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Entry version 152 (31 Jul 2019)
Sequence version 1 (01 Dec 2001)
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Protein

Cyclin-L2

Gene

CCNL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in pre-mRNA splicing. May induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCyclin
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
Q96S94

SIGNOR Signaling Network Open Resource

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SIGNORi
Q96S94

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cyclin-L2
Alternative name(s):
Paneth cell-enhanced expression protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCNL2
ORF Names:SB138
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20570 CCNL2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
613482 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96S94

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
81669

Open Targets

More...
OpenTargetsi
ENSG00000221978

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134973681

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CCNL2

Domain mapping of disease mutations (DMDM)

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DMDMi
74752124

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000804872 – 520Cyclin-L2Add BLAST519

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei330PhosphoserineCombined sources1
Modified residuei338PhosphoserineCombined sources1
Modified residuei348PhosphoserineCombined sources1
Modified residuei351PhosphoserineCombined sources1
Modified residuei369PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q96S94

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96S94

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96S94

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96S94

PeptideAtlas

More...
PeptideAtlasi
Q96S94

PRoteomics IDEntifications database

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PRIDEi
Q96S94

ProteomicsDB human proteome resource

More...
ProteomicsDBi
23998
78087 [Q96S94-1]
78088 [Q96S94-2]
78089 [Q96S94-3]

Consortium for Top Down Proteomics

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TopDownProteomicsi
Q96S94-1 [Q96S94-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q96S94

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q96S94

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000221978 Expressed in 209 organ(s), highest expression level in left lobe of thyroid gland

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96S94 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96S94 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA053137

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CDK11A, CDK11B, CDK12, CDK13 and POLR2A, the hyperphosphorylated C-terminal domain (CTD) of RNA polymerase II (PubMed:14684736, PubMed:18216018). May form a ternary complex with CDK11B and casein kinase II (CKII) (PubMed:18216018).

Interacts with pre-mRNA-splicing factors, including at least SRSF1, SRSF2 AND SRSF7/SLU7 (PubMed:14684736, PubMed:18216018).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
RUNDC3AQ59EK93EBI-1045974,EBI-747225

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
123566, 51 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-343 Cyclin L2-CDK11A(p110) complex
CPX-345 Cyclin L2-CDK11B(p58) complex
CPX-347 Cyclin L2-CDK11A(p58) complex
CPX-349 Cyclin L2-CDK11B(p110) complex

Protein interaction database and analysis system

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IntActi
Q96S94, 31 interactors

Molecular INTeraction database

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MINTi
Q96S94

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000383611

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96S94

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni83 – 185Cyclin-like 1Add BLAST103
Regioni198 – 282Cyclin-like 2Add BLAST85
Regioni385 – 423RSAdd BLAST39

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions (By similarity).By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cyclin family. Cyclin L subfamily.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0835 Eukaryota
COG5333 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000159239

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96S94

Identification of Orthologs from Complete Genome Data

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OMAi
YRKSKDC

Database of Orthologous Groups

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OrthoDBi
1519153at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q96S94

TreeFam database of animal gene trees

More...
TreeFami
TF101011

Family and domain databases

Conserved Domains Database

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CDDi
cd00043 CYCLIN, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR006671 Cyclin_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00385 CYCLIN, 2 hits
SM01332 Cyclin_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47954 SSF47954, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96S94-1) [UniParc]FASTAAdd to basket
Also known as: cyclin L2alpha

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAAAAAGA AGSAAPAAAA GAPGSGGAPS GSQGVLIGDR LYSGVLITLE
60 70 80 90 100
NCLLPDDKLR FTPSMSSGLD TDTETDLRVV GCELIQAAGI LLRLPQVAMA
110 120 130 140 150
TGQVLFQRFF YTKSFVKHSM EHVSMACVHL ASKIEEAPRR IRDVINVFHR
160 170 180 190 200
LRQLRDKKKP VPLLLDQDYV NLKNQIIKAE RRVLKELGFC VHVKHPHKII
210 220 230 240 250
VMYLQVLECE RNQHLVQTSW NYMNDSLRTD VFVRFQPESI ACACIYLAAR
260 270 280 290 300
TLEIPLPNRP HWFLLFGATE EEIQEICLKI LQLYARKKVD LTHLEGEVEK
310 320 330 340 350
RKHAIEEAKA QARGLLPGGT QVLDGTSGFS PAPKLVESPK EGKGSKPSPL
360 370 380 390 400
SVKNTKRRLE GAKKAKADSP VNGLPKGRES RSRSRSREQS YSRSPSRSAS
410 420 430 440 450
PKRRKSDSGS TSGGSKSQSR SRSRSDSPPR QAPRSAPYKG SEIRGSRKSK
460 470 480 490 500
DCKYPQKPHK SRSRSSSRSR SRSRERADNP GKYKKKSHYY RDQRRERSRS
510 520
YERTGRRYER DHPGHSRHRR
Length:520
Mass (Da):58,147
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4341E55D03D7B0E0
GO
Isoform 2 (identifier: Q96S94-2) [UniParc]FASTAAdd to basket
Also known as: CCNL2s

The sequence of this isoform differs from the canonical sequence as follows:
     221-227: NYMNDSL → VASEGIT
     228-520: Missing.

