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR008253 Marvel
Pfamⁱ	View protein in Pfam PF01284 MARVEL, 2 hits
PROSITEⁱ	View protein in PROSITE PS51225 MARVEL, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MYADM_HUMAN
Accessionⁱ	Q96S97Primary (citable) accession number: Q96S97 Secondary accession number(s): B2RE58 , Q542Z1, Q7Z507, Q8N9R4, Q96CS6, Q96SK9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 27, 2002
	Last sequence update:	March 1, 2002
	Last modified:	September 12, 2018
	This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q96S97 (MYADM_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Myeloid-associated differentiation marker

MYADM

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytoskeleton

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