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Protein

Ubiquitin-like protein 7

Gene

UBL7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Keywordsi

Biological processUbl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-like protein 7
Alternative name(s):
Bone marrow stromal cell ubiquitin-like protein
Short name:
BMSC-UbP
Ubiquitin-like protein SB132
Gene namesi
Name:UBL7
Synonyms:BMSCUBP
ORF Names:SB132
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000138629.15
HGNCiHGNC:28221 UBL7
MIMi609748 gene
neXtProtiNX_Q96S82

Pathology & Biotechi

Organism-specific databases

DisGeNETi84993
OpenTargetsiENSG00000138629
PharmGKBiPA142670645

Polymorphism and mutation databases

BioMutaiUBL7
DMDMi48474599

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002110211 – 380Ubiquitin-like protein 7Add BLAST380

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei230PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96S82
MaxQBiQ96S82
PaxDbiQ96S82
PeptideAtlasiQ96S82
PRIDEiQ96S82
ProteomicsDBi78083

PTM databases

iPTMnetiQ96S82
PhosphoSitePlusiQ96S82

Expressioni

Tissue specificityi

Ubiquitous. Highly expressed in heart, skeletal muscle, testis, thyroid and adrenal gland.1 Publication

Inductioni

Down-regulated by phorbol myristate acetate (PMA) in bone marrow stroma cells.

Gene expression databases

BgeeiENSG00000138629 Expressed in 186 organ(s), highest expression level in right frontal lobe
CleanExiHS_UBL7
ExpressionAtlasiQ96S82 baseline and differential
GenevisibleiQ96S82 HS

Organism-specific databases

HPAiHPA040423
HPA041897

Interactioni

Subunit structurei

Binds ubiquitin.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi124418, 50 interactors
IntActiQ96S82, 12 interactors
STRINGi9606.ENSP00000354883

Structurei

Secondary structure

1380
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ96S82
SMRiQ96S82
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96S82

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 98Ubiquitin-likePROSITE-ProRule annotationAdd BLAST81
Domaini333 – 377UBAPROSITE-ProRule annotationAdd BLAST45

Phylogenomic databases

eggNOGiENOG410ISS5 Eukaryota
ENOG410YUJQ LUCA
GeneTreeiENSGT00390000015967
HOVERGENiHBG054051
InParanoidiQ96S82
OMAiHAINLLM
OrthoDBiEOG091G0II5
PhylomeDBiQ96S82
TreeFamiTF327176

Family and domain databases

InterProiView protein in InterPro
IPR015940 UBA
IPR009060 UBA-like_sf
IPR015496 Ubiquilin
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
PANTHERiPTHR10677 PTHR10677, 1 hit
PfamiView protein in Pfam
PF00627 UBA, 1 hit
PF00240 ubiquitin, 1 hit
SMARTiView protein in SMART
SM00165 UBA, 1 hit
SM00213 UBQ, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50030 UBA, 1 hit
PS50053 UBIQUITIN_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q96S82-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLSDWHLAV KLADQPLTPK SILRLPETEL GEYSLGGYSI SFLKQLIAGK
60 70 80 90 100
LQESVPDPEL IDLIYCGRKL KDDQTLDFYG IQPGSTVHVL RKSWPEPDQK
110 120 130 140 150
PEPVDKVAAM REFRVLHTAL HSSSSYREAV FKMLSNKESL DQIIVATPGL
160 170 180 190 200
SSDPIALGVL QDKDLFSVFA DPNMLDTLVP AHPALVNAIV LVLHSVAGSA
210 220 230 240 250
PMPGTDSSSR SMPSSSYRDM PGGFLFEGLS DDEDDFHPNT RSTPSSSTPS
260 270 280 290 300
SRPASLGYSG AAGPRPITQS ELATALALAS TPESSSHTPT PGTQGHSSGT
310 320 330 340 350
SPMSSGVQSG TPITNDLFSQ ALQHALQASG QPSLQSQWQP QLQQLRDMGI
360 370 380
QDDELSLRAL QATGGDIQAA LELIFAGGAP
Length:380
Mass (Da):40,510
Last modified:March 29, 2004 - v2
Checksum:i0B64DF79597E0931
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BV23H3BV23_HUMAN
Ubiquitin-like protein 7
UBL7
162Annotation score:
H3BSQ2H3BSQ2_HUMAN
Ubiquitin-like protein 7
UBL7
182Annotation score:
H3BSE0H3BSE0_HUMAN
Ubiquitin-like protein 7
UBL7
114Annotation score:
H3BUV9H3BUV9_HUMAN
Ubiquitin-like protein 7
UBL7
224Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti262A → V in AAK67643 (PubMed:12644319).Curated1
Sequence conflicti272L → R in AAK67643 (PubMed:12644319).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY037166 mRNA Translation: AAK67643.1
CH471136 Genomic DNA Translation: EAW99332.1
CH471136 Genomic DNA Translation: EAW99335.1
CH471136 Genomic DNA Translation: EAW99339.1
BC007913 mRNA Translation: AAH07913.1
BC030055 mRNA Translation: AAH30055.1
BC033919 mRNA Translation: AAH33919.1
CCDSiCCDS10263.1
RefSeqiNP_001273668.1, NM_001286739.1
NP_001273669.1, NM_001286740.1
NP_001273670.1, NM_001286741.1
NP_001273671.1, NM_001286742.1
NP_116296.1, NM_032907.4
NP_957717.1, NM_201265.1
UniGeneiHs.334713