Show »
Length:227
Mass (Da):24,707
Checksum:iD36EC47ABC9FB2FE
GO
Isoform 3 (identifier: Q96S94-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-222: Missing.

Show »
Length:298
Mass (Da):33,839
Checksum:i96FA9D04F9CCB9F7
GO
Isoform 4 (identifier: Q96S94-4) [UniParc]FASTAAdd to basket
Also known as: cyclin L2betaB

The sequence of this isoform differs from the canonical sequence as follows:
     221-236: NYMNDSLRTDVFVRFQ → VASEDPLLKWDSWQRL
     237-520: Missing.

Show »
Length:236
Mass (Da):25,974
Checksum:iD67DF36F25A43915
GO
Isoform 5 (identifier: Q96S94-5) [UniParc]FASTAAdd to basket
Also known as: cyclin L2betaA

The sequence of this isoform differs from the canonical sequence as follows:
     221-226: NYMNDS → VASEGK
     227-520: Missing.

Show »
Length:226
Mass (Da):24,621
Checksum:i2DA47ABC9FB2FED8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MSF3A0A0A0MSF3_HUMAN
Cyclin-L2
CCNL2
347Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J148C9J148_HUMAN
Cyclin-L2
CCNL2
180Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QSH2J3QSH2_HUMAN
Cyclin-L2
CCNL2
85Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRL1J3KRL1_HUMAN
Cyclin-L2
CCNL2
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH71622 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB84938 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti71T → S in AAH16333 (PubMed:15489334).Curated1
Sequence conflicti324 – 325DG → MS in AAP97201 (Ref. 8) Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0161321 – 222Missing in isoform 3. 2 PublicationsAdd BLAST222
Alternative sequenceiVSP_058301221 – 236NYMND…FVRFQ → VASEDPLLKWDSWQRL in isoform 4. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_058302221 – 227NYMNDSL → VASEGIT in isoform 2. 7
Alternative sequenceiVSP_016130221 – 226NYMNDS → VASEGK in isoform 5. 4 Publications6
Alternative sequenceiVSP_016131227 – 520Missing in isoform 5. 4 PublicationsAdd BLAST294
Alternative sequenceiVSP_058303228 – 520Missing in isoform 2. Add BLAST293
Alternative sequenceiVSP_058304237 – 520Missing in isoform 4. Add BLAST284

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY037150 mRNA Translation: AAK67631.1
AY116620 mRNA Translation: AAM76789.1
AK074112 mRNA Translation: BAB84938.1 Different initiation.
AK056120 mRNA No translation available.
AK027770 mRNA Translation: BAG51376.1
AK292268 mRNA Translation: BAF84957.1
AL391244 Genomic DNA No translation available.
CR628411 Genomic DNA No translation available.
CH471183 Genomic DNA Translation: EAW56213.1
CH471183 Genomic DNA Translation: EAW56215.1
CH471183 Genomic DNA Translation: EAW56216.1
CH471183 Genomic DNA Translation: EAW56217.1
BC016333 mRNA Translation: AAH16333.1
BC071622 mRNA Translation: AAH71622.2 Different initiation.
AL834432 mRNA Translation: CAD39092.1
AL834441 mRNA Translation: CAD39101.1
AF087903 mRNA Translation: AAP97201.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS30557.1 [Q96S94-1]
CCDS30558.1 [Q96S94-5]

NCBI Reference Sequences

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RefSeqi
NP_001034666.1, NM_001039577.3 [Q96S94-5]
NP_001307082.1, NM_001320153.1 [Q96S94-3]
NP_001307084.1, NM_001320155.1 [Q96S94-3]
NP_112199.2, NM_030937.4 [Q96S94-1]
XP_011540523.1, XM_011542221.2
XP_016857911.1, XM_017002422.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000400809; ENSP00000383611; ENSG00000221978 [Q96S94-1]
ENST00000408918; ENSP00000386158; ENSG00000221978 [Q96S94-5]
ENST00000481223; ENSP00000423734; ENSG00000221978 [Q96S94-4]
ENST00000488340; ENSP00000424647; ENSG00000221978 [Q96S94-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
81669

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:81669

UCSC genome browser

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UCSCi
uc001afi.3 human [Q96S94-1]
uc057beg.1 human

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY037150 mRNA Translation: AAK67631.1
AY116620 mRNA Translation: AAM76789.1
AK074112 mRNA Translation: BAB84938.1 Different initiation.
AK056120 mRNA No translation available.
AK027770 mRNA Translation: BAG51376.1
AK292268 mRNA Translation: BAF84957.1
AL391244 Genomic DNA No translation available.
CR628411 Genomic DNA No translation available.
CH471183 Genomic DNA Translation: EAW56213.1
CH471183 Genomic DNA Translation: EAW56215.1
CH471183 Genomic DNA Translation: EAW56216.1
CH471183 Genomic DNA Translation: EAW56217.1
BC016333 mRNA Translation: AAH16333.1
BC071622 mRNA Translation: AAH71622.2 Different initiation.
AL834432 mRNA Translation: CAD39092.1
AL834441 mRNA Translation: CAD39101.1
AF087903 mRNA Translation: AAP97201.1
CCDSiCCDS30557.1 [Q96S94-1]
CCDS30558.1 [Q96S94-5]
RefSeqiNP_001034666.1, NM_001039577.3 [Q96S94-5]
NP_001307082.1, NM_001320153.1 [Q96S94-3]
NP_001307084.1, NM_001320155.1 [Q96S94-3]
NP_112199.2, NM_030937.4 [Q96S94-1]
XP_011540523.1, XM_011542221.2
XP_016857911.1, XM_017002422.1

3D structure databases

SMRiQ96S94
ModBaseiSearch...

Protein-protein interaction databases

BioGridi123566, 51 interactors
ComplexPortaliCPX-343 Cyclin L2-CDK11A(p110) complex
CPX-345 Cyclin L2-CDK11B(p58) complex
CPX-347 Cyclin L2-CDK11A(p58) complex
CPX-349 Cyclin L2-CDK11B(p110) complex
IntActiQ96S94, 31 interactors
MINTiQ96S94
STRINGi9606.ENSP00000383611

PTM databases

iPTMnetiQ96S94
PhosphoSitePlusiQ96S94

Polymorphism and mutation databases

BioMutaiCCNL2
DMDMi74752124

Proteomic databases

EPDiQ96S94
jPOSTiQ96S94
MaxQBiQ96S94
PaxDbiQ96S94
PeptideAtlasiQ96S94
PRIDEiQ96S94
ProteomicsDBi23998
78087 [Q96S94-1]
78088 [Q96S94-2]
78089 [Q96S94-3]
TopDownProteomicsiQ96S94-1 [Q96S94-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000400809; ENSP00000383611; ENSG00000221978 [Q96S94-1]
ENST00000408918; ENSP00000386158; ENSG00000221978 [Q96S94-5]
ENST00000481223; ENSP00000423734; ENSG00000221978 [Q96S94-4]
ENST00000488340; ENSP00000424647; ENSG00000221978 [Q96S94-2]
GeneIDi81669
KEGGihsa:81669
UCSCiuc001afi.3 human [Q96S94-1]
uc057beg.1 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
81669
DisGeNETi81669

GeneCards: human genes, protein and diseases

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GeneCardsi
CCNL2
HGNCiHGNC:20570 CCNL2
HPAiHPA053137
MIMi613482 gene
neXtProtiNX_Q96S94
OpenTargetsiENSG00000221978
PharmGKBiPA134973681

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0835 Eukaryota
COG5333 LUCA
GeneTreeiENSGT00940000159239
InParanoidiQ96S94
OMAiYRKSKDC
OrthoDBi1519153at2759
PhylomeDBiQ96S94
TreeFamiTF101011

Enzyme and pathway databases

SignaLinkiQ96S94
SIGNORiQ96S94

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CCNL2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CCNL2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
81669

Protein Ontology

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PROi
PR:Q96S94

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000221978 Expressed in 209 organ(s), highest expression level in left lobe of thyroid gland
ExpressionAtlasiQ96S94 baseline and differential
GenevisibleiQ96S94 HS

Family and domain databases

CDDicd00043 CYCLIN, 2 hits
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR006671 Cyclin_N
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 2 hits
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCNL2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96S94
Secondary accession number(s): A0A024R072
, A0A024R077, A0A0C4DGC4, A8K8A3, B1B152, F2Z3J5, Q5T2N5, Q5T2N6, Q6IQ12, Q7Z4Z8, Q8N3C9, Q8N3D5, Q8NHE3, Q8TEL0, Q96B00
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: December 1, 2001
Last modified: July 31, 2019
This is version 152 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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