Genome annotation databases

EnsembliENST00000361351; ENSP00000354883; ENSG00000138629
ENST00000395081; ENSP00000378518; ENSG00000138629
ENST00000564488; ENSP00000454828; ENSG00000138629
ENST00000565335; ENSP00000457708; ENSG00000138629
ENST00000567435; ENSP00000457703; ENSG00000138629
GeneIDi84993
KEGGihsa:84993
UCSCiuc002axw.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY037166 mRNA Translation: AAK67643.1
CH471136 Genomic DNA Translation: EAW99332.1
CH471136 Genomic DNA Translation: EAW99335.1
CH471136 Genomic DNA Translation: EAW99339.1
BC007913 mRNA Translation: AAH07913.1
BC030055 mRNA Translation: AAH30055.1
BC033919 mRNA Translation: AAH33919.1
CCDSiCCDS10263.1
RefSeqiNP_001273668.1, NM_001286739.1
NP_001273669.1, NM_001286740.1
NP_001273670.1, NM_001286741.1
NP_001273671.1, NM_001286742.1
NP_116296.1, NM_032907.4
NP_957717.1, NM_201265.1
UniGeneiHs.334713

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CWBNMR-A336-380[»]
2DENNMR-A336-380[»]
ProteinModelPortaliQ96S82
SMRiQ96S82
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124418, 50 interactors
IntActiQ96S82, 12 interactors
STRINGi9606.ENSP00000354883

PTM databases

iPTMnetiQ96S82
PhosphoSitePlusiQ96S82

Polymorphism and mutation databases

BioMutaiUBL7
DMDMi48474599

Proteomic databases

EPDiQ96S82
MaxQBiQ96S82
PaxDbiQ96S82
PeptideAtlasiQ96S82
PRIDEiQ96S82
ProteomicsDBi78083

Protocols and materials databases

DNASUi84993
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361351; ENSP00000354883; ENSG00000138629
ENST00000395081; ENSP00000378518; ENSG00000138629
ENST00000564488; ENSP00000454828; ENSG00000138629
ENST00000565335; ENSP00000457708; ENSG00000138629
ENST00000567435; ENSP00000457703; ENSG00000138629
GeneIDi84993
KEGGihsa:84993
UCSCiuc002axw.3 human

Organism-specific databases

CTDi84993
DisGeNETi84993
EuPathDBiHostDB:ENSG00000138629.15
GeneCardsiUBL7
HGNCiHGNC:28221 UBL7
HPAiHPA040423
HPA041897
MIMi609748 gene
neXtProtiNX_Q96S82
OpenTargetsiENSG00000138629
PharmGKBiPA142670645
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ISS5 Eukaryota
ENOG410YUJQ LUCA
GeneTreeiENSGT00390000015967
HOVERGENiHBG054051
InParanoidiQ96S82
OMAiHAINLLM
OrthoDBiEOG091G0II5
PhylomeDBiQ96S82
TreeFamiTF327176

Miscellaneous databases

ChiTaRSiUBL7 human
EvolutionaryTraceiQ96S82
GenomeRNAii84993
PROiPR:Q96S82
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138629 Expressed in 186 organ(s), highest expression level in right frontal lobe
CleanExiHS_UBL7
ExpressionAtlasiQ96S82 baseline and differential
GenevisibleiQ96S82 HS

Family and domain databases

InterProiView protein in InterPro
IPR015940 UBA
IPR009060 UBA-like_sf
IPR015496 Ubiquilin
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
PANTHERiPTHR10677 PTHR10677, 1 hit
PfamiView protein in Pfam
PF00627 UBA, 1 hit
PF00240 ubiquitin, 1 hit
SMARTiView protein in SMART
SM00165 UBA, 1 hit
SM00213 UBQ, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50030 UBA, 1 hit
PS50053 UBIQUITIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUBL7_HUMAN
AccessioniPrimary (citable) accession number: Q96S82
Secondary accession number(s): D3DW57, Q96I03
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: March 29, 2004
Last modified: September 12, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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